Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primaril...Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.展开更多
“Ruyong(breast abscess)”has a high incidence rate.Traditional Chinese medicine(TCM)diagnosis and treatment of this condition demonstrate significant advantages,including diverse therapeuticmethods,outstanding effica...“Ruyong(breast abscess)”has a high incidence rate.Traditional Chinese medicine(TCM)diagnosis and treatment of this condition demonstrate significant advantages,including diverse therapeuticmethods,outstanding efficacy,and high safety.Based on TCM theory and combining relevant ancient texts and modern research,this paper systematically summarizes the different understandings of“Ruyong(breast abscess)”by physicians throughout history in terms of disease names,etiology,pathogenesis,and treatment.The ancient names for Ruyong(breast abscess)were varied,also referred to as“Duru(stagnation in breast)”or“Naichuang(breast sore)”.Its symptoms are diverse,with the main clinical manifestations being localized redness,swelling,heat,pain,and poor milk discharge in the affected breast.The etiology is primarily attributed to“milk stasis”“liver qi stagnation and stomach heat”and“exposure to external pathogens”.Additionally,this paper summarizes the treatment experiences from ancient and modern medical texts and highlights the complementary effects of internal and external therapies.This study provides a reference for modern clinical understanding and treatment of“Ruyong(breast abscess)”in the hope of further improvement of clinical efficacy.展开更多
Differential evolution(DE)algorithms are simple and efficient evolutionary algorithms that performwell in various optimization problems.Unfortunately,they inevitably stagnate when differential evolutionary algorithms ...Differential evolution(DE)algorithms are simple and efficient evolutionary algorithms that performwell in various optimization problems.Unfortunately,they inevitably stagnate when differential evolutionary algorithms are used to solve complex problems(e.g.,real-world artificial neural network(ANN)training problems).To resolve this issue,this paper proposes a framework based on an efficient elite centroid operator.It continuously monitors the current state of the population.Once stagnation is detected,two dedicated operators,centroid-based mutation(CM)and centroid-based crossover(CX),are executed to replace the classical mutation and binomial crossover operations in DE.CM and CX are centred on the elite centroid composed of multiple elite individuals,constituting a framework consisting of elitism centroid-based operations(CMX)to improve the performance of the individuals who fall into stagnation.In CM,elite centroid provide evolutionary direction for stagnant individuals,and in CX,elite plasmoids address the limitation that stagnant individuals can only obtain limited information about the population.The CMX framework is simple enough to easily incorporate into both classically well-known DEs with constant population sizes and state-of-the-art DEs with varying populations.Numerical experiments on benchmark functions show that the proposed CMX method can significantly enhance the classical DE algorithm and its advanced variants in solving the stagnation problem and improving performance.展开更多
Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12...Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.展开更多
[Objectives]To observe the clinical effect of Tiaoqi Dingxian prescription combined with western medicine on epilepsy of qi constraint and phlegm stagnation type.[Methods]A total of 60 cases of patients of epilepsy of...[Objectives]To observe the clinical effect of Tiaoqi Dingxian prescription combined with western medicine on epilepsy of qi constraint and phlegm stagnation type.[Methods]A total of 60 cases of patients of epilepsy of qi constraint and phlegm stagnation type admitted to Maoming Hospital Affiliated to Guangzhou University of Chinese Medicine from June 2023 to July 2024 were selected as the research subjects.They were randomly divided into the control group and the observation group using a random number table method,with 30 cases in each group.The control group was treated with levetiracetam,while the observation group was treated with Tiaoqi Dingxian prescription on the basis of the control group.Both groups were treated for 3 months,and the clinical efficacy,frequency and duration of epilepsy onset,improvement of electroencephalogram(EEG),Quality of Life in Epilepsy Inventory(QOLIE-31)scores,traditional Chinese medicine(TCM)syndrome scores,and incidence of adverse reactions were evaluated in both groups.[Results]The total effective rate in the observation group was 93.33%(28/30),compared to 73.33%(22/30)in the control group,with a statistically significant difference(P<0.05).Following treatment,the frequency and duration of epilepsy onset in both groups were decreased when compared to the pre-treatment period(P<0.05),and the frequency and duration of epilepsy onset in the observation group were lower than those in the control group(P<0.05).Following treatment,the EEG grading of both groups was improved when compared with that before treatment(P<0.05),and the EEG grading in the observation group was better than that in the control group(P<0.05).Following treatment,the QOLIE-31 scores in both groups,including epilepsy-related concerns,overall health,emotional health,energy,cognitive function,drug effects,and social function,were increased when compared to the scores recorded prior to treatment(P<0.05),and all scores in the observation group were higher than those in the control group(P<0.05).Following treatment,the TCM syndrome scores in both groups were decreased when compared to those prior to treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was observed to be 6.67%(2/30)in the observation group and 13.33%(4/30)in the control group,with no significant difference between the two groups(P>0.05).[Conclusions]The combination of Tiaoqi Dingxian prescription and levetiracetam in the treatment of epilepsy of qi constraint and phlegm stagnation type can improve clinical efficacy,alleviate patient s symptoms and quality of life,and has good safety.展开更多
Objective:To evaluate the therapeutic efficacy of the umbilical acupuncture’s“Wind-Thunder Interaction Method”in treating schizophrenia(SCH)patients with liver stagnation and spleen deficiency.Methods:A total of 12...Objective:To evaluate the therapeutic efficacy of the umbilical acupuncture’s“Wind-Thunder Interaction Method”in treating schizophrenia(SCH)patients with liver stagnation and spleen deficiency.Methods:A total of 120 SCH patients with liver stagnation and spleen deficiency were selected and evenly divided by ball drawing.The umbilical acupuncture group received the“Wind-Thunder Interaction Method”,while the Western medicine group received pure Western medicine treatment.The outcomes were compared in terms of efficacy and other indicators.Results:The umbilical acupuncture group showed a higher total effective rate,a decrease in disease symptom scores,lower scores on the side effect rating scale,improved cognitive function scores,and excellent laboratory indicators,with p<0.05 between the groups.Conclusion:The“Wind-Thunder Interaction Method”of umbilical acupuncture demonstrated a relatively high effectiveness in treating SCH patients with liver stagnation and spleen deficiency,alleviating symptoms,reducing side effects,improving cognitive function,and facilitating the recovery of neuro-vascular regulatory peptide groups.展开更多
