This note is to investigate the properties of strongly semipotent rings.It is proved that every strongly semipotent ring is a idempotent unit regular ring,i.e.,there exist a non-zero idempotent e and a unit u such tha...This note is to investigate the properties of strongly semipotent rings.It is proved that every strongly semipotent ring is a idempotent unit regular ring,i.e.,there exist a non-zero idempotent e and a unit u such that er=eu for all r∉J(R),where J(R)is the Jacobson radical of ring R.展开更多
Multiphase flows widely exist in various scientific and engineering fields,and strongly compressible multiphase flows commonly occur in practical applications,which makes them an important part of computational fluid ...Multiphase flows widely exist in various scientific and engineering fields,and strongly compressible multiphase flows commonly occur in practical applications,which makes them an important part of computational fluid dynamics.In this study,an axisymmetric adaptive multiresolution smooth particle hydrodynamics(SPH)model is proposed to solve various strongly compressible multiphase flow problems.In the present model,the governing equations are discretized in cylindrical polar coordinates,and an improved volume adaptive scheme is developed to better solve the problem of excessive volume change in strongly compressible multiphase flows.On this basis,combined with the adaptive particle refinement technique,an adaptive multiresolution scheme is proposed in this study.In addition,the high-order differential operator and diffusion correction term are utilized to improve the accuracy and stability.The effectiveness of the model is verified by testing four typical strongly compressible multiphase flow problems.By comparing the results of adaptive multiresolution SPH with other numerical results or experimental data,we can conclude that the present SPH method effectively models strongly compressible multiphase flows.展开更多
We investigate the blow-up effect of solutions for a non-homogeneous wave equation u_(tt)−∆u−∆u_(t)=I_(0+)^(α)(|u|^(p))+ω(x),where p>1,0≤α<1 andω(x)with∫_(R)^(N)ω(x)dx>0.By a way of combining the argum...We investigate the blow-up effect of solutions for a non-homogeneous wave equation u_(tt)−∆u−∆u_(t)=I_(0+)^(α)(|u|^(p))+ω(x),where p>1,0≤α<1 andω(x)with∫_(R)^(N)ω(x)dx>0.By a way of combining the argument by contradiction with the test function techniques,we prove that not only any non-trivial solution blows up in finite time under 0<α<1,N≥1 and p>1,but also any non-trivial solution blows up in finite time underα=0,2≤N≤4 and p being the Strauss exponent.展开更多
We find the necessary and sufficient conditions on a coproduct of connected acts over a semigroup to be strongly hopfian. From this, we deduce the conditions of the strong hopfness for unitary acts over groups. Moreov...We find the necessary and sufficient conditions on a coproduct of connected acts over a semigroup to be strongly hopfian. From this, we deduce the conditions of the strong hopfness for unitary acts over groups. Moreover, we prove that a finite coproduct of strongly hopfian acts over an arbitrary semigroup is strongly hopfian.展开更多
In this paper, we mainly investigate some properties of strongly n-Gorenstein projective, injective and flat modules under the extension of rings, which mainly including excellent extensions, morita equivalences, poly...In this paper, we mainly investigate some properties of strongly n-Gorenstein projective, injective and flat modules under the extension of rings, which mainly including excellent extensions, morita equivalences, polynomial extensions and localizations.展开更多
This paper is a study of strongly Ding projective modules with respect to a semidualizing module. The class of strongly Ding flat modules with respect to a semidualizing module is also investigated, and the relationsh...This paper is a study of strongly Ding projective modules with respect to a semidualizing module. The class of strongly Ding flat modules with respect to a semidualizing module is also investigated, and the relationship between strongly Ding projective modules and strongly Ding flat modules with respect to a semidualizing module is characterized.Some well-known results on strongly Ding projective modules, n-strongly Ding projective modules and strongly D_C-projective modules are generalized and unified.展开更多
