In this study,we examine the problem of sliced inverse regression(SIR),a widely used method for sufficient dimension reduction(SDR).It was designed to find reduced-dimensional versions of multivariate predictors by re...In this study,we examine the problem of sliced inverse regression(SIR),a widely used method for sufficient dimension reduction(SDR).It was designed to find reduced-dimensional versions of multivariate predictors by replacing them with a minimally adequate collection of their linear combinations without loss of information.Recently,regularization methods have been proposed in SIR to incorporate a sparse structure of predictors for better interpretability.However,existing methods consider convex relaxation to bypass the sparsity constraint,which may not lead to the best subset,and particularly tends to include irrelevant variables when predictors are correlated.In this study,we approach sparse SIR as a nonconvex optimization problem and directly tackle the sparsity constraint by establishing the optimal conditions and iteratively solving them by means of the splicing technique.Without employing convex relaxation on the sparsity constraint and the orthogonal constraint,our algorithm exhibits superior empirical merits,as evidenced by extensive numerical studies.Computationally,our algorithm is much faster than the relaxed approach for the natural sparse SIR estimator.Statistically,our algorithm surpasses existing methods in terms of accuracy for central subspace estimation and best subset selection and sustains high performance even with correlated predictors.展开更多
BACKGROUND Patients with acute-on-chronic liver failure(ACLF)experience severe immune dysfunction.Liver transplantation(LT)significantly improves survival outcomes.However,the characteristics of peripheral blood lymph...BACKGROUND Patients with acute-on-chronic liver failure(ACLF)experience severe immune dysfunction.Liver transplantation(LT)significantly improves survival outcomes.However,the characteristics of peripheral blood lymphocyte subsets(PBLSs)in this patient population are not well defined,and the dynamics of immune reconstitution post-LT are insufficiently understood.AIM To characterize PBLSs in patients with ACLF prior to LT and to evaluate PBLS reconstitution after LT.METHODS Clinical data from patients undergoing LT in the Transplantation Center,The Third Xiangya Hospital from January 2022 to December 2023 were analyzed retrospectively.Our cohort comprised 44 patients with ACLF,16 patients with acute decompensation of cirrhosis,and 23 patients with compensated cirrhosis.Twenty healthy volunteers were included as controls.PBLSs were evaluated across all groups.The relationship between PBLSs and post-LT prognosis was assessed,and dynamic changes in PBLSs among patients with ACLF were analyzed at different time points.RESULTS Patients with ACLF exhibited a marked reduction in PBLSs compared with healthy volunteers.Natural killer(NK)cell counts were further reduced in patients with ACLF when compared with patients with compensated cirrhosis.PBLSs did not correlate with the etiology or severity of ACLF or with established liver failure scores.Following LT,a rapid restoration of NK cells and B cells was observed in patients with ACLF.However,the cluster of differentiation(CD)3+T cell and CD4+T cell counts decreased 14 days post-LT and subsequently returned to preoperative levels by day 21.CONCLUSION Patients with ACLF exhibited markedly reduced PBLSs,with decreased NK cells potentially linked to progression from compensated cirrhosis to liver failure.NK and B cell were rapidly restored after LT.展开更多
In modal logic,topological semantics is an intuitive and natural special case of neighbourhood semantics.This paper stems from the observation that the satisfaction relation of topological semantics applies to subset ...In modal logic,topological semantics is an intuitive and natural special case of neighbourhood semantics.This paper stems from the observation that the satisfaction relation of topological semantics applies to subset spaces which are more general than topological spaces.The minimal modal logic which is strongly sound and complete with respect to the class of subset spaces is found.Soundness and completeness results of some famous modal logics(e.g.S4,S5 and Tr)with respect to various important classes of subset spaces(eg intersection structures and complete fields of sets)are also proved.In the meantime,some known results,e.g.the soundness and completeness of Tr with respect to the class of discrete topological spaces,are proved directly using some modifications of the method of canonical mode1,without a detour via neighbourhood semantics or relational semantics.展开更多
