1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed.This method offers a protocol to achieve the dearomatization of electron-deficient arenes via t...1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed.This method offers a protocol to achieve the dearomatization of electron-deficient arenes via the redox-neutral hydride transfer process.A series of C3-spiro hydroquinolines can be provided in moderate to excellent yields(up to 98%)with good diastereoselectivities.Significant advantages such as high step-and atomeconomy,as well as redox-neutral and mild conditions,make it an appealing alternative to achieve the dearomatization of quinolines.展开更多
基金support from the Taishan Scholars Construction Projects of Shandong(No.tsqn201909131)the National Natural Science Foundation of China(No.22001144)the Natural Science Foundation of Shandong Province(Nos.ZR2020QB046,ZR2020KB007 and ZR2020QB047).
文摘1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed.This method offers a protocol to achieve the dearomatization of electron-deficient arenes via the redox-neutral hydride transfer process.A series of C3-spiro hydroquinolines can be provided in moderate to excellent yields(up to 98%)with good diastereoselectivities.Significant advantages such as high step-and atomeconomy,as well as redox-neutral and mild conditions,make it an appealing alternative to achieve the dearomatization of quinolines.