Objective To observe the effect of instant moxibustion on the levels of prostaglandin E_2（PGE_2）,prostaglandin F2α（PGE_（2α）） and arginine vasopressin（AVP） in the uterine tissues of dismenorrhea rats with col...Objective To observe the effect of instant moxibustion on the levels of prostaglandin E_2（PGE_2）,prostaglandin F2α（PGE_（2α）） and arginine vasopressin（AVP） in the uterine tissues of dismenorrhea rats with cold-damp congealing and stagnation type and to explore its possible mechanism.Methods Female Wistar rats were randomly divided into blank group,model group,herble medicine group,pre-moxibustion group and instant moxibustion group,with 9 rats in each group.Cold-damp congealing and stagnation type primary dismenorrhea models were established by adopting（0±1）℃ ice waterextraction method combined with estradiol benzoate injection method.After modeling on the 8th day,in herble medicine group,Tongjingbao granules was given to the rats by intragastric administration.In pre-moxibustion group,mild moxibustion was carried out at ＂Shénquè＂（神阙 CV 8） and ＂Guānyuán＂（关元 CV 4） of the rats for 10 min at each acupoint.In instant moxibustion group,moxibustion as that in pre-moxibustion group was conducted for once after injection with oxytocin on the 11 th day.ELISA was adopted to detect the levels of PGE_2 and PGE_（2α） in the uterine tissues of rats,and radioimmunoassay was used for detection of AVP level in the uterine tissues of rats.Results Compared with the model group,the latent period of rats in herbal medicine group,premoxibustion group and instant moxibustion group obviously prolonged,the number of times of torsion reduced,and the total score of torsion decreased（P0.01）;compared with herbal medicine group,the latent period of rats in instant moxibustion group obviously prolonged,and the total score of torsion decreased（P0.05 or P0.01）;compared with pre-moxibustion group,the number of times of torsion of rats in instant moxibustion group reduced,and the total score of torsion decreased（P0.01）.Compared with blank group,the levels of PGE_（2α） and AVP and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in model group significantly increased（P0.01）,and the PGE_2 level significantly reduced（P0.01）;compared with model group,the PGE_（2α） level and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in herble medicine group,pre-moxibustion group and instant moxibustion group obviously reduced（P0.05 or P0.01）,the PGE_2 level obviously increased（P0.01）,and the AVP level in the uterine tissues of rats in pre-moxibustion group and instant moxibustion group obviously reduced（P0.05 or P0.01）;compared with herbal medicine group,the levels of PGE_（2α） and AVP and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in instant moxibustion group significantly reduced（P0.05 or P0.01）;compared with pre-moxibustion group,the PGE_（2α） level and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in instant moxibustion group obviously reduced（P0.05）,and the PGE_2 level obviously increased（P0.01）.Conclusion Both pre-moxibustion and instant moxibustion can obviously inhibit spasmodic uterine smooth muscle contraction of rats with dismenorrhea,regulate imbalanced levels of PGE_（2α） and PGE_2,reduce the AVP level,so as to improve the uterine hypoxia-ischemia,and play a role in alleviating pain.The efficacy of instant moxibustion was superior to that of pre-moxibustion.展开更多
By analysis of published papers on the Yangtze estuary and hydrological and sediments data in Yangshan Harbor area, many similarities are found between Yangshan Harbor area and the Yangtze estuary. These similarities ...By analysis of published papers on the Yangtze estuary and hydrological and sediments data in Yangshan Harbor area, many similarities are found between Yangshan Harbor area and the Yangtze estuary. These similarities include the phenomenon of stagnating flow areas, the distributive characteristics of the highest suspended sediment concentration areas, superficial sediments and shoal bars. The stagnating flow area is the major similarity which causes other similarities. These similarities indicate that: 1) Turbidity Maximum and mouth bars in estuaries are mainly caused by the hydraulic balance of stagnating flow areas of estuaries; 2) The stagnating sand area of sands caused by stagnating flow area often locates on the narrower side of the stagnating flow area; 3) The location (or shape) of fine sediments area caused by stagnating flow area reflects the location (or shape) of the stagnating flow area. Both Yangshan Harbor area and the Yangtze estuary are the important developmental areas in the future (man-made similarity). In-depth studies on these similarities between Yangshan Harbor area and the Yangtze estuary will have momentous theoretical and practical significance.展开更多
OBJECTIVE： To study changes in pulse diagram parameters （PDP） in patients with cervical spondylosis （CS） before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP...OBJECTIVE： To study changes in pulse diagram parameters （PDP） in patients with cervical spondylosis （CS） before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP changes and therapeutic effectiveness, and provide evidence for outcome prediction and objective evaluation of CS treatment before and after acupuncture treatment. METHODS： Patients with CS were treated with acupuncture and measured with a pulse acquisition device based on image （PADBI） before the first and after the tenth acupuncture sessions. Changes in PDP from before until after the acupuncture sessions and patient impressions were analyzed to judge the effect of acupuncture treatment for. RESULTS： The PDP values in effective patients were closer to normal values. This indicated that Qi stagnation and blood stasis of the patients was improved. The PDP changes from before to after the first acupuncture treatment were more obvious than those from before to after the tenth acupunc- ture treatment. This result indicates that the speed of symptom improvement decreased significantly after several acupuncture courses. Analysis of correlation between efficacy and PDP showed that the changes in PDP in five patients was abnormal, which mainly manifested as values of hl, u, p, Pp, and tl, and no significant changes or differences were increased with standard values. This indicated that the symptoms of CS were not improved in these patients. CONCLUSION; PADBI can provide evidence for outcome prediction of acupuncture treatment in patients with CS. PADBI can provide evidence for objective evaluation of acupuncture treatment of CS.展开更多
The double flapper-nozzle servo valve is widely used to launch and guide the equipment. Due to the large instantaneous flow rate of servo valve working under specific operating conditions, the temperature of servo val...The double flapper-nozzle servo valve is widely used to launch and guide the equipment. Due to the large instantaneous flow rate of servo valve working under specific operating conditions, the temperature of servo valve would reach 120℃ and the valve core and valve sleeve deform in a short amount of time. So the control precision of servo valve significantly decreases and the clamping stagnation phenomenon of valve core appears. In order to solve the problem of degraded control accuracy and clamping stagnation of servo valve under large temperature difference circumstance, the numerical simulation of heat-fluid-solid coupling by using finite element method is done. The simulation result shows that zero position leakage of servo valve is basically impacted by oil temperature and change of fit clearance. The clamping stagnation is caused by warpage-deformation and fit clearance reduction of the valve core and valve sleeve. The distribution roles of the temperature and thermal-deformation of shell, valve core and valve sleeve and the pressure, velocity and temperature field of flow channel are also analyzed. Zero position leakage and electromagnet＇s current when valve core moves in full-stroke are tested using Electro-hydraulic Servo-valve Characteristic Test-bed of an aerospace sciences and technology corporation. The experimental results show that the change law of experimental current at different oil temperatures is roughly identical to simulation current. The current curve of the electromagnet is smooth when oil temperature is below 80℃, but the amplitude of current significantly increases and the hairy appears when oil temperature is above 80℃. The current becomes smooth again after the warped valve core and valve sleeve are reground. It indicates that clamping stagnation is caused by warpage-deformation and fit clearance reduction of valve core and valve sleeve. This paper simulates and tests the heat-fluid-solid coupling of double flapper-nozzle servo valve, and the obtained results provide the reference value for the design of double flapper-nozzle force feedback servo valve.展开更多
When perforating with an abrasive water jet, it is possible that the pressure in the hole （perforation） will be higher than that in the annulus because of water jet blasting against the hole wall, which also is the ...When perforating with an abrasive water jet, it is possible that the pressure in the hole （perforation） will be higher than that in the annulus because of water jet blasting against the hole wall, which also is the theoretical basis for the technology of hydro-jet fracturing. This paper analyzes the mechanism of generating pressure stagnation in water jet hole, and puts forward a new concept of hydroseal. Then, the distribution of pressure in the hole was simulated with the finite element method. The simulation results showed that the pressure in the hole was higher than that in the annulus. Also, the lower the annular pressure （confining pressure） and the higher the blasting pressure, the greater the pressure difference. An experiment indicated that the cement sample was lifted up under the pressure stagnation in the hole, which proved the finite element simulation results obviously.展开更多
