Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to Augus...Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to August 2024 were selected as samples and randomly divided into two groups.Group A received conventional medication plus TMS treatment,while Group B received medication only.The efficacy of motor function improvement,neurological symptoms,mental state,sleep quality,quality of life,and adverse reactions was compared between the two groups.Results:The efficacy of Group A was higher than that of Group B(P<0.05).The scores of the Scales for Outcomes in Parkinson’s Disease-Autonomic(SCOPA-AUT),Mini-Mental State Examination(MMSE),and Pittsburgh Sleep Quality Index(PSQI)in Group A were lower than those in Group B(P<0.05).The quality of life scale(SF-36)score in Group A was higher than that in Group B(P<0.05).The adverse reaction rate in Group A was lower than that in Group B(P<0.05).Conclusion:TMS used in the treatment of PD patients can improve patients’mental state and motor function,optimize sleep quality and quality of life,and is safe and efficient.展开更多
By reviewing the development history of shale oil reservoir stimulation technology of PetroChina Company Limited(PetroChina),we have systematically summarized the main progress of shale oil reservoir stimulation techn...By reviewing the development history of shale oil reservoir stimulation technology of PetroChina Company Limited(PetroChina),we have systematically summarized the main progress of shale oil reservoir stimulation technology of CNPC in five aspects:reservoir stimulation mechanism,fracture-controlled fracturing,geological-engineering integrated reservoir stimulation design platform,low-cost materials,and large well-pad three-dimensional development mode.It is made clear that the major stimulation technology for shale oil reservoir is the high density multi-cluster and fracture-controlled staged fracturing aiming to increase fracture-controlled reserves,lower operation costs and increase economic benefits.Based on comprehensive analysis of the challenges shale oil reservoir stimulation technology faces in three-dimensional development,stimulation parameter optimization for fracture-controlled fracturing,refracturing and low-cost stimulation technology,we proposed five development directions of the stimulation technology:(1)Strengthen the research on integration of geology and engineering to make full use of reservoir stimulation.(2)Deepen the study on fracture-controlled fracturing to improve reserves development degree.(3)Promote horizontal well three-dimensional development of shale oil to realize the production of multiple layers vertically.(4)Research refracturing technology of shale oil reservoir through horizontal well to efficiently tap the remaining reserves between fractures.(5)Develop low-cost stimulation supporting technology to help reduce the cost and increase economic benefit of oilfield development.展开更多
The key to realize the commercial production of natural gas hydrate(NGH)is to increase theNGH productivity significantly in the scale of magnitude.Whether NGH production can be commercialized depends on two aspects.Th...The key to realize the commercial production of natural gas hydrate(NGH)is to increase theNGH productivity significantly in the scale of magnitude.Whether NGH production can be commercialized depends on two aspects.The first is whether the in-situ recoverable reserves are large enough to support the basic production period for commercial production.The second is whether the average productivity can reach the standard for commercial production.In this paper,we will analyze mainly about the potential stimulation technologies for NGH development,and discuss about the basic principles,the evaluation methods,and the technical bottlenecks for NGH production and stimulation.The results indicate that the main mechanisms for increasing theNGH productivity are in three respects,namely enlarging the drainage area,increasing the NGH dissociation efficiency,and improving the seepage conditions.With complex-structure wells and multiple-well patterns,combined with novel production methods and/or reservoir stimulation technologies,the NGH productivity can be increased greatly.Particularly,the complexstructure wells and well patterns are very important for increasing NGH productivity.With complex-structure wells and well patterns,combined with heat injection and/or reservoir stimulation,NGH productivity can be increased on a magnitude scale.Currently,in fundamental researches,there are some technical bottlenecks for the studies of NGH production,mainly in sample preparation,simulated reservoir monitoring,and mechanical coupling technologies.Therefore,it is suggested that the study focuses should be on the above technical bottlenecks during the basic research on how to increase the NGH productivity.It is concluded that the combined application of complex-structure wells(horizontal wells and multi-lateral wells),well-pattern production models(with multi-cluster/group well production),the novel production methods(mainly thermal stimulation,together with depressurization),and reservoir stimulation technologies(hydraulic fracturing)are the keys to increase NGH productivity in the scale of magnitude.展开更多
文摘Objective:To study the effect of transcranial magnetic stimulation(TMS)on improving motor symptoms in patients with Parkinson’s disease(PD).Methods:60 PD patients who visited the hospital from September 2023 to August 2024 were selected as samples and randomly divided into two groups.Group A received conventional medication plus TMS treatment,while Group B received medication only.The efficacy of motor function improvement,neurological symptoms,mental state,sleep quality,quality of life,and adverse reactions was compared between the two groups.Results:The efficacy of Group A was higher than that of Group B(P<0.05).The scores of the Scales for Outcomes in Parkinson’s Disease-Autonomic(SCOPA-AUT),Mini-Mental State Examination(MMSE),and Pittsburgh Sleep Quality Index(PSQI)in Group A were lower than those in Group B(P<0.05).The quality of life scale(SF-36)score in Group A was higher than that in Group B(P<0.05).The adverse reaction rate in Group A was lower than that in Group B(P<0.05).Conclusion:TMS used in the treatment of PD patients can improve patients’mental state and motor function,optimize sleep quality and quality of life,and is safe and efficient.
