Nuclear receptors(NRs)are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands,including steroid hormone...Nuclear receptors(NRs)are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands,including steroid hormones,thyroid hormone,vitamin D,retinoic acid,fatty acids,and oxidative steroids.Upon ligand binding,nuclear receptors form dimer complexes with transcriptional cofactors,which interact with specific DNA sequences in the promoter or enhancer regions of target genes to modulate gene expression.This process plays a crucial role in many physiological processes such as reproduction,development,immune responses,metabolism,and homeostasis.Dysregulation of nuclear receptor signaling is implicated in the pathogenesis of numerous diseases,including cancers,metabolic disorders,cardiovascular diseases,and autoimmune conditions.展开更多
基金supported by the following research grants:the Department of Science and Technology of Sichuan Province(2023YFS0037)the National Natural Science Foundation of China(32170759,82303506,82273126)+2 种基金the Sichuan Administration of Traditional Chinese Medicine(2023MS267)Sichuan Science and Technology Department(2025ZNSFSC1893)the Technological Innovation Research and Development Project from the Chengdu Science and Technology Bureau(2022-YF05-01950-SN)the Basic Research Program of Yunnan Province(202401CF070184).
文摘Nuclear receptors(NRs)are a large family of ligand-dependent transcription factors that regulate the expression of a wide range of target genes in response to endogenous and exogenous ligands,including steroid hormones,thyroid hormone,vitamin D,retinoic acid,fatty acids,and oxidative steroids.Upon ligand binding,nuclear receptors form dimer complexes with transcriptional cofactors,which interact with specific DNA sequences in the promoter or enhancer regions of target genes to modulate gene expression.This process plays a crucial role in many physiological processes such as reproduction,development,immune responses,metabolism,and homeostasis.Dysregulation of nuclear receptor signaling is implicated in the pathogenesis of numerous diseases,including cancers,metabolic disorders,cardiovascular diseases,and autoimmune conditions.