The stratospheric airship is affected by harsh conditions in the stratosphere environment.To ensure the safety of the airship,it is necessary to detect the material state of the airship envelope.Since digital image co...The stratospheric airship is affected by harsh conditions in the stratosphere environment.To ensure the safety of the airship,it is necessary to detect the material state of the airship envelope.Since digital image correlation possesses non-contact strain measurement ability,this paper explores the infuence of different shapes of the subset on measurement accuracy.Through the results,it is found that increasing the aspect ratio of subsets can improve the strain accuracy measured in the c-direction,and reducing the aspect ratio can improve the strain accuracy measured in the y-direction.This trend becomes more obvious as the strain increases.Based on this discovery,a subset adaptive algorithm is proposed.The feasibility of the algorithm is verified by experiments,and the precision of strain measurement can be effectively improved by adjusting the threshold value.Therefore,the algorithm can be utilized to increase the measurement accuracy in the larger strain direction without changing the size of the subset.展开更多
BACKGROUND Advanced gastric cancer(AGC)remains a challenging malignancy with poor prognosis.The combination of oxaliplatin and trastuzumab has shown promising results in AGC treatment.This study aimed to investigate t...BACKGROUND Advanced gastric cancer(AGC)remains a challenging malignancy with poor prognosis.The combination of oxaliplatin and trastuzumab has shown promising results in AGC treatment.This study aimed to investigate the effects of oxaliplatin and trastuzumab combination therapy on serum tumor markers and T lymphocyte subsets in patients with AGC and to explore their potential as predictive biomarkers for treatment response.AIM To investigate the impact of oxaliplatin and trastuzumab combination therapy on serum markers and T cell subsets in patients with AGC.METHODS This prospective study enrolled 60 patients with AGC.All patients received oxaliplatin(130 mg/m^(2),every 3 weeks)and trastuzumab(8 mg/kg loading dose,followed by 6 mg/kg every 3 weeks)for six cycles.Serum carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9),and cancer antigen 72-4(CA72-4)were measured before and after treatment.T-lymphocyte subsets,including CD3+,CD4+,CD8+,and CD4+/CD8+ratios,were also evaluated.The clinical response was assessed using the Response Evaluation Criteria in Solid Tumors version 1.1.RESULTS After six cycles of treatment,the CEA,CA19-9,and CA72-4 serum levels significantly decreased compared to baseline levels(P<0.001).The percentages of CD3+and CD4+T lymphocytes increased significantly(P<0.05),whereas the percentage of CD8+T lymphocytes decreased(P<0.05).The CD4+/CD8+ratio also significantly increased after treatment(P<0.05).Patients with a higher decrease in serum tumor markers(≥50%reduction)and a higher increase in CD4+/CD8+ratio(≥1.5-fold)showed better clinical response rates(P<0.05).CONCLUSION Oxaliplatin and trastuzumab combination therapy effectively reduced serum tumor marker levels and modulated T lymphocyte subsets in patients with AGC.Combination therapy not only has a direct antitumor effect,but also enhances the immune response in patients with AGC.Serum tumor markers and T lymphocyte subsets may serve as potential predictive biomarkers for treatment response in patients with AGC receiving combination therapy.展开更多
The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation networks.This study introduces a comprehensive methodology...The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation networks.This study introduces a comprehensive methodology for soil slope stability evaluation,employing Monte Carlo Simulation(MCS)and Subset Simulation(SS)with the"UPSS 3.0 Add-in"in MS-Excel.Focused on an 11.693-meter embankment with a soil slope(inclination ratio of 2H:1V),the investigation considers earthquake coefficients(kh)and pore water pressure ratios(ru)following Indian zoning requirements.The chance of slope failure showed a considerable increase as the Coefficient of Variation(COV),seismic coefficients(kh),and pore water pressure ratios(ru)experienced an escalation.The SS approach showed exceptional efficacy in calculating odds of failure that are notably low.Within computational modeling,the study optimized the worst-case scenario using ANFIS-GA,ANFIS-GWO,ANFIS-PSO,and ANFIS-BBO models.The ANFIS-PSO model exhibits exceptional accuracy(training R2=0.9011,RMSE=0.0549;testing R2=0.8968,RMSE=0.0615),emerging as the most promising.This study highlights the significance of conducting thorough risk assessments and offers practical insights into evaluating and improving the stability of soil slopes in transportation infrastructure.These findings contribute to the enhancement of safety and reliability in real-world situations.展开更多