A new type strongly gain coupled (GC) DFB laser and a new type self alignment spot size converter (SA SSC) are proposed and successfully fabricated.The strongly GC DFB laser is monolithically integrated with the ...A new type strongly gain coupled (GC) DFB laser and a new type self alignment spot size converter (SA SSC) are proposed and successfully fabricated.The strongly GC DFB laser is monolithically integrated with the SA SSC with three step epitaxies.A high single mode yield and large side mode suppression ratio is obtained from the strongly GC DFB laser.A near circle far field pattern is obtained by using the SA SSC.展开更多
In this paper,we prove an existence and uniqueness theorem of the solution for strongly pseudomonotone variational inequalities in reflexive Banach spaces.Based on this result,and investigate the stability behavior of...In this paper,we prove an existence and uniqueness theorem of the solution for strongly pseudomonotone variational inequalities in reflexive Banach spaces.Based on this result,and investigate the stability behavior of the perturbed variational inequalities.Moreover,we obtain an existence theorem of solutions for strongly quasimonotone variational inequalities in finite dimensional spaces.展开更多
We investigate the quantum dynamics of the 1D spinless Fermi-Hubbard model with a linear-tilted potential.Surprisingly in a strong resonance regime,we show that the model can be described by the kinetically constraine...We investigate the quantum dynamics of the 1D spinless Fermi-Hubbard model with a linear-tilted potential.Surprisingly in a strong resonance regime,we show that the model can be described by the kinetically constrained effective Hamiltonian,and it can be spontaneously divided into two commuting parts dubbed Hamiltonian dimerization,which are composed of two distinct sets of constrained nearest-neighbor hopping terms:one set acting exclusively on odd bonds and the other on even bonds.Specifically it is shown that each part can be independently mapped onto the well-known PXP model;therefore the dimerized Hamiltonian is equivalent to a two-fold PXP model.As a consequence,we numerically demonstrate this system can host the so-called quantum many-body scars,which present dynamical revivals and ergodicity-breaking behaviors.However,in sharp contrast with traditional quantum many-body scars,here the scarring states in our model driven by different parts of the Hamiltonian will revive in different periods,and those of double parts can display a biperiodic revival pattern,both originating from the Hamiltonian dimerization.Besides,the condition of off-resonance is also discussed,and we show the crossover from quantum many-body scar to ergodicity breaking is diagnosed via level statistics.Our model provides a platform for understanding the interplay of Hilbert space fragmentation and the constrained quantum systems.展开更多
The concept of the strongly π-regular general ring （with or without unity） is introduced and some extensions of strongly π-regular general rings are considered. Two equivalent characterizations on strongly π- reg...The concept of the strongly π-regular general ring （with or without unity） is introduced and some extensions of strongly π-regular general rings are considered. Two equivalent characterizations on strongly π- regular general rings are provided. It is shown that I is strongly π-regular if and only if, for each x ∈I, x^n =x^n＋1y = zx^n＋1 for n ≥ 1 and y, z ∈ I if and only if every element of I is strongly π-regular. It is also proved that every upper triangular matrix general ring over a strongly π-regular general ring is strongly π-regular and the trivial extension of the strongly π-regular general ring is strongly clean.展开更多
Using the algorithm in this paper, we prove the existence of solutions to the gene-ralized strongly nonlinear quasi-complementarity problems and the convergence of theiterative sequences generated by the algorithm. Ou...Using the algorithm in this paper, we prove the existence of solutions to the gene-ralized strongly nonlinear quasi-complementarity problems and the convergence of theiterative sequences generated by the algorithm. Our results improve and extend thecorresponding results of Noor and Chang-Huang. Moreover, a more general iterativealgorithm for finding the approximate solution of generalized strongly nonlinear quasi-complementarity problems is also given. It is shown that the approximate solution ob-tained by the iterative scheme converges to the exact solution of this quasi-com-plementarity problem.展开更多
The notion of strongly W-Gorenstein complexes is introduced for a self-orthogonal class W of modules. We obtain a characterization of such complexes and apply to strongly Gorenstein injective complexes.
