We present a calculation by including the relativistic and off-shell contributions to the interaction potentials between two spin-1/2 fermions mediated by the exchange of light spin-0 particles,in both momentum and co...We present a calculation by including the relativistic and off-shell contributions to the interaction potentials between two spin-1/2 fermions mediated by the exchange of light spin-0 particles,in both momentum and coordinate spaces.Our calculation is based on the four-point Green's function rather than the scattering amplitude.Among the sixteen potential components,eight that vanish in the non-relativistic limit are shown to acquire nonzero relativistic and off-shell corrections.In addition to providing relativistic and off-shell corrections to the operator basis commonly used in the literature,we introduce an alternative operator basis that facilitates the derivation of interaction potentials in the coordinate space.Furthermore,we calculate both the long-range and short-range components of the potentials,which can be useful for future experimental analyses at both macroscopic and atomic scales.展开更多
Objective Lipid oxidation is involved in the pathogenesis of atherosclerosis and may be contribute to the development of Ischemic stroke(IS).However,the lipid profiles associated with IS have been poorly studied.We co...Objective Lipid oxidation is involved in the pathogenesis of atherosclerosis and may be contribute to the development of Ischemic stroke(IS).However,the lipid profiles associated with IS have been poorly studied.We conducted a pilot study to identify potential IS-related lipid molecules and pathways using lipidomic profiling.Methods Serum lipidomic profiling was performed using LC-MS in 20 patients with IS and 20 age-and sex-matched healthy controls.Univariate and multivariate analyses were simultaneously performed to identify the differential lipids.Multiple testing was controlled for using a false discovery rate(FDR)approach.Enrichment analysis was performed using MetaboAnalyst software.Results Based on the 294 lipids assayed,principal component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLS-DA)models were used to distinguish patients with IS from healthy controls.Fifty-six differential lipids were identified with an FDR-adjusted P less than 0.05 and variable influences in projection(VIP)greater than 1.0.These lipids were significantly enriched in glycerophospholipid metabolism(FDR-adjusted P=0.009,impact score=0.216).Conclusions Serum lipid profiles differed significantly between patients with IS and healthy controls.Thus,glycerophospholipid metabolism may be involved in the development of IS.These results provide initial evidence that lipid molecules and their related metabolites may serve as new biomarkers and potential therapeutic targets for IS.展开更多
Chemical short-range order(SRO),a phenomenon at the atomic scale resulting from inhomogeneities in the local chemical environment,is usually studied using machine learning force field-based molecular dynamics simulati...Chemical short-range order(SRO),a phenomenon at the atomic scale resulting from inhomogeneities in the local chemical environment,is usually studied using machine learning force field-based molecular dynamics simulations due to the limitations of experimental methods.To promote the reliable application of machine potentials in high-entropy alloy simulations,first,this work uses NEP models trained on two different datasets to predict the SRO coefficients of NbMoTaW.The results show that within the same machine learning framework,there are significant differences in the prediction of SRO coefficients for the Nb-Nb atomic pair.Subsequently,this work predicts the SRO coefficients of NbMoTaW using the NEP model and the SNAP model,both of which are trained on the same dataset.The results reveal significant discrepancies in SRO predictions for like-element pairs(e.g.,Nb-Nb and W-W)between the two potentials,despite the identical training data.The findings of this study indicate that discrepancies in the prediction results of SRO coefficients can arise from either the same machine learning framework trained on different datasets or different learning frameworks trained on the same dataset.This reflects possible incompleteness in the current training set's coverage of local chemical environments at the atomic scale.Future research should establish unified evaluation standards to assess the capability of training sets to accurately describe complex atomic-scale behaviors such as SRO.展开更多
We present a comprehensive study of the CO_(2)-CO interaction potential using a 9-dimensional(9D)potential energy surface(PES)constructed with the fundamental invariant-neural networks(FINN)method.The PES was generate...We present a comprehensive study of the CO_(2)-CO interaction potential using a 9-dimensional(9D)potential energy surface(PES)constructed with the fundamental invariant-neural networks(FINN)method.The PES was generated from 65330 CCSD(T)-F12a/aug-cc-pVTZ ab initio data points,with counterpoise correction,applied to eliminate basis set superposition error(BSSE).We performed quasi-classical trajectory simulations using this PES to investigate the rotational energy transfer dynamics.Our results reveal complex energy transfer mechanisms,with significant rotational excitation and relaxation dependent on collision energy and initial rotational states.The 9D PES provides a more accurate representation of the CO_(2)-CO system,offering new insights into molecular dynamics and interaction mechanisms.展开更多
Background:Pistacia integerrima,a cornerstone of traditional medicine,is renowned for its therapeutic applications against various health conditions,including cancer and hepatitis.This study investigates the pharmacol...Background:Pistacia integerrima,a cornerstone of traditional medicine,is renowned for its therapeutic applications against various health conditions,including cancer and hepatitis.This study investigates the pharmacological potential of bioactive compounds derived from Pistacia integerrima in inhibiting 5-lipoxygenase(5-LOX),a key enzyme implicated in inflammation and cancer progression.The current study aimed to evaluate the lipoxygenase inhibitory activity of bioactive compounds from Pistacia integerrima and assess their potential for therapeutic development in the context of inflammation and cancer treatment.Methods:Three major compounds-spinacetin(1),patuletin(2),and pistagremic acid(3)-were isolated from Pistacia integerrima and analyzed for their lipoxygenase inhibitory activity.Biochemical assays and molecular docking studies were performed to assess their effectiveness in inhibiting 5-LOX.Results:All three compounds demonstrated significant inhibition of lipoxygenase activity.Spinacetin(1)and patuletin(2)exhibited the most potent inhibitory effects,with IC_(50)values of 40.34μM and 45.04μM,respectively.Molecular docking studies revealed that patuletin(2)had the highest binding affinity(−7.717 kcal/mol)against 5-LOX,followed by spinacetin(1)with a binding affinity of−6.074 kcal/mol.In-depth in silico analysis highlighted the drug-likeness of spinacetin(1)and its favorable toxicological profile,suggesting its suitability for therapeutic development.Conclusion:The study demonstrates that compounds from Pistacia integerrima,particularly spinacetin and patuletin,have significant lipoxygenase inhibitory activity,with spinacetin showing promise as a lead candidate for lipoxygenase-targeted therapies.The findings reinforce the therapeutic relevance of Pistacia integerrima and suggest that its bioactive compounds may serve as safer,plant-based alternatives to conventional anti-inflammatory and anticancer treatments.展开更多
BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ us...BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ using the competitive reaction time task(CRTT).Further investigation into the ERP correlates of aggression in SCZ would provide valuable insights into the neural processes involved.AIM To explore the neural mechanism of aggressive behavior in SCZ.METHODS Participants of this study included 40 SCZ patients and 42 healthy controls(HCs).The Reactive Proactive Aggression Questionnaire was used to assess trait of aggression.The Barratt Impulsiveness Scale 11 was used to measure impulsiveness.The Positive and Negative Symptom Scale(PANSS)was used to evaluate psychopathological features and disease severity.All participants were measured with ERP while performing the CRTT.Data of behavior,ERP components(P2,N2,and P3),and feedback-related negativity(FRN)were analyzed.RESULTS Analysis of the behavioral data revealed that compared with HCs,SCZ patients exhibited higher punishment choices.Analysis of ERP components showed that compared with HCs,SCZ patients exhibited higher N2 amplitudes and P2 amplitudes during the decision phase of the CRTT;however,SCZ patients exhibited lower FRN amplitudes and lower P3 amplitudes during the outcome phase of the CRTT.The N2 amplitudes evoked by highintensity provocation were positively related to PANSS-P scores.And the P3 amplitudes evoked in the winning trials were negatively correlated with the PANSS-G scores.CONCLUSION SCZ patients exhibit abnormal ERP characteristics evoked by the CRTT,which suggests the neural correlates of aggressive behavior in SCZ.展开更多
BACKGROUND Patients with major depression(MD)exhibit conditional reasoning dysfunction;however,no studies on the event-related potential(ERP)characteristics of conditional reasoning in MD have been reported.AIM To inv...BACKGROUND Patients with major depression(MD)exhibit conditional reasoning dysfunction;however,no studies on the event-related potential(ERP)characteristics of conditional reasoning in MD have been reported.AIM To investigate the ERP characteristics of conditional reasoning in MD patients and explore the neural mechanism of cognitive processing.METHODS Thirty-four patients with MD and 34 healthy controls(HCs)completed ERP measurements while performing the Wason selection task(WST).The clusterbased permutation test in FieldTrip was used to compare the differences in the mean amplitudes between the patients with MD and HCs on the ERP components under different experimental conditions.Behavioral data[accuracy(ACC)and reaction times(RTs)],the ERP P100 and late positive potentials(LPPs)were analyzed.RESULTS Although the mean ACC was greater and the mean of RTs was shorter in HCs than in MD patients,the differences were not statistically significant.However,across both groups,the ACC in the precautionary WST was greater than that in the other tasks,and the RTs in the abstract task were greater than those in the other tasks.Importantly,compared with that of HCs,the P100 of the left centroparietal sites was significantly increased,and the early LPP was attenuated at parietal sites and increased at left frontocentral sites;the medium LPP and late LPP were increased at the left frontocentral sites.CONCLUSION Patients with MD have conditional reasoning dysfunction and exhibit abnormal ERP characteristics evoked by the WST,which suggests neural correlates of abnormalities in conditional reasoning function in MD patients.展开更多
BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognit...BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.展开更多
The inherent asymmetry and diversity of the El Niño-Southern Oscillation(ENSO)pose substantial challenges to its prediction.Potential predictability measures the upper limit of predictability for a certain event....The inherent asymmetry and diversity of the El Niño-Southern Oscillation(ENSO)pose substantial challenges to its prediction.Potential predictability measures the upper limit of predictability for a certain event.Assessing the potential predictability of ENSO across varying phases and intensities with sophisticated climate models is crucial for understanding the upper limits of forecasting capabilities and identifying room for future enhancement.Based on the hindcast dataset with a recently developed ensemble forecasting system(the community earth system model,CESM),this study comprehensively investigates potential predictability for ENSO across different phases and intensities.The findings reveal that La Niña events possess higher potential predictability relative to their El Niño counterparts.Strong events exhibit significantly higher potential predictability than weak events within the same phase.The potential predictability of distinct ENSO types is primarily influenced by the seasonal variation inherent to their predictability.Regardless of the event classification,the potential predictability is characterized by a rapid decline from spring onwards,with the apex of this decline occurring in summer.The intensity of the seasonal predictability barrier inversely correlates with the upper limit of potential predictability.Specifically,a weaker(stronger)seasonal barrier is associated with a higher(lower)potential predictability.In addition,there is significant interdecadal variability both in the predictability of warm and cold ENSO events.The potential predictability for La Niña events decreases more slowly with increasing lead months,particularly in recent decades,resulting in an overall higher upper limit of potential predictability for La Niña events than for El Niño events over the past century.Nevertheless,El Niño events have also maintained a high potential predictability.This suggests substantial potential for improvement in future prediction for both.展开更多
