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Multi-objective topology optimization for cutout design in deployable composite thin-walled structures
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作者 Hao JIN Ning AN +3 位作者 Qilong JIA Chun SHAO Xiaofei MA Jinxiong ZHOU 《Chinese Journal of Aeronautics》 2026年第1期674-694,共21页
Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structu... Deployable Composite Thin-Walled Structures(DCTWS)are widely used in space applications due to their ability to compactly fold and self-deploy in orbit,enabled by cutouts.Cutout design is crucial for balancing structural rigidity and flexibility,ensuring material integrity during large deformations,and providing adequate load-bearing capacity and stability once deployed.Most research has focused on optimizing cutout size and shape,while topology optimization offers a broader design space.However,the anisotropic properties of woven composite laminates,complex failure criteria,and multi-performance optimization needs have limited the exploration of topology optimization in this field.This work derives the sensitivities of bending stiffness,critical buckling load,and the failure index of woven composite materials with respect to element density,and formulates both single-objective and multi-objective topology optimization models using a linear weighted aggregation approach.The developed method was integrated with the commercial finite element software ABAQUS via a Python script,allowing efficient application to cutout design in various DCTWS configurations to maximize bending stiffness and critical buckling load under material failure constraints.Optimization of a classical tubular hinge resulted in improvements of 107.7%in bending stiffness and 420.5%in critical buckling load compared to level-set topology optimization results reported in the literature,validating the effectiveness of the approach.To facilitate future research and encourage the broader adoption of topology optimization techniques in DCTWS design,the source code for this work is made publicly available via a Git Hub link:https://github.com/jinhao-ok1/Topo-for-DCTWS.git. 展开更多
关键词 Composite laminates Deployable structures Multi-objective optimization Thin-walled structures Topology optimization
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A novel Angle-Constrained Optimization method of Conformal Lattice Structures
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作者 Jun Yan Weibin Xu +2 位作者 Fuhao Wang Sixu Huo Kun Yan 《Computer Modeling in Engineering & Sciences》 2026年第2期269-295,共27页
Conformal truss-like lattice structures face significant manufacturability challenges in additive manufac-turing due to overhang angle limitations.To address this problem,we propose a novel angle-constrained optimizat... Conformal truss-like lattice structures face significant manufacturability challenges in additive manufac-turing due to overhang angle limitations.To address this problem,we propose a novel angle-constrained optimization method grounded in the global adjustment of nodal coordinates.First,a build direction is selected to minimize the number of violating struts.Then,an angular-constraint matrix is assembled from strut direction vectors,and analytical sensitivities with respect to nodal coordinates are derived to enable efficient constrained optimization under nonlinear angular inequality constraints.Numerical studies on two complex curved-surface lattices demonstrate that all overhang violations are eliminated while only minor changes are induced in global stiffness and strength.In particular,the maximum displacement of an ergonomic insole varies by only 2.87%after optimization.The results confirm the method’s versatility and engineering robustness,providing a practical approach for additive manufacturing-oriented lattice structure design. 展开更多
关键词 Conformal lattice structures additive manufacturing structural optimization complex structures
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Seismic Optimization Method of Nuclear Power Crane Structure
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作者 Zhengyan Chang Weiwei Wang +4 位作者 Mingliang Yang Heng Yang Qing Dong Keyuan Zhao Jie Yuwen 《Structural Durability & Health Monitoring》 2026年第1期251-267,共17页
To address the neglect of seismic performance in conventional double-girder bridge crane optimization,this paper introduces a time-history analysis-based seismic optimization methodology for crane structures.Using a 2... To address the neglect of seismic performance in conventional double-girder bridge crane optimization,this paper introduces a time-history analysis-based seismic optimization methodology for crane structures.Using a 25-t nuclear power crane as a case study,a bridge frame finite element model is established and validated through static analysis,confirming its accurate representation of the physical entity’s mechanical behavior.Furthermore,with bridge mass reduction as the objective and structural strength,stiffness,stability,and seismic mechanical performance as constraints,an optimization model is developed employing the Whale Optimization Algorithm(WOA). 展开更多
关键词 Bridge crane time history analysis structure optimization seismic analysis