This article compares the size of selected subsets using nonparametric subset selection rules with two different scoring rules for the observations. The scoring rules are based on the expected values of order statisti...This article compares the size of selected subsets using nonparametric subset selection rules with two different scoring rules for the observations. The scoring rules are based on the expected values of order statistics of the uniform distribution (yielding rank values) and of the normal distribution (yielding normal score values). The comparison is made using state motor vehicle traffic fatality rates, published in a 2016 article, with fifty-one states (including DC as a state) and over a nineteen-year period (1994 through 2012). The earlier study considered four block design selection rules—two for choosing a subset to contain the “best” population (i.e., state with lowest mean fatality rate) and two for the “worst” population (i.e., highest mean rate) with a probability of correct selection chosen to be 0.90. Two selection rules based on normal scores resulted in selected subset sizes substantially smaller than corresponding rules based on ranks (7 vs. 16 and 3 vs. 12). For two other selection rules, the subsets chosen were very close in size (within one). A comparison is also made using state homicide rates, published in a 2022 article, with fifty states and covering eight years. The results are qualitatively the same as those obtained with the motor vehicle traffic fatality rates.展开更多
Objective:To study the effect of Helicobacter pylori infection on rheumatoid arthritis and T-lymphocyte subpopulations in patients with rheumatoid arthritis and to provide a new method for the treatment of rheumatoid ...Objective:To study the effect of Helicobacter pylori infection on rheumatoid arthritis and T-lymphocyte subpopulations in patients with rheumatoid arthritis and to provide a new method for the treatment of rheumatoid arthritis by removing Helicobacter pylori from patients.Methods:60 patients with rheumatoid arthritis admitted to the hospital from May 2022 to May 2023 were selected for the study,and all patients underwent a 13-carbon urea breath test to detect gastric H.pylori and the test results showed that 20 cases were negative and 40 cases were positive.The 40 positive patients were divided into the treatment group(n=20)and non-treatment group(n=20)by random number table method and the treatment group was given anti-Helicobacter pylori treatment,and the non-treatment group was given maintenance rheumatoid basic treatment,comparing the anti-cyclic citrulline peptide(CCP),DS28 score,peripheral blood T-lymphocyte subsets(CD4^(+)T-lymphocytes,CD8^(+)T-lymphocytes,CD4^(+)/CD8^(+)ratio)before and after the treatment of patients by 13-carbon urea respiration test(pylori-negative group,20 patients)and those who were positive for the treatment of H pylori(pylori-positive group,40 patients).Besides,the correlation of peripheral blood T-lymphocyte subsets and disease activity between treatment and non-treatment groups in the pylori-positive group was identified together with the correlation of DS28 scores,TNF-αlevels,sedimentation and immunoglobulin,lymphocyte subsets in the pylori-positive treatment group and positive non-treatment group as well as the level of globulin,lymphocyte subsets,and peripheral blood lymphocytes before and after treatment.Results:Before treatment,CCP,DS28 score,CD8^(+)T lymphocyte level of the pylori-negative group were lower than that of the positive group,and CD4^(+)T lymphocyte and CD4^(+)/CD8^(+)ratio were higher than that of the positive group(P<0.05);after treatment,the indexes of the pylori-positive group improved,and there was no significant difference in the comparison of the indexes with those of the pylori-negative group(P>0.05);the positive treatment group had a DS28(3.19±1.02)points,positive non-treatment group DS28(5.36±1.85)points,non-treatment group DS28 score and CD4^(+)T lymphocytes,CD4^(+)/CD8^(+)negative correlation with CD8^(+)T lymphocytes showed a positive