The authors obtain the growth and covering theorems for strongly starlike mappings of order α on bounded starlike circular domains.This kind of domain discussed is rather general,since the domain must be starlike if ...The authors obtain the growth and covering theorems for strongly starlike mappings of order α on bounded starlike circular domains.This kind of domain discussed is rather general,since the domain must be starlike if exists a normalized biholomorphic starlike mapping on it.展开更多
This paper investigates Buck＇s question about which class of spaces is strongly monotonically T2,and if other properties are combined with strongly monotonically T2,which class of spaces could be got. Based on having...This paper investigates Buck＇s question about which class of spaces is strongly monotonically T2,and if other properties are combined with strongly monotonically T2,which class of spaces could be got. Based on having a cushioned pair-base space and compact strongly monotonically T2 space,some results （Theorems 1--3） are obtained.展开更多
Koetzig put forward a question on strongly-regular self-complementary graphs, that is, for any natural number k, whether there exists a strongLy-regular self- complementary graph whose order is 4k ＋ 1, where 4k ＋ 1 ...Koetzig put forward a question on strongly-regular self-complementary graphs, that is, for any natural number k, whether there exists a strongLy-regular self- complementary graph whose order is 4k ＋ 1, where 4k ＋ 1 = x^2 ＋ y^2, x and y are positive integers; what is the minimum number that made there exist at least two non-isomorphic strongly-regular self-complementary graphs. In this paper, we use two famous lemmas to generalize the existential conditions for strongly-regular self-complementary circular graphs with 4k ＋ 1 orders.展开更多
In the Gorenstein homological theory, Gorenstein projective and Gorenstein injective dimensions play an important and fundamental role. In this paper, we aim at studying the closely related strongly Gorenstein flat an...In the Gorenstein homological theory, Gorenstein projective and Gorenstein injective dimensions play an important and fundamental role. In this paper, we aim at studying the closely related strongly Gorenstein flat and Gorenstein FP-injective dimensions, and show that some characterizations similar to Gorenstein homological dimensions hold for these two dimensions.展开更多
In this paper,we introduce and investigate the strongly regular relation.Then we give the relational representations and an intrinsic characterization of strongly algebraic lattices via mapping relation and strongly r...In this paper,we introduce and investigate the strongly regular relation.Then we give the relational representations and an intrinsic characterization of strongly algebraic lattices via mapping relation and strongly regular relation.展开更多
In this paper, the equivalence is established about strongly pseudoinvexity of function and invariant pseudomonotonicity of corresponding gradient map under some suitable conditions.
Strongly acidic wastewater produced in nonferrous metal smelting industries often contains high concentrations of Ni(Ⅱ), which is a valuable metal. In this study, the precipitation of Ni(Ⅱ) from strongly acidic wast...Strongly acidic wastewater produced in nonferrous metal smelting industries often contains high concentrations of Ni(Ⅱ), which is a valuable metal. In this study, the precipitation of Ni(Ⅱ) from strongly acidic wastewater using sodium dimethyldithiocarbamate(DDTC) as the precipitant was evaluated. The effects of various factors on precipitation were investigated, and the precipitation mechanism was also identified. Finally, the nickel in the precipitates was recovered following a pyrometallurgical method. The results show that, under optimised conditions(DDTC:Ni(Ⅱ) molar ratio = 4:1;temperature = 25 ℃), the Ni(Ⅱ) removal efficiency reached 99.3% after 10 min. In strongly acidic wastewater, the dithiocarbamate group of DDTC can react with Ni(Ⅱ) to form DDTC –Ni precipitates. Further recovery experiments revealed that high-purity Ni O can be obtained by the calcination of DDTC –Ni precipitates, with the nickel recovery efficiency reaching 98.2%. The gas released during the calcination process was composed of NO_(2), CS_(2), H_(2)O, CO_(2), and SO_(2). These results provide a basis for an effective Ni(Ⅱ) recovery method from strongly acidic wastewater.展开更多
Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihyd...Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25（OH）2D] are mediated through binding to the vitamin D receptor （VDR）. Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad （MDA-MB-231）, subcutaneously （PC3） or intra-tibially （both cell lines） in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls. These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/0-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1, interleukin-6 （IL-6）, and IL-8. Stabilization of 0-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer.展开更多
文摘This note is to investigate the properties of strongly semipotent rings.It is proved that every strongly semipotent ring is a idempotent unit regular ring,i.e.,there exist a non-zero idempotent e and a unit u such that er=eu for all r∉J(R),where J(R)is the Jacobson radical of ring R.