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Research progress of structural regulation and composition optimization to strengthen absorbing mechanism in emerging composites for efficient electromagnetic protection 被引量:4
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作者 Pengfei Yin Di Lan +7 位作者 Changfang Lu Zirui Jia Ailing Feng Panbo Liu Xuetao Shi Hua Guo Guanglei Wu Jian Wang 《Journal of Materials Science & Technology》 2025年第1期204-223,共20页
With the increasing complexity of the current electromagnetic environment,excessive microwave radi-ation not only does harm to human health but also forms various electromagnetic interference to so-phisticated electro... With the increasing complexity of the current electromagnetic environment,excessive microwave radi-ation not only does harm to human health but also forms various electromagnetic interference to so-phisticated electronic instruments.Therefore,the design and preparation of electromagnetic absorbing composites represent an efficient approach to mitigate the current hazards of electromagnetic radiation.However,traditional electromagnetic absorbers are difficult to satisfy the demands of actual utilization in the face of new challenges,and emerging absorbents have garnered increasing attention due to their structure and performance-based advantages.In this review,several emerging composites of Mxene-based,biochar-based,chiral,and heat-resisting are discussed in detail,including their synthetic strategy,structural superiority and regulation method,and final optimization of electromagnetic absorption ca-pacity.These insights provide a comprehensive reference for the future development of new-generation electromagnetic-wave absorption composites.Moreover,the potential development directions of these emerging absorbers have been proposed as well. 展开更多
关键词 Microwave absorption structural regulation Performance optimization Emerging composites Synthetic strategy
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Structural Optimization and Innovative Practice in the Mechanical Design of Amusement Equipment
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作者 Bin Liu 《Journal of Electronic Research and Application》 2025年第5期93-99,共7页
Materials mechanics and structural dynamics provide theoretical support for the structural optimization of amusement facilities.The design code system guides the design process,covering aspects such as strength and fa... Materials mechanics and structural dynamics provide theoretical support for the structural optimization of amusement facilities.The design code system guides the design process,covering aspects such as strength and fatigue life.This paper introduces optimization methods like standardized module interfaces and variable density methods,as well as topics related to finite element simulation,reliability enhancement,innovative practices,and their significance. 展开更多
关键词 Amusement equipment structural optimization Mechanical design
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Review of Vibration Analysis and Structural Optimization Research for Rotating Blades
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作者 Saifeng Zhong Guoyong Jin +2 位作者 Yukun Chen Tiangui Ye Tuo Zhou 《哈尔滨工程大学学报(英文版)》 2025年第1期120-136,共17页
Blades are important parts of rotating machinery such as marine gas turbines and wind turbines,which are exposed to harsh environments during mechanical operations,including centrifugal loads,aerodynamic forces,or hig... Blades are important parts of rotating machinery such as marine gas turbines and wind turbines,which are exposed to harsh environments during mechanical operations,including centrifugal loads,aerodynamic forces,or high temperatures.These demanding working conditions considerably influence the dynamic performance of blades.Therefore,because of the challenges posed by blades in complex working environments,in-depth research and optimization are necessary to ensure that blades can operate safely and efficiently,thus guaranteeing the reliability and performance of mechanical systems.Focusing on the vibration analysis of blades in rotating machinery,this paper conducts a comprehensive literature review on the research advancements in vibration modeling and structural optimization of blades under complex operational conditions.First,the paper outlines the development of several modeling theories for rotating blades,including one-dimensional beam theory,two-dimensional plate-shell theory,and three-dimensional solid theory.Second,the research progress in the vibrational analysis of blades under aerodynamic loads,thermal environments,and crack factors is separately discussed.Finally,the developments in rotating blade structural optimization are presented from material optimization and shape optimization perspectives.The methodology and theory of analyzing and optimizing blade vibration characteristics under multifactorial operating conditions are comprehensively outlined,aiming to assist future researchers in proposing more effective and practical approaches for the vibration analysis and optimization of blades. 展开更多
关键词 Rotating blade Vibration characteristics structural optimization Harsh operating conditions REVIEW
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Multi-Objective Structural Optimization of Composite Wind Turbine Blade Using a Novel Hybrid Approach of Artificial Bee Colony Algorithm Based on the Stochastic Method