In the urban environment,subsurface contamination is caused by municipal solid waste(MSW)and industrial and agricultural discharges.About 2.01 billion tons of MSW is generated globally each year,most of which is dispo...In the urban environment,subsurface contamination is caused by municipal solid waste(MSW)and industrial and agricultural discharges.About 2.01 billion tons of MSW is generated globally each year,most of which is disposed of in landfills.Countries in Asia and Pacific regions account for 43%of global waste generation,while India and China account for 27.45%of global waste generation.Most of the landfills operated in South-Asian countries are non-sanitary,leading to the percolation of leachate in the subsurface.Conventional hydrogeological and geochemical methods are primary indicators and detect high levels of critical parameters near landfills,indicating subsurface contamination from leachate.展开更多
By combining neuroevolution potential(NEP)with phonon Boltzmann transport theory,we systematically investigate the thermal transport properties of three two-dimensional(2D)narrow bandgap semiconductors:Ca_(3)N_(2),Ba_...By combining neuroevolution potential(NEP)with phonon Boltzmann transport theory,we systematically investigate the thermal transport properties of three two-dimensional(2D)narrow bandgap semiconductors:Ca_(3)N_(2),Ba_(3)P_(2),and Ba_(3)As_(2).The room-temperature lattice thermal conductivities(κ_(L))of Ca_(3)N_(2),Ba_(3)P_(2),and Ba_(3)As_(2)considering only three-phonon scattering are 6.60 W/m K,11.90 W/m K,and 8.88 W/m K,respectively.When taking into account the higherorder phonon(four-phonon)scattering processes,theκL of these three materials decrease to 6.12 W/m K,9.73 W/m K and6.77 W/m K,respectively.Among these systems,Ba_(3)As_(2)undergoes the most pronounced suppression with a reduction of 23.8%.This is mainly due to the greater scattering phase space which enhances the four-phonon scattering.Meanwhile,it is revealed that unlike the traditional evaluation using the P_(4)/P_(3)ratio as an indicator of the strength of four-phonon interactions,the thermal conductivity of Ba_(3)P_(2)exhibits weaker four-phonon suppression behavior compared to Ba_(3)As_(2),despite hosting a higher P_(4)/P_(3)ratio.That is to say,the strength of four-phonon scattering cannot be evaluated solely by the ratio of P_(4)/P_(3).These results presented in this work shed light on the thermal transport properties of such new 2D semiconductors with narrow bandgaps.展开更多
Based on researches of the crop potential productivity,the potential productivity of light,temperature,water and land from wheat in China were calculated respectively,and converted into the potential productivity of w...Based on researches of the crop potential productivity,the potential productivity of light,temperature,water and land from wheat in China were calculated respectively,and converted into the potential productivity of wheat straw according to the coefficient of grain-straw ratio of wheat.Furthermore,based on the wheat planting area in 2006,the potential yield of wheat straw fiber in China was estimated.The results showed that the potential yield of wheat straw fiber in China could reach 94.91 million ton,which could provide evidence for the further potential analysis of bio-ethanol.展开更多
The lowest energy structures of peroxynitric acid have been studied with B3LYP/6-311＋ G（2d,2p） method. The potential energy surfaces （PES） along the O-N and O-O bonds have been scanned at CCSD（T）/aug-cc-pVDZ le...The lowest energy structures of peroxynitric acid have been studied with B3LYP/6-311＋ G（2d,2p） method. The potential energy surfaces （PES） along the O-N and O-O bonds have been scanned at CCSD（T）/aug-cc-pVDZ level, respectively. The calculated results show that on the O-N PES, the O3-N4 bond length of the loose transition state is 2.82A^° and the corresponding energy barrier is 25.6 kcal/mol, while on the O-O PES, the loose transition state with of O2-O3 bond length of 2.35A^° has the energy barrier of 37.4 kcal/mol. Thus the primary reaction path for peroxynitric acid is the dissociation into HO2 and NO2.展开更多
The key zones of returning farmland to forestland and grassland in Ningxia were studied. By using the ＂stepwise revised method＂,the climate productive potential,light and temperature productive potential in the zone...The key zones of returning farmland to forestland and grassland in Ningxia were studied. By using the ＂stepwise revised method＂,the climate productive potential,light and temperature productive potential in the zone in recent 50 years were counted. The light and temperature productive potential of corn in Ningxia irrigated area,the central arid zone and the southern mountain area presented the linear increase trend. But when considered the climate productive potentials of light,temperature and water,the numerical value was very low because of the scarce rainfall,and no agriculture without the irrigation. The light and temperature productive potential,climate productive potential of winter wheat in the central arid zone had no significant trend,but the variation range of climate productive potential was very big. The light and temperature productive potential of winter wheat in the southern mountain area had no significant variation trend,and the climate productive potential presented the weak decline trend. It illustrated that the productive of winter wheat was greatly restricted by the water content. By using the meteorological factor data which were simulated by RegCM3-WOFOST/LINGRA coupled model,the future climate productive potentials of winter wheat in the central south of Ningxia was counted. They both presented the weak increase trend. It illustrated that the climate in Ningxia was favorable to improve the yield of winter wheat after returning farmland to forestland.展开更多
Although high resolution can be provided by electrical logging, the measured electrical log range is narrow and is limited to near the well. Borehole-surface electric potential measurements are able to detect a wide e...Although high resolution can be provided by electrical logging, the measured electrical log range is narrow and is limited to near the well. Borehole-surface electric potential measurements are able to detect a wide enough range but its resolution is limited, particularly for reservoirs with complex oil and water distribution or complicated structure. In this study, we attempt to accurately locate the 3-D reservoir water and oil distribution by combining borehole-surface and crosswell electric potentials. First, the distributions of oil and water in both vertical and horizontal directions are detected by the borehole-surface and erosswell electric potential methods, respectively, and then the measured crosswell potential result is used to calibrate the measured borehole-surface electric potential data to improve vertical resolution so that the residual oil distribution is determined in a lower half-space with three dimensions. The evaluation of residual oil distribution is obtained by investigation of differences between the simulation results of the reservoir with and without water flooding. The finite difference numerical simulation results prove that the spatial residual oil distribution can be effectively determined by combining the crosswell and borehole-surface electric potentials.展开更多
