Unresectable hepatocellular carcinoma(HCC)remains a global challenge,with limited effective treatment options for advanced-stage disease.The HIMALAYA trial(phase III randomized study that evaluated the STRIDE regimen)...Unresectable hepatocellular carcinoma(HCC)remains a global challenge,with limited effective treatment options for advanced-stage disease.The HIMALAYA trial(phase III randomized study that evaluated the STRIDE regimen)introduced the Single Tremelimumab Regular Interval Durvalumab(STRIDE)regimen,an immunotherapy-based approach that achieved a median overall survival(OS)of 16.43 months compared to 13.77 months with sorafenib.While statistically significant,this~2.7 months OS gain warrants scrutiny in light of STRIDE’s increased immune-related toxicity and cost.This commentary evaluates STRIDE’s impact within the broader landscape of first-line systemic therapy for unresectable HCC,alongside other regimens such as atezolizumab plus bevacizumab and nivolumab plus ipilimumab.We explore STRIDE’s mechanism of action,safety profile,modest progression-free survival(PFS)improvement,and implementation challenges,incorporating insights from 2023-2025 research.In addition,we discussed its limitations in non-viral HCC and Child-Pugh B patients,the role of emerging biomarkers,and the potential of radiation to enhance immunotherapy efficacy.As a dual immune checkpoint inhibitor(ICI)strategy,STRIDE offers an important advance that may not only extend survival but also open the door to future curative approaches.However,optimizing its use will require refined patient selection and further investigation of synergistic combination therapies.展开更多
解决高校关键业务系统潜在的风险和漏洞的方法有很多种,现利用STRIDE威胁模型对高校关键业务系统所面临的威胁进行实践研究。通过建立STRIDE安全威胁模型,对关键业务系统的数据流进行梳理和风险分析,量化和细化各类安全威胁,并结合OWASP...解决高校关键业务系统潜在的风险和漏洞的方法有很多种,现利用STRIDE威胁模型对高校关键业务系统所面临的威胁进行实践研究。通过建立STRIDE安全威胁模型,对关键业务系统的数据流进行梳理和风险分析,量化和细化各类安全威胁,并结合OWASP TOP 10进行漏洞验证,进而有针对性地提出各类威胁相应的解决方法和应对策略。展开更多
Background： Lower body positive pressure （LBPP） treadmills can be used in rehabilitation programs and/or to supplement tun mileage in healthy runners by reducing the effective body weight and impact associated with...Background： Lower body positive pressure （LBPP） treadmills can be used in rehabilitation programs and/or to supplement tun mileage in healthy runners by reducing the effective body weight and impact associated with running. The purpose of this study is to determine if body weight support influences the stride length （SL）-velocity as well as leg impact acceleration relationship during running. Methods： Subjects （n = 10, 21.4 ± 2.0 years, 72.4 ± 10.3 kg, 1.76 ± 0.09 m） completed 16 run conditions consisting of specific body weight support and velocity combinations. Velocities tested were 100%, 110%, 120%, and 130% of the preferred velocity （2.75± 0.36 m/s）. Body weight support conditions consisted of 0, 60%,5, 70%, and 80% body weight support. SL and leg impact accelerations were determined using a light-weight accelerometer mounted on the surface of the anterior-distal aspect of the tibia. A 4 × 4 （velocity x body weight support） repeated measures ANOVA was used for each dependent variable （a = 0.05）. Results： Neither SL nor leg impact acceleration were influenced by the interaction of body weight support and velocity （p 〉 0.05）. SL was least during no body weight support （p 〈 0.05） but not different between 60%, 70%, and 80% support （p 〉 0.05）. Leg impact acceleration was greatest during no body weight support （p 〈 0.05） but not different between 60%, 70%, and 80% support （p 〉 0.05）. SL and leg impact accelerations increased with velocity regardless of support （p 〈 0.05）. Conclusion： The relationships between SL and leg impact accelerations with velocity were not influenced by body weight support.展开更多
The year 1994 will see the promotion of further economic restructuring in China and key breakthroughs. The reform of the foreign exchange system, in particular, has provided a rare opportunity for exports in foreign t...The year 1994 will see the promotion of further economic restructuring in China and key breakthroughs. The reform of the foreign exchange system, in particular, has provided a rare opportunity for exports in foreign trade. Facing this favourable situation, the Shandong provincial government has decided export earnings are its main priority and wants to see a 16 to 20 percent growth above the US$5.7 billion earned last year. It will speed up the linking展开更多
on the basis of the self-organizing theories the thesis analyzes how enterprises realize the stride development through the technology stride. At First the thesis sets up the stride development system of enterprises a...on the basis of the self-organizing theories the thesis analyzes how enterprises realize the stride development through the technology stride. At First the thesis sets up the stride development system of enterprises and then the thesis reveals the mechanism that the technology stride will give rise to the stride development of ente^fises. In the end the thesis puts forward the enlightenment for the stride development of enterprises from the stride development system of enterprises.展开更多
As low cost and highly portable sensors, inertial measurements units (IMU) have become increas-ingly used in gait analysis, embodying an efficient alternative to motion capture systems. Mean-while, being able to compu...As low cost and highly portable sensors, inertial measurements units (IMU) have become increas-ingly used in gait analysis, embodying an efficient alternative to motion capture systems. Mean-while, being able to compute reliably accurate spatial gait parameters using few sensors remains a relatively complex problematic. Providing a clinical oriented solution, our study presents a gy-rometer and accelerometer based algorithm for stride length estimation. Compared to most of the numerous existing works where only an averaged stride length is computed from several IMU, or where the use of the magnetometer is incompatible with everyday use, our challenge here has been to extract each individual stride length in an easy-to-use algorithm requiring only one inertial sensor attached to the subject shank. Our results were validated on healthy subjects and patients suffering from Parkinson’s disease (PD). Estimated stride lengths were compared to GAITRite? walkway system data: the mean error over all the strides was less than 6% for healthy group and 10.3% for PD group. This method provides a reliable portable solution for monitoring the in-stantaneous stride length and opens the way to promising applications.展开更多
