Objectives Our study aims to examine the value of endovascular therapy(EVT)and its comparison to medical management(MM)in ischaemic stroke patients accompanied by large artery atherosclerosis(LAA)and non-LAA Methods m...Objectives Our study aims to examine the value of endovascular therapy(EVT)and its comparison to medical management(MM)in ischaemic stroke patients accompanied by large artery atherosclerosis(LAA)and non-LAA Methods modified Rankin scale score(mRS)was evaluated at 90 days post the stroke attack and was considered as the primary outcome.Other outcomes measured in this study included score changes of 0-2 and 0-3 on the mRS.The occurrence of symptomatic intracranial haemorrhage at 24 hours after EVT was also measured as a safety endpoint.Logistic regression analysis was used to determine the associations.Results In the LAA group,no significant difference in mRS at 90-day(median IQR 3(2-5)vs 4(3-4),95%CI 0.53 to 2.00,p=0.924),mRS 0-2 and mRS 0-3 was observed between EVT and MM groups.However,in the non-LAA group,patients who underwent EVT had lower 90-day mRS scores(4(2-5)vs 4(3-5),generalised OR 1.47,95%CI 1.14 to 1.88,p<0.001).No interaction effect on the primary outcomes between treatment options and aetiology.More intracranial haemorrhage events within 48 hours were identified in the EVT group for both LAA and non-LAA cohorts(LAA:40.98%vs 9.62%,relative risk(RR)4.26,95%CI 1.76 to 10.34,p<0.001;non-LAA,52.07%vs 19.65%,RR 2.65,95%CI 1.90 to 3.70,respectively).Conclusions For large infarcts,EVT may be more effective than MM for patients with non-LAA aetiology,but not for those with LAA stroke.As no interaction effect was found,the benefit of EVT compared with MM did not vary by stroke subtypes.展开更多
To the Editor:Depression is a common psychiatric disorder,affecting over 260 million people of all ages globally.[1]Prior studies investigating the association between antidepressant use and stroke risk have yielded i...To the Editor:Depression is a common psychiatric disorder,affecting over 260 million people of all ages globally.[1]Prior studies investigating the association between antidepressant use and stroke risk have yielded inconsistent results.[2,3]Consequently,it remains unclear which of the various antidepressant categories may affect stroke.Thus,the rational use of antidepressants is important for reducing stroke risk and recurrence,while offering candidate therapeutic targets.Drug-target Mendelian randomization(MR)analysis,which uses genetic variants located in or near the region of drug target genes as proxies for drug effects,is a promising tool for identifying causal links between drug targets and diseases.展开更多
It is unanimously accepted that stroke is a highly heterogeneous disorder. Different subtypes of ischemic stroke may have different risk factors, clinical features, and prognoses. The aim of this study was to evaluate...It is unanimously accepted that stroke is a highly heterogeneous disorder. Different subtypes of ischemic stroke may have different risk factors, clinical features, and prognoses. The aim of this study was to evaluate the risk factors, clinical characteristics, and prognoses of different subtypes of ischemic stroke defined by the Trial of ORG10172 in Acute Stroke Treatment （TOAST） criteria. We prospectively analyzed the data from 530 consecutive patients who were admitted to our hospital with acute ischemic stroke within 7 days of stroke onset during the study period. Standardized data assessment was used and the cause of ischemic stroke was classified according to the TOAST criteria. Patients were followed up till 30 and 90 days after stroke onset. It was found that large-artery atherosclerosis was the most frequent etiology of stroke （37.4%）, and showed the highest male preponderance, the highest prevalence of previous transient ischemic attack, and the longest hospital stay among all subtypes. Small artery disease （36.4%） was associated with higher body mass index, higher plasma triglycerides, and lower plasma high-density lipoprotein cholesterol than cardioembolism. Cardioembolism （7.7%）, which was particularly common in the elderly （i.e., individuals aged 65 years and older）, showed the highest female preponderance, the highest prevalence of atrial fibrillation, the earliest presentation to hospital after stroke onset, the most severe symptoms on admission, the maximum complications associated with an adverse outcome, and the highest rate of stroke recurrence and mortality. Our results suggest that ischemic stroke should be regarded as a highly heterogeneous disorder. Studies involving risk factors, clinical features, and prognoses of ischemic stroke should differentiate between etiologic stroke subtypes.展开更多
