Despite advances in current anti-cancer therapies,challenges such as drug resistance,toxicity,and tumor heterogeneity persist.The limitations of traditional single-target drugs and simple combination therapies are bec...Despite advances in current anti-cancer therapies,challenges such as drug resistance,toxicity,and tumor heterogeneity persist.The limitations of traditional single-target drugs and simple combination therapies are becoming increasingly apparent1.To address these issues,a novel treatment strategy,the artificially intelligent synergistic engineered drug(AISED)paradigm,merits further exploration.This paradigm is based on the systematic engineered integration of multiple active ingredients into a unified single entity through artificial intelligence(AI).This strategy is aimed at developing new anti-cancer drug designs involving multiple ingredients,multiple molecular targets,and multiple biological effects,for multiple cancer types,thereby providing a novel theoretical paradigm for overcoming existing treatment bottlenecks.展开更多
By employing carbon-packed zeolite nanocrystals as primary building blocks,hierarchically porous MFItype zeolites with precise dimensions spanning meso-and micro-length scales were successfully synthesized using an in...By employing carbon-packed zeolite nanocrystals as primary building blocks,hierarchically porous MFItype zeolites with precise dimensions spanning meso-and micro-length scales were successfully synthesized using an in situ crystallization strategy.The generalized Murray’s law was firstly used to theoretically investigate the advantage of the porous hierarchy of the zeolites.The porosity distribution and coordination in the resultant zeolite crystals were found to be basically following the generalized Murray’s law.Probing using the catalytic cracking reaction of isopropyl benzene revealed that as-prepared HierZSM-5 exhibited much higher conversion(∼74.5%),compared with nanoZSM-5(∼30%)and bulky ZSM-5(∼28.6%).The outstanding catalytic performance was ascribed to the highly enhanced mass transfer of the Murray zeolite material in the heterogeneous catalytic reaction.Such a hierarchical single zeolite structure,designed by adopting the generalized Murray’s law,can improve the thermal/hydrothermal stability of nanozeolites,and offer an alternative option for a long-term stable catalyst.展开更多
Two-dimensional fence-like Co-doped NiSe_(2)/C(Co-NiSe_(2)/C)nanosheets are fabricated via a facile solvothermal method followed by a selenization strategy.The Co-NiSe_(2)/C nanosheets are composed of interlaced nanor...Two-dimensional fence-like Co-doped NiSe_(2)/C(Co-NiSe_(2)/C)nanosheets are fabricated via a facile solvothermal method followed by a selenization strategy.The Co-NiSe_(2)/C nanosheets are composed of interlaced nanorods,which are made up of small nanoparticles with a size of 20 nm.The surfaces of these small nanoparticles are covered in thin carbon layers.展开更多
The fabrication of nonlinear optical(NLO)materials that exhibit both a pronounced second harmonic generation(SHG)response and a broad ultraviolet(UV)transmission range remains a big challenge.In this study,we employed...The fabrication of nonlinear optical(NLO)materials that exhibit both a pronounced second harmonic generation(SHG)response and a broad ultraviolet(UV)transmission range remains a big challenge.In this study,we employed a flux method to extract a potential rare-earth borate UV NLO crystal,K_(7.5)Lu_(2.5)B_(15)O_(30),by the chemical cosubstitution strategy.The title compound crystallizes in the trigonal space group R32(no.155)with a three-dimensional structural framework consisting of[B5O10]and[LuO6]groups.Remarkably,K_(7.5)Lu_(2.5)B_(15)O_(30) possesses a notably short cutoff edge of 198 nm and a wide band gap of 6.3 eV.Moreover,it demonstrates a strong phase-matched SHG efficiency of 1.2×KDP,which represents an optimal balance between a strong NLO effect and a wide UV transmission range.Besides,theoretical calculations and structural analyses unveil that the NLO properties observed in K_(7.5)Lu_(2.5)B_(15)O_(30) are primarily attributable to the synergistic effect of the[B5O10]groups and[LuO6]octahedra.These findings indicate that K_(7.5)Lu_(2.5)B_(15)O_(30) has potential applications as beryllium-free UV NLO materials.展开更多
Facile synthesis of single-atom catalytic sites on various supports for the electrochemical carbon dioxide reduction reaction(CO_(2)RR)has attracted increasing attention.Herein,atomically dispersed Ni species supporte...Facile synthesis of single-atom catalytic sites on various supports for the electrochemical carbon dioxide reduction reaction(CO_(2)RR)has attracted increasing attention.Herein,atomically dispersed Ni species supported on nitrogen-doped hollow carbon spheres(SA-Ni/N-CS)were fabricated by using a semisacrificial template strategy.The obtained SA-Ni/N-CS was employed as an electrocatalyst for the CO_(2)RR.We found that the SA-Ni/N-CS displayed ultra-high efficiency and selectivity for CO_(2) conversion into CO with a faradaic efficiency(FE)of 95.1%.Moreover,the SA-Ni/N-CS also exhibited an excellent stability with current density and FE maintained over 99%and 95%,respectively,after 24 h of the CO_(2)RR test.Furthermore,density functional theory(DFT)calculations revealed that the CO_(2) activation process with an activation energy barrier of 2.16 eV is the reaction control step when using SA-Ni/N-CS as a CO_(2)RR catalyst.This work will open up the opportunity for the hard-template synthesis of novel single-atom catalysts for application in electrocatalysis,and suggests that promoting the CO_(2) activation process could be a crucial approach to boosting the CO_(2)RR.展开更多
文摘Despite advances in current anti-cancer therapies,challenges such as drug resistance,toxicity,and tumor heterogeneity persist.The limitations of traditional single-target drugs and simple combination therapies are becoming increasingly apparent1.To address these issues,a novel treatment strategy,the artificially intelligent synergistic engineered drug(AISED)paradigm,merits further exploration.This paradigm is based on the systematic engineered integration of multiple active ingredients into a unified single entity through artificial intelligence(AI).This strategy is aimed at developing new anti-cancer drug designs involving multiple ingredients,multiple molecular targets,and multiple biological effects,for multiple cancer types,thereby providing a novel theoretical paradigm for overcoming existing treatment bottlenecks.
