Introduction:Tuberculosis(TB)remains a major public health challenge in China,which ranks fourth among the 30 high-burden countries worldwide.Individuals with asymptomatic Pulmonary TB(aPTB)may act as“silent transmit...Introduction:Tuberculosis(TB)remains a major public health challenge in China,which ranks fourth among the 30 high-burden countries worldwide.Individuals with asymptomatic Pulmonary TB(aPTB)may act as“silent transmitters”,contributing to undetected community transmission and hindering progress toward the End-TB goals.This study examined the epidemiological characteristics of patients with aPTB in China from 2021 to 2024 to inform targeted control strategies.Methods:Data were obtained from the China Information System for Disease Control and Prevention for the period 2021-2024 and included TB cases with complete symptom records.aPTB was defined as cases without recorded cough symptoms,whereas symptomatic TB was defined as cases with recorded cough symptoms.Descriptive statistical analyses compared the demographic,clinical,and healthcare-seeking characteristics of patients with aPTB and symptomatic TB.Results:Among 973,299 PTB cases with complete symptom records,16.66%were classified as aPTB.This proportion remained relatively stable throughout the study period,with a slight peak observed in 2022.Higher proportions of aPTB were observed among individuals aged 55-64 years(17.07%),65-74 years(15.51%),and 15-24 years(14.03%),and among farmers and herders(50.87%).A mild seasonal trend was observed.Geographically,high-incidence areas were concentrated in western and southwestern China.Conclusions:aPTB constitutes a substantial component of the total TB burden in China.Strengthening active case detection in high-risk populations,optimizing medical resources in western China,and integrating aPTB control programs into national prevention and control plans for TB to mitigate hidden transmissions and advance national End-TB objectives.展开更多
Introduction:Mountain-type zoonotic visceral leishmaniasis(MT-ZVL)has re-emerged in China with shifting demographic patterns and expanding geographical distribution.This study aimed to characterize its epidemiological...Introduction:Mountain-type zoonotic visceral leishmaniasis(MT-ZVL)has re-emerged in China with shifting demographic patterns and expanding geographical distribution.This study aimed to characterize its epidemiological and spatial-temporal dynamics to guide targeted control strategies.Methods:Case data from 2010–2024 were analyzed usingχ^(2) tests and proportional analyses.Temporal trends were assessed by Joinpoint regression,projections by autoregressive integrated moving average(ARIMA)models,spatial clustering and directional tendency by Moran’s I and Standard Deviational Ellipse(SDE)analyses.Results:A total of 2,260 cases were reported,showing a bimodal age distribution(<5 years and 60–75 years)with marked male predominance and a shifting occupational risk toward adults.Affected counties expanded from 19 to 69 and after a decline in 2010–2015,incidence increased and spread eastward during 2015–2024,with projections indicating continued growth by 2030 without strengthened control.Conclusions:MT-ZVL in China shows expanding risk areas and changing occupational patterns,highlighting the need for strengthened surveillance and targeted control interventions in the regions.展开更多
Objective:To investigate the prevalence and severity of menopausal symptoms among Chinese women aged 40-60 years and provide evidence for developing personalized health management strategies.Methods:Using a multi-stag...Objective:To investigate the prevalence and severity of menopausal symptoms among Chinese women aged 40-60 years and provide evidence for developing personalized health management strategies.Methods:Using a multi-stage stratified cluster sampling approach,we conducted a nationwide crosssectional survey across representative provincial-level administrative divisions(PLADs)and prefecture-level cities,encompassing 26 district/county survey sites.The questionnaire collected information on demographic characteristics,menopausal status,and symptoms.Data analysis employed means and standard deviations(X±S)or rates and proportion ratios to describe menopausal symptom occurrence,with group differences analyzed using Mann-Whitney or Kruskal-Wallis tests.Results:The study included 42,304 women with a mean age of 49.9±5.7 years.The overall prevalence of menopausal symptoms was 46.3%[95%confidence interval(CI):45.8%,46.7%],predominantly mild to moderate in severity.The prevalence of mild