文摘Unresectable hepatocellular carcinoma(HCC)remains a global challenge,with limited effective treatment options for advanced-stage disease.The HIMALAYA trial(phase III randomized study that evaluated the STRIDE regimen)introduced the Single Tremelimumab Regular Interval Durvalumab(STRIDE)regimen,an immunotherapy-based approach that achieved a median overall survival(OS)of 16.43 months compared to 13.77 months with sorafenib.While statistically significant,this~2.7 months OS gain warrants scrutiny in light of STRIDE’s increased immune-related toxicity and cost.This commentary evaluates STRIDE’s impact within the broader landscape of first-line systemic therapy for unresectable HCC,alongside other regimens such as atezolizumab plus bevacizumab and nivolumab plus ipilimumab.We explore STRIDE’s mechanism of action,safety profile,modest progression-free survival(PFS)improvement,and implementation challenges,incorporating insights from 2023-2025 research.In addition,we discussed its limitations in non-viral HCC and Child-Pugh B patients,the role of emerging biomarkers,and the potential of radiation to enhance immunotherapy efficacy.As a dual immune checkpoint inhibitor(ICI)strategy,STRIDE offers an important advance that may not only extend survival but also open the door to future curative approaches.However,optimizing its use will require refined patient selection and further investigation of synergistic combination therapies.
文摘解决高校关键业务系统潜在的风险和漏洞的方法有很多种,现利用STRIDE威胁模型对高校关键业务系统所面临的威胁进行实践研究。通过建立STRIDE安全威胁模型,对关键业务系统的数据流进行梳理和风险分析,量化和细化各类安全威胁,并结合OWASP TOP 10进行漏洞验证,进而有针对性地提出各类威胁相应的解决方法和应对策略。
文摘Background： Lower body positive pressure （LBPP） treadmills can be used in rehabilitation programs and/or to supplement tun mileage in healthy runners by reducing the effective body weight and impact associated with running. The purpose of this study is to determine if body weight support influences the stride length （SL）-velocity as well as leg impact acceleration relationship during running. Methods： Subjects （n = 10, 21.4 ± 2.0 years, 72.4 ± 10.3 kg, 1.76 ± 0.09 m） completed 16 run conditions consisting of specific body weight support and velocity combinations. Velocities tested were 100%, 110%, 120%, and 130% of the preferred velocity （2.75± 0.36 m/s）. Body weight support conditions consisted of 0, 60%,5, 70%, and 80% body weight support. SL and leg impact accelerations were determined using a light-weight accelerometer mounted on the surface of the anterior-distal aspect of the tibia. A 4 × 4 （velocity x body weight support） repeated measures ANOVA was used for each dependent variable （a = 0.05）. Results： Neither SL nor leg impact acceleration were influenced by the interaction of body weight support and velocity （p 〉 0.05）. SL was least during no body weight support （p 〈 0.05） but not different between 60%, 70%, and 80% support （p 〉 0.05）. Leg impact acceleration was greatest during no body weight support （p 〈 0.05） but not different between 60%, 70%, and 80% support （p 〉 0.05）. SL and leg impact accelerations increased with velocity regardless of support （p 〈 0.05）. Conclusion： The relationships between SL and leg impact accelerations with velocity were not influenced by body weight support.
文摘The year 1994 will see the promotion of further economic restructuring in China and key breakthroughs. The reform of the foreign exchange system, in particular, has provided a rare opportunity for exports in foreign trade. Facing this favourable situation, the Shandong provincial government has decided export earnings are its main priority and wants to see a 16 to 20 percent growth above the US$5.7 billion earned last year. It will speed up the linking
文摘on the basis of the self-organizing theories the thesis analyzes how enterprises realize the stride development through the technology stride. At First the thesis sets up the stride development system of enterprises and then the thesis reveals the mechanism that the technology stride will give rise to the stride development of ente^fises. In the end the thesis puts forward the enlightenment for the stride development of enterprises from the stride development system of enterprises.
基金supported by an INRIA internal financial support:ADT SENSBIO and a Montpellier Hospital internal financial support(AOI PARKDEMAR CHU Montpellier).
文摘As low cost and highly portable sensors, inertial measurements units (IMU) have become increas-ingly used in gait analysis, embodying an efficient alternative to motion capture systems. Mean-while, being able to compute reliably accurate spatial gait parameters using few sensors remains a relatively complex problematic. Providing a clinical oriented solution, our study presents a gy-rometer and accelerometer based algorithm for stride length estimation. Compared to most of the numerous existing works where only an averaged stride length is computed from several IMU, or where the use of the magnetometer is incompatible with everyday use, our challenge here has been to extract each individual stride length in an easy-to-use algorithm requiring only one inertial sensor attached to the subject shank. Our results were validated on healthy subjects and patients suffering from Parkinson’s disease (PD). Estimated stride lengths were compared to GAITRite? walkway system data: the mean error over all the strides was less than 6% for healthy group and 10.3% for PD group. This method provides a reliable portable solution for monitoring the in-stantaneous stride length and opens the way to promising applications.
