We theoretically investigate a cooling scheme assisted by a quantum well(QW)and coherent feedback within a hybrid optomechanical system.Although the exciton mode in the QW and the mechanical resonator(MR)are initially...We theoretically investigate a cooling scheme assisted by a quantum well(QW)and coherent feedback within a hybrid optomechanical system.Although the exciton mode in the QW and the mechanical resonator(MR)are initially uncoupled,their interaction via the microcavity field leads to an indirect exciton-mode–mechanical-mode coupling.The coherent feedback loop is applied by feeding back a fraction of the output field of the cavity through a controllable beam splitter to the cavity’s input mirror.It is shown that the cooling capability is enhanced by effectively suppressing the Stokes process through coupling with the QW.Furthermore,the effect of the anti-Stokes process is enhanced through the application of the coherent feedback loop.This particular system configuration enables cooling of the mechanical resonator even in the unresolved sideband regime(USR).This study has some important guiding significance in the field of quantum information processing.展开更多
The aim of the present study is to explore how native Chinese trainee teachers reflect on their usages of oral corrective feedback in class and what their actual teaching practices are in Chinese as a second language(...The aim of the present study is to explore how native Chinese trainee teachers reflect on their usages of oral corrective feedback in class and what their actual teaching practices are in Chinese as a second language(CSL)classroom.To this end,a mixed-methods approach was adopted in this study,including the questionnaire to explore teachers’perceptions as well as classroom observation to understand teachers’pedagogical practices during class.Fifteen trainee teachers from the same teacher training program in a university in China were identified and recruited to help complete the current research.The present study indicates that in the CSL context,teachers play an essential role in the language classroom and serve as the main resource of classroom feedback.When comparing trainee teachers’stated beliefs to their teaching practices,some similarities could be identified between them,however,clear divergence was also noticeable in the present study.Compared to the previous studies on oral corrective feedback in ESL and EFL contexts,most of the findings in the current study could correspond to those outcomes.The implication emphasizes the importance of offering more support to trainee teachers to help them deal with the complex classroom context such as through teacher training programs.Further investigations on students’perceptions of oral corrective feedback in class would also contribute to the understanding of oral corrective feedback in the CSL context.展开更多
Background:U2AF homology motif kinase 1(UHMK1)has been associated with RNA processing and protein phosphorylation,thereby influencing tumor progression.The study aimed to explore its regulatory mechanisms and biologic...Background:U2AF homology motif kinase 1(UHMK1)has been associated with RNA processing and protein phosphorylation,thereby influencing tumor progression.The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer(PCa).Methods:In this study,we systematically evaluated the expression and prognostic significance of UHMK1 in public databases,followed by validation through immunohis-tochemistry(IHC)in PCa specimens.Both gain-of-function and loss-of-function experiments were conducted to elucidate the role of UHMK1 in vitro and in vivo.Additionally,a series of molecular and biochemical assays were performed to investigate the regulatory mechanisms underlying UHMK1 activity.Results:Our findings revealed that UHMK1 expression was significantly upregulated in PCa tissues and correlated with poor patient prognosis,as demonstrated by analysis of public datasets and confirmed by immunohistochemical staining.Functional studies showed that UHMK1 depletion suppressed tumor cell proliferation and metastasis,while its overexpression promoted these processes.Mechanistically,we identified that UHMK1 phosphorylates nuclear receptor coactivator 3(NCOA3),which subsequently activates activating transcription factor 4(ATF4)to upregulate methylenetetrahydrofolate dehy-drogenase 2(MTHFD2)transcription.Interestingly,MTHFD2 was found to reciprocally enhance UHMK1 expression,establishing a positive feedback loop.Conclusions:In conclusion,our data suggest that the UHMK1-MTHFD2 axis forms a positive feedback loop that drives PCa progression.Targeting this loop represents a promising therapeutic strategy for restraining prostate cancer development and progression.展开更多
For the n-qubit stochastic open quantum systems,based on the Lyapunov stability theorem and LaSalle’s invariant set principle,a pure state switching control based on on-line estimated state feedback(short for OQST-SF...For the n-qubit stochastic open quantum systems,based on the Lyapunov stability theorem and LaSalle’s invariant set principle,a pure state switching control based on on-line estimated state feedback(short for OQST-SFC)is proposed to realize the state transition the pure state of the target state including eigenstate and superposition state.The proposed switching control consists of a constant control and a control law designed based on the Lyapunov method,in which the Lyapunov function is the state distance of the system.The constant control is used to drive the system state from an initial state to the convergence domain only containing the target state,and a Lyapunov-based control is used to make the state enter the convergence domain and then continue to converge to the target state.At the same time,the continuous weak measurement of quantum system and the quantum state tomography method based on the on-line alternating direction multiplier(QST-OADM)are used to obtain the system information and estimate the quantum state which is used as the input of the quantum system controller.Then,the pure state feedback switching control method based on the on-line estimated state feedback is realized in an n-qubit stochastic open quantum system.The complete derivation process of n-qubit QST-OADM algorithm is given;Through strict theoretical proof and analysis,the convergence conditions to ensure any initial state of the quantum system to converge the target pure state are given.The proposed control method is applied to a 2-qubit stochastic open quantum system for numerical simulation experiments.Four possible different position cases between the initial estimated state and that of the controlled system are studied and discussed,and the performances of the state transition under the corresponding cases are analyzed.展开更多