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作者 Ramazan Özkan Mustafa Serdar Genç Ìlker Kayali 《Computer Modeling in Engineering & Sciences》 2025年第12期3349-3380,共32页
The optimization of turbine blades is crucial in improving the efficiency of wind energy systems and developing clean energy production models.This paper presented a novel approach to the structural design of smallsca... The optimization of turbine blades is crucial in improving the efficiency of wind energy systems and developing clean energy production models.This paper presented a novel approach to the structural design of smallscale turbine blades using the Artificial Bee Colony(ABC)Algorithm based on the stochastic method to optimize both mass and cost(objective functions).The study used computational fluid dynamics(CFD)and structural analysis to consider the fluid-structure interaction.The optimization algorithm defined several variables:structural constraints,the type of composite material,and the number of composite layers to form a mathematical model.The numerical modeling was performed using the Ansys Fluent software and its Fluid-Structure Interaction(FSI)module.The ANSYS Composite PrePost(ACP)advanced composite modeling method was utilized in the structural design of composite materials.This study showed that the structurally optimized small-scale turbine blades provided a sustainable solution with improved efficiency compared to traditional designs.Furthermore,using CFD,structural analysis,and material characterization techniques first considered in this study highlights the importance of considering structural behavior when optimizing turbine blade designs. 展开更多
关键词 Turbine blade modeling structural optimization COMPOSITE artificial bee colony algorithm
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Dynamic Characteristic Analysis and Structural Optimization of Entire Double-Shaft-Driven Needle Punching Machine for C/C Crucible Preforms
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作者 SUN Zhihong DENG Qicai +4 位作者 QU Zhiyang WANG Zhenxi WANG Bing ZHANG Xi ZHANG Jingzhang 《Journal of Donghua University(English Edition)》 2025年第4期399-408,共10页
Double-shaft-driven needle punching machine is a specialized equipment designed for processing C/C crucible preforms.Its main needle punching module is operated by two sets of reciprocating crank-slider mechanisms.The... Double-shaft-driven needle punching machine is a specialized equipment designed for processing C/C crucible preforms.Its main needle punching module is operated by two sets of reciprocating crank-slider mechanisms.The intense vibration during needle punching not only generates huge noise,but also substantially reduces the quality of the preform.It is imperative to perform a dynamic analysis and optimization of the entire needle punching machine.In this paper,the three-dimensional(3D)model of the entire double-shaft-driven needle punching machine for C/C crucible preforms is established.Based on the modal analysis theory,the modal characteristics of the needle punching machine under various operating conditions are analyzed and its natural frequencies and vibration modes are determined.The harmonic response analysis is then employed to obtain the amplitude of the needle plate at different frequencies,and the structural weak points of the needle punching machine are identified and improved.The feasibility of the optimized scheme is subsequently reevaluated and verified.The results indicate that the first six natural frequencies of the machine increase,and the maximum amplitude of the needle plate decreases by 70.3%.The enhanced dynamic characteristics of the machine significantly improve its performance,enabling more efficient needle punching of C/C crucible preforms. 展开更多
关键词 needle punching machine dynamic characteristic modal analysis harmonic response analysis structural optimization
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APPROXIMATION TECHNIQUES FOR APPLICATION OF GENETIC ALGORITHMS TO STRUCTURAL OPTIMIZATION 被引量:1
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作者 金海波 丁运亮 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2003年第2期147-154,共8页
Although the genetic algorithm (GA) has very powerful robustness and fitness, it needs a large size of population and a large number of iterations to reach the optimum result. Especially when GA is used in complex str... Although the genetic algorithm (GA) has very powerful robustness and fitness, it needs a large size of population and a large number of iterations to reach the optimum result. Especially when GA is used in complex structural optimization problems, if the structural reanalysis technique is not adopted, the more the number of finite element analysis (FEA) is, the more the consuming time is. In the conventional structural optimization the number of FEA can be reduced by the structural reanalysis technique based on the approximation techniques and sensitivity analysis. With these techniques, this paper provides a new approximation model-segment approximation model, adopted for the GA application. This segment approximation model can decrease the number of FEA and increase the convergence rate of GA. So it can apparently decrease the computation time of GA. Two examples demonstrate the availability of the new segment approximation model. 展开更多
