The number of structural heart disease interventions has greatly increased in the past decade.Moreover,interest in the sex-specific outcomes of various cardiovascular conditions and procedures has increased.In this re...The number of structural heart disease interventions has greatly increased in the past decade.Moreover,interest in the sex-specific outcomes of various cardiovascular conditions and procedures has increased.In this review,we discuss the sex differences in the clinical profiles and outcomes of patients undergoing the most commonly performed structural procedures:transcatheter aortic valve replacement,transcatheter edge to edge repair of the mitral and tricuspid valve,transcatheter pulmonary valve replacement,patent foramen ovale closure and left atrial appendage occlusion.We shed light on potential reasons for these differences and emphasize the importance of increasing the representation of women in randomized clinical trials,to understand these differences and support the application of these cutting-edge technologies.展开更多
Health state of shield tunnels is one of the most important parameters for structure maintenance.Usually,the shield tunnel is extremely long in longitude direction and composed by many segments.It is difficult to quan...Health state of shield tunnels is one of the most important parameters for structure maintenance.Usually,the shield tunnel is extremely long in longitude direction and composed by many segments.It is difficult to quantify the relationship between the structure damage state and shield tunnel structure deformation by the model test because of unpredictable effects of different scales between model test and prototype tunnel structure.Here,an in-situ monitoring project was conducted to study the excavation induced shield tunnel structure damage,which could be considered a prototype test on the tunnel deformation.The disaster performance of tunnel leakage,segment crack,segment dislocation and segment block drop-off during longitude deformation and cross-section ovality developments was analyzed.The results indicate that instead of the longitude deformation,the ovality value has the strongest correlation to the rest disease performance,which could be used as the assessment index of the tunnel health.For this tunnel,it is in health state when the ovality is less than 0.5%,and the serious damage could be found when the ovality value is higher than 0.77%.The research results provide valuable reference to shield tunnel health assessment and help complete the standard of shield tunnel construction.展开更多
Charcot-Marie-Tooth disease type 1A（CMT1A） is caused by duplication of the peripheral myelin protein 22（PMP22） gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes melli...Charcot-Marie-Tooth disease type 1A（CMT1A） is caused by duplication of the peripheral myelin protein 22（PMP22） gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy. In this study, we report the occurrence of CMT1 A in a Chinese family affected by type 2 diabetes mellitus. In this family, seven individuals had duplication of the PMP22 gene, although only four had clinical features of polyneuropathy. All CMT1 A patients with a clinical phenotype also presented with type 2 diabetes mellitus. The other three individuals had no signs of CMT1 A or type 2 diabetes mellitus. We believe that there may be a genetic link between these two diseases.展开更多
文摘The number of structural heart disease interventions has greatly increased in the past decade.Moreover,interest in the sex-specific outcomes of various cardiovascular conditions and procedures has increased.In this review,we discuss the sex differences in the clinical profiles and outcomes of patients undergoing the most commonly performed structural procedures:transcatheter aortic valve replacement,transcatheter edge to edge repair of the mitral and tricuspid valve,transcatheter pulmonary valve replacement,patent foramen ovale closure and left atrial appendage occlusion.We shed light on potential reasons for these differences and emphasize the importance of increasing the representation of women in randomized clinical trials,to understand these differences and support the application of these cutting-edge technologies.
基金Projects(BK20150337,BK20140845,BK20140844)supported by the Natural Science Foundation of Jiangsu Province,ChinaProject(2015Y04)supported by the Transportation Science and Technology Project of Jiangsu Province,China+1 种基金Project(41504081)supported by the National Natural Science Foundation of ChinaProjects(2014M561567,2016T90416)supported by the China Postdoctoral Science Foundation
文摘Health state of shield tunnels is one of the most important parameters for structure maintenance.Usually,the shield tunnel is extremely long in longitude direction and composed by many segments.It is difficult to quantify the relationship between the structure damage state and shield tunnel structure deformation by the model test because of unpredictable effects of different scales between model test and prototype tunnel structure.Here,an in-situ monitoring project was conducted to study the excavation induced shield tunnel structure damage,which could be considered a prototype test on the tunnel deformation.The disaster performance of tunnel leakage,segment crack,segment dislocation and segment block drop-off during longitude deformation and cross-section ovality developments was analyzed.The results indicate that instead of the longitude deformation,the ovality value has the strongest correlation to the rest disease performance,which could be used as the assessment index of the tunnel health.For this tunnel,it is in health state when the ovality is less than 0.5%,and the serious damage could be found when the ovality value is higher than 0.77%.The research results provide valuable reference to shield tunnel health assessment and help complete the standard of shield tunnel construction.
文摘Charcot-Marie-Tooth disease type 1A（CMT1A） is caused by duplication of the peripheral myelin protein 22（PMP22） gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy. In this study, we report the occurrence of CMT1 A in a Chinese family affected by type 2 diabetes mellitus. In this family, seven individuals had duplication of the PMP22 gene, although only four had clinical features of polyneuropathy. All CMT1 A patients with a clinical phenotype also presented with type 2 diabetes mellitus. The other three individuals had no signs of CMT1 A or type 2 diabetes mellitus. We believe that there may be a genetic link between these two diseases.