In this paper, an enhanced adaptive nonlinear extended state observer (EANESO) for single-input single-output pure feedback systems in the presence of external time-varying disturbances is proposed. In this paper, a n...In this paper, an enhanced adaptive nonlinear extended state observer (EANESO) for single-input single-output pure feedback systems in the presence of external time-varying disturbances is proposed. In this paper, a nonlinear system with matched and mismatched disturbances is considered. The conventional extended state observer (ESO) can only be applied to systems that are in the form of integral chains. Moreover, this method has limitations in the face of mismatched disturbances. In the presence of time-varying disturbances, the traditional ESOs cannot estimate the disturbances accurately. To overcome this limitation, an EANESO is proposed in this paper. The main idea is to design the nonlinear ESO (NESO) to estimate the states of the system and multiple disturbances simultaneously. The observer gains are considered time-varying and adjusted with adaptation laws to improve the estimation accuracy and overcome the peaking phenomenon. Next, the proposed controller is designed based on output feedback to eliminate the effects of multiple disturbances and stabilize the closed-loop system. Subsequently, the stability analysis of the closed-loop system and convergence of the observer error are discussed. Finally, the proposed method is applied to the inverted pendulum system. The simulated results show good performance of the proposed method as compared with a recently published scheme in the related literature.展开更多
Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,curr...Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity degradation.Additionally,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model performance.To address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural network.Firstly,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity curves.Next,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network model.To validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging dataset.The experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.展开更多
This paper investigates the prescribed-time tracking control problem for a class of multi-input multi-output(MIMO)nonlinear strict-feedback systems subject to non-vanishing uncertainties. The inherent unmatched and no...This paper investigates the prescribed-time tracking control problem for a class of multi-input multi-output(MIMO)nonlinear strict-feedback systems subject to non-vanishing uncertainties. The inherent unmatched and non-vanishing uncertainties make the prescribed-time control problem become much more nontrivial. The solution to address the challenges mentioned above involves incorporating a prescribed-time filter, as opposed to a finite-time filter, and formulating a prescribed-time Lyapunov stability lemma(Lemma 5). The prescribed-time Lyapunov stability lemma is based on time axis shifting time-varying yet bounded gain, which establishes a novel link between the fixed-time and prescribed-time control method. This allows the restriction condition that the time-varying gain function must satisfy as imposed in most exist prescribed-time control works to be removed. Under the proposed control method, the desire trajectory is ensured to closely track the output of the system in prescribed time. The effectiveness of the theoretical results are verified through numerical simulation.展开更多
Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate...Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.展开更多
This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with ...This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with 84 students from a middle school selected as the research subjects(44 in the experimental group and 40 in the control group).The experimental group used the reflective feedback model,while the control group used the factual feedback model.The results show that,compared with factual feedback,the reflective feedback model based on the pedagogical agent significantly improves students’problem-solving ability,especially at the action and thinking levels.In addition,this model effectively reduces students’cognitive load,especially in terms of internal and external load.展开更多
Implementing quantum wireless multi-hop network communication is essential to improve the global quantum network system. In this paper, we employ eight-level GHZ states as quantum channels to realize multi-hop quantum...Implementing quantum wireless multi-hop network communication is essential to improve the global quantum network system. In this paper, we employ eight-level GHZ states as quantum channels to realize multi-hop quantum communication, and utilize the logical relationship between the measurements of each node to derive the unitary operation performed by the end node. The hierarchical simultaneous entanglement switching(HSES) method is adopted, resulting in a significant reduction in the consumption of classical information compared to multi-hop quantum teleportation(QT)based on general simultaneous entanglement switching(SES). In addition, the proposed protocol is simulated on the IBM Quantum Experiment platform(IBM QE). Then, the data obtained from the experiment are analyzed using quantum state tomography, which verifies the protocol's good fidelity and accuracy. Finally, by calculating fidelity, we analyze the impact of four different types of noise(phase-damping, amplitude-damping, phase-flip and bit-flip) in this protocol.展开更多
In both Traditional Chinese Medicine(TCM)and modern medicine,they agree that the integrity and healthy structure of the vascular endothelium are essential for normal hemodynamics.Damage to the vascular endothelium can...In both Traditional Chinese Medicine(TCM)and modern medicine,they agree that the integrity and healthy structure of the vascular endothelium are essential for normal hemodynamics.Damage to the vascular endothelium can quickly activate the extrinsic coagulation pathway by triggering the tissue factor(TF)and lead to coagulation.This damage,along with a loss of anticoagulant properties through antithrombinⅢ(ATⅢ),TF pathway inhibitors,and the protein C system,can result in a hypercoagulable state and even thrombosis.Hypercoagulability is not only a common feature of many cancers but also an important factor promoting tumor development and metastasis,which corresponds to the TCM theory of“blood stasis leading to tumors.”The pharmacological effects of heparin and aspirin have similarities with TCM's“activating blood circulation and removing blood stasis”theory in improving blood circulation,treating related diseases,and their anti-inflammatory effects.展开更多
