Dementia and Alzheimer's disease (AD) are both age-related conditions that predominantly affect older adults.According to prevalence studies,the burden of these diseases on society is expected to increase in the c...Dementia and Alzheimer's disease (AD) are both age-related conditions that predominantly affect older adults.According to prevalence studies,the burden of these diseases on society is expected to increase in the coming years,particularly in relation to rising longevity and life expectancy.Advances in therapeutic and preventive strategies are needed to help reduce their global burden,which remains among the most significant health challenges in aging populations (Brookmeyer et al.,2007).展开更多
Cohort studies are important epidemiological methods to investigate associations between environmental factors,individual characteristics,and disease or other health outcomes.As a paradigm of cohort studies,the Framin...Cohort studies are important epidemiological methods to investigate associations between environmental factors,individual characteristics,and disease or other health outcomes.As a paradigm of cohort studies,the Framingham Heart Study(FHS)is the longest-running cardiovascular epidemiological study,starting in 1948.展开更多
Tea is acknowledged by the U.S.Food and Drug Administration(FDA)as an important functional food,and is classified as‘Generally Recognized as Safe’(GRAS).Extensive research conducted over the past few decades has dem...Tea is acknowledged by the U.S.Food and Drug Administration(FDA)as an important functional food,and is classified as‘Generally Recognized as Safe’(GRAS).Extensive research conducted over the past few decades has demonstrated tea consumption’s numerous health benefits through in vitro animal and in vivo studies.The impact of sex and gender differences on health outcomes related to tea consumption has been overlooked,resulting in numerous errors and underestimations that could impact various outcomes.The objective is to provide a comprehensive overview of tea consumption and its effects on multiple health outcomes,while also analyzing the influence of sex and gender on these outcomes.To investigate the association between tea consumption and human health risk,a comprehensive search of the PubMed and Embase databases up to April 2023 was conducted.Cross-sectional studies,prospective cohort studies,and case-control studies that met the inclusion criteria were reanalyzed.Some studies suggest that drinking tea can have a positive impact on health;additionally,gender differences regarding tea drinking’s protective effects have been observed,particularly in women.By considering the specific impact of gender factors on patients,a more comprehensive personalized medicine approach can be achieved.展开更多
Through the elaborate design of an ethynyl-naphthalimide ligand with a phenylethylamino group as chiral origin,we report the synthesis,characterization,photophysical and electroluminescence properties of a pair of chi...Through the elaborate design of an ethynyl-naphthalimide ligand with a phenylethylamino group as chiral origin,we report the synthesis,characterization,photophysical and electroluminescence properties of a pair of chiral PtAu_(2)trinuclear clusters with high-efficiency circularly polarized narrow-band red emission.As demonstrated by experimental and theoretical studies,the phosphorescence of the trinuclear cluster originates from the intraligand(^(3)IL)triplet state of ethynyl-naphthalimide having a chiral benzylamino moiety.The R/S-PtAu_(2)clusters exhibit significant circularly polarized luminescence(CPL)properties with an asymmetry factor of approximately±1×10^(-3).Organic light-emitting diodes(OLEDs)based on chiral PtAu_(2)clusters demonstrate circularly polarized electroluminescence(CPEL)performance with an asymmetry factor of approximately±7×10^(-4)and an external quantum efficiency(EQE)of 13.7%.The devices exhibit narrow-band red emission and high color purity with CIE 1931 coordinates of(0.68,0.32)and a full width at half maximum(FWHM)of 29 nm.Both circular dichroism(CD)and CPL studies demonstrate the excellent chiral absorption and emission characteristics of trinuclear cluster enantiomers in the ground state as well as in the excited state.展开更多
文摘Dementia and Alzheimer's disease (AD) are both age-related conditions that predominantly affect older adults.According to prevalence studies,the burden of these diseases on society is expected to increase in the coming years,particularly in relation to rising longevity and life expectancy.Advances in therapeutic and preventive strategies are needed to help reduce their global burden,which remains among the most significant health challenges in aging populations (Brookmeyer et al.,2007).
文摘Cohort studies are important epidemiological methods to investigate associations between environmental factors,individual characteristics,and disease or other health outcomes.As a paradigm of cohort studies,the Framingham Heart Study(FHS)is the longest-running cardiovascular epidemiological study,starting in 1948.
文摘Tea is acknowledged by the U.S.Food and Drug Administration(FDA)as an important functional food,and is classified as‘Generally Recognized as Safe’(GRAS).Extensive research conducted over the past few decades has demonstrated tea consumption’s numerous health benefits through in vitro animal and in vivo studies.The impact of sex and gender differences on health outcomes related to tea consumption has been overlooked,resulting in numerous errors and underestimations that could impact various outcomes.The objective is to provide a comprehensive overview of tea consumption and its effects on multiple health outcomes,while also analyzing the influence of sex and gender on these outcomes.To investigate the association between tea consumption and human health risk,a comprehensive search of the PubMed and Embase databases up to April 2023 was conducted.Cross-sectional studies,prospective cohort studies,and case-control studies that met the inclusion criteria were reanalyzed.Some studies suggest that drinking tea can have a positive impact on health;additionally,gender differences regarding tea drinking’s protective effects have been observed,particularly in women.By considering the specific impact of gender factors on patients,a more comprehensive personalized medicine approach can be achieved.
基金financial support from the National Natural Science Foundation of China(grants 92061202 and 21801242).
文摘Through the elaborate design of an ethynyl-naphthalimide ligand with a phenylethylamino group as chiral origin,we report the synthesis,characterization,photophysical and electroluminescence properties of a pair of chiral PtAu_(2)trinuclear clusters with high-efficiency circularly polarized narrow-band red emission.As demonstrated by experimental and theoretical studies,the phosphorescence of the trinuclear cluster originates from the intraligand(^(3)IL)triplet state of ethynyl-naphthalimide having a chiral benzylamino moiety.The R/S-PtAu_(2)clusters exhibit significant circularly polarized luminescence(CPL)properties with an asymmetry factor of approximately±1×10^(-3).Organic light-emitting diodes(OLEDs)based on chiral PtAu_(2)clusters demonstrate circularly polarized electroluminescence(CPEL)performance with an asymmetry factor of approximately±7×10^(-4)and an external quantum efficiency(EQE)of 13.7%.The devices exhibit narrow-band red emission and high color purity with CIE 1931 coordinates of(0.68,0.32)and a full width at half maximum(FWHM)of 29 nm.Both circular dichroism(CD)and CPL studies demonstrate the excellent chiral absorption and emission characteristics of trinuclear cluster enantiomers in the ground state as well as in the excited state.
