The deep convolutional neural network U-net has been introduced into adaptive subtraction, which is a critical step in effectively suppressing seismic multiples. The U-net approach has higher precision than the tradit...The deep convolutional neural network U-net has been introduced into adaptive subtraction, which is a critical step in effectively suppressing seismic multiples. The U-net approach has higher precision than the traditional linear regression approach. However, the existing 2D U-net approach with 2D data windows can not deal with elaborate discrepancies between the actual and simulated multiples along the gather direction. It may lead to erroneous preservation of primaries or generate obvious vestigial multiples, especially in complex media. To further enhance the multiple suppression accuracy, we present an adaptive subtraction approach utilizing 3D U-net architecture, which can adaptively separate primaries and multiples utilizing 3D windows. The utilization of 3D windows allows for enhanced depiction of spatial continuity and anisotropy of seismic events along the gather direction in comparison to 2D windows. The 3D U-net approach with 3D windows can more effectively preserve the continuity of primaries and manage the complex disparities between the actual and simulated multiples. The proposed 3D U-net approach exhibits 1 dB improvement in the signal-to-noise ratio compared to the 2D U-net approach, as observed in the synthesis data section, and exhibits more outstanding performance in the preservation of primaries and removal of residual multiples in both synthesis and reality data sections. Moreover, to expedite network training in our proposed 3D U-net approach we employ the transfer learning (TL) strategy by utilizing the network parameters of 3D U-net estimated in the preceding data segment as the initial network parameters of 3D U-net for the subsequent data segment. In the reality data section, the 3D U-net approach incorporating TL reduces the computational expense by 70% compared to the one without TL.展开更多
Reconstituting membrane proteins in liposomes and determining their structure is a common method for determining membrane protein structures using single-particle cryo-electron microscopy(cryo-EM).However,the strong s...Reconstituting membrane proteins in liposomes and determining their structure is a common method for determining membrane protein structures using single-particle cryo-electron microscopy(cryo-EM).However,the strong signal of liposomes under cryo-EM imaging conditions often interferes with the structural determination of the embedded membrane proteins.Here,we propose a liposome signal subtraction method based on single-particle two-dimensional(2D)classification average images,aimed at enhancing the reconstruction resolution of membrane proteins.We analyzed the signal distribution characteristics of liposomes and proteins within the 2D classification average images of protein–liposome complexes in the frequency domain.Based on this analysis,we designed a method to subtract the liposome signals from the original particle images.After the subtraction,the accuracy of single-particle three-dimensional(3D)alignment was improved,enhancing the resolution of the final 3D reconstruction.We demonstrated this method using a PIEZO1-proteoliposome dataset by improving the resolution of the PIEZO1 protein.展开更多
BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after detachment.This case innova...BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after detachment.This case innovatively used ultrasound guidance combined with digital subtraction angiography(DSA)to completely remove the occluder,accumulating some experience.CASE SUMMARY The patient underwent left atrial appendage occlusion surgery in our hospital due to atrial fibrillation.After the surgery,the occluder fell off and became free in the left ventricle,which is very dangerous.We innovatively used ultrasound guidance,combined with DSA,and interventional surgery to successfully capture the free occluder using a catcher,completely remove it,and then re implant a new left atrial appendage occluder.After the surgery,the patient recovered very well.CONCLUSION The size selection of the occluder is slightly conservative,and the shape of the left atrial appendage opening is irregular.展开更多
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of d...BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS procedure.METHODS We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided group.Our analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the surgery.RESULTS The study included 52 patients with esophagogastric varices due to chronic hepatic schistosomiasis.Results demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided group.Additionally,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both groups.Notably,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.展开更多
Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , ...Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , for instance 5, ), an even number divisible by 3 and 2, and Group 2 for all primes that are after ζ (such that , for instance 7), then we find a simple function: for each prime in each group, , where n is any natural number. If we start a sequence of primes with 5 for Group 1 and 7 for Group 2, we can attribute a μ value for each prime. The μ value can be attributed to every prime greater than 7. Thus for Group 1, and . Using this formula, all the primes appear for , where μ is any natural number.展开更多