An internal state variable(ISV)model was established according to the experimental results of hot plane strain compression(PSC)to predict the microstructure evolution during hot spinning of ZK61 alloy.The effects of t...An internal state variable(ISV)model was established according to the experimental results of hot plane strain compression(PSC)to predict the microstructure evolution during hot spinning of ZK61 alloy.The effects of the internal variables were considered in this ISV model,and the parameters were optimized by genetic algorithm.After validation,the ISV model was used to simulate the evolution of grain size(GS)and dynamic recrystallization(DRX)fraction during hot spinning via Abaqus and its subroutine Vumat.By comparing the simulated results with the experimental results,the application of the ISV model was proven to be reliable.Meanwhile,the strength of the thin-walled spun ZK61 tube increased from 303 to 334 MPa due to grain refinement by DRX and texture strengthening.Besides,some ultrafine grains(0.5μm)that played an important role in mechanical properties were formed due to the proliferation,movement,and entanglement of dislocations during the spinning process.展开更多
1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-...1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-sized particles(5-50μm)to fabricate coatings[1-3].CS has been extensively used in a variety of coating applications,such as aerospace,automotive,energy,medical,marine,and others,to provide protection against high temperatures,corrosion,erosion,oxidation,and chemicals[4,5].Nowadays,the technical interest in CS is twofold:(i)as a repair process for damaged components,and(ii)as a solid-state additive manufacturing process.Compared to other fusion-based additive manufacturing(AM)technologies,Cold Spray Additive Manufacturing(CSAM)is a new member of the AM family that can enable the fabrication of deposits without undergoing melting.The chemical composition has been largely preserved from the powder to the deposit due to the minimal oxidation.The significant advantages of CSAM over other additive manufacturing processes include a high production rate,unlimited deposition size,high flexibility,and suitability for repairing damaged parts.展开更多
The effects of plasma screening on the ^(1)P^(o) resonance states of H-and He below the n=3 and n=4 thresholds of the respective subsystemsare investigated using the stabilization method and correlated exponential wav...The effects of plasma screening on the ^(1)P^(o) resonance states of H-and He below the n=3 and n=4 thresholds of the respective subsystemsare investigated using the stabilization method and correlated exponential wave functions.Two plasma mediums,namely,the Debye plasma and quantum plasma environments are considered.The screened Coulomb potential(SCP)obtained from Debye-Hückel model is used to represent Debye plasma environments and the exponential cosine screened Coulomb potential(ECSCP)obtained from a modified Debye-Hückel model is used to represent quantum plasma environments.The resonance parameters(resonance positions and widths)are presented in terms of the screening parameters.展开更多
This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and stru...This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and structural response of the platform are studied,considering the actual platform motion and free surface rise under extreme sea states.First,the effects of the wave frequency and direction on the wave-induced loads and dynamic responses were examined.The motion at a wave direction angle of 0°is relatively low.On this basis,the angle constrained by the two sides of the Sharp Eagle floaters should be aligned with the main wave direction to avoid significant platform motion under extreme sea states.Additionally,the structural response of the platform,including the wave-absorbing floaters,is investigated.The results highlighted that the conditions or locations where yielding,buckling,and fatigue failures occur were different.In this context,the connection area of the Sharp Eagle floaters and platform is prone to yielding failure under oblique wave action,whereas the pontoon and side of the Sharp Eagle floaters are prone to buckling failure during significant vertical motion.Additionally,fatigue damage is most likely to occur at the connection between the middle column on both sides of the Sharp Eagle floaters and the pontoons.The findings of this paper revealed an intrinsic connection between wave-induced loads and the dynamic and structural responses of the platform,which provides a useful reference for the improved design of WECs.展开更多
Written feedback in English writing classes serves as the primary mode of feedback.By comparing direct corrective feedback and indirect corrective feedback in addressing content and form,this paper argues that indirec...Written feedback in English writing classes serves as the primary mode of feedback.By comparing direct corrective feedback and indirect corrective feedback in addressing content and form,this paper argues that indirect corrective feedback better aligns with the needs of English majors.Multiple factors influence the choice of written feedback methods,and teachers should carefully select the most appropriate approach based on student characteristics to maximize the effectiveness of feedback.展开更多