To understand the physical meaning of phase time further more, we discuss the reflection phase time of quantum-particles passing though a potential well It is shown that the reflection phase time is equal to the trans...To understand the physical meaning of phase time further more, we discuss the reflection phase time of quantum-particles passing though a potential well It is shown that the reflection phase time is equal to the transmission phase time in value and negative under certain conditions for a square potential well by analyzing While quantum-particles passing through the potential well, we think that this course can be described only with the velocity of energy of quantum mechanics whether or not they are reflected or transmitted eventually展开更多
Nanobubble flotation technology is an important research topic in the field of fine mineral particle separation.The basic characteristics of nanobubbles,including their size,concentration,surface zeta potential,and st...Nanobubble flotation technology is an important research topic in the field of fine mineral particle separation.The basic characteristics of nanobubbles,including their size,concentration,surface zeta potential,and stability have a significant impact on the nanobubble flotation performance.In this paper,bulk nanobubbles generated based on the principle of hydrodynamic cavitation were investigated to determine the effects of different parameters(e.g.,surfactant(frother)dosage,air flow,air pressure,liquid flow rate,and solution pH value)on their size distribution and zeta potential,as measured using a nanoparticle analyzer.The results demonstrated that the nanobubble size decreased with increasing pH value,surfactant concentration,and cavitation-tube liquid flow rate but increased with increasing air pressure and increasing air flow rate.The magnitude of the negative surface charge of the nanobubbles was positively correlated with the pH value,and a certain relationship was observed between the zeta potential of the nanobubbles and their size.The structural parameters of the cavitation tube also strongly affected the characteristics of the nanobubbles.The results of this study offer certain guidance for optimizing the nanobubble flotation technology.展开更多
Drylands are among those regions most sensitive to climate and environmental changes and human-induced perturbations.The most widely accepted definition of the term dryland is a ratio,called the Surface Wetness Index(...Drylands are among those regions most sensitive to climate and environmental changes and human-induced perturbations.The most widely accepted definition of the term dryland is a ratio,called the Surface Wetness Index(SWI),of annual precipitation to potential evapotranspiration(PET)being below 0.65.PET is commonly estimated using the Thornthwaite(PET Th)and Penman–Monteith equations(PET PM).The present study compared spatiotemporal characteristics of global drylands based on the SWI with PET Th and PET PM.Results showed vast differences between PET Th and PET PM;however,the SWI derived from the two kinds of PET showed broadly similar characteristics in the interdecadal variability of global and continental drylands,except in North America,with high correlation coefficients ranging from 0.58 to 0.89.It was found that,during 1901–2014,global hyper-arid and semi-arid regions expanded,arid and dry sub-humid regions contracted,and drylands underwent interdecadal fluctuation.This was because precipitation variations made major contributions,whereas PET changes contributed to a much lesser degree.However,distinct differences in the interdecadal variability of semi-arid and dry sub-humid regions were found.This indicated that the influence of PET changes was comparable to that of precipitation variations in the global dry–wet transition zone.Additionally,the contribution of PET changes to the variations in global and continental drylands gradually enhanced with global warming,and the Thornthwaite method was found to be increasingly less applicable under climate change.展开更多
Air pollution has environmental issue owing become a serious to its diverse harmful effects on the physical and biological environment. According to the Environmental Protection Agency （EPA） and the World Health Org...Air pollution has environmental issue owing become a serious to its diverse harmful effects on the physical and biological environment. According to the Environmental Protection Agency （EPA） and the World Health Organization （WHO）, air pollution affects millions of people worldwide. Hundreds of thousands of deaths each year and a range of diseases, particularly among vulnerable groups （i.e., children, the elderly, and people with special medical conditions）, are attributed to air pollution. These effects are not always caused by single pollutant in the air; rather, they are considered consequences of the multi-pollutants to which people are simultaneously exposed.展开更多
In the light of the theory on moist potential vorticity (MPV) investigation was undertaken of the 700 hPa vertical (horizontal) component MP1 (MPV2) for the heavy rain event occurring in July 5–6, 1991. Results show ...In the light of the theory on moist potential vorticity (MPV) investigation was undertaken of the 700 hPa vertical (horizontal) component MP1 (MPV2) for the heavy rain event occurring in July 5–6, 1991. Results show that the distribution features of the two components were closely related to the development of a mesoscale cyclone as a rainstorm-causing weather system in the lower troposphere in such a way that the ambient atmosphere of which MPV1 > 0 and MPV2 < 0 with |MPV1| ≥ |MPV2| favored the genesis of conditional symmetric instability (CSI) and that, as indicated by calculations, a CSI sector was really existent in the lower troposphere during the heavy rain happening and contributed greatly to its development.展开更多
基金funded in part by the National Natural Science Foundations of China under Grants Nos.12150013,12075058 and 11975090the Science Foundation of Hebei Normal University with Grant No.L2023B09。
文摘We present a calculation by including the relativistic and off-shell contributions to the interaction potentials between two spin-1/2 fermions mediated by the exchange of light spin-0 particles,in both momentum and coordinate spaces.Our calculation is based on the four-point Green's function rather than the scattering amplitude.Among the sixteen potential components,eight that vanish in the non-relativistic limit are shown to acquire nonzero relativistic and off-shell corrections.In addition to providing relativistic and off-shell corrections to the operator basis commonly used in the literature,we introduce an alternative operator basis that facilitates the derivation of interaction potentials in the coordinate space.Furthermore,we calculate both the long-range and short-range components of the potentials,which can be useful for future experimental analyses at both macroscopic and atomic scales.
