Hyperthermia therapy is considered an effective anticancer strategy.However,high temperature can trigger an excessive inflammatory response,leading to tumor self-protection,immunosuppression,metastasis,and recurrence....Hyperthermia therapy is considered an effective anticancer strategy.However,high temperature can trigger an excessive inflammatory response,leading to tumor self-protection,immunosuppression,metastasis,and recurrence.To address this issue,we reported a multifunctional photothermal nanoplatform to achieve mild hyperthermia photothermal therapy(mild PTT)based on cisplatin(DDP)and a ferrocene metal-organic framework(MOF-Fc)nanocomposite,which can specifically enhance ferroptosis-triggered oxidative stress levels and synchronously amplify mild hyperthermia PTT-mediated anticancer responses.Both in vitro and in vivo antineoplastic results verify the superiority of mild PTT with DDP/MOF-Fc@HA.The combination of DDP and MOF-Fc exhibits Fenton catalytic activity and glutathione depletion capacity,magnifying mild hyperthermia effects via the radical oxygen species(ROS)-adenosine triphosphate(ATP)-HSP silencing pathway,with important implications for clinical hyperthermia therapy.展开更多
基金supported by the Postdoctoral Fellowship Program of CPSF[grant number BX20230068]the National Natural Science Foundation of China[grant numbers 82160341 and 82260345]+2 种基金the Natural Science Foundation of Guangxi[grant number 2022GXNSFDA035060]the China Postdoctoral Science Foundation[grant number 2023MD744192]the Key Research and Development Plan of Guangxi[grant number GUIKEAB22080066].
文摘Hyperthermia therapy is considered an effective anticancer strategy.However,high temperature can trigger an excessive inflammatory response,leading to tumor self-protection,immunosuppression,metastasis,and recurrence.To address this issue,we reported a multifunctional photothermal nanoplatform to achieve mild hyperthermia photothermal therapy(mild PTT)based on cisplatin(DDP)and a ferrocene metal-organic framework(MOF-Fc)nanocomposite,which can specifically enhance ferroptosis-triggered oxidative stress levels and synchronously amplify mild hyperthermia PTT-mediated anticancer responses.Both in vitro and in vivo antineoplastic results verify the superiority of mild PTT with DDP/MOF-Fc@HA.The combination of DDP and MOF-Fc exhibits Fenton catalytic activity and glutathione depletion capacity,magnifying mild hyperthermia effects via the radical oxygen species(ROS)-adenosine triphosphate(ATP)-HSP silencing pathway,with important implications for clinical hyperthermia therapy.