correlation(P<0.05);before the treatment,pylori-positive treatment group and non-treatment group DS28 scores,TNF-αlevels,peripheral blood T lymphocyte subpopulation levels were not significantly different(P>0.05);after treatment,DS28 score,TNF-αlevel,CD8^(+)T of the treatment group were lower than those of the non-treatment group,and CD4^(+)T lymphocytes and CD4^(+)/CD8^(+)ratio were higher than those of the non-treatment group(P<0.05).Conclusion:H.pylori affects the level of T lymphocyte subsets in patients with rheumatoid arthritis,and there is a certain correlation between the two.Removal of H.pylori can improve the level of T lymphocyte subsets,which is important for the treatment of patients with rheumatoid arthritis.展开更多
隐私集合交集(private set intersection,PSI)协议一直是解决用户隐私保护需求和合作共享需求间矛盾的有效工具.面对计算资源受限场景下的多方求交计算,本文提出了支持子集匹配且可验证的云辅助多方PSI协议(tag-based and verifiable cl...隐私集合交集(private set intersection,PSI)协议一直是解决用户隐私保护需求和合作共享需求间矛盾的有效工具.面对计算资源受限场景下的多方求交计算,本文提出了支持子集匹配且可验证的云辅助多方PSI协议(tag-based and verifiable cloud-assisted multi-party PSI,TVC-MPSI).首先,TVC-MPSI应用星型网络拓扑结构,增加对单个云服务器的安全要求,仅利用密文交集基数和交集的多项式形式确保了交集的可验证性;其次,当客户端的集合包含多个子集时,引入了Pedersen门限可验证的秘密共享技术来实现对集合子集的匹配,从而实现细粒度的交集运算;除此之外,引入基于RSA的局部可验证签名算法(local verifiable aggregate signatures,LVS),保证云服务器端和客户端身份的不可伪造性;最后,通过正确性和安全性分析,以及全面的性能对比,表明协议在保证安全性的同时拥有较好的性能.展开更多
文摘In this study,we examine the problem of sliced inverse regression(SIR),a widely used method for sufficient dimension reduction(SDR).It was designed to find reduced-dimensional versions of multivariate predictors by replacing them with a minimally adequate collection of their linear combinations without loss of information.Recently,regularization methods have been proposed in SIR to incorporate a sparse structure of predictors for better interpretability.However,existing methods consider convex relaxation to bypass the sparsity constraint,which may not lead to the best subset,and particularly tends to include irrelevant variables when predictors are correlated.In this study,we approach sparse SIR as a nonconvex optimization problem and directly tackle the sparsity constraint by establishing the optimal conditions and iteratively solving them by means of the splicing technique.Without employing convex relaxation on the sparsity constraint and the orthogonal constraint,our algorithm exhibits superior empirical merits,as evidenced by extensive numerical studies.Computationally,our algorithm is much faster than the relaxed approach for the natural sparse SIR estimator.Statistically,our algorithm surpasses existing methods in terms of accuracy for central subspace estimation and best subset selection and sustains high performance even with correlated predictors.
基金Supported by the National Natural Science Foundation of China,No.82300857.
文摘BACKGROUND Patients with acute-on-chronic liver failure(ACLF)experience severe immune dysfunction.Liver transplantation(LT)significantly improves survival outcomes.However,the characteristics of peripheral blood lymphocyte subsets(PBLSs)in this patient population are not well defined,and the dynamics of immune reconstitution post-LT are insufficiently understood.AIM To characterize PBLSs in patients with ACLF prior to LT and to evaluate PBLS reconstitution after LT.METHODS Clinical data from patients undergoing LT in the Transplantation Center,The Third Xiangya Hospital from January 2022 to December 2023 were analyzed retrospectively.Our cohort comprised 44 patients with ACLF,16 patients with acute decompensation of cirrhosis,and 23 patients with compensated cirrhosis.Twenty healthy volunteers were included as controls.PBLSs were evaluated across all groups.The relationship between PBLSs and post-LT prognosis was assessed,and dynamic changes in PBLSs among patients with ACLF were analyzed at different time points.RESULTS Patients with ACLF exhibited a marked reduction in PBLSs compared with healthy volunteers.Natural killer(NK)cell counts were further reduced in patients with ACLF when compared with patients with compensated cirrhosis.PBLSs did not correlate with the etiology or severity of ACLF or with established liver failure scores.Following LT,a rapid restoration of NK cells and B cells was observed in patients with ACLF.However,the cluster of differentiation(CD)3+T cell and CD4+T cell counts decreased 14 days post-LT and subsequently returned to preoperative levels by day 21.CONCLUSION Patients with ACLF exhibited markedly reduced PBLSs,with decreased NK cells potentially linked to progression from compensated cirrhosis to liver failure.NK and B cell were rapidly restored after LT.