Although substantial research shows the effectiveness of written corrective feedback(WCF)in treating simple grammar structures,more research is still needed to refute Truscott’s claim that WCF may not work on complex...Although substantial research shows the effectiveness of written corrective feedback(WCF)in treating simple grammar structures,more research is still needed to refute Truscott’s claim that WCF may not work on complex grammar structures.Similarly,a previous body of research has shown that the degree of explicitness of feedback moderates the efficacy of WCF.However,most WCF studies have systematically manipulated only direct corrective feedback.The current study was therefore conducted to fill these gaps in the literature.To this end,five intact classes of Functional English were recruited and later randomly assigned to four treatment groups:DCF,DCF+ME,ICF,and ICF+ME,and one control group that received no feedback.All the groups took part in three WCF treatment sessions,during which they wrote two different pieces:a news report and a picture description.Later,only the treatment groups received the WCF.The WCF’s effectiveness was measured by writing tests and grammaticality judgment tasks(GJT).The results demonstrated that WCF helped L2 learners improve their grammatical accuracy of passive voice tenses.The study further showed that the group that received the most explicit type of WCF fared better than the ones that received the least explicit type of WCF.Important pedagogical implications for ESL/EFL teachers are discussed.展开更多
Background: Undergoing ultrasound scanning (USS) during the first trimester of pregnancy is highly imperative for expecting mothers, as it supports the early detection of any malformations, identifying the fetal numbe...Background: Undergoing ultrasound scanning (USS) during the first trimester of pregnancy is highly imperative for expecting mothers, as it supports the early detection of any malformations, identifying the fetal number, fetal growth, fetal sex, and calculation of delivery. Previous studies have shown that undergoing such prenatal screening procedures could reduce the antenatal anxiety levels of expectant mothers. The present study aimed to explore the impact of first-trimester ultrasound scanning towards the antenatal anxiety and identify the predictors of antenatal anxiety among expectant mothers in the first trimester. Methods: A repeated measure design study was conducted in Maternity Clinics of University Hospital KDU, Ninewells Care Hospital and Navy General Hospital over 4 months with one hundred and fifteen (n = 115) expectant mothers. Participants completed a general information sheet first and State Trait Anxiety Inventory (STAI) (Spielberger et al., 1970) was administered before and after undergoing the USS. Results: Mean age of the participants was 28.84 ± 3.68. The Wilcoxon Signed Rank test showed that there is a significant reduction of participants’ antenatal anxiety levels following the USS z = −5.658, p Conclusions: Findings suggest that undergoing the first trimester USS significantly reduces the antenatal state anxiety and partner’s support is an important factor in reducing the antenatal anxiety experienced by expectant mothers in the first trimester. Future studies can focus on how USS can contribute to alleviating antenatal anxiety in second and third trimesters.展开更多
Compared to traditional single-frequency bound states in the continuum(BIC),dual-band BIC of-fers higher degrees of freedom and functionality.Moveover,implementing independent control of dual-band BICs can further enh...Compared to traditional single-frequency bound states in the continuum(BIC),dual-band BIC of-fers higher degrees of freedom and functionality.Moveover,implementing independent control of dual-band BICs can further enhance their advantages and maximize their performance.This study presents a design for a dielectric metasurface that achieves dual-band BICs in the terahertz(THz)range.By adjusting two asym-metry parameters of the structure,independent control of the two symmetry-protected BICs is achieved.Fur-thermore,by varying the shape of the silicon holes,the design's robustness to geometric variations is demon-strated.Finally,the test results show that the figures of merit(FOMs)for both BICs reach 109.This work provides a new approach for realizing and tuning dual-frequency BICs,offering expanded possibilities for applications in multimode lasers,nonlinear optics,multi-channel filtering,and optical sensing.展开更多
Exploring the quantum advantages of various non-classical quantum states in noisy environments is a central subject in quantum sensing.Here we provide a complete picture for the frequency estimation precision of three...Exploring the quantum advantages of various non-classical quantum states in noisy environments is a central subject in quantum sensing.Here we provide a complete picture for the frequency estimation precision of three important states(the Greenberger-Horne-Zeilinger(GHZ)state,the maximal spin squeezed state,and the spin coherent state)of a spin-S under both individual dephasing and collective dephasing by general Gaussian noise,ranging from the Markovian limit to the extreme non-Markovian limit.Whether or not the noise is Markovian,the spin coherent state is always worse than the classical scheme under collective dephasing although it is equivalent to the classical scheme under individual dephasing.Moreover,the maximal spin squeezed state always give the best sensing precision(and outperforms the widely studied GHZ state)in all cases.This establishes the general advantage of the spin squeezed state for noisy frequency estimation in many quantum sensing platforms.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.62061028 and 62461035)the Key Project of Natural Science Foundation of Jiangxi Province(Grant No.20232ACB202003)+2 种基金the Finance Science and Technology Special“contract system”Project of Nanchang University Jiangxi Province(Grant No.ZBG20230418015)the Natural Science Foundation of Chongqing(Grant No.CSTB2024NSCQ-MSX0412)the Opening Project of Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology(Grant No.ammt2021A-4).
文摘We theoretically investigate a cooling scheme assisted by a quantum well(QW)and coherent feedback within a hybrid optomechanical system.Although the exciton mode in the QW and the mechanical resonator(MR)are initially uncoupled,their interaction via the microcavity field leads to an indirect exciton-mode–mechanical-mode coupling.The coherent feedback loop is applied by feeding back a fraction of the output field of the cavity through a controllable beam splitter to the cavity’s input mirror.It is shown that the cooling capability is enhanced by effectively suppressing the Stokes process through coupling with the QW.Furthermore,the effect of the anti-Stokes process is enhanced through the application of the coherent feedback loop.This particular system configuration enables cooling of the mechanical resonator even in the unresolved sideband regime(USR).This study has some important guiding significance in the field of quantum information processing.