Background： Differentiating intracerebral hemorrhage （ICH） from cerebral infarction as early as possible is vital tbr the timely initiation of different treatments. This study developed an applicable model for the ...Background： Differentiating intracerebral hemorrhage （ICH） from cerebral infarction as early as possible is vital tbr the timely initiation of different treatments. This study developed an applicable model for the ambulance system to differentiate stroke subtypes. Methods： From 26,163 patients initially screened over 4 years, this study comprised 1989 consecutive patients with potential first-ever acute stroke with sudden onset of the focal neurological deficit, conscious or not, and given ambulance transport for admission to two county hospitals in Yutian County of Hebei Province. All the patients underwent cranial computed tomography （CT） or magnetic resonance imaging to confirm the final diagnosis based on stroke criteria. Correlation with stroke subtype clinical features was calculated and Bayes＇ discriminant model was applied to discriminate stroke subtypes. Results： Among the 1989 patients, 797,689, 109, and 394 received diagnoses of cerebral infarction, ICH, subarachnoid hemorrhage, and other forms of nonstroke, respectively. A history of atrial fibrillation, vomiting, and diabetes mellitus were associated with cerebral infarction, while vomiting, systolic blood pressure _〉180 mmHg, and age 〈65 years were more typical of ICH. For noncomatose stroke patients, Bayes＇ discriminant model for stroke subtype yielded a combination of multiple items that provided 72.3% agreement in the test model and 79.3% in the validation model; for comatose patients, corresponding agreement rates were 75.4% and 73.5%. Conclusions： The model herein presented, with multiple parameters, can predict stroke subtypes with acceptable sensitivity and specificity before CT scanning, either in alert or comatose patients. This may facilitate prehospital management for patients with stroke.展开更多
基金supported by unrestricted grants from Covidien Healthcare International Trading(Shanghai)Johnson&Johnson MedTech,Genesis MedTech(Shanghai)+4 种基金Shanghai HeartCare Medical TechnologyNational Health Commission Capacity Building and Continuing Education Center Nervous System and Minimally Invasive Intervention Program.No.GWJJ2022100106.Tianjin Health Science and Technology Project No.MS20015Beijing-Tianjin Hebei Basic Research Cooperation Project(Grant number:22JCZXJC00190)Beijing Postdoctoral Research Foundation,Grant/Award Number:2021-ZZ 029Tianjin Key Research and Development Program in Science and Technology,No.19YFZCSY00260.
文摘Objectives Our study aims to examine the value of endovascular therapy(EVT)and its comparison to medical management(MM)in ischaemic stroke patients accompanied by large artery atherosclerosis(LAA)and non-LAA Methods modified Rankin scale score(mRS)was evaluated at 90 days post the stroke attack and was considered as the primary outcome.Other outcomes measured in this study included score changes of 0-2 and 0-3 on the mRS.The occurrence of symptomatic intracranial haemorrhage at 24 hours after EVT was also measured as a safety endpoint.Logistic regression analysis was used to determine the associations.Results In the LAA group,no significant difference in mRS at 90-day(median IQR 3(2-5)vs 4(3-4),95%CI 0.53 to 2.00,p=0.924),mRS 0-2 and mRS 0-3 was observed between EVT and MM groups.However,in the non-LAA group,patients who underwent EVT had lower 90-day mRS scores(4(2-5)vs 4(3-5),generalised OR 1.47,95%CI 1.14 to 1.88,p<0.001).No interaction effect on the primary outcomes between treatment options and aetiology.More intracranial haemorrhage events within 48 hours were identified in the EVT group for both LAA and non-LAA cohorts(LAA:40.98%vs 9.62%,relative risk(RR)4.26,95%CI 1.76 to 10.34,p<0.001;non-LAA,52.07%vs 19.65%,RR 2.65,95%CI 1.90 to 3.70,respectively).Conclusions For large infarcts,EVT may be more effective than MM for patients with non-LAA aetiology,but not for those with LAA stroke.As no interaction effect was found,the benefit of EVT compared with MM did not vary by stroke subtypes.
