Background Cognitive decline is a significant concern for stroke survivors,affecting their quality of life and increasing their burden on the healthcare system.DL-3-n butylphthalide(butylphthalide)has shown efficacy i...Background Cognitive decline is a significant concern for stroke survivors,affecting their quality of life and increasing their burden on the healthcare system.DL-3-n butylphthalide(butylphthalide)has shown efficacy in the short-term treatment of various cognitive impairments.This study evaluated the efficacy of butylphthalide in preventing cognitive decline over a 12-month period in patients with ischaemic stroke.Methods This prospective following-up study involved patients newly diagnosed with ischaemic stroke between 1 month and 6 months after stroke onset and not in the acute phase.Patients were assigned to either the butylphthalide or control group.Cognitive function was assessed using the mini-mental state examination(MMSE)at baseline and at the 12-month follow-up.Statistical analyses included t-tests,χ2 tests and multivariate regression analyses.Results Butylphthalide was negatively associated with the MMSE D-value(β=−0.122;95%CI−1.932 to−0.298;p=0.003)and the MMSE D-value percentage(β=−0.117;95%CI−0.057 to−0.011;p=0.004).A multivariate analysis indicated that butylphthalide treatment was negatively associated with both changes in orientation and language score.Additionally,the incidence of cognitive decline was significantly lower in the butylphthalide group(OR,0.612;p=0.020)than the control group.An age of≥60 years and lower educational level were identified as risk factors for lower cognitive score and cognitive decline.Conclusion This study demonstrated that butylphthalide is effective in preventing cognitive decline in patients with ischaemic stroke.These findings have significant implications for clinical practice,suggesting that butylphthalide could be incorporated into standard post-stroke care regimens to improve patient outcomes and reduce the healthcare burden.Additional multicentre double-blind trials are recommended to confirm these results in diverse populations.展开更多
目的:调查四川地区北川羌族和西昌彝族两个少数民族群体中19个X-STRs基因座的遗传多态性,评估其法医学应用价值,并分析其群体结构。方法:收集北川羌族人群无关个体246例(男性188例,女性58例)和西昌彝族人群无关个体281例(男性116例,女性...目的:调查四川地区北川羌族和西昌彝族两个少数民族群体中19个X-STRs基因座的遗传多态性,评估其法医学应用价值,并分析其群体结构。方法:收集北川羌族人群无关个体246例(男性188例,女性58例)和西昌彝族人群无关个体281例(男性116例,女性165例)干血斑样本,采用Microreader^(TM)19X ID System kit直接扩增干血斑样本,ABI3500遗传分析仪对PCR产物进行毛细管电泳,GeneMapper■ ID-X软件自动分型。结果:在北川羌族群体中,共检测到150个等位基因,频率范围0.0033~0.8289;在西昌彝族群体中,共检测到164个等位基因,频率范围0.0022~0.8004。经统计学检验,两个少数民族群体基因频率分布均符合Hardy-Weinberg平衡定律(P>0.05),经Bonferroni校正后,不存在连锁不平衡的基因座。在北川羌族群体中,男性个体识别能力(PDM)和女性个体识别能力(PDF)分别是0.999999999945624、0.99999999999999999322,二联体和三联体累积平均排除概率分别是0.999999591813975、0.999999999465296;在西昌彝族群体中,男性个体识别能力(PDM)和女性个体识别能力(PDF)分别为0.999999999873529、1;二联体和三联体累积平均排除概率分别是0.999999284224924、0.999999998931424。结论:Microreader TM 19X ID荧光检测试剂盒在北川羌族和西昌彝族人群中总体多态性较高,鉴别能力较好,可作为亲权关系和个体识别有力的补充和验证手段。展开更多
基金funded by Tianjin Municipal Health Commission(TJWJ2023QN115)。
文摘Background Cognitive decline is a significant concern for stroke survivors,affecting their quality of life and increasing their burden on the healthcare system.DL-3-n butylphthalide(butylphthalide)has shown efficacy in the short-term treatment of various cognitive impairments.This study evaluated the efficacy of butylphthalide in preventing cognitive decline over a 12-month period in patients with ischaemic stroke.Methods This prospective following-up study involved patients newly diagnosed with ischaemic stroke between 1 month and 6 months after stroke onset and not in the acute phase.Patients were assigned to either the butylphthalide or control group.Cognitive function was assessed using the mini-mental state examination(MMSE)at baseline and at the 12-month follow-up.Statistical analyses included t-tests,χ2 tests and multivariate regression analyses.Results Butylphthalide was negatively associated with the MMSE D-value(β=−0.122;95%CI−1.932 to−0.298;p=0.003)and the MMSE D-value percentage(β=−0.117;95%CI−0.057 to−0.011;p=0.004).A multivariate analysis indicated that butylphthalide treatment was negatively associated with both changes in orientation and language score.Additionally,the incidence of cognitive decline was significantly lower in the butylphthalide group(OR,0.612;p=0.020)than the control group.An age of≥60 years and lower educational level were identified as risk factors for lower cognitive score and cognitive decline.Conclusion This study demonstrated that butylphthalide is effective in preventing cognitive decline in patients with ischaemic stroke.These findings have significant implications for clinical practice,suggesting that butylphthalide could be incorporated into standard post-stroke care regimens to improve patient outcomes and reduce the healthcare burden.Additional multicentre double-blind trials are recommended to confirm these results in diverse populations.
基金supported by grants from Guangdong Key Laboratory of Forensic Genetics(2010A060801001)Guangdong Scientific and Technological Project(2013B021500010)Applied-innovation Project of Ministry of Public Security(2011YYCXGDST076)~~
文摘目的:调查四川地区北川羌族和西昌彝族两个少数民族群体中19个X-STRs基因座的遗传多态性,评估其法医学应用价值,并分析其群体结构。方法:收集北川羌族人群无关个体246例(男性188例,女性58例)和西昌彝族人群无关个体281例(男性116例,女性165例)干血斑样本,采用Microreader^(TM)19X ID System kit直接扩增干血斑样本,ABI3500遗传分析仪对PCR产物进行毛细管电泳,GeneMapper■ ID-X软件自动分型。结果:在北川羌族群体中,共检测到150个等位基因,频率范围0.0033~0.8289;在西昌彝族群体中,共检测到164个等位基因,频率范围0.0022~0.8004。经统计学检验,两个少数民族群体基因频率分布均符合Hardy-Weinberg平衡定律(P>0.05),经Bonferroni校正后,不存在连锁不平衡的基因座。在北川羌族群体中,男性个体识别能力(PDM)和女性个体识别能力(PDF)分别是0.999999999945624、0.99999999999999999322,二联体和三联体累积平均排除概率分别是0.999999591813975、0.999999999465296;在西昌彝族群体中,男性个体识别能力(PDM)和女性个体识别能力(PDF)分别为0.999999999873529、1;二联体和三联体累积平均排除概率分别是0.999999284224924、0.999999998931424。结论:Microreader TM 19X ID荧光检测试剂盒在北川羌族和西昌彝族人群中总体多态性较高,鉴别能力较好,可作为亲权关系和个体识别有力的补充和验证手段。
