Objective:To examine the relationship between metabolic syndrome(MS)and its key components in granulomatous mastitis(GM),we explored potential pathological mechanisms through the lens of traditional Chinese medicine(T...Objective:To examine the relationship between metabolic syndrome(MS)and its key components in granulomatous mastitis(GM),we explored potential pathological mechanisms through the lens of traditional Chinese medicine(TCM),particularly the concept of intermingled phlegm-blood stasis.Methods:In this retrospective study,we enrolled 172 patients with GM and 164 patients with non-inflammatory benign breast masses.Metabolic indicators(waist circumference[WC],blood lipids,etc.),inflammatory markers(C-reactive protein,interleukin-6,tumor necrosis factor-α),and adipose tissue CD68 expression were measured.Logistic regression was used to analyze risk factors and receiver operating characteristic curves were used to evaluate diagnostic efficacy.The correlation between TCM pathogenesis and biomarkers was also examined.Results:MS prevalence was significantly higher in the GM group than in the controls(26.16%vs.6.10%,P<.001).Multivariate analysis identified abdominal obesity(WC≥80 cm,odds ratio[OR]=1.065)and low levels of high-density lipoprotein cholesterol(HDL-C;<1.29 mmol/L,OR=0.066)as independent risk factors for GM(P<.001 for both).Among patients with GM,HDL-C levels were inversely correlated with inflammatory markers(r=−0.341 to−0.440),whereas patients with concurrent MS demonstrated greater CD68 macrophage infiltration(P<.001).According to TCM,abdominal obesity corresponds to“spleen deficiency with phlegm-dampness accumulation,”and low HDL-C reflects“deficiency of vital qi,”which collectively lead to phlegm-blood stasis obstruction in the mammary collaterals;this aligns with the key MS driving mechanisms of chronic inflammation and immune dysregulation.Conclusion:MS promotes GM development through chronic inflammation and immune dysregulation,with abdominal obesity and low HDL-C levels serving as core risk factors.The TCM theory of intermingled phlegm-blood stasis provides a novel interpretation of the metabolic-inflammatory mechanisms underlying GM.Accordingly,we propose phlegm-resolving and blood-activating strategies as potential therapeutic approaches for metabolic-immune axis regulation.展开更多
Accurately predicting relative permeability is an important issue in the research of multiphase flow in tight reservoirs.Existing predictive models typically rely on the capillary tube bundle model featuring circular ...Accurately predicting relative permeability is an important issue in the research of multiphase flow in tight reservoirs.Existing predictive models typically rely on the capillary tube bundle model featuring circular cross-sections,often overlooking the impact of pore geometry on fluid flow behavior within reservoirs.In this work,the intermingled fractal theory of porous media is introduced to characterize the intricate local features within the internal space of tight rocks.Initially,iterative rules for diverse fractal units are skillfully designed to capture the actual characteristics of pore cross-sectional shapes.Subsequently,analytical relationships are derived between the iterative parameters and the area,wetted perimeter,and hydraulic diameter of pores generated by these units,followed by the establishment of a relative permeability model that considers pore geometry.The model's validity is confirmed through comparisons with experimental data and published relative permeability models,with correlation coefficients exceeding 0.996.Finally,various factors affecting two-phase flow characteristics are analyzed.The results reveal that pore geometry has a significant impact on flow behavior in porous media.Assuming that the flow channels are cylindrical typically leads to an overestimation of permeability,with the maximum relative error reaching 46.91%.Additionally,the tortuosity fractal dimension is a determinant factor influencing the relative permeability of both wetting and nonwetting fluids,and the phase permeability is sensitive to variations in solid particle size and porosity.The proposed intermingled fractal model enhances the accuracy of evaluating fluid flow characteristics in microscale pore channels and offers a novel framework for simulating porous media with complex geometries.展开更多
Objective To scrutinize the effect of growth factors resulting from the intermingled skin graft onwound healing. Methods By means of RT-PCR technique, mRNA expressions of TGFα, TGFβ1, PDGF andbFGF of autografts and ...Objective To scrutinize the effect of growth factors resulting from the intermingled skin graft onwound healing. Methods By means of RT-PCR technique, mRNA expressions of TGFα, TGFβ1, PDGF andbFGF of autografts and allografts on burnt rats were quantitatively analysed. Results (1) mRNA expressions ofall the four growth factors mentioned above were found both in allografts and autografts, the expressions beinghigher in autografts than allografts; (2) In autografts, TGFα expression began to rise from second post transplantday (D2), reaching a peak on D18,. TGFβ1 expression gained a high level on D2 and had itS peak on D18; PDGFexpression had its peak on D4, rebounding on D25; bFGF expression, exceedingly high on D2, dropped andrebounded in the same manner as in PDGF; (3) In the early stage of the wound healing, mRNA expression of thefour growth factors was lower in allografts, rising up in varying degrees thereafter. Conclusion (1) Graftsurvival took place both in autografts and allografts, with the former pederming better than the latter; (2) Thecombining action of growth factors that reached the affected area through autosecretion and bysecretion probablypromoted the healing of the burn wound, following signal transmission channels; (3) Rejection, which occurred inallogralts, was responsible for the decreasing viability of allografts and their replacement by the host skin.展开更多
Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the fir...Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the first consideration should be the protection of cardiac function.Based on the theory of intermingled phlegm,blood stasis and toxin of heart disease put forward by Master Lei Zhongyi,the dialectical treatment thinking of COVID-19 patients from the concept of damage of phlegm,blood stasis and toxin to the heart were discussed.During the diagnosis,critical stage and recovery period of COVID-19,expectorant and blood-activating agents,heat and detoxification agents can be added to promote lung and asthma,free Bizheng and remove blood stasis,calm the heart and calm the mind,and promote the recovery of cardiopulmonary functions.展开更多
Through literature review,we found that evaluations of urban planning implementation often focus narrowly on either the subject(stakeholders)or the object(projects),while micro-level aspects such as site selection and...Through literature review,we found that evaluations of urban planning implementation often focus narrowly on either the subject(stakeholders)or the object(projects),while micro-level aspects such as site selection and construction are primarily considered within the context of planning implementation.There is insufficient research on the evaluation of implementation.Community daycare centers play a crucial role in the community home care model,yet there is relatively little research on their usage efficiency,satisfaction levels,and spatial evaluation of planning implementation.Based on the theoretical understanding of the human environment,including the subject,object,and their interactions,an evaluation system for the planning and implementation of community day care centers was constructed,incorporating subjective evaluation,objective evaluation,and comparative analysis.展开更多
目的系统评价桃核承气汤联合西药治疗子宫内膜异位症的效果。方法计算机检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、PubMed、Web of Science、Embase和The Cochrane Library等数据库,收集有关桃核承气汤联合西药...目的系统评价桃核承气汤联合西药治疗子宫内膜异位症的效果。方法计算机检索中国知网、万方数据知识服务平台、维普资讯中文期刊服务平台、PubMed、Web of Science、Embase和The Cochrane Library等数据库,收集有关桃核承气汤联合西药治疗子宫内膜异位症的随机对照研究。对纳入的文献进行筛选、资料提取和质量评价后,采用RevMan 5.4软件进行Meta分析。结果共纳入9项随机对照研究。Meta分析结果显示,观察组的临床总有效率高于对照组,血清雌二醇、孕酮、糖类抗原125水平和卵巢动脉搏动指数、阻力指数低于对照组,卵巢动脉收缩期峰值血流速度、卵泡平均生长速度优于对照组(P<0.05)。结论桃核承气汤联合西药治疗子宫内膜异位症可以降低患者的血清雌二醇、孕酮、糖类抗原125水平,在一定程度上促进卵泡发育,改善卵巢动脉血流动力学,提高治疗效果,值得临床应用和推广。展开更多
基金supported by the Major Clinical Research Project of Shanghai Shenkang Hospital Development Center(SHDC2020CR2051B)the Natural Science Foundation Project of Shanghai“Science and Technology Innovation Action Plan”(23ZR1463800)Shanghai University of Traditional Chinese Medicine“Visiting Leading Universities and Mentorship by Masters”Talent Development Program(HR018).
文摘Objective:To examine the relationship between metabolic syndrome(MS)and its key components in granulomatous mastitis(GM),we explored potential pathological mechanisms through the lens of traditional Chinese medicine(TCM),particularly the concept of intermingled phlegm-blood stasis.Methods:In this retrospective study,we enrolled 172 patients with GM and 164 patients with non-inflammatory benign breast masses.Metabolic indicators(waist circumference[WC],blood lipids,etc.),inflammatory markers(C-reactive protein,interleukin-6,tumor necrosis factor-α),and adipose tissue CD68 expression were measured.Logistic regression was used to analyze risk factors and receiver operating characteristic curves were used to evaluate diagnostic efficacy.The correlation between TCM pathogenesis and biomarkers was also examined.Results:MS prevalence was significantly higher in the GM group than in the controls(26.16%vs.6.10%,P<.001).Multivariate analysis identified abdominal obesity(WC≥80 cm,odds ratio[OR]=1.065)and low levels of high-density lipoprotein cholesterol(HDL-C;<1.29 mmol/L,OR=0.066)as independent risk factors for GM(P<.001 for both).Among patients with GM,HDL-C levels were inversely correlated with inflammatory markers(r=−0.341 to−0.440),whereas patients with concurrent MS demonstrated greater CD68 macrophage infiltration(P<.001).According to TCM,abdominal obesity corresponds to“spleen deficiency with phlegm-dampness accumulation,”and low HDL-C reflects“deficiency of vital qi,”which collectively lead to phlegm-blood stasis obstruction in the mammary collaterals;this aligns with the key MS driving mechanisms of chronic inflammation and immune dysregulation.Conclusion:MS promotes GM development through chronic inflammation and immune dysregulation,with abdominal obesity and low HDL-C levels serving as core risk factors.The TCM theory of intermingled phlegm-blood stasis provides a novel interpretation of the metabolic-inflammatory mechanisms underlying GM.Accordingly,we propose phlegm-resolving and blood-activating strategies as potential therapeutic approaches for metabolic-immune axis regulation.