基金supported by the National Natural Science Foundation of China (Nos. 81903384and 82173596)Suzhou Municipal Science and Technology Bureau (No. SKY2023041 and SKY2023180)+3 种基金the Inner Mongolia Autonomous Region Science and Technology Program (Nos.2022YFSH0054 and 2023GLLH0387)the Clinical Research Center of Neurological Disease of The Second Affiliated Hospital of Soochow University(ND2023B06)the Shaanxi Provincial Natural Science Basic Research Program (2025JC-YBMS-1020)Undergraduate Extracurricular Academic Research Funding of Soochow University (KY2023442B)
文摘Objective Lipid oxidation is involved in the pathogenesis of atherosclerosis and may be contribute to the development of Ischemic stroke(IS).However,the lipid profiles associated with IS have been poorly studied.We conducted a pilot study to identify potential IS-related lipid molecules and pathways using lipidomic profiling.Methods Serum lipidomic profiling was performed using LC-MS in 20 patients with IS and 20 age-and sex-matched healthy controls.Univariate and multivariate analyses were simultaneously performed to identify the differential lipids.Multiple testing was controlled for using a false discovery rate(FDR)approach.Enrichment analysis was performed using MetaboAnalyst software.Results Based on the 294 lipids assayed,principal component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLS-DA)models were used to distinguish patients with IS from healthy controls.Fifty-six differential lipids were identified with an FDR-adjusted P less than 0.05 and variable influences in projection(VIP)greater than 1.0.These lipids were significantly enriched in glycerophospholipid metabolism(FDR-adjusted P=0.009,impact score=0.216).Conclusions Serum lipid profiles differed significantly between patients with IS and healthy controls.Thus,glycerophospholipid metabolism may be involved in the development of IS.These results provide initial evidence that lipid molecules and their related metabolites may serve as new biomarkers and potential therapeutic targets for IS.
基金Project supported by the Hunan Provincial Natural Science Foundation(Grant Nos.2024JJ6190 and 2024JK2007-1)。
文摘Chemical short-range order(SRO),a phenomenon at the atomic scale resulting from inhomogeneities in the local chemical environment,is usually studied using machine learning force field-based molecular dynamics simulations due to the limitations of experimental methods.To promote the reliable application of machine potentials in high-entropy alloy simulations,first,this work uses NEP models trained on two different datasets to predict the SRO coefficients of NbMoTaW.The results show that within the same machine learning framework,there are significant differences in the prediction of SRO coefficients for the Nb-Nb atomic pair.Subsequently,this work predicts the SRO coefficients of NbMoTaW using the NEP model and the SNAP model,both of which are trained on the same dataset.The results reveal significant discrepancies in SRO predictions for like-element pairs(e.g.,Nb-Nb and W-W)between the two potentials,despite the identical training data.The findings of this study indicate that discrepancies in the prediction results of SRO coefficients can arise from either the same machine learning framework trained on different datasets or different learning frameworks trained on the same dataset.This reflects possible incompleteness in the current training set's coverage of local chemical environments at the atomic scale.Future research should establish unified evaluation standards to assess the capability of training sets to accurately describe complex atomic-scale behaviors such as SRO.
基金financially supported by the National Natural Science Foundation of China(No.22173104)。
文摘We present a comprehensive study of the CO_(2)-CO interaction potential using a 9-dimensional(9D)potential energy surface(PES)constructed with the fundamental invariant-neural networks(FINN)method.The PES was generated from 65330 CCSD(T)-F12a/aug-cc-pVTZ ab initio data points,with counterpoise correction,applied to eliminate basis set superposition error(BSSE).We performed quasi-classical trajectory simulations using this PES to investigate the rotational energy transfer dynamics.Our results reveal complex energy transfer mechanisms,with significant rotational excitation and relaxation dependent on collision energy and initial rotational states.The 9D PES provides a more accurate representation of the CO_(2)-CO system,offering new insights into molecular dynamics and interaction mechanisms.
文摘Background:Pistacia integerrima,a cornerstone of traditional medicine,is renowned for its therapeutic applications against various health conditions,including cancer and hepatitis.This study investigates the pharmacological potential of bioactive compounds derived from Pistacia integerrima in inhibiting 5-lipoxygenase(5-LOX),a key enzyme implicated in inflammation and cancer progression.The current study aimed to evaluate the lipoxygenase inhibitory activity of bioactive compounds from Pistacia integerrima and assess their potential for therapeutic development in the context of inflammation and cancer treatment.Methods:Three major compounds-spinacetin(1),patuletin(2),and pistagremic acid(3)-were isolated from Pistacia integerrima and analyzed for their lipoxygenase inhibitory activity.Biochemical assays and molecular docking studies were performed to assess their effectiveness in inhibiting 5-LOX.Results:All three compounds demonstrated significant inhibition of lipoxygenase activity.Spinacetin(1)and patuletin(2)exhibited the most potent inhibitory effects,with IC_(50)values of 40.34μM and 45.04μM,respectively.Molecular docking studies revealed that patuletin(2)had the highest binding affinity(−7.717 kcal/mol)against 5-LOX,followed by spinacetin(1)with a binding affinity of−6.074 kcal/mol.In-depth in silico analysis highlighted the drug-likeness of spinacetin(1)and its favorable toxicological profile,suggesting its suitability for therapeutic development.Conclusion:The study demonstrates that compounds from Pistacia integerrima,particularly spinacetin and patuletin,have significant lipoxygenase inhibitory activity,with spinacetin showing promise as a lead candidate for lipoxygenase-targeted therapies.The findings reinforce the therapeutic relevance of Pistacia integerrima and suggest that its bioactive compounds may serve as safer,plant-based alternatives to conventional anti-inflammatory and anticancer treatments.