基金Supported by the Guangxi Natural Science Foundation(Grant No.2021GXNSFBA196008)the Guangxi Science and Technology Development Program(Grant No.GuikeAD22035189).
文摘Multiphase flows widely exist in various scientific and engineering fields,and strongly compressible multiphase flows commonly occur in practical applications,which makes them an important part of computational fluid dynamics.In this study,an axisymmetric adaptive multiresolution smooth particle hydrodynamics(SPH)model is proposed to solve various strongly compressible multiphase flow problems.In the present model,the governing equations are discretized in cylindrical polar coordinates,and an improved volume adaptive scheme is developed to better solve the problem of excessive volume change in strongly compressible multiphase flows.On this basis,combined with the adaptive particle refinement technique,an adaptive multiresolution scheme is proposed in this study.In addition,the high-order differential operator and diffusion correction term are utilized to improve the accuracy and stability.The effectiveness of the model is verified by testing four typical strongly compressible multiphase flow problems.By comparing the results of adaptive multiresolution SPH with other numerical results or experimental data,we can conclude that the present SPH method effectively models strongly compressible multiphase flows.
基金Supported by National Natural Science Foundation of China(Grant No.62363005).
文摘We investigate the blow-up effect of solutions for a non-homogeneous wave equation u_(tt)−∆u−∆u_(t)=I_(0+)^(α)(|u|^(p))+ω(x),where p>1,0≤α<1 andω(x)with∫_(R)^(N)ω(x)dx>0.By a way of combining the argument by contradiction with the test function techniques,we prove that not only any non-trivial solution blows up in finite time under 0<α<1,N≥1 and p>1,but also any non-trivial solution blows up in finite time underα=0,2≤N≤4 and p being the Strauss exponent.
文摘We find the necessary and sufficient conditions on a coproduct of connected acts over a semigroup to be strongly hopfian. From this, we deduce the conditions of the strong hopfness for unitary acts over groups. Moreover, we prove that a finite coproduct of strongly hopfian acts over an arbitrary semigroup is strongly hopfian.
基金Supported by the NNSF of China(10901129)Supported by the SRFDP(20096203120001)
文摘In this paper, we mainly investigate some properties of strongly n-Gorenstein projective, injective and flat modules under the extension of rings, which mainly including excellent extensions, morita equivalences, polynomial extensions and localizations.
基金Supported by the Postdoctoral Science Foundation of China（2017M611851）, the Jiangsu Planned Projects for Postdoctoral Research Funds（1601151C） and the Provincial Natural Science Foundation of Anhui Province（KJ2017A040）
文摘This paper is a study of strongly Ding projective modules with respect to a semidualizing module. The class of strongly Ding flat modules with respect to a semidualizing module is also investigated, and the relationship between strongly Ding projective modules and strongly Ding flat modules with respect to a semidualizing module is characterized.Some well-known results on strongly Ding projective modules, n-strongly Ding projective modules and strongly D_C-projective modules are generalized and unified.