Drought risk assessment plays a crucial role in effective drought management.However,it is often challenging due to the intricate relationships among various indicators and the lack of practical guidance.This study pr...Drought risk assessment plays a crucial role in effective drought management.However,it is often challenging due to the intricate relationships among various indicators and the lack of practical guidance.This study presents a drought risk assessment model developed using the Semi-partial Quadratic Subtraction Set Pair Potential(SQSSPP)method,which is derived from the theory of set pair analysis.The indicator system comprises 21 indicators divided into four subsystems.The SQSSPP method utilizes uncertainty information in the overall development trend of regional drought risk states by extracting connection numbers from the Sub-traction Set Pair Potential(SSPP),improving the reliability of evaluation results.The SQSSPP method is validated through a case study of Suzhou City,China,from 2007 to 2017.Three grades are used to evaluate comprehensive drought risk.The result shows an overall decreasing trend over time,with a level III risk in 2010 and consistently at level II from 2011 to 2017.Indicators in the hazard and resilience subsystems are the primary factors influencing drought risk in the Suzhou City.Specific indicators requiring emphasis for improvement are identified,including arable land rate,agricultural population ratio,reservoir regulation rate,current water supply capacity,and irrigation index.The SQSSPP method not only provides targeted drought risk assessment but also provides valuable guidance for future water resource management.While the study focuses on Suzhou City,the proposed approach is applicable to broader-scale risk management evaluations and practices.展开更多
基金supported by National Natural Science Foundation of China(42364008,41804110)in part by Guizhou Provincial Basic Research Program(Natural Science)(ZK[2022]060)+1 种基金in part by China Postdoctoral Science Foundation(2022M723127)in part by Youth Innovation Team Project of Shandong Provincial Education Department(2022KJ141).
文摘The deep convolutional neural network U-net has been introduced into adaptive subtraction, which is a critical step in effectively suppressing seismic multiples. The U-net approach has higher precision than the traditional linear regression approach. However, the existing 2D U-net approach with 2D data windows can not deal with elaborate discrepancies between the actual and simulated multiples along the gather direction. It may lead to erroneous preservation of primaries or generate obvious vestigial multiples, especially in complex media. To further enhance the multiple suppression accuracy, we present an adaptive subtraction approach utilizing 3D U-net architecture, which can adaptively separate primaries and multiples utilizing 3D windows. The utilization of 3D windows allows for enhanced depiction of spatial continuity and anisotropy of seismic events along the gather direction in comparison to 2D windows. The 3D U-net approach with 3D windows can more effectively preserve the continuity of primaries and manage the complex disparities between the actual and simulated multiples. The proposed 3D U-net approach exhibits 1 dB improvement in the signal-to-noise ratio compared to the 2D U-net approach, as observed in the synthesis data section, and exhibits more outstanding performance in the preservation of primaries and removal of residual multiples in both synthesis and reality data sections. Moreover, to expedite network training in our proposed 3D U-net approach we employ the transfer learning (TL) strategy by utilizing the network parameters of 3D U-net estimated in the preceding data segment as the initial network parameters of 3D U-net for the subsequent data segment. In the reality data section, the 3D U-net approach incorporating TL reduces the computational expense by 70% compared to the one without TL.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.32241023 and 92254306)the Fund from the Tsinghua–Peking Joint Center for Life SciencesBeijing Frontier Research Center for Biological Structure。
文摘Reconstituting membrane proteins in liposomes and determining their structure is a common method for determining membrane protein structures using single-particle cryo-electron microscopy(cryo-EM).However,the strong signal of liposomes under cryo-EM imaging conditions often interferes with the structural determination of the embedded membrane proteins.Here,we propose a liposome signal subtraction method based on single-particle two-dimensional(2D)classification average images,aimed at enhancing the reconstruction resolution of membrane proteins.We analyzed the signal distribution characteristics of liposomes and proteins within the 2D classification average images of protein–liposome complexes in the frequency domain.Based on this analysis,we designed a method to subtract the liposome signals from the original particle images.After the subtraction,the accuracy of single-particle three-dimensional(3D)alignment was improved,enhancing the resolution of the final 3D reconstruction.We demonstrated this method using a PIEZO1-proteoliposome dataset by improving the resolution of the PIEZO1 protein.