基金Supported by Wuxi Municipal Health Commission Major Project,No.Z202107Wuxi Taihu Talent Project,No.WXTTP 2021.
文摘BACKGROUND The neural mechanisms underlying aggressive behavior in schizophrenia(SCZ)remain poorly understood.To date,no studies have reported on the event-related potential(ERP)characteristics of aggression in SCZ using the competitive reaction time task(CRTT).Further investigation into the ERP correlates of aggression in SCZ would provide valuable insights into the neural processes involved.AIM To explore the neural mechanism of aggressive behavior in SCZ.METHODS Participants of this study included 40 SCZ patients and 42 healthy controls(HCs).The Reactive Proactive Aggression Questionnaire was used to assess trait of aggression.The Barratt Impulsiveness Scale 11 was used to measure impulsiveness.The Positive and Negative Symptom Scale(PANSS)was used to evaluate psychopathological features and disease severity.All participants were measured with ERP while performing the CRTT.Data of behavior,ERP components(P2,N2,and P3),and feedback-related negativity(FRN)were analyzed.RESULTS Analysis of the behavioral data revealed that compared with HCs,SCZ patients exhibited higher punishment choices.Analysis of ERP components showed that compared with HCs,SCZ patients exhibited higher N2 amplitudes and P2 amplitudes during the decision phase of the CRTT;however,SCZ patients exhibited lower FRN amplitudes and lower P3 amplitudes during the outcome phase of the CRTT.The N2 amplitudes evoked by highintensity provocation were positively related to PANSS-P scores.And the P3 amplitudes evoked in the winning trials were negatively correlated with the PANSS-G scores.CONCLUSION SCZ patients exhibit abnormal ERP characteristics evoked by the CRTT,which suggests the neural correlates of aggressive behavior in SCZ.
基金Supported by Wuxi Taihu Talent Project,No.WXTTP 2021the General Scientific Research Program of Wuxi Municipal Health Commission,No.M202447.
文摘BACKGROUND Patients with major depression(MD)exhibit conditional reasoning dysfunction;however,no studies on the event-related potential(ERP)characteristics of conditional reasoning in MD have been reported.AIM To investigate the ERP characteristics of conditional reasoning in MD patients and explore the neural mechanism of cognitive processing.METHODS Thirty-four patients with MD and 34 healthy controls(HCs)completed ERP measurements while performing the Wason selection task(WST).The clusterbased permutation test in FieldTrip was used to compare the differences in the mean amplitudes between the patients with MD and HCs on the ERP components under different experimental conditions.Behavioral data[accuracy(ACC)and reaction times(RTs)],the ERP P100 and late positive potentials(LPPs)were analyzed.RESULTS Although the mean ACC was greater and the mean of RTs was shorter in HCs than in MD patients,the differences were not statistically significant.However,across both groups,the ACC in the precautionary WST was greater than that in the other tasks,and the RTs in the abstract task were greater than those in the other tasks.Importantly,compared with that of HCs,the P100 of the left centroparietal sites was significantly increased,and the early LPP was attenuated at parietal sites and increased at left frontocentral sites;the medium LPP and late LPP were increased at the left frontocentral sites.CONCLUSION Patients with MD have conditional reasoning dysfunction and exhibit abnormal ERP characteristics evoked by the WST,which suggests neural correlates of abnormalities in conditional reasoning function in MD patients.
基金Supported by Wuxi Taihu Talent Project,No.WXTTP 2021the General Scientific Research Program of Wuxi Municipal Health Commission,No.M202447.
文摘BACKGROUND Research has consistently demonstrated that patients with major depressive disorder(MDD)exhibit attentional switching dysfunction,and the dual-task paradigm has emerged as a valuable tool for probing cognitive deficits.However,the neuroelectrophysiological mechanism underlying this deficit has not been clarified.AIM To investigate the event-related potential(ERP)characteristics of attentional switching dysfunction and further explore the neuroelectrophysiological mechanism of the cognitive processing deficits underlying attentional switching dysfunction in MDD.METHODS The participants included 29 MDD patients and 29 healthy controls(HCs).The ERPs of the participants were measured while they performed the dual-task para digm.The behavioral and ERP N100,P200,P300,and late positive potential(LPP)data were analyzed.RESULTS This study revealed greater accuracy in HCs and slower reaction times(RTs)in MDD patients.Angry facial pictures led to lower accuracy.The results also revealed shorter RTs for happy facial pictures and the longest RTs for the 500-ms stimulus onset asynchrony.With respect to ERP characteristics,happy facial pictures and neutral facial pictures evoked higher amplitudes.The N100,P200,P300,and LPP amplitudes at Pz were the highest.MDD patients had lower P200 mean amplitudes and LPP amplitudes than HCs did.CONCLUSION In conclusion,MDD patients exhibited abnormal ERP characteristics evoked by the dual-task paradigm,which could be the neural correlates of the known abnormalities in attentional switching in patients with MDD.These results provide valuable insights into the understanding of the neural mechanisms of attentional switching function and may guide targeted interventions in patients with MDD.
基金The fund from Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract No.SML2021SP310the National Natural Science Foundation of China under contract Nos 42227901 and 42475061the Key R&D Program of Zhejiang Province under contract No.2024C03257.