关键词 approximation techniques segment approximation model genetic algorithms structural optimization sensitivity analysis
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Surrogate-Based Dimensional Optimization of a Polymeric Roller for Ore Belt Conveyors Considering Viscoelastic Effects
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作者 Rafiq Said Dias Jabour Marco Antonio Luersen Euclides Alexandre Bernardelli 《Computers, Materials & Continua》 2026年第3期603-623,共21页
The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft ... The roller is one of the fundamental elements of ore belt conveyor systems since it supports,guides,and directs material on the belt.This component comprises a body(the external tube)that rotates around a fixed shaft supported by easels.The external tube and shaft of rollers used in ore conveyor belts are mostly made of steel,resulting in high mass,hindering maintenance and replacement.Aiming to achieve mass reduction,we conducted a structural optimization of a roller with a polymeric external tube(hereafter referred to as a polymeric roller),seeking the optimal values for two design parameters:the inner diameter of the external tube and the shaft diameter.The optimization was constrained by admissible values for maximum stress,maximum deflection and misalignment angle between the shaft and bearings.A finite element model was built in Ansys Workbench to obtain the structural response of the system.The roller considered is composed of an external tube made of high-density polyethylene(HDPE),bearing seats of polyamide 6(PA6),and a steel shaft.To characterize the polymeric materials(HDPE and PA6),stress relaxation tests were conducted,and the data on shear modulus variation over time were inserted into the model to calculate Prony series terms to account for viscoelastic effects.The roller optimization was performed using surrogate modeling based on radial basis functions,with the Globalized Bounded Nelder-Mead(GBNM)algorithm as the optimizer.Two optimization cases were conducted.In the first case,concerning the roller’s initial material settings,the designs found violated the constraints and could not reduce mass.In the second case,by using PA6 in both bearing seats and the tube,a design configuration was found that respected all constraints and reduced the roller mass by 15.5%,equivalent to 5.15 kg.This study is among the first to integrate experimentally obtained viscoelastic data into the surrogate-based optimization of polymeric rollers,combining methodological innovation with industrial relevance. 展开更多
关键词 Conveyor belt rollers structural optimization surrogate modelling VISCOELASTICITY
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CFD Simulation and Thermal Performance Optimization of a Helical Coil Heat Exchanger in a Heating Furnace
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作者 Yumeng Li Fuyong Su 《Frontiers in Heat and Mass Transfer》 2026年第1期228-246,共19页
Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance.... Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance.The results show that when the equivalent diameter of the spiral tube increased from 16.68 to 21.23 mm,its surface heat transfer coefficient decreased from 22,040 to 17,230 W/m^(2)⋅K,and the outlet air temperature dropped from 822.3 to 807.3 K.However,the pressure loss decreased from 2.692 to 0.958 kPa.which reveals the contradiction between the heat transfer efficiency and the flow resistance.By adding a baffle to enhance the turbulent disturbance,the wall heat flux density is increased by 21.17%,the surface heat transfer coefficient is increased by 12.1%,and the outlet temperature is optimized,which verifies the significant improvement of the heat transfer performance by the countercurrent design.Comprehensive research shows that the collaborative optimization of spiral tube equivalent diameter parameters and baffle flow control is the key to improve the comprehensive performance of heat exchanger.Theresearch results provide a theoretical basis for energy-saving design of industrial heat exchangers. 展开更多
关键词 Spiral tube heat exchanger computational fluid dynamics structural optimization convective heat transfer
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OptimizationDesign and Numerical Simulation of Variable Tube Diameter Heat Exchanger for Split Air Conditioning Indoor Unit
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作者 Zheming Cheng Xinping Ou Yang +2 位作者 Leren Tao Zihao Wang Ke Sun 《Frontiers in Heat and Mass Transfer》 2026年第1期288-313,共26页
