Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge.We demonstrate the translational potential of functional ultrasound(fUS)imaging for this purpose.In 6 comat...Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge.We demonstrate the translational potential of functional ultrasound(fUS)imaging for this purpose.In 6 comatose patients(Glasgow coma scale≤8)with cranial windows after decompressive craniectomy,we used a 7.8-MHz transducer optimized for cortical depths of 1.5 to 4 cm to perform real-time fUS during auditory stimulation.We observed task-related increases in regional cerebral blood flow(rCBF)in relevant brain regions(P<0.001,t test),which correlated with subsequent neurological recovery at 9-month follow-up.These findings establish fUS as a sensitive and portable tool for bedside brain function assessment,offering potential for improved prognostication,treatment guidance,and development of targeted rehabilitative strategies.展开更多
基金supported in part by the National Key Research and Development Program of China(grant no.2023YFC2410900)the National Natural Science Foundation of China(32371151)+4 种基金Guangdong High Level Innovation Research Institute(2021B0909050004)the Hong Kong Research Grants Council Collaborative Research Fund(C5053-22GF)General Research Fund(15224323 and 15104520)Hong Kong Innovation Technology Fund(MHP/014/19)internal funding from the Hong Kong Polytechnic University(G-SACD and 1-CDJM).
文摘Bedside monitoring of brain function in severely brain-injured patients remains a critical clinical challenge.We demonstrate the translational potential of functional ultrasound(fUS)imaging for this purpose.In 6 comatose patients(Glasgow coma scale≤8)with cranial windows after decompressive craniectomy,we used a 7.8-MHz transducer optimized for cortical depths of 1.5 to 4 cm to perform real-time fUS during auditory stimulation.We observed task-related increases in regional cerebral blood flow(rCBF)in relevant brain regions(P<0.001,t test),which correlated with subsequent neurological recovery at 9-month follow-up.These findings establish fUS as a sensitive and portable tool for bedside brain function assessment,offering potential for improved prognostication,treatment guidance,and development of targeted rehabilitative strategies.