文摘The inherent asymmetry and diversity of the El Niño-Southern Oscillation(ENSO)pose substantial challenges to its prediction.Potential predictability measures the upper limit of predictability for a certain event.Assessing the potential predictability of ENSO across varying phases and intensities with sophisticated climate models is crucial for understanding the upper limits of forecasting capabilities and identifying room for future enhancement.Based on the hindcast dataset with a recently developed ensemble forecasting system(the community earth system model,CESM),this study comprehensively investigates potential predictability for ENSO across different phases and intensities.The findings reveal that La Niña events possess higher potential predictability relative to their El Niño counterparts.Strong events exhibit significantly higher potential predictability than weak events within the same phase.The potential predictability of distinct ENSO types is primarily influenced by the seasonal variation inherent to their predictability.Regardless of the event classification,the potential predictability is characterized by a rapid decline from spring onwards,with the apex of this decline occurring in summer.The intensity of the seasonal predictability barrier inversely correlates with the upper limit of potential predictability.Specifically,a weaker(stronger)seasonal barrier is associated with a higher(lower)potential predictability.In addition,there is significant interdecadal variability both in the predictability of warm and cold ENSO events.The potential predictability for La Niña events decreases more slowly with increasing lead months,particularly in recent decades,resulting in an overall higher upper limit of potential predictability for La Niña events than for El Niño events over the past century.Nevertheless,El Niño events have also maintained a high potential predictability.This suggests substantial potential for improvement in future prediction for both.
基金support to bring out this publication(NGRI/Lib/2023/Pub-104)the Department of Science and Technology(DST),Government of India,for the INSPIRE fellowship(IF220569)+1 种基金carried out as a part of the project[GAP-861-28(TA)]supported by the Ministry of Earth Sciences(MoES),India,tenable at CSIR-NGRI,Hyderabad.
文摘In the urban environment,subsurface contamination is caused by municipal solid waste(MSW)and industrial and agricultural discharges.About 2.01 billion tons of MSW is generated globally each year,most of which is disposed of in landfills.Countries in Asia and Pacific regions account for 43%of global waste generation,while India and China account for 27.45%of global waste generation.Most of the landfills operated in South-Asian countries are non-sanitary,leading to the percolation of leachate in the subsurface.Conventional hydrogeological and geochemical methods are primary indicators and detect high levels of critical parameters near landfills,indicating subsurface contamination from leachate.
基金supported by the National Natural Science Foundation of China(Grant No.52372260)the Science Fund for Distinguished Young Scholars of Hunan Province(Grant Nos.2024JJ2048 and 2021JJ10036)+1 种基金the Science and Technology Innovation Program of Hunan Province(Grant No.2022RC1197)the Scientific Research Fund of Hunan Provincial Education Department(Grant No.22B0512)。
文摘By combining neuroevolution potential(NEP)with phonon Boltzmann transport theory,we systematically investigate the thermal transport properties of three two-dimensional(2D)narrow bandgap semiconductors:Ca_(3)N_(2),Ba_(3)P_(2),and Ba_(3)As_(2).The room-temperature lattice thermal conductivities(κ_(L))of Ca_(3)N_(2),Ba_(3)P_(2),and Ba_(3)As_(2)considering only three-phonon scattering are 6.60 W/m K,11.90 W/m K,and 8.88 W/m K,respectively.When taking into account the higherorder phonon(four-phonon)scattering processes,theκL of these three materials decrease to 6.12 W/m K,9.73 W/m K and6.77 W/m K,respectively.Among these systems,Ba_(3)As_(2)undergoes the most pronounced suppression with a reduction of 23.8%.This is mainly due to the greater scattering phase space which enhances the four-phonon scattering.Meanwhile,it is revealed that unlike the traditional evaluation using the P_(4)/P_(3)ratio as an indicator of the strength of four-phonon interactions,the thermal conductivity of Ba_(3)P_(2)exhibits weaker four-phonon suppression behavior compared to Ba_(3)As_(2),despite hosting a higher P_(4)/P_(3)ratio.That is to say,the strength of four-phonon scattering cannot be evaluated solely by the ratio of P_(4)/P_(3).These results presented in this work shed light on the thermal transport properties of such new 2D semiconductors with narrow bandgaps.
基金Supported by National Natural Science Foundation(70741032)~~
文摘Based on researches of the crop potential productivity,the potential productivity of light,temperature,water and land from wheat in China were calculated respectively,and converted into the potential productivity of wheat straw according to the coefficient of grain-straw ratio of wheat.Furthermore,based on the wheat planting area in 2006,the potential yield of wheat straw fiber in China was estimated.The results showed that the potential yield of wheat straw fiber in China could reach 94.91 million ton,which could provide evidence for the further potential analysis of bio-ethanol.
基金This work was supported by the National Natural Science Foundation of China （No.21103003）.
文摘The lowest energy structures of peroxynitric acid have been studied with B3LYP/6-311＋ G（2d,2p） method. The potential energy surfaces （PES） along the O-N and O-O bonds have been scanned at CCSD（T）/aug-cc-pVDZ level, respectively. The calculated results show that on the O-N PES, the O3-N4 bond length of the loose transition state is 2.82A^° and the corresponding energy barrier is 25.6 kcal/mol, while on the O-O PES, the loose transition state with of O2-O3 bond length of 2.35A^° has the energy barrier of 37.4 kcal/mol. Thus the primary reaction path for peroxynitric acid is the dissociation into HO2 and NO2.