Energy shortage has become one of themost concerning issues in the world today,and improving energy utilization efficiency is a key area of research for experts and scholars worldwide.Small-diameter heat exchangers of... Energy shortage has become one of themost concerning issues in the world today,and improving energy utilization efficiency is a key area of research for experts and scholars worldwide.Small-diameter heat exchangers offer advantages such as reduced material usage,lower refrigerant charge,and compact structure.However,they also face challenges,including increased refrigerant pressure drop and smaller heat transfer area inside the tubes.This paper combines the advantages and disadvantages of both small and large-diameter tubes and proposes a combined-diameter heat exchanger,consisting of large and small diameters,for use in the indoor units of split-type air conditioners.There are relatively few studies in this area.In this paper,A theoretical and numerical computation method is employed to establish a theoretical-numerical calculation model,and its reliability is verified through experiments.Using this model,the optimal combined diameters and flow path design for a combined-diameter heat exchanger using R32 as the working fluid are derived.The results show that the heat transfer performance of all combined diameter configurations improves by 2.79%to 8.26%compared to the baseline design,with the coefficient of performance(COP)increasing from 4.15 to 4.27~4.5.These designs can save copper material,but at the cost of an increase in pressure drop by 66.86%to 131.84%.The scheme IIIH,using R32,is the optimal combined-diameter and flow path configuration that balances both heat transfer performance and economic cost. 展开更多
关键词 Split air condition variable tube diameter enhanced heat transfer numerical simulation structural design optimization
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An efficient deep learning-based topology optimization method for continuous fiber composite structure 被引量:1
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作者 Jicheng Li Hongling Ye +3 位作者 Yongjia Dong Zhanli Liu Tianfeng Sun Haisheng Wu 《Acta Mechanica Sinica》 2025年第4期82-96,共15页
This paper presents a deep learning-based topology optimization method for the joint design of material layout and fiber orientation in continuous fiber-reinforced composite structure(CFRCS).The proposed method mainly... This paper presents a deep learning-based topology optimization method for the joint design of material layout and fiber orientation in continuous fiber-reinforced composite structure(CFRCS).The proposed method mainly includes three steps:(1)a ResUNet-involved generative and adversarial network(ResUNet-GAN)is developed to establish the end-to-end mapping from structural design parameters to fiber-reinforced composite optimized structure,and a fiber orientation chromatogram is presented to represent continuous fiber angles;(2)to avoid the local optimum problem,the independent continuous mapping method(ICM method)considering the improved principal stress orientation interpolated continuous fiber angle optimization(PSO-CFAO)strategy is utilized to construct CFRCS topology optimization dataset;(3)the well-trained ResUNet-GAN is deployed to design the optimal structural material distribution together with the corresponding continuous fiber orientations.Numerical simulations for benchmark structure verify that the proposed method greatly improves the design efficiency of CFRCS along with high design accuracy.Furthermore,the CFRCS topology configuration designed by ResUNet-GAN is fabricated by additive manufacturing.Compression experiments of the specimens show that both the stiffness structure and peak load of the CFRCS topology configuration designed by the proposed method have significantly enhanced.The proposed deep learning-based topology optimization method will provide great flexibility in CFRCS for engineering applications. 展开更多
关键词 Topology optimization Fiber-reinforced composite structure Generative and adversarial networks Additive manufacturing
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Progress on Microstructure and Performance Optimization in H/MEAs Regulated by Single and Hierarchical Heterostructures
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作者 Wang Bing Li Chunyan +2 位作者 Wang Xinhua Li Xiaocheng Kou Shengzhong 《稀有金属材料与工程》 北大核心 2025年第3期640-664,共25页
The development of high-performance structural and functional materials is vital in many industrial fields.High-and medium-entropy alloys(H/MEAs)with superior comprehensive properties owing to their specific microstru... The development of high-performance structural and functional materials is vital in many industrial fields.High-and medium-entropy alloys(H/MEAs)with superior comprehensive properties owing to their specific microstructures are promising candidates for structural materials.More importantly,multitudinous efforts have been made to regulate the microstructures and the properties of H/MEAs to further expand their industrial applications.The various heterostructures have enormous potential for the development of H/MEAs with outstanding performance.Herein,multiple heterogeneous structures with single and hierarchical heterogeneities were discussed in detail.Moreover,preparation methods for compositional inhomogeneity,bimodal structures,dualphase structures,lamella/layered structures,harmonic structures(core-shell),multiscale precipitates and heterostructures coupled with specific microstructures in H/MEAs were also systematically reviewed.The deformation mechanisms induced by the different heterostructures were thoroughly discussed to explore the relationship between the heterostructures and the optimized properties of H/MEAs.The contributions of the heterostructures and advanced microstructures to the H/MEAs were comprehensively elucidated to further improve the properties of the alloys.Finally,this review discussed the future challenges of high-performance H/MEAs for industrial applications and provides feasible methods for optimizing heterostructures to enhance the comprehensive properties of H/MEAs. 展开更多