OBJECTIVE:To explore the pathologic characteristics of hyperplasia of the mammary gland(HMG) by observing differences in infrared radiation temperature of points of HMG in patients with different syndromes compared wi...OBJECTIVE:To explore the pathologic characteristics of hyperplasia of the mammary gland(HMG) by observing differences in infrared radiation temperature of points of HMG in patients with different syndromes compared with healthy controls.METHODS:AFLIRSystems Therma CAM P30 infrared thermal camera was used to detect the infrared temperature of Shanzhong(CV 17),Qimen(LR 14),Zhongwan(CV 12),Qihai(CV 6),Guanyuan(CV 4),Taixi(KI 3),and Taichong(LR 3) in 113 patients with HMG.Of these patients,71 were placed in the Liver Qi stagnation group,34 were placed in the Dysfunction of conception and thoroughfare vessels group,and 8 were placed in the Phlegm and blood stasis in combination group.The infrared radiation temperature of each point in the patients was compared with that of healthy controls,and the differences in the infrared radiation temperatures of the points in the patients were analyzed.RESULTS:Overall,the bilateral corresponding point in both the controls and patients exhibited no significant difference in infrared radiation temperature.In all cases,the infrared radiation temperature of the points from proximal to distal tended to decrease.In a comparison of the patients and controls,the infrared radiation temperature of the trunk points Shanzhong(CV 17),Qimen(LR 14),Zhongwan(CV12),Qihai(CV6),and Guanyuan(CV 4) of the patients was higher than that of the controls,while the infrared radiation temperature of the lower extremity points Taixi(KI 3) and Taichong(LR 3) was lower than that of the controls.Of these points,Shanzhong(CV 17)(P=0.0368),Zhongwan(CV 12)(P=0.0028),Qihai(CV 6)(P=0.0085),and Guanyuan(CV4)(P=0.0018) showed significant differences.In a comparison of the corresponding point on the same side in the Liver Qi stagnation group and controls,the infrared radiation temperature of Shanzhong(CV17)(P=0.0089),right-side Qimen(LR 14)(P=0.0382),Zhongwan(CV 12)(P= 0.0000),Qihai(CV 6)(P=0.0011),and Guanyuan(CV 4)(P=0.0000) of the patients was significantly higher than that of the controls,while the differences in the infrared radiation temperature of the other points were not statistically significant(P= 0.0833-0.8397).In a comparison of the corresponding point on the same side in the Dysfunction of conception and thoroughfare vessels group and controls,the infrared radiation temperature of left-side Taichong(LR 3)(P=0.0048),right-side Taichong(LR 3)(P=0.0329),left-side Taixi(KI 3)(P= 0.0171),and right-side Taixi(KI 3)(t=0.544,P= 0.0165) of the patients was significantly lower than that of the controls,while the differences in the infrared radiation temperature of the other points were not statistically significant(P=0.3793-0.9197).In a comparison of the corresponding point on the same side in the Phlegm and blood stasis in combination group and controls,the infrared radiation temperature of Shanzhong(CV 17),Qimen(LR 14),Qihai(CV 6),Guanyuan(CV 4),Taixi(KI 3),Taichong(LR 3),and Zhongwan(CV 12) tended to increase,but without statistical significance(P=0.175-.759).CONCLUSION:The corresponding points of HMG patients with different syndromes are in different deficiency/excess states.Changes in the infrared radiation temperature of the trunk points Shanzhong(CV 17),Qimen(LR 14),Zhongwan(CV 12),Qihai(CV 6),and Guanyuan(CV 4) are closely related to the pathological characteristics of the Liver Qi stagnation syndrome of HMG patients,while changes in the infrared radiation temperature of the lower extremity points Taixi(KI 3) and Taichong(LR 3) are closely related to the pathological characteristics of the Dysfunction of conception and thoroughfare vessels syndrome of HMG patients.On the whole,HMG patients with Liver Qi stagnation syndrome are characterized by "upper excess," and those with Dysfunction of conception and thoroughfare vessels syndrome are characterized by"lowerdeficiency."展开更多
In this paper a mathematical model is built for a buried hot crude oil pipeline during shutdown, and an unstructured grid and polar coordinate grid are respectively applied to generating grids for the soil region and ...In this paper a mathematical model is built for a buried hot crude oil pipeline during shutdown, and an unstructured grid and polar coordinate grid are respectively applied to generating grids for the soil region and the three layers in the pipe （wax layer, pipe wall, and corrosion-inhibiting coating）. The governing equations are discretized using the finite volume method. The variations in temperatures of static oil and soil were investigated during pipeline shutdown in both summer and winter, in which some important parameters of the soil and crude oils of a Northeast pipeline are employed.展开更多
This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After bou...This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After boundary layer approximation,the governing equations are achieved(namely Maxwell,upper convected material derivative,thermal and concentration diffusions).By using the self-similarity transformations the governing PDEs are converted into nonlinear ODEs and solved by RK-4 method in combination with Newton Raphson(shooting technique).The effects of developed parameters on velocity,temperature,concentration,fraction factor,heat and mass diffusions are exemplified through graphs and tabular form and are deliberated in detail.Numerical values of fraction factor,heat and mass transfer rates with several parameters are computed and examined.It is noticed that the temperature is more impactable for higher values of radiative heat transport,thermal conductivity and viscous dissipation.The comparison data for some limiting case are acquired and are originated to be in good agreement with previously published articles.展开更多
Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted...Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted was the multi-centered, randomized, positive parallel controlled method, 448 patients with CHD-AP-XBSS were enrolled and divided into two groups, 336 in the tested group treated with SYI and 112 in the control group treated with Salvia injection by intravenous dripping once a day for 14 days, so as to observe the conditions of angina, electrocardiogram, and therapeutic effect on traditinal Chinese medicine （TCM） symptoms as well as the safety of the treatment. Results： The significantly effective rate and total effective rate in the tested group were 60.06% （194/323） and 91.02 % （294/323） respectively; those in improvement of TOM symptoms were 40. 18% （129/321） and 75.23% （243/323） respectively, which were better than those in the control group （P〈0.01）. Conclusion： SYI Injection is effective and safe in treating OHD-AP-XBSS.展开更多
Objective： To observe the differences in analgesic effect of moxibustion at different intervention times on dysmenorrhea rats and explore its effect mechanism.Methods： Forty-five female Wistar rats were randomly div...Objective： To observe the differences in analgesic effect of moxibustion at different intervention times on dysmenorrhea rats and explore its effect mechanism.Methods： Forty-five female Wistar rats were randomly divided into blank control group（group A）, model group（group B）, pre-moxibustion group（group C）, instant moxibustion group（group D） and pre-instant moxibustion group（group E）,with 9 rats in each group. Cold-damp coagulation and stagnation type dysmenorrhea models were established. In group C,mild moxibustion on ＂Shenque（神阙 CV 8） ＂ and＂Guanyuan（关元 CV 4）＂ was carried out from the time after modeling on the 8 th day for 3 consecutive days. In group D, mild moxibustion was given as the same methods with group C after injection with oxytocin on the 11 th day. In group E, mild moxibustion was given as the same methods from the time after modeling on the 8 th day to that after injection with oxytocin on the 11 th day for 4 consecutive days. The writhing behavior and the changes in levels of ET-1 and NO in uterine tissues of rats with dysmenorrhea in each group were observed.Results： Comparison of the latent period： compared with（4.38 ± 1.06） min in group B,the latent period of rats in group C（9.67 ± 1.32） min,group D（11.78 ± 1.30） min and group E（15.00 ± 1.22） min obviously prolonged（all p 0.01）. Compared with group C, the latent period of group E obviously prolonged（p 0.01）. Compared with group D, the latent period of group E obviously prolonged（p 0.01）.Comparison of the writhing times： compared with（4.38 ± 1.06） in group B,the writhing times of rats in group C（9.67 ± 1.32）,group D（11.78 ± 1.30） and group E（15.00 ± 1.22） reduced（all p 0.01）. Compared with group C,the writhing times of rats in group D and group E reduced（both p 0.01）. Compared with group D, the writhing times in group E reduced（p 0.05）. Comparison of the total writhing score：compared with（4.38 ± 1.06） in group B,the total writhing score of rats in group C（9.67±1.32）,group D（11.78 ± 1.30） and group E（15.00 ± 1.22） decreased（all p 