Under the demand of strategic air traffic flow management and the concept of trajectory based operations（TBO）,the network-wide 4D flight trajectories planning（N4DFTP） problem has been investigated with the purpose...Under the demand of strategic air traffic flow management and the concept of trajectory based operations（TBO）,the network-wide 4D flight trajectories planning（N4DFTP） problem has been investigated with the purpose of safely and efficiently allocating 4D trajectories（4DTs）（3D position and time） for all the flights in the whole airway network.Considering that the introduction of large-scale 4DTs inevitably increases the problem complexity,an efficient model for strategiclevel conflict management is developed in this paper.Specifically,a bi-objective N4 DFTP problem that aims to minimize both potential conflicts and the trajectory cost is formulated.In consideration of the large-scale,high-complexity,and multi-objective characteristics of the N4DFTP problem,a multi-objective multi-memetic algorithm（MOMMA） that incorporates an evolutionary global search framework together with three problem-specific local search operators is implemented.It is capable of rapidly and effectively allocating 4DTs via rerouting,target time controlling,and flight level changing.Additionally,to balance the ability of exploitation and exploration of the algorithm,a special hybridization scheme is adopted for the integration of local and global search.Empirical studies using real air traffic data in China with different network complexities show that the proposed MOMMA is effective to solve the N4 DFTP problem.The solutions achieved are competitive for elaborate decision support under a TBO environment.展开更多
Acupuncture is a traditional medical therapy widely validated in scientific research.Recent advancements have deepened our understanding of their mechanisms,particularly in the regulation of inflammatory responses.In ...Acupuncture is a traditional medical therapy widely validated in scientific research.Recent advancements have deepened our understanding of their mechanisms,particularly in the regulation of inflammatory responses.In recent years,with in-depth research on the mechanisms through which acupuncture regulates inflammation,scientific studies on the use of acupuncture for sepsis have also been conducted.This paper reviews relevant studies to summarize the clinical efficacy and mechanisms of acupuncture in treating sepsis and analyzes the current limitations,potential advantages,and optimization strategies for acupuncture as an adjunctive therapy.Based on the findings of basic research,we found that acupuncture regulates immune-inflammatory responses and the autonomic nervous system,offering crucial insights that serve as the primary scientific basis for acupuncture in sepsis treatment.In clinical research,results from multiple randomized controlled trials indicate that acupuncture is an effective adjuvant therapy for sepsis,which alleviates multi-organ dysfunction,reduces mortality,and enhances the quality of life.However,acupuncture for sepsis has limitations,such as incomplete scientific issues,insufficient clinical application,and lack of standardization.Currently,acupuncture primarily serves as adjunctive therapy and cannot be used independently for the treatment of sepsis.Therefore,we believes that high-quality research is needed to elevate the therapeutic status of acupuncture in sepsis management,and we should promote the standardization of its clinical application to fully leverage the potential value of acupuncture for sepsis.展开更多
基金co-supported by the National Science Foundation for Young Scientists of China(No.61401011)the National Key Technologies R&D Program of China(No.2015BAG15B01)the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.61521091)
文摘Under the demand of strategic air traffic flow management and the concept of trajectory based operations（TBO）,the network-wide 4D flight trajectories planning（N4DFTP） problem has been investigated with the purpose of safely and efficiently allocating 4D trajectories（4DTs）（3D position and time） for all the flights in the whole airway network.Considering that the introduction of large-scale 4DTs inevitably increases the problem complexity,an efficient model for strategiclevel conflict management is developed in this paper.Specifically,a bi-objective N4 DFTP problem that aims to minimize both potential conflicts and the trajectory cost is formulated.In consideration of the large-scale,high-complexity,and multi-objective characteristics of the N4DFTP problem,a multi-objective multi-memetic algorithm（MOMMA） that incorporates an evolutionary global search framework together with three problem-specific local search operators is implemented.It is capable of rapidly and effectively allocating 4DTs via rerouting,target time controlling,and flight level changing.Additionally,to balance the ability of exploitation and exploration of the algorithm,a special hybridization scheme is adopted for the integration of local and global search.Empirical studies using real air traffic data in China with different network complexities show that the proposed MOMMA is effective to solve the N4 DFTP problem.The solutions achieved are competitive for elaborate decision support under a TBO environment.
基金Supported by the National Natural Science Foundation of China:82575215,82374563Tianjin Science and Technology Planning Project:25YDTPJC00430。
文摘Acupuncture is a traditional medical therapy widely validated in scientific research.Recent advancements have deepened our understanding of their mechanisms,particularly in the regulation of inflammatory responses.In recent years,with in-depth research on the mechanisms through which acupuncture regulates inflammation,scientific studies on the use of acupuncture for sepsis have also been conducted.This paper reviews relevant studies to summarize the clinical efficacy and mechanisms of acupuncture in treating sepsis and analyzes the current limitations,potential advantages,and optimization strategies for acupuncture as an adjunctive therapy.Based on the findings of basic research,we found that acupuncture regulates immune-inflammatory responses and the autonomic nervous system,offering crucial insights that serve as the primary scientific basis for acupuncture in sepsis treatment.In clinical research,results from multiple randomized controlled trials indicate that acupuncture is an effective adjuvant therapy for sepsis,which alleviates multi-organ dysfunction,reduces mortality,and enhances the quality of life.However,acupuncture for sepsis has limitations,such as incomplete scientific issues,insufficient clinical application,and lack of standardization.Currently,acupuncture primarily serves as adjunctive therapy and cannot be used independently for the treatment of sepsis.Therefore,we believes that high-quality research is needed to elevate the therapeutic status of acupuncture in sepsis management,and we should promote the standardization of its clinical application to fully leverage the potential value of acupuncture for sepsis.