基金Supported by the National Natural Science Fund Item (40675071)~~
文摘The key zones of returning farmland to forestland and grassland in Ningxia were studied. By using the ＂stepwise revised method＂,the climate productive potential,light and temperature productive potential in the zone in recent 50 years were counted. The light and temperature productive potential of corn in Ningxia irrigated area,the central arid zone and the southern mountain area presented the linear increase trend. But when considered the climate productive potentials of light,temperature and water,the numerical value was very low because of the scarce rainfall,and no agriculture without the irrigation. The light and temperature productive potential,climate productive potential of winter wheat in the central arid zone had no significant trend,but the variation range of climate productive potential was very big. The light and temperature productive potential of winter wheat in the southern mountain area had no significant variation trend,and the climate productive potential presented the weak decline trend. It illustrated that the productive of winter wheat was greatly restricted by the water content. By using the meteorological factor data which were simulated by RegCM3-WOFOST/LINGRA coupled model,the future climate productive potentials of winter wheat in the central south of Ningxia was counted. They both presented the weak increase trend. It illustrated that the climate in Ningxia was favorable to improve the yield of winter wheat after returning farmland to forestland.
文摘Although high resolution can be provided by electrical logging, the measured electrical log range is narrow and is limited to near the well. Borehole-surface electric potential measurements are able to detect a wide enough range but its resolution is limited, particularly for reservoirs with complex oil and water distribution or complicated structure. In this study, we attempt to accurately locate the 3-D reservoir water and oil distribution by combining borehole-surface and crosswell electric potentials. First, the distributions of oil and water in both vertical and horizontal directions are detected by the borehole-surface and erosswell electric potential methods, respectively, and then the measured crosswell potential result is used to calibrate the measured borehole-surface electric potential data to improve vertical resolution so that the residual oil distribution is determined in a lower half-space with three dimensions. The evaluation of residual oil distribution is obtained by investigation of differences between the simulation results of the reservoir with and without water flooding. The finite difference numerical simulation results prove that the spatial residual oil distribution can be effectively determined by combining the crosswell and borehole-surface electric potentials.
文摘To understand the physical meaning of phase time further more, we discuss the reflection phase time of quantum-particles passing though a potential well It is shown that the reflection phase time is equal to the transmission phase time in value and negative under certain conditions for a square potential well by analyzing While quantum-particles passing through the potential well, we think that this course can be described only with the velocity of energy of quantum mechanics whether or not they are reflected or transmitted eventually
文摘Nanobubble flotation technology is an important research topic in the field of fine mineral particle separation.The basic characteristics of nanobubbles,including their size,concentration,surface zeta potential,and stability have a significant impact on the nanobubble flotation performance.In this paper,bulk nanobubbles generated based on the principle of hydrodynamic cavitation were investigated to determine the effects of different parameters(e.g.,surfactant(frother)dosage,air flow,air pressure,liquid flow rate,and solution pH value)on their size distribution and zeta potential,as measured using a nanoparticle analyzer.The results demonstrated that the nanobubble size decreased with increasing pH value,surfactant concentration,and cavitation-tube liquid flow rate but increased with increasing air pressure and increasing air flow rate.The magnitude of the negative surface charge of the nanobubbles was positively correlated with the pH value,and a certain relationship was observed between the zeta potential of the nanobubbles and their size.The structural parameters of the cavitation tube also strongly affected the characteristics of the nanobubbles.The results of this study offer certain guidance for optimizing the nanobubble flotation technology.
基金sponsored by the National K&D Program of China (Grant No. 2016YFA0600404)the China Special Fund for Meteorological Research in the Public Interest (Grant No. GYHY201106028 and GYHY2015060011)+1 种基金the National Natural Science Foundation of China (Grant No. 41530532)the Jiangsu Collaborative Innovation Center for Climate Change
文摘Drylands are among those regions most sensitive to climate and environmental changes and human-induced perturbations.The most widely accepted definition of the term dryland is a ratio,called the Surface Wetness Index(SWI),of annual precipitation to potential evapotranspiration(PET)being below 0.65.PET is commonly estimated using the Thornthwaite(PET Th)and Penman–Monteith equations(PET PM).The present study compared spatiotemporal characteristics of global drylands based on the SWI with PET Th and PET PM.Results showed vast differences between PET Th and PET PM;however,the SWI derived from the two kinds of PET showed broadly similar characteristics in the interdecadal variability of global and continental drylands,except in North America,with high correlation coefficients ranging from 0.58 to 0.89.It was found that,during 1901–2014,global hyper-arid and semi-arid regions expanded,arid and dry sub-humid regions contracted,and drylands underwent interdecadal fluctuation.This was because precipitation variations made major contributions,whereas PET changes contributed to a much lesser degree.However,distinct differences in the interdecadal variability of semi-arid and dry sub-humid regions were found.This indicated that the influence of PET changes was comparable to that of precipitation variations in the global dry–wet transition zone.Additionally,the contribution of PET changes to the variations in global and continental drylands gradually enhanced with global warming,and the Thornthwaite method was found to be increasingly less applicable under climate change.
文摘Air pollution has environmental issue owing become a serious to its diverse harmful effects on the physical and biological environment. According to the Environmental Protection Agency （EPA） and the World Health Organization （WHO）, air pollution affects millions of people worldwide. Hundreds of thousands of deaths each year and a range of diseases, particularly among vulnerable groups （i.e., children, the elderly, and people with special medical conditions）, are attributed to air pollution. These effects are not always caused by single pollutant in the air; rather, they are considered consequences of the multi-pollutants to which people are simultaneously exposed.
文摘In the light of the theory on moist potential vorticity (MPV) investigation was undertaken of the 700 hPa vertical (horizontal) component MP1 (MPV2) for the heavy rain event occurring in July 5–6, 1991. Results show that the distribution features of the two components were closely related to the development of a mesoscale cyclone as a rainstorm-causing weather system in the lower troposphere in such a way that the ambient atmosphere of which MPV1 > 0 and MPV2 < 0 with |MPV1| ≥ |MPV2| favored the genesis of conditional symmetric instability (CSI) and that, as indicated by calculations, a CSI sector was really existent in the lower troposphere during the heavy rain happening and contributed greatly to its development.