0.01）. Compared with group C,the total writhing score of rats in group D and group E decreased（both p 0.01）. Compared with group D,the total writhing score of rats in group E decreased（p 0.05）. Comparison of ET-1 level： compared with（4.80 ± 0.47） in group A,the ET-1 level in uterine tissues of rats in group B（7.57±0.69） significantly increased（P 0.01）. Compared with group B, the ET-1 level in uterine tissues of rats in group C（6.20 ±0.50）,group D（5.67 ±0.29） and group E（5.16±0.33） obviously decreased（all p 0.01）. Compared with group C, the ET-1 level in uterine tissues of rats in group D and group E obviously decreased（p 0.05, p 0.01）. Compared with group D, the ET-1 level in uterine tissues of rats in group Eobviously decreased（p 0.05）. Comparison of NO level： compared with（6.63±1.83） in group A, the NO level in uterine tissues of rats in group B（1.62 ±0.58） significantly decreased（p 0.01）. Compared with group B, the NO level in uterine tissues of rats in group C（3.60±0.59）,group D（4.77 ±0.67） and group E（5.99±0.63） obviously increased（all p 0.01）. Compared with group C,the NO level in uterine tissues of rats in group Dand group E obviously increased（p 0.05, p 0.01）. Compared with group D, the NO level in uterine tissues of rats in group E obviously increased（p 0.01）.Conclusion： The analgesic effect of mild moxibustion at different intervention times on cold-damp coagulation and stagnation type dysmenorrhea rats was different, which was the most significant in pre-instant moxibustion group. One of the mechanisms of action may be related with the adjustment of abnormal levels of ET-1 and NO.展开更多
OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastere...OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy.展开更多
Objective： To observe the effect of thermosensitive moxibustion on anxiety and depression in the patients of insomnia differentiated as liver qi stagnation.Methods： From January 2015 to January 2017, 60 patients of ...Objective： To observe the effect of thermosensitive moxibustion on anxiety and depression in the patients of insomnia differentiated as liver qi stagnation.Methods： From January 2015 to January 2017, 60 patients of insomnia differentiated as liver qi stagnation were collected in Shijiazhuang Municipal Chinese Medicine Hospital. According to the random number table, the patients were randomized into a moxibustion group（30 cases） and an estazolam group（30 cases）. In the moxibustion group, the thermosensitive moxibustion was adopted alternatively to the bilateral yuan-source points of the liver and gallbladder meridians. In the estazolam group, estazolam, 1 mg was prescribed for oral administration before sleep every day. After 15-day treatments, the sleep quality, the severity of anxiety and depression and the therapeutic effects were observed before and after treatment in the two groups.Results： Before treatment, the differences were not significant in the scores of Pittsburgh sleep quality index（PSQI）, the self-rating anxiety scale（SAS） and the self-rating depression scale（SDS） between the two groups（all P〉0.05）. After treatment, the scores of PSQJ, SAS and SDS were all reduced remarkably as compared with those before treatment in the two groups（all P〈0.05）. PSQI score was（6.72 ±2.311）points in the moxibustion group and was（5.37 ±2.621） points in the estazolam group. SAS score was（31.76 ± 6.511） points in the moxibustion group and was（39.62 ± 4.371） points in the estazolam group.SDS score was（35.98 ±5.161） points in the moxibustion group and was（46.38 ±4.971） points in the estazolam group. After treatment, the scores of PSQI, SAS and SDS in the moxibustion group were reduced more remarkably as compared with the estazolam group, indicating the significant differences（all P 〈0.05）. After treatment, the scores of sleep efficacy and TCM symptoms were（72.65 ± 14.36） points and（69.36 ±4.28） points respectively in the moxibustion group, better than the estazolam group, indicating the significant differences（all P〈0.05）.Conclusion： The thermosensitive moxibustion at the yuan-source points of the liver and gallbladder meridians significantly improves the sleep quality, relieves the symptoms of anxiety and depression and enhances the therapeutic effects in the patients of insomnia differentiated as liver qi stagnation. Hence,this therapy deserves to be recommended in clinical practice.展开更多
The self-excited DC air circuit breaker(SE-DCCB)has been widely used in urban rail transit due to its excellent stability.It can realize forward and reverse interruption,but has difficulty interrupting small currents ...The self-excited DC air circuit breaker(SE-DCCB)has been widely used in urban rail transit due to its excellent stability.It can realize forward and reverse interruption,but has difficulty interrupting small currents due to the phenomenon of arc root sticking at the entrance of the arc chamber in the splitting process,which is known as arc root stagnation.A coupling model of the self-excited magnetic field and magnetohydrodynamics is established for the SE-DCCB with the traditional structure.The magnetic field,temperature and airflow distribution in the arc chamber are investigated with an interrupting current of 150 A.The simulation results show that the direction and magnitude of the magnetic blowout force are the dominant factors in the arc root stagnation.The local high temperature of the arc chamber due to arc root stagnation increases the obstruction effect of the airflow vortex on the arc root movement,which significantly increases the arc duration time of small current interruption.Based on the research,the structure of the magnetic conductance plate of the actual product is improved,which can improve the direction and magnitude of the magnetic blowout force at the arc root so as to restrain the development of the airflow vortex effectively and solve the problem of arc root stagnation when the small current is interrupted.The simulation results show that the circuit breaker with improved structure has a better performance for a small current interruption range from 100 A to 350 A.展开更多
An analytical solution of the governing equations of the interacting shear flows for unsteady oblique stagnation point flow is obtained. It has the same form as that of the exact solution obtained from the complete NS...An analytical solution of the governing equations of the interacting shear flows for unsteady oblique stagnation point flow is obtained. It has the same form as that of the exact solution obtained from the complete NS equations and physical analysis and relevant discussions are then presented.展开更多
基金supported by the Higher Institution Centre of Excellence(HICoE)program(MO002-2019&TIDREC-2023)funded by the Bernhard Nocht Institute for Tropical Medicine,Hamburg,Germany[100-TNCPI/INT 16/6/2(005/2020)].
文摘Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.
基金supported by 2024 Henan Provincial Special Research Project on Traditional Chinese Medicine(2024ZY2158)Henan Provincial Key Discipline Construction Project of Traditional Chinese Medicine{Yuwei Traditional Chinese Medicine Science and Education[2024]No.1}+1 种基金Key Disciplines of History and Literature of Chinese Medicine in Henan University of Chinese Medicine for the Year 2025{Henan Traditional Chinese Medicine Office[2025]No.13}National Chinese Medicine Advantage Specialty Construction Project{Chinese Traditional Chinese Medicine Political Letter(2024)No.90}.
文摘“Ruyong(breast abscess)”has a high incidence rate.Traditional Chinese medicine(TCM)diagnosis and treatment of this condition demonstrate significant advantages,including diverse therapeuticmethods,outstanding efficacy,and high safety.Based on TCM theory and combining relevant ancient texts and modern research,this paper systematically summarizes the different understandings of“Ruyong(breast abscess)”by physicians throughout history in terms of disease names,etiology,pathogenesis,and treatment.The ancient names for Ruyong(breast abscess)were varied,also referred to as“Duru(stagnation in breast)”or“Naichuang(breast sore)”.Its symptoms are diverse,with the main clinical manifestations being localized redness,swelling,heat,pain,and poor milk discharge in the affected breast.The etiology is primarily attributed to“milk stasis”“liver qi stagnation and stomach heat”and“exposure to external pathogens”.Additionally,this paper summarizes the treatment experiences from ancient and modern medical texts and highlights the complementary effects of internal and external therapies.This study provides a reference for modern clinical understanding and treatment of“Ruyong(breast abscess)”in the hope of further improvement of clinical efficacy.
基金funded by National Special Project Number for International Cooperation under Grant 2015DFR11050the Applied Science and Technology Research and Development Special Fund Project of Guangdong Province under Grant 2016B010126004.