to severe symptoms began increasing in women over age 44,peaking at age 52.Moderate to severe symptoms showed an uptick after age 46,also peaking at 52 years,while severe symptoms increased after age 48,reaching maximum prevalence at age 56.The most commonly reported symptoms were insomnia(50.0%,95%CI:49.5%,50.5%),fatigue(48.2%,95%CI:47.7%,48.7%),and nervousness(46.9%,95%CI:46.5%,47.4%).Significant differences in symptom severity between premenopausal and postmenopausal women were observed in the 45-49(P<0.001)and 50-54(P=0.019<0.05)age groups.Conclusions:The study revealed distinct patterns in the prevalence,severity,and manifestation of menopausal symptoms across different age groups in China.The age-related progression of symptoms provides a scientific foundation for developing targeted healthcare interventions for women at various stages of menopause.展开更多
Introduction:China’s rapidly aging population poses profound public health challenges.Current research overlooks health heterogeneity across older subgroups,limiting the effectiveness of policy responses.This study a...Introduction:China’s rapidly aging population poses profound public health challenges.Current research overlooks health heterogeneity across older subgroups,limiting the effectiveness of policy responses.This study addresses these gaps to inform targeted health strategies.Methods:Using data from the Global Burden of Disease Study 2023,we analyzed age-specific mortality rate(MR)and years lived with disability(YLDs)among Chinese older adults(60–74,75–89,and 90 years and above)from 1990 to 2023.Temporal trends were assessed using average annual percentage change(AAPC).Results:From 1990–2023,all-cause MR declined substantially;YLDs remained stable.Stroke,ischemic heart disease(IHD),and chronic obstructive pulmonary disease remained the leading causes of mortality.Alzheimer’s disease and other dementias(ADOD)showed the most rapid MR increase[AAPC=1.76,95% confidence interval(CI):1.63,1.87].Age-related hearing loss and falls dominated YLDs.IHD accounted for 26.20%of deaths in the 90+age group,whereas ADOD accounted for 13.24%.Conclusion:The evolving disease burden among older Chinese adults is increasingly dominated by nonfatal health loss and shows distinct patterns across age subgroups.This integrated evidence-based policy shift from disease-centered care to function-oriented strategies is essential to systematically reduce disability and promote healthy aging among the elderly population in China.展开更多
基金Supported by the National Key R&D Program(Reference numbers:2024YFC2311204 and 2024YFC2310905)the Prevention and Control of Emerging and Major Infectious Diseases-National Science and Technology Major Project(Reference number:2025ZD01901000).
文摘Introduction:Tuberculosis(TB)remains a major public health challenge in China,which ranks fourth among the 30 high-burden countries worldwide.Individuals with asymptomatic Pulmonary TB(aPTB)may act as“silent transmitters”,contributing to undetected community transmission and hindering progress toward the End-TB goals.This study examined the epidemiological characteristics of patients with aPTB in China from 2021 to 2024 to inform targeted control strategies.Methods:Data were obtained from the China Information System for Disease Control and Prevention for the period 2021-2024 and included TB cases with complete symptom records.aPTB was defined as cases without recorded cough symptoms,whereas symptomatic TB was defined as cases with recorded cough symptoms.Descriptive statistical analyses compared the demographic,clinical,and healthcare-seeking characteristics of patients with aPTB and symptomatic TB.Results:Among 973,299 PTB cases with complete symptom records,16.66%were classified as aPTB.This proportion remained relatively stable throughout the study period,with a slight peak observed in 2022.Higher proportions of aPTB were observed among individuals aged 55-64 years(17.07%),65-74 years(15.51%),and 15-24 years(14.03%),and among farmers and herders(50.87%).A mild seasonal trend was observed.Geographically,high-incidence areas were concentrated in western and southwestern China.Conclusions:aPTB constitutes a substantial component of the total TB burden in China.Strengthening active case detection in high-risk populations,optimizing medical resources in western China,and integrating aPTB control programs into national prevention and control plans for TB to mitigate hidden transmissions and advance national End-TB objectives.
基金Supported by the National Natural Science Foundation of China(Grant No.82473688).