基金Supported by the National Science and Technology Major Project(2016ZX05023,2017ZX05013-005)。
文摘By reviewing the development history of shale oil reservoir stimulation technology of PetroChina Company Limited(PetroChina),we have systematically summarized the main progress of shale oil reservoir stimulation technology of CNPC in five aspects:reservoir stimulation mechanism,fracture-controlled fracturing,geological-engineering integrated reservoir stimulation design platform,low-cost materials,and large well-pad three-dimensional development mode.It is made clear that the major stimulation technology for shale oil reservoir is the high density multi-cluster and fracture-controlled staged fracturing aiming to increase fracture-controlled reserves,lower operation costs and increase economic benefits.Based on comprehensive analysis of the challenges shale oil reservoir stimulation technology faces in three-dimensional development,stimulation parameter optimization for fracture-controlled fracturing,refracturing and low-cost stimulation technology,we proposed five development directions of the stimulation technology:(1)Strengthen the research on integration of geology and engineering to make full use of reservoir stimulation.(2)Deepen the study on fracture-controlled fracturing to improve reserves development degree.(3)Promote horizontal well three-dimensional development of shale oil to realize the production of multiple layers vertically.(4)Research refracturing technology of shale oil reservoir through horizontal well to efficiently tap the remaining reserves between fractures.(5)Develop low-cost stimulation supporting technology to help reduce the cost and increase economic benefit of oilfield development.
基金Project supported by the National Key R&D Project“Application Demonstration of Trial Production,Environmental Monitoring and Comprehensive Evaluation of Hydrate”(No.:2017YFC0307600)Shandong Provincial Taishan Scholars Special Expert Project(No.ts201712079)Shandong Provincial Natural Science Foundation Project“Numerical Simulation of the Influence of Hydraulic Cutting on the Productivity of Depressurization Production of Silty Hydrate in the South China Sea”(No.ZR2019BD058).
文摘The key to realize the commercial production of natural gas hydrate(NGH)is to increase theNGH productivity significantly in the scale of magnitude.Whether NGH production can be commercialized depends on two aspects.The first is whether the in-situ recoverable reserves are large enough to support the basic production period for commercial production.The second is whether the average productivity can reach the standard for commercial production.In this paper,we will analyze mainly about the potential stimulation technologies for NGH development,and discuss about the basic principles,the evaluation methods,and the technical bottlenecks for NGH production and stimulation.The results indicate that the main mechanisms for increasing theNGH productivity are in three respects,namely enlarging the drainage area,increasing the NGH dissociation efficiency,and improving the seepage conditions.With complex-structure wells and multiple-well patterns,combined with novel production methods and/or reservoir stimulation technologies,the NGH productivity can be increased greatly.Particularly,the complexstructure wells and well patterns are very important for increasing NGH productivity.With complex-structure wells and well patterns,combined with heat injection and/or reservoir stimulation,NGH productivity can be increased on a magnitude scale.Currently,in fundamental researches,there are some technical bottlenecks for the studies of NGH production,mainly in sample preparation,simulated reservoir monitoring,and mechanical coupling technologies.Therefore,it is suggested that the study focuses should be on the above technical bottlenecks during the basic research on how to increase the NGH productivity.It is concluded that the combined application of complex-structure wells(horizontal wells and multi-lateral wells),well-pattern production models(with multi-cluster/group well production),the novel production methods(mainly thermal stimulation,together with depressurization),and reservoir stimulation technologies(hydraulic fracturing)are the keys to increase NGH productivity in the scale of magnitude.