文摘Differential evolution(DE)algorithms are simple and efficient evolutionary algorithms that performwell in various optimization problems.Unfortunately,they inevitably stagnate when differential evolutionary algorithms are used to solve complex problems(e.g.,real-world artificial neural network(ANN)training problems).To resolve this issue,this paper proposes a framework based on an efficient elite centroid operator.It continuously monitors the current state of the population.Once stagnation is detected,two dedicated operators,centroid-based mutation(CM)and centroid-based crossover(CX),are executed to replace the classical mutation and binomial crossover operations in DE.CM and CX are centred on the elite centroid composed of multiple elite individuals,constituting a framework consisting of elitism centroid-based operations(CMX)to improve the performance of the individuals who fall into stagnation.In CM,elite centroid provide evolutionary direction for stagnant individuals,and in CX,elite plasmoids address the limitation that stagnant individuals can only obtain limited information about the population.The CMX framework is simple enough to easily incorporate into both classically well-known DEs with constant population sizes and state-of-the-art DEs with varying populations.Numerical experiments on benchmark functions show that the proposed CMX method can significantly enhance the classical DE algorithm and its advanced variants in solving the stagnation problem and improving performance.
基金supported by the National Natural Science Foundation of China(T2341019)NSFC-Guangdong Joint Fund(U1132001)+9 种基金General Program of the National Natural Science Foundation of China(82174243 and 82204948)Natural Science Foundation of Guangdong Province,China(2023A1515110757)Guangzhou Science and Technology Plan Project(2024B03J1343)Major Scientific and Technological Project of Guangzhou Municipal Health Commission(20252D003)Research Project of Traditional Chinese Medicine Bureau of Guangdong Province(20241208)General project of Beijing Natural Science Foundation(7242227)Fundamental Research Funds for the Central Universities(BZY-JMZY-2022-001 and 2023-JYB-JBZD-009)High-level Key Discipline of the National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine(zyyzdxk-2023251)Major Science and Technology Special Projects in Hubei Province(2023BCA005)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0002).
文摘Objective:To study the relationship between qi stagnation constitution and suboptimal health status(SHS)or lifestyle.Methods:From 2012 to 2013,we conducted a cross-sectional survey of 24159 Chinese individuals aged 12-80 years.The qi stagnation constitution was assessed using the Constitution in Chinese Medicine Questionnaire.Health status was evaluated through medical records and the Subhealth Measurement Scale V1.0(SHMS V1.0).Health-promoting lifestyles were measured using the Health-Promoting Lifestyle Profile Ⅱ(HPLP-Ⅱ).Results:Of the 24159 participants,16.1%and 15.2%were classified as“always”and“sometimes”having the qi stagnation constitution,respectively.Those classified as“rarely”having the qi stagnation constitution scored higher on both the HPLP-Ⅱ and SHMS V1.0.The participants classified as“always”having the qi stagnation constitution showed a significant association with SHS or disease compared to other imbalanced constitutions.Those in the“always”category were approximately 21 times more likely to be classified as having SHS(odds ratio[OR]:21.17,95%confidence interval[CI]:15.74-28.45),whereas those in the“sometimes”category were approximately six times more likely(OR:5.89,95%CI:5.04-6.90).Accordingly,the qi stagnation constitution score was significantly associated with the diagnosis of SHS,with an area under the curve of 0.77(P<.001).A score of 18.75 yielded the highest Youden Index(0.407),with a sensitivity of 60.5%and a specificity of 80.3%.Significant associations were observed between health-promoting lifestyles and qi stagnation constitution severity in an ordinal regression analysis(P<.001).Protective factors included stress management(OR:1.59),self-actualization(OR:1.57),and exercise(OR:1.36).In contrast,poorer interpersonal relationships(OR:0.79),greater health responsibilities(OR:0.86),and poorer nutrition(OR:0.91)were associated with increased severity.Conclusion:Modulating the qi stagnation constitution through lifestyle interventions may help prevent the progression of SHS to disease,which aligns with core preventive principles in traditional Chinese medicine.
文摘[Objectives]To observe the clinical effect of Tiaoqi Dingxian prescription combined with western medicine on epilepsy of qi constraint and phlegm stagnation type.[Methods]A total of 60 cases of patients of epilepsy of qi constraint and phlegm stagnation type admitted to Maoming Hospital Affiliated to Guangzhou University of Chinese Medicine from June 2023 to July 2024 were selected as the research subjects.They were randomly divided into the control group and the observation group using a random number table method,with 30 cases in each group.The control group was treated with levetiracetam,while the observation group was treated with Tiaoqi Dingxian prescription on the basis of the control group.Both groups were treated for 3 months,and the clinical efficacy,frequency and duration of epilepsy onset,improvement of electroencephalogram(EEG),Quality of Life in Epilepsy Inventory(QOLIE-31)scores,traditional Chinese medicine(TCM)syndrome scores,and incidence of adverse reactions were evaluated in both groups.[Results]The total effective rate in the observation group was 93.33%(28/30),compared to 73.33%(22/30)in the control group,with a statistically significant difference(P<0.05).Following treatment,the frequency and duration of epilepsy onset in both groups were decreased when compared to the pre-treatment period(P<0.05),and the frequency and duration of epilepsy onset in the observation group were lower than those in the control group(P<0.05).Following treatment,the EEG grading of both groups was improved when compared with that before treatment(P<0.05),and the EEG grading in the observation group was better than that in the control group(P<0.05).Following treatment,the QOLIE-31 scores in both groups,including epilepsy-related concerns,overall health,emotional health,energy,cognitive function,drug effects,and social function,were increased when compared to the scores recorded prior to treatment(P<0.05),and all scores in the observation group were higher than those in the control group(P<0.05).Following treatment,the TCM syndrome scores in both groups were decreased when compared to those prior to treatment(P<0.05),and the scores in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions was observed to be 6.67%(2/30)in the observation group and 13.33%(4/30)in the control group,with no significant difference between the two groups(P>0.05).[Conclusions]The combination of Tiaoqi Dingxian prescription and levetiracetam in the treatment of epilepsy of qi constraint and phlegm stagnation type can improve clinical efficacy,alleviate patient s symptoms and quality of life,and has good safety.
文摘Objective:To evaluate the therapeutic efficacy of the umbilical acupuncture’s“Wind-Thunder Interaction Method”in treating schizophrenia(SCH)patients with liver stagnation and spleen deficiency.Methods:A total of 120 SCH patients with liver stagnation and spleen deficiency were selected and evenly divided by ball drawing.The umbilical acupuncture group received the“Wind-Thunder Interaction Method”,while the Western medicine group received pure Western medicine treatment.The outcomes were compared in terms of efficacy and other indicators.Results:The umbilical acupuncture group showed a higher total effective rate,a decrease in disease symptom scores,lower scores on the side effect rating scale,improved cognitive function scores,and excellent laboratory indicators,with p<0.05 between the groups.Conclusion:The“Wind-Thunder Interaction Method”of umbilical acupuncture demonstrated a relatively high effectiveness in treating SCH patients with liver stagnation and spleen deficiency,alleviating symptoms,reducing side effects,improving cognitive function,and facilitating the recovery of neuro-vascular regulatory peptide groups.
