Dear Editor,BCUDCCo African spiny mouse,Acomys dimidiatus,is a mammalian model for regeneration studies because of its ability to functionally regenerate several tissues.As limited regenerative abilities in mammals ar...Dear Editor,BCUDCCo African spiny mouse,Acomys dimidiatus,is a mammalian model for regeneration studies because of its ability to functionally regenerate several tissues.As limited regenerative abilities in mammals are viewed as an antitumor strategy,it is intriguing how Acomys balances regeneration and tumor suppression.In this study,we investigated if Acomys is susceptible to carcinogenesis.We report that,like in mice,two oncogenic hits-activation of oncogenic RasG12v and inactivation of p53 or pRb-are sufficient to malignantly transform skin fibroblasts from Acomys.However,in viuo,Acomys showed resistance to DMBA/TPA-induced skin carcinogenesis.展开更多
基金supported by grants from the US National Institute on Aging to V.G.and A.S.All institutional guidelines for the care and use of laboratory animals were followedAll animal experiments were approved and performed in accordance with guidelines set forth by the University of Rochester Committee on Animal Resources with protocol number 2017-033(mouse)and 2017-027(Acomys dimidiatus,African spiny mice)All authors have read and approved the manuscript for publication,The data,analytic methods,and study materials will be made available to other researchers for purposes of reproducing the results or replicating the procedure.The RNA-seq raw data and count tables have been deposited in GEO(GSE287010).
文摘Dear Editor,BCUDCCo African spiny mouse,Acomys dimidiatus,is a mammalian model for regeneration studies because of its ability to functionally regenerate several tissues.As limited regenerative abilities in mammals are viewed as an antitumor strategy,it is intriguing how Acomys balances regeneration and tumor suppression.In this study,we investigated if Acomys is susceptible to carcinogenesis.We report that,like in mice,two oncogenic hits-activation of oncogenic RasG12v and inactivation of p53 or pRb-are sufficient to malignantly transform skin fibroblasts from Acomys.However,in viuo,Acomys showed resistance to DMBA/TPA-induced skin carcinogenesis.