文摘Introduction:Mountain-type zoonotic visceral leishmaniasis(MT-ZVL)has re-emerged in China with shifting demographic patterns and expanding geographical distribution.This study aimed to characterize its epidemiological and spatial-temporal dynamics to guide targeted control strategies.Methods:Case data from 2010–2024 were analyzed usingχ^(2) tests and proportional analyses.Temporal trends were assessed by Joinpoint regression,projections by autoregressive integrated moving average(ARIMA)models,spatial clustering and directional tendency by Moran’s I and Standard Deviational Ellipse(SDE)analyses.Results:A total of 2,260 cases were reported,showing a bimodal age distribution(<5 years and 60–75 years)with marked male predominance and a shifting occupational risk toward adults.Affected counties expanded from 19 to 69 and after a decline in 2010–2015,incidence increased and spread eastward during 2015–2024,with projections indicating continued growth by 2030 without strengthened control.Conclusions:MT-ZVL in China shows expanding risk areas and changing occupational patterns,highlighting the need for strengthened surveillance and targeted control interventions in the regions.
基金Supported by the National Key R&D Program of China(2022YFC2703801).
文摘Objective:To investigate the prevalence and severity of menopausal symptoms among Chinese women aged 40-60 years and provide evidence for developing personalized health management strategies.Methods:Using a multi-stage stratified cluster sampling approach,we conducted a nationwide crosssectional survey across representative provincial-level administrative divisions(PLADs)and prefecture-level cities,encompassing 26 district/county survey sites.The questionnaire collected information on demographic characteristics,menopausal status,and symptoms.Data analysis employed means and standard deviations(X±S)or rates and proportion ratios to describe menopausal symptom occurrence,with group differences analyzed using Mann-Whitney or Kruskal-Wallis tests.Results:The study included 42,304 women with a mean age of 49.9±5.7 years.The overall prevalence of menopausal symptoms was 46.3%[95%confidence interval(CI):45.8%,46.7%],predominantly mild to moderate in severity.The prevalence of mild to severe symptoms began increasing in women over age 44,peaking at age 52.Moderate to severe symptoms showed an uptick after age 46,also peaking at 52 years,while severe symptoms increased after age 48,reaching maximum prevalence at age 56.The most commonly reported symptoms were insomnia(50.0%,95%CI:49.5%,50.5%),fatigue(48.2%,95%CI:47.7%,48.7%),and nervousness(46.9%,95%CI:46.5%,47.4%).Significant differences in symptom severity between premenopausal and postmenopausal women were observed in the 45-49(P<0.001)and 50-54(P=0.019<0.05)age groups.Conclusions:The study revealed distinct patterns in the prevalence,severity,and manifestation of menopausal symptoms across different age groups in China.The age-related progression of symptoms provides a scientific foundation for developing targeted healthcare interventions for women at various stages of menopause.
基金supported by the National Key Research and Development Program of China(Grant Numbers:2023YFC3605004 and 2023YFC3605000).
文摘Introduction:China’s rapidly aging population poses profound public health challenges.Current research overlooks health heterogeneity across older subgroups,limiting the effectiveness of policy responses.This study addresses these gaps to inform targeted health strategies.Methods:Using data from the Global Burden of Disease Study 2023,we analyzed age-specific mortality rate(MR)and years lived with disability(YLDs)among Chinese older adults(60–74,75–89,and 90 years and above)from 1990 to 2023.Temporal trends were assessed using average annual percentage change(AAPC).Results:From 1990–2023,all-cause MR declined substantially;YLDs remained stable.Stroke,ischemic heart disease(IHD),and chronic obstructive pulmonary disease remained the leading causes of mortality.Alzheimer’s disease and other dementias(ADOD)showed the most rapid MR increase[AAPC=1.76,95% confidence interval(CI):1.63,1.87].Age-related hearing loss and falls dominated YLDs.IHD accounted for 26.20%of deaths in the 90+age group,whereas ADOD accounted for 13.24%.Conclusion:The evolving disease burden among older Chinese adults is increasingly dominated by nonfatal health loss and shows distinct patterns across age subgroups.This integrated evidence-based policy shift from disease-centered care to function-oriented strategies is essential to systematically reduce disability and promote healthy aging among the elderly population in China.