基金Supported by youth fund project fanded by Hebei Education Department:QN2015027scientific project funded by Administration of Traditional Chinese Medicine of Hebei Province:2015089
文摘Objective To observe the effect of instant moxibustion on the levels of prostaglandin E_2（PGE_2）,prostaglandin F2α（PGE_（2α）） and arginine vasopressin（AVP） in the uterine tissues of dismenorrhea rats with cold-damp congealing and stagnation type and to explore its possible mechanism.Methods Female Wistar rats were randomly divided into blank group,model group,herble medicine group,pre-moxibustion group and instant moxibustion group,with 9 rats in each group.Cold-damp congealing and stagnation type primary dismenorrhea models were established by adopting（0±1）℃ ice waterextraction method combined with estradiol benzoate injection method.After modeling on the 8th day,in herble medicine group,Tongjingbao granules was given to the rats by intragastric administration.In pre-moxibustion group,mild moxibustion was carried out at ＂Shénquè＂（神阙 CV 8） and ＂Guānyuán＂（关元 CV 4） of the rats for 10 min at each acupoint.In instant moxibustion group,moxibustion as that in pre-moxibustion group was conducted for once after injection with oxytocin on the 11 th day.ELISA was adopted to detect the levels of PGE_2 and PGE_（2α） in the uterine tissues of rats,and radioimmunoassay was used for detection of AVP level in the uterine tissues of rats.Results Compared with the model group,the latent period of rats in herbal medicine group,premoxibustion group and instant moxibustion group obviously prolonged,the number of times of torsion reduced,and the total score of torsion decreased（P0.01）;compared with herbal medicine group,the latent period of rats in instant moxibustion group obviously prolonged,and the total score of torsion decreased（P0.05 or P0.01）;compared with pre-moxibustion group,the number of times of torsion of rats in instant moxibustion group reduced,and the total score of torsion decreased（P0.01）.Compared with blank group,the levels of PGE_（2α） and AVP and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in model group significantly increased（P0.01）,and the PGE_2 level significantly reduced（P0.01）;compared with model group,the PGE_（2α） level and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in herble medicine group,pre-moxibustion group and instant moxibustion group obviously reduced（P0.05 or P0.01）,the PGE_2 level obviously increased（P0.01）,and the AVP level in the uterine tissues of rats in pre-moxibustion group and instant moxibustion group obviously reduced（P0.05 or P0.01）;compared with herbal medicine group,the levels of PGE_（2α） and AVP and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in instant moxibustion group significantly reduced（P0.05 or P0.01）;compared with pre-moxibustion group,the PGE_（2α） level and the ratio of PGE_（2α） and PGE_2 in the uterine tissues of rats in instant moxibustion group obviously reduced（P0.05）,and the PGE_2 level obviously increased（P0.01）.Conclusion Both pre-moxibustion and instant moxibustion can obviously inhibit spasmodic uterine smooth muscle contraction of rats with dismenorrhea,regulate imbalanced levels of PGE_（2α） and PGE_2,reduce the AVP level,so as to improve the uterine hypoxia-ischemia,and play a role in alleviating pain.The efficacy of instant moxibustion was superior to that of pre-moxibustion.
基金Key Project of Science and Technology,Ministry of Education, No. 01079
文摘By analysis of published papers on the Yangtze estuary and hydrological and sediments data in Yangshan Harbor area, many similarities are found between Yangshan Harbor area and the Yangtze estuary. These similarities include the phenomenon of stagnating flow areas, the distributive characteristics of the highest suspended sediment concentration areas, superficial sediments and shoal bars. The stagnating flow area is the major similarity which causes other similarities. These similarities indicate that: 1) Turbidity Maximum and mouth bars in estuaries are mainly caused by the hydraulic balance of stagnating flow areas of estuaries; 2) The stagnating sand area of sands caused by stagnating flow area often locates on the narrower side of the stagnating flow area; 3) The location (or shape) of fine sediments area caused by stagnating flow area reflects the location (or shape) of the stagnating flow area. Both Yangshan Harbor area and the Yangtze estuary are the important developmental areas in the future (man-made similarity). In-depth studies on these similarities between Yangshan Harbor area and the Yangtze estuary will have momentous theoretical and practical significance.
基金Supported by the National Natural Science Foundation of China(Study on the Formation and Influencing Factors of the Pulse in Traditional Chinese Medicine,No.81173202)National Basic Research Program of China(973 program,Study on the Original Thoughts of Traditional Chinese Medicine and the System of Recognition Methods of Health State,No.2011CB505406)Natural Science Foundation of Tianjin(the Theory and Methods of Objective Evaluation of Chinese Medicine Efficacy on Major Diseases,No.10JCZDJC20000)
文摘OBJECTIVE： To study changes in pulse diagram parameters （PDP） in patients with cervical spondylosis （CS） before and after acupuncture treatment, explore the characteristics of PDP and the relationship between PDP changes and therapeutic effectiveness, and provide evidence for outcome prediction and objective evaluation of CS treatment before and after acupuncture treatment. METHODS： Patients with CS were treated with acupuncture and measured with a pulse acquisition device based on image （PADBI） before the first and after the tenth acupuncture sessions. Changes in PDP from before until after the acupuncture sessions and patient impressions were analyzed to judge the effect of acupuncture treatment for. RESULTS： The PDP values in effective patients were closer to normal values. This indicated that Qi stagnation and blood stasis of the patients was improved. The PDP changes from before to after the first acupuncture treatment were more obvious than those from before to after the tenth acupunc- ture treatment. This result indicates that the speed of symptom improvement decreased significantly after several acupuncture courses. Analysis of correlation between efficacy and PDP showed that the changes in PDP in five patients was abnormal, which mainly manifested as values of hl, u, p, Pp, and tl, and no significant changes or differences were increased with standard values. This indicated that the symptoms of CS were not improved in these patients. CONCLUSION; PADBI can provide evidence for outcome prediction of acupuncture treatment in patients with CS. PADBI can provide evidence for objective evaluation of acupuncture treatment of CS.
基金Supposed by National Natural Science Foundation of China(Grant No.51075348)Hebei Provincial Natural Science Foundation of China(Grant No.E2011203151)Research Fund for Doctoral Program of Higher Education of China(Grant No.20101333110002)
文摘The double flapper-nozzle servo valve is widely used to launch and guide the equipment. Due to the large instantaneous flow rate of servo valve working under specific operating conditions, the temperature of servo valve would reach 120℃ and the valve core and valve sleeve deform in a short amount of time. So the control precision of servo valve significantly decreases and the clamping stagnation phenomenon of valve core appears. In order to solve the problem of degraded control accuracy and clamping stagnation of servo valve under large temperature difference circumstance, the numerical simulation of heat-fluid-solid coupling by using finite element method is done. The simulation result shows that zero position leakage of servo valve is basically impacted by oil temperature and change of fit clearance. The clamping stagnation is caused by warpage-deformation and fit clearance reduction of the valve core and valve sleeve. The distribution roles of the temperature and thermal-deformation of shell, valve core and valve sleeve and the pressure, velocity and temperature field of flow channel are also analyzed. Zero position leakage and electromagnet＇s current when valve core moves in full-stroke are tested using Electro-hydraulic Servo-valve Characteristic Test-bed of an aerospace sciences and technology corporation. The experimental results show that the change law of experimental current at different oil temperatures is roughly identical to simulation current. The current curve of the electromagnet is smooth when oil temperature is below 80℃, but the amplitude of current significantly increases and the hairy appears when oil temperature is above 80℃. The current becomes smooth again after the warped valve core and valve sleeve are reground. It indicates that clamping stagnation is caused by warpage-deformation and fit clearance reduction of valve core and valve sleeve. This paper simulates and tests the heat-fluid-solid coupling of double flapper-nozzle servo valve, and the obtained results provide the reference value for the design of double flapper-nozzle force feedback servo valve.
文摘When perforating with an abrasive water jet, it is possible that the pressure in the hole （perforation） will be higher than that in the annulus because of water jet blasting against the hole wall, which also is the theoretical basis for the technology of hydro-jet fracturing. This paper analyzes the mechanism of generating pressure stagnation in water jet hole, and puts forward a new concept of hydroseal. Then, the distribution of pressure in the hole was simulated with the finite element method. The simulation results showed that the pressure in the hole was higher than that in the annulus. Also, the lower the annular pressure （confining pressure） and the higher the blasting pressure, the greater the pressure difference. An experiment indicated that the cement sample was lifted up under the pressure stagnation in the hole, which proved the finite element simulation results obviously.