文摘The aim of the present study is to explore how native Chinese trainee teachers reflect on their usages of oral corrective feedback in class and what their actual teaching practices are in Chinese as a second language(CSL)classroom.To this end,a mixed-methods approach was adopted in this study,including the questionnaire to explore teachers’perceptions as well as classroom observation to understand teachers’pedagogical practices during class.Fifteen trainee teachers from the same teacher training program in a university in China were identified and recruited to help complete the current research.The present study indicates that in the CSL context,teachers play an essential role in the language classroom and serve as the main resource of classroom feedback.When comparing trainee teachers’stated beliefs to their teaching practices,some similarities could be identified between them,however,clear divergence was also noticeable in the present study.Compared to the previous studies on oral corrective feedback in ESL and EFL contexts,most of the findings in the current study could correspond to those outcomes.The implication emphasizes the importance of offering more support to trainee teachers to help them deal with the complex classroom context such as through teacher training programs.Further investigations on students’perceptions of oral corrective feedback in class would also contribute to the understanding of oral corrective feedback in the CSL context.
基金supported by the National Natural Science Foundation of China(Grant Nos.81902617 and 82100816)Guangdong Natural Science Foundation(Grant No.2021A1515012322)Guangzhou Basic and Applied Basic Research Subject-Young Doctor’s“Sailing”Project(Grant No.2024A04J4702).
文摘Background:U2AF homology motif kinase 1(UHMK1)has been associated with RNA processing and protein phosphorylation,thereby influencing tumor progression.The study aimed to explore its regulatory mechanisms and biological functions in human prostate cancer(PCa).Methods:In this study,we systematically evaluated the expression and prognostic significance of UHMK1 in public databases,followed by validation through immunohis-tochemistry(IHC)in PCa specimens.Both gain-of-function and loss-of-function experiments were conducted to elucidate the role of UHMK1 in vitro and in vivo.Additionally,a series of molecular and biochemical assays were performed to investigate the regulatory mechanisms underlying UHMK1 activity.Results:Our findings revealed that UHMK1 expression was significantly upregulated in PCa tissues and correlated with poor patient prognosis,as demonstrated by analysis of public datasets and confirmed by immunohistochemical staining.Functional studies showed that UHMK1 depletion suppressed tumor cell proliferation and metastasis,while its overexpression promoted these processes.Mechanistically,we identified that UHMK1 phosphorylates nuclear receptor coactivator 3(NCOA3),which subsequently activates activating transcription factor 4(ATF4)to upregulate methylenetetrahydrofolate dehy-drogenase 2(MTHFD2)transcription.Interestingly,MTHFD2 was found to reciprocally enhance UHMK1 expression,establishing a positive feedback loop.Conclusions:In conclusion,our data suggest that the UHMK1-MTHFD2 axis forms a positive feedback loop that drives PCa progression.Targeting this loop represents a promising therapeutic strategy for restraining prostate cancer development and progression.
基金supported by the National Natural Science Foundation of China(62473354).
文摘For the n-qubit stochastic open quantum systems,based on the Lyapunov stability theorem and LaSalle’s invariant set principle,a pure state switching control based on on-line estimated state feedback(short for OQST-SFC)is proposed to realize the state transition the pure state of the target state including eigenstate and superposition state.The proposed switching control consists of a constant control and a control law designed based on the Lyapunov method,in which the Lyapunov function is the state distance of the system.The constant control is used to drive the system state from an initial state to the convergence domain only containing the target state,and a Lyapunov-based control is used to make the state enter the convergence domain and then continue to converge to the target state.At the same time,the continuous weak measurement of quantum system and the quantum state tomography method based on the on-line alternating direction multiplier(QST-OADM)are used to obtain the system information and estimate the quantum state which is used as the input of the quantum system controller.Then,the pure state feedback switching control method based on the on-line estimated state feedback is realized in an n-qubit stochastic open quantum system.The complete derivation process of n-qubit QST-OADM algorithm is given;Through strict theoretical proof and analysis,the convergence conditions to ensure any initial state of the quantum system to converge the target pure state are given.The proposed control method is applied to a 2-qubit stochastic open quantum system for numerical simulation experiments.Four possible different position cases between the initial estimated state and that of the controlled system are studied and discussed,and the performances of the state transition under the corresponding cases are analyzed.