文摘A new type strongly gain coupled (GC) DFB laser and a new type self alignment spot size converter (SA SSC) are proposed and successfully fabricated.The strongly GC DFB laser is monolithically integrated with the SA SSC with three step epitaxies.A high single mode yield and large side mode suppression ratio is obtained from the strongly GC DFB laser.A near circle far field pattern is obtained by using the SA SSC.
文摘In this paper,we prove an existence and uniqueness theorem of the solution for strongly pseudomonotone variational inequalities in reflexive Banach spaces.Based on this result,and investigate the stability behavior of the perturbed variational inequalities.Moreover,we obtain an existence theorem of solutions for strongly quasimonotone variational inequalities in finite dimensional spaces.
基金supported by the National Key R&D Program of China(Grant No.2023YFA1406002)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0301200)。
文摘We investigate the quantum dynamics of the 1D spinless Fermi-Hubbard model with a linear-tilted potential.Surprisingly in a strong resonance regime,we show that the model can be described by the kinetically constrained effective Hamiltonian,and it can be spontaneously divided into two commuting parts dubbed Hamiltonian dimerization,which are composed of two distinct sets of constrained nearest-neighbor hopping terms:one set acting exclusively on odd bonds and the other on even bonds.Specifically it is shown that each part can be independently mapped onto the well-known PXP model;therefore the dimerized Hamiltonian is equivalent to a two-fold PXP model.As a consequence,we numerically demonstrate this system can host the so-called quantum many-body scars,which present dynamical revivals and ergodicity-breaking behaviors.However,in sharp contrast with traditional quantum many-body scars,here the scarring states in our model driven by different parts of the Hamiltonian will revive in different periods,and those of double parts can display a biperiodic revival pattern,both originating from the Hamiltonian dimerization.Besides,the condition of off-resonance is also discussed,and we show the crossover from quantum many-body scar to ergodicity breaking is diagnosed via level statistics.Our model provides a platform for understanding the interplay of Hilbert space fragmentation and the constrained quantum systems.
基金The Foundation for Excellent Doctoral Dissertationof Southeast University (NoYBJJ0507)the National Natural ScienceFoundation of China (No10571026)the Natural Science Foundation ofJiangsu Province (NoBK2005207)
文摘The concept of the strongly π-regular general ring （with or without unity） is introduced and some extensions of strongly π-regular general rings are considered. Two equivalent characterizations on strongly π- regular general rings are provided. It is shown that I is strongly π-regular if and only if, for each x ∈I, x^n =x^n＋1y = zx^n＋1 for n ≥ 1 and y, z ∈ I if and only if every element of I is strongly π-regular. It is also proved that every upper triangular matrix general ring over a strongly π-regular general ring is strongly π-regular and the trivial extension of the strongly π-regular general ring is strongly clean.
文摘Using the algorithm in this paper, we prove the existence of solutions to the gene-ralized strongly nonlinear quasi-complementarity problems and the convergence of theiterative sequences generated by the algorithm. Our results improve and extend thecorresponding results of Noor and Chang-Huang. Moreover, a more general iterativealgorithm for finding the approximate solution of generalized strongly nonlinear quasi-complementarity problems is also given. It is shown that the approximate solution ob-tained by the iterative scheme converges to the exact solution of this quasi-com-plementarity problem.
基金Supported by the National Natural Science Foundation of China(Grant No.11501451)The Fund for Talent Introduction of Northwest Minzu University(Grant No.xbmuyjrc201406)
文摘The notion of strongly W-Gorenstein complexes is introduced for a self-orthogonal class W of modules. We obtain a characterization of such complexes and apply to strongly Gorenstein injective complexes.
文摘The authors obtain the growth and covering theorems for strongly starlike mappings of order α on bounded starlike circular domains.This kind of domain discussed is rather general,since the domain must be starlike if exists a normalized biholomorphic starlike mapping on it.