基金supported by the National Social Science Fund of China(No.20CZX048)。
文摘In modal logic,topological semantics is an intuitive and natural special case of neighbourhood semantics.This paper stems from the observation that the satisfaction relation of topological semantics applies to subset spaces which are more general than topological spaces.The minimal modal logic which is strongly sound and complete with respect to the class of subset spaces is found.Soundness and completeness results of some famous modal logics(e.g.S4,S5 and Tr)with respect to various important classes of subset spaces(eg intersection structures and complete fields of sets)are also proved.In the meantime,some known results,e.g.the soundness and completeness of Tr with respect to the class of discrete topological spaces,are proved directly using some modifications of the method of canonical mode1,without a detour via neighbourhood semantics or relational semantics.
文摘The stratospheric airship is affected by harsh conditions in the stratosphere environment.To ensure the safety of the airship,it is necessary to detect the material state of the airship envelope.Since digital image correlation possesses non-contact strain measurement ability,this paper explores the infuence of different shapes of the subset on measurement accuracy.Through the results,it is found that increasing the aspect ratio of subsets can improve the strain accuracy measured in the c-direction,and reducing the aspect ratio can improve the strain accuracy measured in the y-direction.This trend becomes more obvious as the strain increases.Based on this discovery,a subset adaptive algorithm is proposed.The feasibility of the algorithm is verified by experiments,and the precision of strain measurement can be effectively improved by adjusting the threshold value.Therefore,the algorithm can be utilized to increase the measurement accuracy in the larger strain direction without changing the size of the subset.
文摘BACKGROUND Advanced gastric cancer(AGC)remains a challenging malignancy with poor prognosis.The combination of oxaliplatin and trastuzumab has shown promising results in AGC treatment.This study aimed to investigate the effects of oxaliplatin and trastuzumab combination therapy on serum tumor markers and T lymphocyte subsets in patients with AGC and to explore their potential as predictive biomarkers for treatment response.AIM To investigate the impact of oxaliplatin and trastuzumab combination therapy on serum markers and T cell subsets in patients with AGC.METHODS This prospective study enrolled 60 patients with AGC.All patients received oxaliplatin(130 mg/m^(2),every 3 weeks)and trastuzumab(8 mg/kg loading dose,followed by 6 mg/kg every 3 weeks)for six cycles.Serum carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9),and cancer antigen 72-4(CA72-4)were measured before and after treatment.T-lymphocyte subsets,including CD3+,CD4+,CD8+,and CD4+/CD8+ratios,were also evaluated.The clinical response was assessed using the Response Evaluation Criteria in Solid Tumors version 1.1.RESULTS After six cycles of treatment,the CEA,CA19-9,and CA72-4 serum levels significantly decreased compared to baseline levels(P<0.001).The percentages of CD3+and CD4+T lymphocytes increased significantly(P<0.05),whereas the percentage of CD8+T lymphocytes decreased(P<0.05).The CD4+/CD8+ratio also significantly increased after treatment(P<0.05).Patients with a higher decrease in serum tumor markers(≥50%reduction)and a higher increase in CD4+/CD8+ratio(≥1.5-fold)showed better clinical response rates(P<0.05).CONCLUSION Oxaliplatin and trastuzumab combination therapy effectively reduced serum tumor marker levels and modulated T lymphocyte subsets in patients with AGC.Combination therapy not only has a direct antitumor effect,but also enhances the immune response in patients with AGC.Serum tumor markers and T lymphocyte subsets may serve as potential predictive biomarkers for treatment response in patients with AGC receiving combination therapy.
文摘The maintenance of safety and dependability in rail and road embankments is of utmost importance in order to facilitate the smooth operation of transportation networks.This study introduces a comprehensive methodology for soil slope stability evaluation,employing Monte Carlo Simulation(MCS)and Subset Simulation(SS)with the"UPSS 3.0 Add-in"in MS-Excel.Focused on an 11.693-meter embankment with a soil slope(inclination ratio of 2H:1V),the investigation considers earthquake coefficients(kh)and pore water pressure ratios(ru)following Indian zoning requirements.The chance of slope failure showed a considerable increase as the Coefficient of Variation(COV),seismic coefficients(kh),and pore water pressure ratios(ru)experienced an escalation.The SS approach showed exceptional efficacy in calculating odds of failure that are notably low.Within computational modeling,the study optimized the worst-case scenario using ANFIS-GA,ANFIS-GWO,ANFIS-PSO,and ANFIS-BBO models.The ANFIS-PSO model exhibits exceptional accuracy(training R2=0.9011,RMSE=0.0549;testing R2=0.8968,RMSE=0.0615),emerging as the most promising.This study highlights the significance of conducting thorough risk assessments and offers practical insights into evaluating and improving the stability of soil slopes in transportation infrastructure.These findings contribute to the enhancement of safety and reliability in real-world situations.