文摘In this paper, an enhanced adaptive nonlinear extended state observer (EANESO) for single-input single-output pure feedback systems in the presence of external time-varying disturbances is proposed. In this paper, a nonlinear system with matched and mismatched disturbances is considered. The conventional extended state observer (ESO) can only be applied to systems that are in the form of integral chains. Moreover, this method has limitations in the face of mismatched disturbances. In the presence of time-varying disturbances, the traditional ESOs cannot estimate the disturbances accurately. To overcome this limitation, an EANESO is proposed in this paper. The main idea is to design the nonlinear ESO (NESO) to estimate the states of the system and multiple disturbances simultaneously. The observer gains are considered time-varying and adjusted with adaptation laws to improve the estimation accuracy and overcome the peaking phenomenon. Next, the proposed controller is designed based on output feedback to eliminate the effects of multiple disturbances and stabilize the closed-loop system. Subsequently, the stability analysis of the closed-loop system and convergence of the observer error are discussed. Finally, the proposed method is applied to the inverted pendulum system. The simulated results show good performance of the proposed method as compared with a recently published scheme in the related literature.
基金supported by the National Natural Science Foundation of China(NSFC)under Grant(No.51677058).
文摘Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity degradation.Additionally,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model performance.To address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural network.Firstly,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity curves.Next,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network model.To validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging dataset.The experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.
基金supported in part by the National Key Research and Development Program of China(2023YFA1011803)the National Natural Science Foundation of China(62273064,61991400/61991403,61933012,62250710167,62203078)+2 种基金Natural Science Foundation of Chongqing(CSTB2023NSCQ-MSX0588)the Central University Project(2023CDJKYJH047)the Innovation Support Program for International Students Returning to China(cx2022016)
文摘This paper investigates the prescribed-time tracking control problem for a class of multi-input multi-output(MIMO)nonlinear strict-feedback systems subject to non-vanishing uncertainties. The inherent unmatched and non-vanishing uncertainties make the prescribed-time control problem become much more nontrivial. The solution to address the challenges mentioned above involves incorporating a prescribed-time filter, as opposed to a finite-time filter, and formulating a prescribed-time Lyapunov stability lemma(Lemma 5). The prescribed-time Lyapunov stability lemma is based on time axis shifting time-varying yet bounded gain, which establishes a novel link between the fixed-time and prescribed-time control method. This allows the restriction condition that the time-varying gain function must satisfy as imposed in most exist prescribed-time control works to be removed. Under the proposed control method, the desire trajectory is ensured to closely track the output of the system in prescribed time. The effectiveness of the theoretical results are verified through numerical simulation.
基金supported in part by the National Natural Science Foundation of China(62173051)the Fundamental Research Funds for the Central Universities(2024CDJCGJ012,2023CDJXY-010)+1 种基金the Chongqing Technology Innovation and Application Development Special Key Project(CSTB2022TIADCUX0015,CSTB2022TIAD-KPX0162)the China Postdoctoral Science Foundation(2024M763865)
文摘Dear Editor,This letter addresses the impulse game problem for a general scope of deterministic,multi-player,nonzero-sum differential games wherein all participants adopt impulse controls.Our objective is to formulate this impulse game problem with the modified objective function including interaction costs among the players in a discontinuous fashion,and subsequently,to derive a verification theorem for identifying the feedback Nash equilibrium strategy.
基金023 Zhejiang Provincial Department of Education General Project:Research on an interdisciplinary teaching model to promote the development of computational thinking in the context of the new curriculum standards[Grant NO:Y202351596]Key Project of Zhejiang Provincial Education Science Planning:Research on an interdisciplinary teaching model to promote students’computational thinking from multiple analytical perspectives[Grant NO:2025SB103].
文摘This study constructs a reflective feedback model based on a pedagogical agent(PA)and explores its impact on students’problem-solving ability and cognitive load.A quasi-experimental design was used in the study,with 84 students from a middle school selected as the research subjects(44 in the experimental group and 40 in the control group).The experimental group used the reflective feedback model,while the control group used the factual feedback model.The results show that,compared with factual feedback,the reflective feedback model based on the pedagogical agent significantly improves students’problem-solving ability,especially at the action and thinking levels.In addition,this model effectively reduces students’cognitive load,especially in terms of internal and external load.
基金Project supported by the Open Fund of Anhui Key Laboratory of Mine Intelligent Equipment and Technology (Grant No. ZKSYS202204)the Talent Introduction Fund of Anhui University of Science and Technology (Grant No. 2021yjrc34)the Scientific Research Fund of Anhui Provincial Education Department (Grant No. KJ2020A0301)。
文摘Implementing quantum wireless multi-hop network communication is essential to improve the global quantum network system. In this paper, we employ eight-level GHZ states as quantum channels to realize multi-hop quantum communication, and utilize the logical relationship between the measurements of each node to derive the unitary operation performed by the end node. The hierarchical simultaneous entanglement switching(HSES) method is adopted, resulting in a significant reduction in the consumption of classical information compared to multi-hop quantum teleportation(QT)based on general simultaneous entanglement switching(SES). In addition, the proposed protocol is simulated on the IBM Quantum Experiment platform(IBM QE). Then, the data obtained from the experiment are analyzed using quantum state tomography, which verifies the protocol's good fidelity and accuracy. Finally, by calculating fidelity, we analyze the impact of four different types of noise(phase-damping, amplitude-damping, phase-flip and bit-flip) in this protocol.