基金Supported by the National Basic Research Program of China(2009CB522901)the Key Program of the State Administration of Traditional Chinese Medicine of the People's Republic of Chinathe Shanghai Municipal Science Foundation(11DZ1973300,11ZR1436700)
文摘OBJECTIVE:To explore the pathologic characteristics of hyperplasia of the mammary gland(HMG) by observing differences in infrared radiation temperature of points of HMG in patients with different syndromes compared with healthy controls.METHODS:AFLIRSystems Therma CAM P30 infrared thermal camera was used to detect the infrared temperature of Shanzhong(CV 17),Qimen(LR 14),Zhongwan(CV 12),Qihai(CV 6),Guanyuan(CV 4),Taixi(KI 3),and Taichong(LR 3) in 113 patients with HMG.Of these patients,71 were placed in the Liver Qi stagnation group,34 were placed in the Dysfunction of conception and thoroughfare vessels group,and 8 were placed in the Phlegm and blood stasis in combination group.The infrared radiation temperature of each point in the patients was compared with that of healthy controls,and the differences in the infrared radiation temperatures of the points in the patients were analyzed.RESULTS:Overall,the bilateral corresponding point in both the controls and patients exhibited no significant difference in infrared radiation temperature.In all cases,the infrared radiation temperature of the points from proximal to distal tended to decrease.In a comparison of the patients and controls,the infrared radiation temperature of the trunk points Shanzhong(CV 17),Qimen(LR 14),Zhongwan(CV12),Qihai(CV6),and Guanyuan(CV 4) of the patients was higher than that of the controls,while the infrared radiation temperature of the lower extremity points Taixi(KI 3) and Taichong(LR 3) was lower than that of the controls.Of these points,Shanzhong(CV 17)(P=0.0368),Zhongwan(CV 12)(P=0.0028),Qihai(CV 6)(P=0.0085),and Guanyuan(CV4)(P=0.0018) showed significant differences.In a comparison of the corresponding point on the same side in the Liver Qi stagnation group and controls,the infrared radiation temperature of Shanzhong(CV17)(P=0.0089),right-side Qimen(LR 14)(P=0.0382),Zhongwan(CV 12)(P= 0.0000),Qihai(CV 6)(P=0.0011),and Guanyuan(CV 4)(P=0.0000) of the patients was significantly higher than that of the controls,while the differences in the infrared radiation temperature of the other points were not statistically significant(P= 0.0833-0.8397).In a comparison of the corresponding point on the same side in the Dysfunction of conception and thoroughfare vessels group and controls,the infrared radiation temperature of left-side Taichong(LR 3)(P=0.0048),right-side Taichong(LR 3)(P=0.0329),left-side Taixi(KI 3)(P= 0.0171),and right-side Taixi(KI 3)(t=0.544,P= 0.0165) of the patients was significantly lower than that of the controls,while the differences in the infrared radiation temperature of the other points were not statistically significant(P=0.3793-0.9197).In a comparison of the corresponding point on the same side in the Phlegm and blood stasis in combination group and controls,the infrared radiation temperature of Shanzhong(CV 17),Qimen(LR 14),Qihai(CV 6),Guanyuan(CV 4),Taixi(KI 3),Taichong(LR 3),and Zhongwan(CV 12) tended to increase,but without statistical significance(P=0.175-.759).CONCLUSION:The corresponding points of HMG patients with different syndromes are in different deficiency/excess states.Changes in the infrared radiation temperature of the trunk points Shanzhong(CV 17),Qimen(LR 14),Zhongwan(CV 12),Qihai(CV 6),and Guanyuan(CV 4) are closely related to the pathological characteristics of the Liver Qi stagnation syndrome of HMG patients,while changes in the infrared radiation temperature of the lower extremity points Taixi(KI 3) and Taichong(LR 3) are closely related to the pathological characteristics of the Dysfunction of conception and thoroughfare vessels syndrome of HMG patients.On the whole,HMG patients with Liver Qi stagnation syndrome are characterized by "upper excess," and those with Dysfunction of conception and thoroughfare vessels syndrome are characterized by"lowerdeficiency."
基金supported by National High-tech R&D Program of China (No. 2006AA09Z357)the National Science Foundation of China (No. 50876114, No. 10602043)+1 种基金the Program for New Century Excellent Talents in University (NCET-07-0843) and SRF for ROCS, SEMsupported by the State Key Laboratory of Multiphase Flow in Power Engineering (Xi'an Jiaotong University)
文摘In this paper a mathematical model is built for a buried hot crude oil pipeline during shutdown, and an unstructured grid and polar coordinate grid are respectively applied to generating grids for the soil region and the three layers in the pipe （wax layer, pipe wall, and corrosion-inhibiting coating）. The governing equations are discretized using the finite volume method. The variations in temperatures of static oil and soil were investigated during pipeline shutdown in both summer and winter, in which some important parameters of the soil and crude oils of a Northeast pipeline are employed.
基金funding this work through research groups program under grant number R.G.P-59/40.
文摘This paper concerns the characteristics of heat and mass transfer in upper convected Maxwell fluid flow over a linear stretching sheet with solar radiation,viscous desperation and temperature based viscosity.After boundary layer approximation,the governing equations are achieved(namely Maxwell,upper convected material derivative,thermal and concentration diffusions).By using the self-similarity transformations the governing PDEs are converted into nonlinear ODEs and solved by RK-4 method in combination with Newton Raphson(shooting technique).The effects of developed parameters on velocity,temperature,concentration,fraction factor,heat and mass diffusions are exemplified through graphs and tabular form and are deliberated in detail.Numerical values of fraction factor,heat and mass transfer rates with several parameters are computed and examined.It is noticed that the temperature is more impactable for higher values of radiative heat transport,thermal conductivity and viscous dissipation.The comparison data for some limiting case are acquired and are originated to be in good agreement with previously published articles.
文摘Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted was the multi-centered, randomized, positive parallel controlled method, 448 patients with CHD-AP-XBSS were enrolled and divided into two groups, 336 in the tested group treated with SYI and 112 in the control group treated with Salvia injection by intravenous dripping once a day for 14 days, so as to observe the conditions of angina, electrocardiogram, and therapeutic effect on traditinal Chinese medicine （TCM） symptoms as well as the safety of the treatment. Results： The significantly effective rate and total effective rate in the tested group were 60.06% （194/323） and 91.02 % （294/323） respectively; those in improvement of TOM symptoms were 40. 18% （129/321） and 75.23% （243/323） respectively, which were better than those in the control group （P〈0.01）. Conclusion： SYI Injection is effective and safe in treating OHD-AP-XBSS.