文摘This paper investigates Buck＇s question about which class of spaces is strongly monotonically T2,and if other properties are combined with strongly monotonically T2,which class of spaces could be got. Based on having a cushioned pair-base space and compact strongly monotonically T2 space,some results （Theorems 1--3） are obtained.
文摘Koetzig put forward a question on strongly-regular self-complementary graphs, that is, for any natural number k, whether there exists a strongLy-regular self- complementary graph whose order is 4k ＋ 1, where 4k ＋ 1 = x^2 ＋ y^2, x and y are positive integers; what is the minimum number that made there exist at least two non-isomorphic strongly-regular self-complementary graphs. In this paper, we use two famous lemmas to generalize the existential conditions for strongly-regular self-complementary circular graphs with 4k ＋ 1 orders.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1120137711261050)+1 种基金China Postdoctoral Science Foundation(Grant No.2013M541509)Program of Science and Technique of Gansu Province(Grant No.1208RJZA145)
文摘In the Gorenstein homological theory, Gorenstein projective and Gorenstein injective dimensions play an important and fundamental role. In this paper, we aim at studying the closely related strongly Gorenstein flat and Gorenstein FP-injective dimensions, and show that some characterizations similar to Gorenstein homological dimensions hold for these two dimensions.
基金Supported by the National Natural Science Foundation of China(10861007)
文摘In this paper,we introduce and investigate the strongly regular relation.Then we give the relational representations and an intrinsic characterization of strongly algebraic lattices via mapping relation and strongly regular relation.
基金Supported by the National Science Foundation of China(10831009)Supported by the Special Fund of Chongqing Key Laboratory(CSTC)Supported by the Education Committee Research Foundation of Chongqing(KJ110625)
文摘In this paper, the equivalence is established about strongly pseudoinvexity of function and invariant pseudomonotonicity of corresponding gradient map under some suitable conditions.
基金supported by the National Key Research and Development Project (No. 2019YFC1907603 )the National Natural Science Foundation of China (Nos. 21976195 , 21707153 )。
文摘Strongly acidic wastewater produced in nonferrous metal smelting industries often contains high concentrations of Ni(Ⅱ), which is a valuable metal. In this study, the precipitation of Ni(Ⅱ) from strongly acidic wastewater using sodium dimethyldithiocarbamate(DDTC) as the precipitant was evaluated. The effects of various factors on precipitation were investigated, and the precipitation mechanism was also identified. Finally, the nickel in the precipitates was recovered following a pyrometallurgical method. The results show that, under optimised conditions(DDTC:Ni(Ⅱ) molar ratio = 4:1;temperature = 25 ℃), the Ni(Ⅱ) removal efficiency reached 99.3% after 10 min. In strongly acidic wastewater, the dithiocarbamate group of DDTC can react with Ni(Ⅱ) to form DDTC –Ni precipitates. Further recovery experiments revealed that high-purity Ni O can be obtained by the calcination of DDTC –Ni precipitates, with the nickel recovery efficiency reaching 98.2%. The gas released during the calcination process was composed of NO_(2), CS_(2), H_(2)O, CO_(2), and SO_(2). These results provide a basis for an effective Ni(Ⅱ) recovery method from strongly acidic wastewater.
基金supported by Cancer Institute NSW CDF fellowship (YZ)Cure Cancer Foundation of Australia (YZ)+3 种基金Cancer Council New South Wales (MJS, YZ, HZ, and CRD)Prostate Cancer Foundation of Australia (MJS, YZ, HZ, and CRD)NH and MRC Early Career Fellowship 596870 (YZ)German Research Foundation HO 5109/2-1 and HO 5109/2-2 (KH)
文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25（OH）2D] are mediated through binding to the vitamin D receptor （VDR）. Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad （MDA-MB-231）, subcutaneously （PC3） or intra-tibially （both cell lines） in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls. These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/0-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1, interleukin-6 （IL-6）, and IL-8. Stabilization of 0-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer.
