The sensitivity problem to mesh distortion and the low accuracy problem of the stress solutions are two inherent difficulties in the finite element method.By applying the fundamental analytical solutions (in global Ca...The sensitivity problem to mesh distortion and the low accuracy problem of the stress solutions are two inherent difficulties in the finite element method.By applying the fundamental analytical solutions (in global Cartesian coordinates) to the Airy stress function of the anisotropic materials,8-and 12-node plane quadrilateral hybrid stress-function (HS-F) elements are successfully developed based on the principle of the minimum complementary energy.Numerical results show that the present new elements exhibit much better and more robust performance in both displacement and stress solutions than those obtained from other models.They can still perform very well even when the element shapes degenerate into a triangle and a concave quadrangle.It is also demonstrated that the proposed construction procedure is an effective way for developing shape-free finite element models which can completely overcome the sensitivity problem to mesh distortion and can produce highly accurate stress solutions.展开更多
细胞自噬作为真核生物中高度保守的保护机制,通过降解并循环利用细胞成分,在植物生长发育和逆境响应中发挥着关键作用。本研究旨在全面阐述植物自噬的生物发生机制及其生理功能,为后续深入研究提供理论基础,并探索其在作物养分高效和抗...细胞自噬作为真核生物中高度保守的保护机制,通过降解并循环利用细胞成分,在植物生长发育和逆境响应中发挥着关键作用。本研究旨在全面阐述植物自噬的生物发生机制及其生理功能,为后续深入研究提供理论基础,并探索其在作物养分高效和抗逆育种中的应用潜力。植物自噬包括巨自噬、微自噬和分子伴侣介导自噬,其生物发生过程包括激活启动、膜延伸、自噬体形成及与液泡融合降解4个阶段,受ATG基因(autophagyrelated gene,ATG)和SnRK1/TOR(SNF1-related protein kinase,SnRK1/target of rapamycin,TOR)相关信号通路调控。Sn RK1可通过TOR依赖和非依赖方式调节自噬,ATG基因在自噬各阶段发挥关键作用,如ATG1/ATG13复合体、ATG12-ATG5-ATG16复合体、ATG8脂化等。自噬调控植物根系发育、养分高效吸收以及衰老与养分循环利用,并增强植物对氮、磷和锌、铁、镉等微量元素胁迫,以及盐、干旱、高温、水淹等非生物胁迫的耐受性。未来研究需深入解析自噬的时空调控网络,整合多组学技术,系统探索其在养分跨膜转运中的机制,及其与激素信号和营养代谢之间的交互作用,同时,结合作物育种,聚焦养分高效吸收、利用与抗逆,推动“自噬-养分高效-抗逆”协同调控,为培育高效抗逆作物提供理论支持,推动农业高效、可持续发展。展开更多
目的:分析利拉鲁肽治疗糖尿病肾脏病的临床效果及安全性。方法:选取2022年1月—2024年9月中国人民解放军联勤保障部队第910医院收治的255例糖尿病肾脏病患者作为研究对象,随机分为对照组(n=127)和观察组(n=128)。对照组应用达格列净治疗...目的:分析利拉鲁肽治疗糖尿病肾脏病的临床效果及安全性。方法:选取2022年1月—2024年9月中国人民解放军联勤保障部队第910医院收治的255例糖尿病肾脏病患者作为研究对象,随机分为对照组(n=127)和观察组(n=128)。对照组应用达格列净治疗,观察组在对照组基础上联合利拉鲁肽治疗。患者均连续治疗10周。对比两组患者血糖指标、肾功能指标及氧化应激指标,并记录不良反应发生率。结果:治疗后,观察组患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)均低于对照组(P<0.05);治疗后,观察组Scr、尿微量白蛋白与尿肌酐比值(UACR)、24 h尿蛋白定量(24 h UTP)均低于对照组(P<0.05);治疗后,观察组丙二醛(MDA)及脂质过氧化氢(LPO)低于对照组,且谷胱甘肽过氧化物酶(GSH-Px)及总抗氧化能力(T-AOC)高于对照组(P<0.05);两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:利拉鲁肽能够提高糖尿病肾脏病的治疗效果,改善肾脏功能及血糖水平,提高抗氧化能力。展开更多