基金supported by the Guizhou Provincial Basic Research Program(Natural Science)Youth Guidance Project{Qian Kehe Foundation-[2024]Youth 307}。
文摘In both Traditional Chinese Medicine(TCM)and modern medicine,they agree that the integrity and healthy structure of the vascular endothelium are essential for normal hemodynamics.Damage to the vascular endothelium can quickly activate the extrinsic coagulation pathway by triggering the tissue factor(TF)and lead to coagulation.This damage,along with a loss of anticoagulant properties through antithrombinⅢ(ATⅢ),TF pathway inhibitors,and the protein C system,can result in a hypercoagulable state and even thrombosis.Hypercoagulability is not only a common feature of many cancers but also an important factor promoting tumor development and metastasis,which corresponds to the TCM theory of“blood stasis leading to tumors.”The pharmacological effects of heparin and aspirin have similarities with TCM's“activating blood circulation and removing blood stasis”theory in improving blood circulation,treating related diseases,and their anti-inflammatory effects.
基金supported by the National Natural Science Foundation of China(No.51905123)Major Scientific and Technological Innovation Program of Shandong Province,China(Nos.2020CXGC010303,2022ZLGX04)Key R&D Programme of Shandong Province,China(No.2022JMRH0308).
文摘An internal state variable(ISV)model was established according to the experimental results of hot plane strain compression(PSC)to predict the microstructure evolution during hot spinning of ZK61 alloy.The effects of the internal variables were considered in this ISV model,and the parameters were optimized by genetic algorithm.After validation,the ISV model was used to simulate the evolution of grain size(GS)and dynamic recrystallization(DRX)fraction during hot spinning via Abaqus and its subroutine Vumat.By comparing the simulated results with the experimental results,the application of the ISV model was proven to be reliable.Meanwhile,the strength of the thin-walled spun ZK61 tube increased from 303 to 334 MPa due to grain refinement by DRX and texture strengthening.Besides,some ultrafine grains(0.5μm)that played an important role in mechanical properties were formed due to the proliferation,movement,and entanglement of dislocations during the spinning process.
基金supported by the National Natural Science Foundation of China(No.52061135101 and 52001078)the German Research Foundation(DFG,No.448318292)+3 种基金the Technology Innovation Guidance Special Foundation of Shaanxi Province(No.2023GXLH-085)the Fundamental Research Funds for the Central Universities(No.D5000240161)the Project of Key areas of innovation team in Shaanxi Province(No.2024RS-CXTD-20)The author Yingchun Xie thanks the support from the National Key R&D Program(No.2023YFE0108000).
文摘1.Introduction.Cold Spray(CS)is a highly advanced solid-state metal depo-sition process that was first developed in the 1980s.This innovative technique involves the high-speed(300-1200 m/s)impact deposition of micron-sized particles(5-50μm)to fabricate coatings[1-3].CS has been extensively used in a variety of coating applications,such as aerospace,automotive,energy,medical,marine,and others,to provide protection against high temperatures,corrosion,erosion,oxidation,and chemicals[4,5].Nowadays,the technical interest in CS is twofold:(i)as a repair process for damaged components,and(ii)as a solid-state additive manufacturing process.Compared to other fusion-based additive manufacturing(AM)technologies,Cold Spray Additive Manufacturing(CSAM)is a new member of the AM family that can enable the fabrication of deposits without undergoing melting.The chemical composition has been largely preserved from the powder to the deposit due to the minimal oxidation.The significant advantages of CSAM over other additive manufacturing processes include a high production rate,unlimited deposition size,high flexibility,and suitability for repairing damaged parts.
基金Supported by the Natural Science Foundation of Heilongjiang Province(LH2024A025)。
文摘The effects of plasma screening on the ^(1)P^(o) resonance states of H-and He below the n=3 and n=4 thresholds of the respective subsystemsare investigated using the stabilization method and correlated exponential wave functions.Two plasma mediums,namely,the Debye plasma and quantum plasma environments are considered.The screened Coulomb potential(SCP)obtained from Debye-Hückel model is used to represent Debye plasma environments and the exponential cosine screened Coulomb potential(ECSCP)obtained from a modified Debye-Hückel model is used to represent quantum plasma environments.The resonance parameters(resonance positions and widths)are presented in terms of the screening parameters.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFC3003805)Youth Innovation Promotion Association of the Chinese Academy of Sciences(Grant No.2022356)Guangzhou Basic and Applied Basic Research Project(Grant No.2023A04J0955).
文摘This paper presents a new type of triangular Sharp Eagle wave energy converter(WEC)platform.On the basis of the linear potential flow theory and the finite element analysis method,the hydrodynamic performance and structural response of the platform are studied,considering the actual platform motion and free surface rise under extreme sea states.First,the effects of the wave frequency and direction on the wave-induced loads and dynamic responses were examined.The motion at a wave direction angle of 0°is relatively low.On this basis,the angle constrained by the two sides of the Sharp Eagle floaters should be aligned with the main wave direction to avoid significant platform motion under extreme sea states.Additionally,the structural response of the platform,including the wave-absorbing floaters,is investigated.The results highlighted that the conditions or locations where yielding,buckling,and fatigue failures occur were different.In this context,the connection area of the Sharp Eagle floaters and platform is prone to yielding failure under oblique wave action,whereas the pontoon and side of the Sharp Eagle floaters are prone to buckling failure during significant vertical motion.Additionally,fatigue damage is most likely to occur at the connection between the middle column on both sides of the Sharp Eagle floaters and the pontoons.The findings of this paper revealed an intrinsic connection between wave-induced loads and the dynamic and structural responses of the platform,which provides a useful reference for the improved design of WECs.