基金supported by Program for Changjiang Scholars and Innovative Research Team in University(IRT_15R52)of the Chinese Ministry of Education.B.L.Su acknowledges the Chinese Central Government for an“Expert of the State”position in the Program of the“Thousand Talents”,the Chinese Ministry of Education for a“Changjiang Chaire Professor”position and a Clare Hall Life Membership at the Clare Hall College and the financial support of the Department of Chemistry,University of Cambridge.L.H.Chen acknowledges Hubei Provincial Department of Education for the“Chutian Scholar”programThis work is also financially supported by NSFC-21671155,NSFC-U1663225+2 种基金Major programs of technical innovation in Hubei(2018AAA012)Hubei Provincial Natural Science Foundation(2018CFA054)Shanghai Rising-Star Program(18QB1404500).
文摘By employing carbon-packed zeolite nanocrystals as primary building blocks,hierarchically porous MFItype zeolites with precise dimensions spanning meso-and micro-length scales were successfully synthesized using an in situ crystallization strategy.The generalized Murray’s law was firstly used to theoretically investigate the advantage of the porous hierarchy of the zeolites.The porosity distribution and coordination in the resultant zeolite crystals were found to be basically following the generalized Murray’s law.Probing using the catalytic cracking reaction of isopropyl benzene revealed that as-prepared HierZSM-5 exhibited much higher conversion(∼74.5%),compared with nanoZSM-5(∼30%)and bulky ZSM-5(∼28.6%).The outstanding catalytic performance was ascribed to the highly enhanced mass transfer of the Murray zeolite material in the heterogeneous catalytic reaction.Such a hierarchical single zeolite structure,designed by adopting the generalized Murray’s law,can improve the thermal/hydrothermal stability of nanozeolites,and offer an alternative option for a long-term stable catalyst.
基金funded by the National Natural Science Foundation of China(grant number 11774188)the Natural Science Foundation of Shandong Province(grant number ZR2018QB003)the Youth Innovation and Technology Support Plan of Shandong Province(No.2019KJA006).
文摘Two-dimensional fence-like Co-doped NiSe_(2)/C(Co-NiSe_(2)/C)nanosheets are fabricated via a facile solvothermal method followed by a selenization strategy.The Co-NiSe_(2)/C nanosheets are composed of interlaced nanorods,which are made up of small nanoparticles with a size of 20 nm.The surfaces of these small nanoparticles are covered in thin carbon layers.
基金supported by the National Key R&D Program of China(2021YFA0717800)the National Natural Science Foundation of China(Grant No.62475191,52002273,and 62104124).
文摘The fabrication of nonlinear optical(NLO)materials that exhibit both a pronounced second harmonic generation(SHG)response and a broad ultraviolet(UV)transmission range remains a big challenge.In this study,we employed a flux method to extract a potential rare-earth borate UV NLO crystal,K_(7.5)Lu_(2.5)B_(15)O_(30),by the chemical cosubstitution strategy.The title compound crystallizes in the trigonal space group R32(no.155)with a three-dimensional structural framework consisting of[B5O10]and[LuO6]groups.Remarkably,K_(7.5)Lu_(2.5)B_(15)O_(30) possesses a notably short cutoff edge of 198 nm and a wide band gap of 6.3 eV.Moreover,it demonstrates a strong phase-matched SHG efficiency of 1.2×KDP,which represents an optimal balance between a strong NLO effect and a wide UV transmission range.Besides,theoretical calculations and structural analyses unveil that the NLO properties observed in K_(7.5)Lu_(2.5)B_(15)O_(30) are primarily attributable to the synergistic effect of the[B5O10]groups and[LuO6]octahedra.These findings indicate that K_(7.5)Lu_(2.5)B_(15)O_(30) has potential applications as beryllium-free UV NLO materials.
基金financially supported by the National Natural Science Foundation of China(no.21701002,21775138,and 21607135)Jinhua Science and Technology Bureau(no.2018-4-006).
文摘Facile synthesis of single-atom catalytic sites on various supports for the electrochemical carbon dioxide reduction reaction(CO_(2)RR)has attracted increasing attention.Herein,atomically dispersed Ni species supported on nitrogen-doped hollow carbon spheres(SA-Ni/N-CS)were fabricated by using a semisacrificial template strategy.The obtained SA-Ni/N-CS was employed as an electrocatalyst for the CO_(2)RR.We found that the SA-Ni/N-CS displayed ultra-high efficiency and selectivity for CO_(2) conversion into CO with a faradaic efficiency(FE)of 95.1%.Moreover,the SA-Ni/N-CS also exhibited an excellent stability with current density and FE maintained over 99%and 95%,respectively,after 24 h of the CO_(2)RR test.Furthermore,density functional theory(DFT)calculations revealed that the CO_(2) activation process with an activation energy barrier of 2.16 eV is the reaction control step when using SA-Ni/N-CS as a CO_(2)RR catalyst.This work will open up the opportunity for the hard-template synthesis of novel single-atom catalysts for application in electrocatalysis,and suggests that promoting the CO_(2) activation process could be a crucial approach to boosting the CO_(2)RR.