基金financially supported by the Hebei Provincial Natural Science Foundation of China(No.D2023402012)the Major Science and Technology Project of China National Petroleum Corporation(No.2024DJ87)。
文摘Accurately predicting relative permeability is an important issue in the research of multiphase flow in tight reservoirs.Existing predictive models typically rely on the capillary tube bundle model featuring circular cross-sections,often overlooking the impact of pore geometry on fluid flow behavior within reservoirs.In this work,the intermingled fractal theory of porous media is introduced to characterize the intricate local features within the internal space of tight rocks.Initially,iterative rules for diverse fractal units are skillfully designed to capture the actual characteristics of pore cross-sectional shapes.Subsequently,analytical relationships are derived between the iterative parameters and the area,wetted perimeter,and hydraulic diameter of pores generated by these units,followed by the establishment of a relative permeability model that considers pore geometry.The model's validity is confirmed through comparisons with experimental data and published relative permeability models,with correlation coefficients exceeding 0.996.Finally,various factors affecting two-phase flow characteristics are analyzed.The results reveal that pore geometry has a significant impact on flow behavior in porous media.Assuming that the flow channels are cylindrical typically leads to an overestimation of permeability,with the maximum relative error reaching 46.91%.Additionally,the tortuosity fractal dimension is a determinant factor influencing the relative permeability of both wetting and nonwetting fluids,and the phase permeability is sensitive to variations in solid particle size and porosity.The proposed intermingled fractal model enhances the accuracy of evaluating fluid flow characteristics in microscale pore channels and offers a novel framework for simulating porous media with complex geometries.
文摘Objective To scrutinize the effect of growth factors resulting from the intermingled skin graft onwound healing. Methods By means of RT-PCR technique, mRNA expressions of TGFα, TGFβ1, PDGF andbFGF of autografts and allografts on burnt rats were quantitatively analysed. Results (1) mRNA expressions ofall the four growth factors mentioned above were found both in allografts and autografts, the expressions beinghigher in autografts than allografts; (2) In autografts, TGFα expression began to rise from second post transplantday (D2), reaching a peak on D18,. TGFβ1 expression gained a high level on D2 and had itS peak on D18; PDGFexpression had its peak on D4, rebounding on D25; bFGF expression, exceedingly high on D2, dropped andrebounded in the same manner as in PDGF; (3) In the early stage of the wound healing, mRNA expression of thefour growth factors was lower in allografts, rising up in varying degrees thereafter. Conclusion (1) Graftsurvival took place both in autografts and allografts, with the former pederming better than the latter; (2) Thecombining action of growth factors that reached the affected area through autosecretion and bysecretion probablypromoted the healing of the burn wound, following signal transmission channels; (3) Rejection, which occurred inallogralts, was responsible for the decreasing viability of allografts and their replacement by the host skin.
基金the Project of the Third National Master of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine/National Famous Traditional Chinese Medicine Inheritance Studio Construction(No.119(2018)of Education Letter of the State Office of Traditional Chinese Medicine).
文摘Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the first consideration should be the protection of cardiac function.Based on the theory of intermingled phlegm,blood stasis and toxin of heart disease put forward by Master Lei Zhongyi,the dialectical treatment thinking of COVID-19 patients from the concept of damage of phlegm,blood stasis and toxin to the heart were discussed.During the diagnosis,critical stage and recovery period of COVID-19,expectorant and blood-activating agents,heat and detoxification agents can be added to promote lung and asthma,free Bizheng and remove blood stasis,calm the heart and calm the mind,and promote the recovery of cardiopulmonary functions.
基金Scientific and Technological Research Project of Chongqing Municipal Education Commission:Evaluation and Optimization of Planning and Implementation of Community Day Care Centers from the Perspective of Subject-Object Relationship(Project number:KJQN202301901).
文摘Through literature review,we found that evaluations of urban planning implementation often focus narrowly on either the subject(stakeholders)or the object(projects),while micro-level aspects such as site selection and construction are primarily considered within the context of planning implementation.There is insufficient research on the evaluation of implementation.Community daycare centers play a crucial role in the community home care model,yet there is relatively little research on their usage efficiency,satisfaction levels,and spatial evaluation of planning implementation.Based on the theoretical understanding of the human environment,including the subject,object,and their interactions,an evaluation system for the planning and implementation of community day care centers was constructed,incorporating subjective evaluation,objective evaluation,and comparative analysis.