文摘Written feedback in English writing classes serves as the primary mode of feedback.By comparing direct corrective feedback and indirect corrective feedback in addressing content and form,this paper argues that indirect corrective feedback better aligns with the needs of English majors.Multiple factors influence the choice of written feedback methods,and teachers should carefully select the most appropriate approach based on student characteristics to maximize the effectiveness of feedback.
文摘Although substantial research shows the effectiveness of written corrective feedback(WCF)in treating simple grammar structures,more research is still needed to refute Truscott’s claim that WCF may not work on complex grammar structures.Similarly,a previous body of research has shown that the degree of explicitness of feedback moderates the efficacy of WCF.However,most WCF studies have systematically manipulated only direct corrective feedback.The current study was therefore conducted to fill these gaps in the literature.To this end,five intact classes of Functional English were recruited and later randomly assigned to four treatment groups:DCF,DCF+ME,ICF,and ICF+ME,and one control group that received no feedback.All the groups took part in three WCF treatment sessions,during which they wrote two different pieces:a news report and a picture description.Later,only the treatment groups received the WCF.The WCF’s effectiveness was measured by writing tests and grammaticality judgment tasks(GJT).The results demonstrated that WCF helped L2 learners improve their grammatical accuracy of passive voice tenses.The study further showed that the group that received the most explicit type of WCF fared better than the ones that received the least explicit type of WCF.Important pedagogical implications for ESL/EFL teachers are discussed.
文摘Background: Undergoing ultrasound scanning (USS) during the first trimester of pregnancy is highly imperative for expecting mothers, as it supports the early detection of any malformations, identifying the fetal number, fetal growth, fetal sex, and calculation of delivery. Previous studies have shown that undergoing such prenatal screening procedures could reduce the antenatal anxiety levels of expectant mothers. The present study aimed to explore the impact of first-trimester ultrasound scanning towards the antenatal anxiety and identify the predictors of antenatal anxiety among expectant mothers in the first trimester. Methods: A repeated measure design study was conducted in Maternity Clinics of University Hospital KDU, Ninewells Care Hospital and Navy General Hospital over 4 months with one hundred and fifteen (n = 115) expectant mothers. Participants completed a general information sheet first and State Trait Anxiety Inventory (STAI) (Spielberger et al., 1970) was administered before and after undergoing the USS. Results: Mean age of the participants was 28.84 ± 3.68. The Wilcoxon Signed Rank test showed that there is a significant reduction of participants’ antenatal anxiety levels following the USS z = −5.658, p Conclusions: Findings suggest that undergoing the first trimester USS significantly reduces the antenatal state anxiety and partner’s support is an important factor in reducing the antenatal anxiety experienced by expectant mothers in the first trimester. Future studies can focus on how USS can contribute to alleviating antenatal anxiety in second and third trimesters.
文摘Compared to traditional single-frequency bound states in the continuum(BIC),dual-band BIC of-fers higher degrees of freedom and functionality.Moveover,implementing independent control of dual-band BICs can further enhance their advantages and maximize their performance.This study presents a design for a dielectric metasurface that achieves dual-band BICs in the terahertz(THz)range.By adjusting two asym-metry parameters of the structure,independent control of the two symmetry-protected BICs is achieved.Fur-thermore,by varying the shape of the silicon holes,the design's robustness to geometric variations is demon-strated.Finally,the test results show that the figures of merit(FOMs)for both BICs reach 109.This work provides a new approach for realizing and tuning dual-frequency BICs,offering expanded possibilities for applications in multimode lasers,nonlinear optics,multi-channel filtering,and optical sensing.
基金supported by the National Natural Science Foundation of China(NSFC)Grant No.12274019the NSAF grant in NSFC with Grant No.U2230402。
文摘Exploring the quantum advantages of various non-classical quantum states in noisy environments is a central subject in quantum sensing.Here we provide a complete picture for the frequency estimation precision of three important states(the Greenberger-Horne-Zeilinger(GHZ)state,the maximal spin squeezed state,and the spin coherent state)of a spin-S under both individual dephasing and collective dephasing by general Gaussian noise,ranging from the Markovian limit to the extreme non-Markovian limit.Whether or not the noise is Markovian,the spin coherent state is always worse than the classical scheme under collective dephasing although it is equivalent to the classical scheme under individual dephasing.Moreover,the maximal spin squeezed state always give the best sensing precision(and outperforms the widely studied GHZ state)in all cases.This establishes the general advantage of the spin squeezed state for noisy frequency estimation in many quantum sensing platforms.