基金Supported by Youth fund project of Hebei Education Department:QN2015027scientific project supported by Administration of Traditional Chinese Medicine of Hebei Province:2015089scientific program supported by Hebei Provincial Science and Technology Department:152777143~~
文摘Objective： To observe the differences in analgesic effect of moxibustion at different intervention times on dysmenorrhea rats and explore its effect mechanism.Methods： Forty-five female Wistar rats were randomly divided into blank control group（group A）, model group（group B）, pre-moxibustion group（group C）, instant moxibustion group（group D） and pre-instant moxibustion group（group E）,with 9 rats in each group. Cold-damp coagulation and stagnation type dysmenorrhea models were established. In group C,mild moxibustion on ＂Shenque（神阙 CV 8） ＂ and＂Guanyuan（关元 CV 4）＂ was carried out from the time after modeling on the 8 th day for 3 consecutive days. In group D, mild moxibustion was given as the same methods with group C after injection with oxytocin on the 11 th day. In group E, mild moxibustion was given as the same methods from the time after modeling on the 8 th day to that after injection with oxytocin on the 11 th day for 4 consecutive days. The writhing behavior and the changes in levels of ET-1 and NO in uterine tissues of rats with dysmenorrhea in each group were observed.Results： Comparison of the latent period： compared with（4.38 ± 1.06） min in group B,the latent period of rats in group C（9.67 ± 1.32） min,group D（11.78 ± 1.30） min and group E（15.00 ± 1.22） min obviously prolonged（all p 0.01）. Compared with group C, the latent period of group E obviously prolonged（p 0.01）. Compared with group D, the latent period of group E obviously prolonged（p 0.01）.Comparison of the writhing times： compared with（4.38 ± 1.06） in group B,the writhing times of rats in group C（9.67 ± 1.32）,group D（11.78 ± 1.30） and group E（15.00 ± 1.22） reduced（all p 0.01）. Compared with group C,the writhing times of rats in group D and group E reduced（both p 0.01）. Compared with group D, the writhing times in group E reduced（p 0.05）. Comparison of the total writhing score：compared with（4.38 ± 1.06） in group B,the total writhing score of rats in group C（9.67±1.32）,group D（11.78 ± 1.30） and group E（15.00 ± 1.22） decreased（all p 0.01）. Compared with group C,the total writhing score of rats in group D and group E decreased（both p 0.01）. Compared with group D,the total writhing score of rats in group E decreased（p 0.05）. Comparison of ET-1 level： compared with（4.80 ± 0.47） in group A,the ET-1 level in uterine tissues of rats in group B（7.57±0.69） significantly increased（P 0.01）. Compared with group B, the ET-1 level in uterine tissues of rats in group C（6.20 ±0.50）,group D（5.67 ±0.29） and group E（5.16±0.33） obviously decreased（all p 0.01）. Compared with group C, the ET-1 level in uterine tissues of rats in group D and group E obviously decreased（p 0.05, p 0.01）. Compared with group D, the ET-1 level in uterine tissues of rats in group Eobviously decreased（p 0.05）. Comparison of NO level： compared with（6.63±1.83） in group A, the NO level in uterine tissues of rats in group B（1.62 ±0.58） significantly decreased（p 0.01）. Compared with group B, the NO level in uterine tissues of rats in group C（3.60±0.59）,group D（4.77 ±0.67） and group E（5.99±0.63） obviously increased（all p 0.01）. Compared with group C,the NO level in uterine tissues of rats in group Dand group E obviously increased（p 0.05, p 0.01）. Compared with group D, the NO level in uterine tissues of rats in group E obviously increased（p 0.01）.Conclusion： The analgesic effect of mild moxibustion at different intervention times on cold-damp coagulation and stagnation type dysmenorrhea rats was different, which was the most significant in pre-instant moxibustion group. One of the mechanisms of action may be related with the adjustment of abnormal levels of ET-1 and NO.
基金Supported by Special Project of National Clinical Research Base of TCM (No. JDZX2012140)Innovation Team Development Plan of the Ministry of Education (No. IRT1276)
文摘OBJECTIVE:To master the syndrome patterns characteristics and explore the effective therapy methods ofTraditional Chinese Medicine(TCM) for cardiac syndrome X(CSX).METHODS:The TCM syndrome characteristics were mastered and the TCM intervention programs were determined by clinical investigations for TCM syndrome patterns characteristics of CSX patients.Then,the clinical efficacy studies on TCM intervention for CSX were carried out through randomized controlled trials.RESULTS:CSX is a clinical syndrome with the main manifestations of chest pain and chest stuffiness,and Qi stagnation,phlegm retention and blood stasis are the basic symptoms of CSX.As a result,the Qi-regulating,chest-relaxing and blood-activating therapy integrated with some Western Medicines was adopted for treatment.The effect of Qi-regulating,chest-relaxing and blood-activating therapy can reduce the frequency and degree of angina,improve the symptoms and exercise the tolerance of patients,inhibit the inflammatory response of vascular walls and protect the function of vascular endothelial cells,which is better than that of the simple and conventionalWestern Medicine alone.CONCLUSION:A good effect was achieved in the integration of Chinese and Western Medicines for CSX.The therapy is worthy to be applied further in clinical practice.On the other hand,more long-term and randomised controlled studies with large samples are still required to further determine the clinical efficacy and safety of the therapy.
基金Supported by Funding project of Hebei Administration of Traditional Chinese Medicine(2015190)Funding project of Natural Science Foundation of China(81072883,81173342,81473773)~~
文摘Objective： To observe the effect of thermosensitive moxibustion on anxiety and depression in the patients of insomnia differentiated as liver qi stagnation.Methods： From January 2015 to January 2017, 60 patients of insomnia differentiated as liver qi stagnation were collected in Shijiazhuang Municipal Chinese Medicine Hospital. According to the random number table, the patients were randomized into a moxibustion group（30 cases） and an estazolam group（30 cases）. In the moxibustion group, the thermosensitive moxibustion was adopted alternatively to the bilateral yuan-source points of the liver and gallbladder meridians. In the estazolam group, estazolam, 1 mg was prescribed for oral administration before sleep every day. After 15-day treatments, the sleep quality, the severity of anxiety and depression and the therapeutic effects were observed before and after treatment in the two groups.Results： Before treatment, the differences were not significant in the scores of Pittsburgh sleep quality index（PSQI）, the self-rating anxiety scale（SAS） and the self-rating depression scale（SDS） between the two groups（all P〉0.05）. After treatment, the scores of PSQJ, SAS and SDS were all reduced remarkably as compared with those before treatment in the two groups（all P〈0.05）. PSQI score was（6.72 ±2.311）points in the moxibustion group and was（5.37 ±2.621） points in the estazolam group. SAS score was（31.76 ± 6.511） points in the moxibustion group and was（39.62 ± 4.371） points in the estazolam group.SDS score was（35.98 ±5.161） points in the moxibustion group and was（46.38 ±4.971） points in the estazolam group. After treatment, the scores of PSQI, SAS and SDS in the moxibustion group were reduced more remarkably as compared with the estazolam group, indicating the significant differences（all P 〈0.05）. After treatment, the scores of sleep efficacy and TCM symptoms were（72.65 ± 14.36） points and（69.36 ±4.28） points respectively in the moxibustion group, better than the estazolam group, indicating the significant differences（all P〈0.05）.Conclusion： The thermosensitive moxibustion at the yuan-source points of the liver and gallbladder meridians significantly improves the sleep quality, relieves the symptoms of anxiety and depression and enhances the therapeutic effects in the patients of insomnia differentiated as liver qi stagnation. Hence,this therapy deserves to be recommended in clinical practice.
基金supported by National Natural Science Foundation of China(No.51977132)the Key Special Science and Technology Project of Liaoning Province(No.2020JH1/10100012)the General Program of the Education Department of Liaoning Province(No.LJKZ0126).
文摘The self-excited DC air circuit breaker(SE-DCCB)has been widely used in urban rail transit due to its excellent stability.It can realize forward and reverse interruption,but has difficulty interrupting small currents due to the phenomenon of arc root sticking at the entrance of the arc chamber in the splitting process,which is known as arc root stagnation.A coupling model of the self-excited magnetic field and magnetohydrodynamics is established for the SE-DCCB with the traditional structure.The magnetic field,temperature and airflow distribution in the arc chamber are investigated with an interrupting current of 150 A.The simulation results show that the direction and magnitude of the magnetic blowout force are the dominant factors in the arc root stagnation.The local high temperature of the arc chamber due to arc root stagnation increases the obstruction effect of the airflow vortex on the arc root movement,which significantly increases the arc duration time of small current interruption.Based on the research,the structure of the magnetic conductance plate of the actual product is improved,which can improve the direction and magnitude of the magnetic blowout force at the arc root so as to restrain the development of the airflow vortex effectively and solve the problem of arc root stagnation when the small current is interrupted.The simulation results show that the circuit breaker with improved structure has a better performance for a small current interruption range from 100 A to 350 A.
文摘An analytical solution of the governing equations of the interacting shear flows for unsteady oblique stagnation point flow is obtained. It has the same form as that of the exact solution obtained from the complete NS equations and physical analysis and relevant discussions are then presented.
