New bioactive 13-epi-neoverrucosane diterpenoid,5β-acetoxy-13-epi-neoverrucosanic acid(1)along with three known secondary metabolites,13-epi-neoverrucosan-5β-ol(2),chelodane(3)and(E)-β-farnesene(4)were isolated fro...New bioactive 13-epi-neoverrucosane diterpenoid,5β-acetoxy-13-epi-neoverrucosanic acid(1)along with three known secondary metabolites,13-epi-neoverrucosan-5β-ol(2),chelodane(3)and(E)-β-farnesene(4)were isolated from the MeOH extract of east Malaysia’s liverwort Pleurozia subinfata.The chemical structure of new compound was elucidated by the analyses of its spectroscopic data(FTIR,NMR and HR-ESI-MS).These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P.subinfata in Borneo.Compound 3 was widespread in marine sponges however this is the frst record for 3 to be found in liverwort.These metabolites were tested for their antifungal potentials against selected fungi from the marine environment.Compound 1 exhibited efective antifungal activity against Lagenidium thermophilum.展开更多
基金supported by SaBC Grant[No.GL0070]and UMS Grant[SBK0258-SG-2016].
文摘New bioactive 13-epi-neoverrucosane diterpenoid,5β-acetoxy-13-epi-neoverrucosanic acid(1)along with three known secondary metabolites,13-epi-neoverrucosan-5β-ol(2),chelodane(3)and(E)-β-farnesene(4)were isolated from the MeOH extract of east Malaysia’s liverwort Pleurozia subinfata.The chemical structure of new compound was elucidated by the analyses of its spectroscopic data(FTIR,NMR and HR-ESI-MS).These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P.subinfata in Borneo.Compound 3 was widespread in marine sponges however this is the frst record for 3 to be found in liverwort.These metabolites were tested for their antifungal potentials against selected fungi from the marine environment.Compound 1 exhibited efective antifungal activity against Lagenidium thermophilum.