文摘This article compares the size of selected subsets using nonparametric subset selection rules with two different scoring rules for the observations. The scoring rules are based on the expected values of order statistics of the uniform distribution (yielding rank values) and of the normal distribution (yielding normal score values). The comparison is made using state motor vehicle traffic fatality rates, published in a 2016 article, with fifty-one states (including DC as a state) and over a nineteen-year period (1994 through 2012). The earlier study considered four block design selection rules—two for choosing a subset to contain the “best” population (i.e., state with lowest mean fatality rate) and two for the “worst” population (i.e., highest mean rate) with a probability of correct selection chosen to be 0.90. Two selection rules based on normal scores resulted in selected subset sizes substantially smaller than corresponding rules based on ranks (7 vs. 16 and 3 vs. 12). For two other selection rules, the subsets chosen were very close in size (within one). A comparison is also made using state homicide rates, published in a 2022 article, with fifty states and covering eight years. The results are qualitatively the same as those obtained with the motor vehicle traffic fatality rates.
文摘Objective:To study the effect of Helicobacter pylori infection on rheumatoid arthritis and T-lymphocyte subpopulations in patients with rheumatoid arthritis and to provide a new method for the treatment of rheumatoid arthritis by removing Helicobacter pylori from patients.Methods:60 patients with rheumatoid arthritis admitted to the hospital from May 2022 to May 2023 were selected for the study,and all patients underwent a 13-carbon urea breath test to detect gastric H.pylori and the test results showed that 20 cases were negative and 40 cases were positive.The 40 positive patients were divided into the treatment group(n=20)and non-treatment group(n=20)by random number table method and the treatment group was given anti-Helicobacter pylori treatment,and the non-treatment group was given maintenance rheumatoid basic treatment,comparing the anti-cyclic citrulline peptide(CCP),DS28 score,peripheral blood T-lymphocyte subsets(CD4^(+)T-lymphocytes,CD8^(+)T-lymphocytes,CD4^(+)/CD8^(+)ratio)before and after the treatment of patients by 13-carbon urea respiration test(pylori-negative group,20 patients)and those who were positive for the treatment of H pylori(pylori-positive group,40 patients).Besides,the correlation of peripheral blood T-lymphocyte subsets and disease activity between treatment and non-treatment groups in the pylori-positive group was identified together with the correlation of DS28 scores,TNF-αlevels,sedimentation and immunoglobulin,lymphocyte subsets in the pylori-positive treatment group and positive non-treatment group as well as the level of globulin,lymphocyte subsets,and peripheral blood lymphocytes before and after treatment.Results:Before treatment,CCP,DS28 score,CD8^(+)T lymphocyte level of the pylori-negative group were lower than that of the positive group,and CD4^(+)T lymphocyte and CD4^(+)/CD8^(+)ratio were higher than that of the positive group(P<0.05);after treatment,the indexes of the pylori-positive group improved,and there was no significant difference in the comparison of the indexes with those of the pylori-negative group(P>0.05);the positive treatment group had a DS28(3.19±1.02)points,positive non-treatment group DS28(5.36±1.85)points,non-treatment group DS28 score and CD4^(+)T lymphocytes,CD4^(+)/CD8^(+)negative correlation with CD8^(+)T lymphocytes showed a positive correlation(P<0.05);before the treatment,pylori-positive treatment group and non-treatment group DS28 scores,TNF-αlevels,peripheral blood T lymphocyte subpopulation levels were not significantly different(P>0.05);after treatment,DS28 score,TNF-αlevel,CD8^(+)T of the treatment group were lower than those of the non-treatment group,and CD4^(+)T lymphocytes and CD4^(+)/CD8^(+)ratio were higher than those of the non-treatment group(P<0.05).Conclusion:H.pylori affects the level of T lymphocyte subsets in patients with rheumatoid arthritis,and there is a certain correlation between the two.Removal of H.pylori can improve the level of T lymphocyte subsets,which is important for the treatment of patients with rheumatoid arthritis.