文摘To the Editor:Depression is a common psychiatric disorder,affecting over 260 million people of all ages globally.[1]Prior studies investigating the association between antidepressant use and stroke risk have yielded inconsistent results.[2,3]Consequently,it remains unclear which of the various antidepressant categories may affect stroke.Thus,the rational use of antidepressants is important for reducing stroke risk and recurrence,while offering candidate therapeutic targets.Drug-target Mendelian randomization(MR)analysis,which uses genetic variants located in or near the region of drug target genes as proxies for drug effects,is a promising tool for identifying causal links between drug targets and diseases.
文摘It is unanimously accepted that stroke is a highly heterogeneous disorder. Different subtypes of ischemic stroke may have different risk factors, clinical features, and prognoses. The aim of this study was to evaluate the risk factors, clinical characteristics, and prognoses of different subtypes of ischemic stroke defined by the Trial of ORG10172 in Acute Stroke Treatment （TOAST） criteria. We prospectively analyzed the data from 530 consecutive patients who were admitted to our hospital with acute ischemic stroke within 7 days of stroke onset during the study period. Standardized data assessment was used and the cause of ischemic stroke was classified according to the TOAST criteria. Patients were followed up till 30 and 90 days after stroke onset. It was found that large-artery atherosclerosis was the most frequent etiology of stroke （37.4%）, and showed the highest male preponderance, the highest prevalence of previous transient ischemic attack, and the longest hospital stay among all subtypes. Small artery disease （36.4%） was associated with higher body mass index, higher plasma triglycerides, and lower plasma high-density lipoprotein cholesterol than cardioembolism. Cardioembolism （7.7%）, which was particularly common in the elderly （i.e., individuals aged 65 years and older）, showed the highest female preponderance, the highest prevalence of atrial fibrillation, the earliest presentation to hospital after stroke onset, the most severe symptoms on admission, the maximum complications associated with an adverse outcome, and the highest rate of stroke recurrence and mortality. Our results suggest that ischemic stroke should be regarded as a highly heterogeneous disorder. Studies involving risk factors, clinical features, and prognoses of ischemic stroke should differentiate between etiologic stroke subtypes.
文摘Background： Differentiating intracerebral hemorrhage （ICH） from cerebral infarction as early as possible is vital tbr the timely initiation of different treatments. This study developed an applicable model for the ambulance system to differentiate stroke subtypes. Methods： From 26,163 patients initially screened over 4 years, this study comprised 1989 consecutive patients with potential first-ever acute stroke with sudden onset of the focal neurological deficit, conscious or not, and given ambulance transport for admission to two county hospitals in Yutian County of Hebei Province. All the patients underwent cranial computed tomography （CT） or magnetic resonance imaging to confirm the final diagnosis based on stroke criteria. Correlation with stroke subtype clinical features was calculated and Bayes＇ discriminant model was applied to discriminate stroke subtypes. Results： Among the 1989 patients, 797,689, 109, and 394 received diagnoses of cerebral infarction, ICH, subarachnoid hemorrhage, and other forms of nonstroke, respectively. A history of atrial fibrillation, vomiting, and diabetes mellitus were associated with cerebral infarction, while vomiting, systolic blood pressure _〉180 mmHg, and age 〈65 years were more typical of ICH. For noncomatose stroke patients, Bayes＇ discriminant model for stroke subtype yielded a combination of multiple items that provided 72.3% agreement in the test model and 79.3% in the validation model; for comatose patients, corresponding agreement rates were 75.4% and 73.5%. Conclusions： The model herein presented, with multiple parameters, can predict stroke subtypes with acceptable sensitivity and specificity before CT scanning, either in alert or comatose patients. This may facilitate prehospital management for patients with stroke.
