Background:The correlation between the morphological structure of the patellofemoral joint(PFJ)and the severity of knee joint osteoarthritis(KOA)remains uncertain.This study aims to investigate the correlation between...Background:The correlation between the morphological structure of the patellofemoral joint(PFJ)and the severity of knee joint osteoarthritis(KOA)remains uncertain.This study aims to investigate the correlation between the severity of knee joint osteoarthritis and the alignment of patellofemoral and patellar height on radiographs.Methods:This multi-center,retrospective study analyzed the magnetic resonance imaging(MRI)scans and anteroposterior radiographs of 534 adult outpatients with KOA.To evaluate the radiographic severity of KOA,anteroposterior radiographs of the knee and the Kellgren-Lawrence(K-L)grade were used.Knee MRI scans were used to measure the patellar length ratio(PLR),sulcus angle(SA),lateral patellar tilt angle(LPTA),and the distance between tibial tuberosity and trochlear groove(TT-TG).We examined the association between the configuration of the PFJ,arrangement,and harshness of the KOA.Information on participants’demographics,such as age,sex,side,height,and weight,was collected.A chi-squared test was used for the correlation of radiographic severity of KOA with sex and the affected side.Spearman correlation was used for patellofemoral alignment or morphology and the radiographic severity of lateral KOA.Multiple linear regression models were used for the association between LPTA,SA,TT-TG,and severity of KOA after accounting for demographic variables.Results:The study comprised of 534 patients;of these,339(63%)were female.A total of 586 knees were evaluated in this study.Age showed a strong positive correlation with KOA severity(r=0.516,P<0.01),whereas LPTA showed a strong negative correlation(r=–0.662,P<0.01).Additionally,SA(r=0.616,P<0.05),and TT-TG showed a strong positive correlation(r=0.770,P<0.01)with tibiofemoral osteoarthritis(TFOA)severity.Multiple linear regression analysis indicated that knee osteoarthritis severity(β=–2.946,P<0.001)and side(β=–0.839,P=0.001)was associated with LPTA;knee osteoarthritis severity(β=5.032,P<0.001)and age(β=–0.095,P<0.001)was associated with SA;knee osteoarthritis severity(β=2.445,P<0.001),sex(β=–0.326,P=0.041),body mass index(β=–0.061,P=0.017)and age(β=–0.025,P<0.001)was associated with TT-TG.Conclusion:Radiographic severity of KOA was positively associated with age,SA,and TT-TG but negatively associated with LPTA.展开更多
基金supported by Shandong Province Medical and Health Science Technology Development Program(No.202104070134)the Guangxi Key Research and Development Plan(No.AB22035014)the Special Fund of Characteristic Innovation Team of the First Affiliated Hospital of Guangxi MedicalUniversity(No.YYZS2022003)
文摘Background:The correlation between the morphological structure of the patellofemoral joint(PFJ)and the severity of knee joint osteoarthritis(KOA)remains uncertain.This study aims to investigate the correlation between the severity of knee joint osteoarthritis and the alignment of patellofemoral and patellar height on radiographs.Methods:This multi-center,retrospective study analyzed the magnetic resonance imaging(MRI)scans and anteroposterior radiographs of 534 adult outpatients with KOA.To evaluate the radiographic severity of KOA,anteroposterior radiographs of the knee and the Kellgren-Lawrence(K-L)grade were used.Knee MRI scans were used to measure the patellar length ratio(PLR),sulcus angle(SA),lateral patellar tilt angle(LPTA),and the distance between tibial tuberosity and trochlear groove(TT-TG).We examined the association between the configuration of the PFJ,arrangement,and harshness of the KOA.Information on participants’demographics,such as age,sex,side,height,and weight,was collected.A chi-squared test was used for the correlation of radiographic severity of KOA with sex and the affected side.Spearman correlation was used for patellofemoral alignment or morphology and the radiographic severity of lateral KOA.Multiple linear regression models were used for the association between LPTA,SA,TT-TG,and severity of KOA after accounting for demographic variables.Results:The study comprised of 534 patients;of these,339(63%)were female.A total of 586 knees were evaluated in this study.Age showed a strong positive correlation with KOA severity(r=0.516,P<0.01),whereas LPTA showed a strong negative correlation(r=–0.662,P<0.01).Additionally,SA(r=0.616,P<0.05),and TT-TG showed a strong positive correlation(r=0.770,P<0.01)with tibiofemoral osteoarthritis(TFOA)severity.Multiple linear regression analysis indicated that knee osteoarthritis severity(β=–2.946,P<0.001)and side(β=–0.839,P=0.001)was associated with LPTA;knee osteoarthritis severity(β=5.032,P<0.001)and age(β=–0.095,P<0.001)was associated with SA;knee osteoarthritis severity(β=2.445,P<0.001),sex(β=–0.326,P=0.041),body mass index(β=–0.061,P=0.017)and age(β=–0.025,P<0.001)was associated with TT-TG.Conclusion:Radiographic severity of KOA was positively associated with age,SA,and TT-TG but negatively associated with LPTA.