基金supported by the National Natural Science Foundation of China(Grant No.10872108,10876100)the Program for New Century Excellent Talents in University(Grant No. NCET-07-0477)+1 种基金the National Basic Research Program of China(Grant No. 2010CB832701)ASFC
文摘The sensitivity problem to mesh distortion and the low accuracy problem of the stress solutions are two inherent difficulties in the finite element method.By applying the fundamental analytical solutions (in global Cartesian coordinates) to the Airy stress function of the anisotropic materials,8-and 12-node plane quadrilateral hybrid stress-function (HS-F) elements are successfully developed based on the principle of the minimum complementary energy.Numerical results show that the present new elements exhibit much better and more robust performance in both displacement and stress solutions than those obtained from other models.They can still perform very well even when the element shapes degenerate into a triangle and a concave quadrangle.It is also demonstrated that the proposed construction procedure is an effective way for developing shape-free finite element models which can completely overcome the sensitivity problem to mesh distortion and can produce highly accurate stress solutions.
文摘细胞自噬作为真核生物中高度保守的保护机制,通过降解并循环利用细胞成分,在植物生长发育和逆境响应中发挥着关键作用。本研究旨在全面阐述植物自噬的生物发生机制及其生理功能,为后续深入研究提供理论基础,并探索其在作物养分高效和抗逆育种中的应用潜力。植物自噬包括巨自噬、微自噬和分子伴侣介导自噬,其生物发生过程包括激活启动、膜延伸、自噬体形成及与液泡融合降解4个阶段,受ATG基因(autophagyrelated gene,ATG)和SnRK1/TOR(SNF1-related protein kinase,SnRK1/target of rapamycin,TOR)相关信号通路调控。Sn RK1可通过TOR依赖和非依赖方式调节自噬,ATG基因在自噬各阶段发挥关键作用,如ATG1/ATG13复合体、ATG12-ATG5-ATG16复合体、ATG8脂化等。自噬调控植物根系发育、养分高效吸收以及衰老与养分循环利用,并增强植物对氮、磷和锌、铁、镉等微量元素胁迫,以及盐、干旱、高温、水淹等非生物胁迫的耐受性。未来研究需深入解析自噬的时空调控网络,整合多组学技术,系统探索其在养分跨膜转运中的机制,及其与激素信号和营养代谢之间的交互作用,同时,结合作物育种,聚焦养分高效吸收、利用与抗逆,推动“自噬-养分高效-抗逆”协同调控,为培育高效抗逆作物提供理论支持,推动农业高效、可持续发展。
文摘目的:分析利拉鲁肽治疗糖尿病肾脏病的临床效果及安全性。方法:选取2022年1月—2024年9月中国人民解放军联勤保障部队第910医院收治的255例糖尿病肾脏病患者作为研究对象,随机分为对照组(n=127)和观察组(n=128)。对照组应用达格列净治疗,观察组在对照组基础上联合利拉鲁肽治疗。患者均连续治疗10周。对比两组患者血糖指标、肾功能指标及氧化应激指标,并记录不良反应发生率。结果:治疗后,观察组患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)均低于对照组(P<0.05);治疗后,观察组Scr、尿微量白蛋白与尿肌酐比值(UACR)、24 h尿蛋白定量(24 h UTP)均低于对照组(P<0.05);治疗后,观察组丙二醛(MDA)及脂质过氧化氢(LPO)低于对照组,且谷胱甘肽过氧化物酶(GSH-Px)及总抗氧化能力(T-AOC)高于对照组(P<0.05);两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:利拉鲁肽能够提高糖尿病肾脏病的治疗效果,改善肾脏功能及血糖水平,提高抗氧化能力。