文摘BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after detachment.This case innovatively used ultrasound guidance combined with digital subtraction angiography(DSA)to completely remove the occluder,accumulating some experience.CASE SUMMARY The patient underwent left atrial appendage occlusion surgery in our hospital due to atrial fibrillation.After the surgery,the occluder fell off and became free in the left ventricle,which is very dangerous.We innovatively used ultrasound guidance,combined with DSA,and interventional surgery to successfully capture the free occluder using a catcher,completely remove it,and then re implant a new left atrial appendage occluder.After the surgery,the patient recovered very well.CONCLUSION The size selection of the occluder is slightly conservative,and the shape of the left atrial appendage opening is irregular.
基金Jinshan Science and Technology Committee(the data collection for this study was partially funded by the project),No.2021-3-05.
文摘BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a pivotal intervention for managing esophagogastric variceal bleeding in patients with chronic hepatic schistosomiasis.AIM To evaluate the efficacy of digital subtraction angiography image overlay tech-nology(DIT)in guiding the TIPS procedure.METHODS We conducted a retrospective analysis of patients who underwent TIPS at our hospital,comparing outcomes between an ultrasound-guided group and a DIT-guided group.Our analysis focused on the duration of the portosystemic shunt puncture,the number of punctures needed,the total surgical time,and various clinical indicators related to the surgery.RESULTS The study included 52 patients with esophagogastric varices due to chronic hepatic schistosomiasis.Results demonstrated that the DIT-guided group expe-rienced significantly shorter puncture times(P<0.001)and surgical durations(P=0.022)compared to the ultrasound-guided group.Additionally,postoperative assessments showed significant reductions in aspartate aminotransferase,B-type natriuretic peptide,and portal vein pressure in both groups.Notably,the DIT-guided group also showed significant reductions in total bilirubin(P=0.001)and alanine aminotransferase(P=0.023).CONCLUSION The use of DIT for guiding TIPS procedures highlights its potential to enhance procedural efficiency and reduce surgical times in the treatment of esophagogastric variceal bleeding in patients with chronic hepatic schistoso-miasis.
文摘Are all prime numbers linked by four simple functions? Can we predict when a prime will appear in a sequence of primes? If we classify primes into two groups, Group 1 for all primes that appear before ζ (such that , for instance 5, ), an even number divisible by 3 and 2, and Group 2 for all primes that are after ζ (such that , for instance 7), then we find a simple function: for each prime in each group, , where n is any natural number. If we start a sequence of primes with 5 for Group 1 and 7 for Group 2, we can attribute a μ value for each prime. The μ value can be attributed to every prime greater than 7. Thus for Group 1, and . Using this formula, all the primes appear for , where μ is any natural number.
基金Natural Science Foundation of Anhui Province,Grant/Award Numbers:2308085US13,2208085US03National Natural Science Foundation of China,Grant/Award Number:U2243228+1 种基金the Belt and Road Special Foundation of the National Key Laboratory of Water Disaster Prevention,Grant/Award Number:2022nkms04The Ministry of Education of Humanities and Social Science Project,Grant/Award Number:23YJCZH332。
文摘Drought risk assessment plays a crucial role in effective drought management.However,it is often challenging due to the intricate relationships among various indicators and the lack of practical guidance.This study presents a drought risk assessment model developed using the Semi-partial Quadratic Subtraction Set Pair Potential(SQSSPP)method,which is derived from the theory of set pair analysis.The indicator system comprises 21 indicators divided into four subsystems.The SQSSPP method utilizes uncertainty information in the overall development trend of regional drought risk states by extracting connection numbers from the Sub-traction Set Pair Potential(SSPP),improving the reliability of evaluation results.The SQSSPP method is validated through a case study of Suzhou City,China,from 2007 to 2017.Three grades are used to evaluate comprehensive drought risk.The result shows an overall decreasing trend over time,with a level III risk in 2010 and consistently at level II from 2011 to 2017.Indicators in the hazard and resilience subsystems are the primary factors influencing drought risk in the Suzhou City.Specific indicators requiring emphasis for improvement are identified,including arable land rate,agricultural population ratio,reservoir regulation rate,current water supply capacity,and irrigation index.The SQSSPP method not only provides targeted drought risk assessment but also provides valuable guidance for future water resource management.While the study focuses on Suzhou City,the proposed approach is applicable to broader-scale risk management evaluations and practices.