关键词 heterogeneous structures H/MEAs HDI effect microstructure regulation performance optimization
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A NEW METHOD FOR STRUCTURAL TOPOLOGICAL OPTIMIZATION BASED ON THE CONCEPT OF INDEPENDENT CONTINUOUS VARIABLES AND SMOOTH MODEL 被引量:84
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作者 隋允康 杨德庆 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 1998年第2期179-185,共7页
A concept of the independent-continuous topological variable is proposed to establish its corresponding smooth model of structural topological optimization. The method can overcome difficulties that are encountered in... A concept of the independent-continuous topological variable is proposed to establish its corresponding smooth model of structural topological optimization. The method can overcome difficulties that are encountered in conventional models and algorithms for the optimization of the structural topology. Its application to truss topological optimization with stress and displacement constraints is satisfactory, with convergence faster than that of sectional optimizations. 展开更多
关键词 structural topological optimization smooth model adaptive algorithm truss structure independent-continuous variable filter function
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Topology,Size,and Shape Optimization in Civil Engineering Structures:A Review
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作者 Ahmed Manguri Hogr Hassan +1 位作者 Najmadeen Saeed Robert Jankowski 《Computer Modeling in Engineering & Sciences》 2025年第2期933-971,共39页
The optimization of civil engineering structures is critical for enhancing structural performance and material efficiency in engineering applications.Structural optimization approaches seek to determine the optimal de... The optimization of civil engineering structures is critical for enhancing structural performance and material efficiency in engineering applications.Structural optimization approaches seek to determine the optimal design,by considering material performance,cost,and structural safety.The design approaches aim to reduce the built environment’s energy use and carbon emissions.This comprehensive review examines optimization techniques,including size,shape,topology,and multi-objective approaches,by integrating these methodologies.The trends and advancements that contribute to developing more efficient,cost-effective,and reliable structural designs were identified.The review also discusses emerging technologies,such as machine learning applications with different optimization techniques.Optimization of truss,frame,tensegrity,reinforced concrete,origami,pantographic,and adaptive structures are covered and discussed.Optimization techniques are explained,including metaheuristics,genetic algorithm,particle swarm,ant-colony,harmony search algorithm,and their applications with mentioned structure types.Linear and non-linear structures,including geometric and material nonlinearity,are distinguished.The role of optimization in active structures,structural design,seismic design,form-finding,and structural control is taken into account,and the most recent techniques and advancements are mentioned. 展开更多
关键词 structural optimization topology optimization size optimization shape optimization multi-objective optimization
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Recent development in structural design and optimization 被引量:51
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作者 Xu Guo Geng-Dong Cheng 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第6期807-823,共17页
With the fast development of computational mechanics and the capacity as well as the speed of modern computers,simulation-based structural optimization has become an indispensable tool in the design process of competi... With the fast development of computational mechanics and the capacity as well as the speed of modern computers,simulation-based structural optimization has become an indispensable tool in the design process of competitive products.This paper presents a brief description of the current status of structural optimization by reviewing some significant progress made in the last decades.Potential research topics are also discussed.The entire literatures of the field are not covered due to the limitation of the length of paper.The scope of this review is limited and closely related to the authors'own research interests. 展开更多
关键词 structural optimization MULTI-SCALE UNCERTAINTY MULTI-PHYSICS SOFTWARE
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Structure-based optimization of isoaurostatin as novel PDE4 inhibitors with anti-fibrotic effects
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作者 Yi-You Huang Xiang Luo +9 位作者 Kai Zhang Yulan Liang Furong Zhang Guochao Liao Shenghong Xie Pei-Luo Huang Siyu Hou Qian Zhou Yong Zou Hai-Bin Luo 《Chinese Chemical Letters》 2025年第8期344-349,共6页
Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were ... Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease and its incidence rate is rapidly rising.However,effective therapies for the treatment of IPF are still lacking.Phosphodiesterase 4(PDE4)inhibitors were reported to be potential anti-fibrotic agents.Herein,structure-based hit-to-lead optimization of natural isoaurostatin(8.98μmol/L)resulted in several potent inhibitors of PDE4 with half maximal inhibitory concentration(IC_(50))values ranging from 35 nmol/L to 126 nmol/L.Co-crystal structures revealed that isoaurostatin compounds exhibited different binding patterns from the classic PDE4 inhibitor rolipram and the analogues would favor to be Z configurations other than the corresponding E isomers.Finally,lead 2–9 showed remarkable in vitro/in vivo anti-fibrotic effects indicating its potential as a novel anti-IPF agent. 展开更多
关键词 PDE4 Isoaurone structural optimization Crystal structure IPF
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A novel optimization scheme for structure and balance of compound balanced beam pumping units using the PSO, GA, and GWO algorithms
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作者 Jie Wang Quan-Ying Guo +3 位作者 Cheng-Long Fu Gang Dai Cheng-Yu Xia Li-Qin Qian 《Petroleum Science》 2025年第3期1340-1359,共20页
The beam pumping unit(BPU)remains the most stable and reliable equipment for crude oil lifting.Despite its simple four-link mechanism,the structural design of the BPU presents a constrained single-objective optimizati... The beam pumping unit(BPU)remains the most stable and reliable equipment for crude oil lifting.Despite its simple four-link mechanism,the structural design of the BPU presents a constrained single-objective optimization problem.Currently,a comprehensive framework for the structural design and optimization of compound balanced BPUs is lacking.Therefore,this study proposes a novel structural design scheme for BPUs,aiming to meet the practical needs of designers and operators by sequentially optimizing both the dynamic characteristics and balance properties of the BPUs.A dynamic model of compound balanced BPU was established based on D'Alembert's principle.The constraints for structural dimensions were formulated based on the actual operational requirements and design experience with BPUs.To optimize the structure,three algorithms were employed:the particle swarm optimization(PSO)algorithm,the genetic algorithm(GA),and the gray wolf optimization(GWO)algorithm.Each newly generated individuals are regulated by constraints to ensure the rationality of the outcomes.Furthermore,the integration of three algorithms ensures the increased likelihood of attaining the global optimal solution.The polished rod acceleration of the optimized structure is significantly reduced,and the dynamic characteristics of the up and down strokes are essentially symmetrical.Additionally,these three algorithms are also applied to the balance optimization of BPUs based on the measured dynamometer card.The calculation results demonstrate that the GWO-based optimization method exhibits excellent robustness in terms of structural optimization by enhancing the operational smoothness of the BPU,as well as in balance optimization by achieving energy conservation.By applying the optimization scheme proposed in this paper,the CYJW7-3-23HF type of BPU was designed,achieving a maximum polished rod acceleration of±0.675 m/s^(2) when operating at a stroke of 6 min^(−1).When deployed in two wells,the root-mean-square(RMS)torque was minimized,reaching values of 7.539 kN·m and 12.921 kN·m,respectively.The proposed design method not only contributes to the personalized customization but also improves the design efficiency of compound balanced BPUs. 展开更多
关键词 Compound balanced BPU Dynamic model structural optimization Balance optimization CONSTRAINTS
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Composite Structural Optimization by Genetic Algorithm and Neural Network Response Surface Modeling 被引量:14
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作者 徐元铭 李烁 荣晓敏 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2005年第4期310-316,共7页
Neural-Network Response Surfaces (NNRS) is applied to replace the actual expensive finite element analysis during the composite structural optimization process. The Orthotropic Experiment Method (OEM) is used to s... Neural-Network Response Surfaces (NNRS) is applied to replace the actual expensive finite element analysis during the composite structural optimization process. The Orthotropic Experiment Method (OEM) is used to select the most appropriate design samples for network training. The trained response surfaces can either be objective function or constraint conditions. Together with other conven- tional constraints, an optimization model is then set up and can be solved by Genetic Algorithm (GA). This allows the separation between design analysis modeling and optimization searching. Through an example of a hat-stiffened composite plate design, the weight response surface is constructed to be objective function, and strength and buckling response surfaces as constraints; and all of them are trained through NASTRAN finite element analysis. The results of optimization study illustrate that the cycles of structural analysis ean be remarkably reduced or even eliminated during the optimization, thus greatly raising the efficiency of optimization process. It also observed that NNRS approximation can achieve equal or even better accuracy than conventional functional response surfaces. 展开更多
关键词 neural network genetic algorithm response surface composite structural optimization
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