Background:Gene expression profiling plays a key role in cancer research,but its high dimensionality and redundancy pose challenges for effective analysis.Feature selection and robust classification are critical for i...Background:Gene expression profiling plays a key role in cancer research,but its high dimensionality and redundancy pose challenges for effective analysis.Feature selection and robust classification are critical for improving predictive performance,while explainable machine learning techniques support transparency and biomarker discovery.Methods:To propose a hybrid explainable machine learning framework that combines stability-guided multi-source(SGMS)feature selection with classification models for gene expression-based cancer prediction and biomarker identification.SGMS integrates Mutual Information,F-statistic,and random forest(RF)importance to select informative genes.These features are used to train classifiers,including novel elasticnet logistic regression(NEN-LR),RF,and Support Vector Machine(SVM).Performance is evaluated using accuracy,precision,recall,F1-score,and Matthews correlation coefficient(MCC).SHapley Additive exPlanations(SHAP)values are used to interpret gene-level contributions,and co-expression networks help identify functional gene modules.Results:The proposed NEN-LR classifier achieved the highest performance with 99.8%accuracy,99.9%precision,and 0.997 MCC using the top 200 SGMS-selected genes.Biomarker discovery identified both class-specific and shared genes across five cancer types,with top genes like gene_230,gene_5380,and gene_18570 consistently appearing across multiple classes.Visualization tools,including heatmaps,Venn diagrams,and co-expression networks,were used to interpret expression dynamics and regulatory patterns,enhancing the biological relevance of findings.SHAP analysis revealed top biomarkers with strong predictive influence,while co-expression clustering uncovered biologically meaningful gene modules.Other models also showed marked improvement using SGMS-selected features.Conclusion:The proposed framework successfully integrates feature selection,interpretable classification,and biomarker discovery,providing a powerful tool for precision oncology and molecular diagnostics.展开更多
In modern electromagnetic environment, radar emitter signal recognition is an important research topic. On the basis of multi-resolution wavelet analysis, an adaptive radar emitter signal recognition method based on m...In modern electromagnetic environment, radar emitter signal recognition is an important research topic. On the basis of multi-resolution wavelet analysis, an adaptive radar emitter signal recognition method based on multi-scale wavelet entropy feature extraction and feature weighting was proposed. With the only priori knowledge of signal to noise ratio(SNR), the method of extracting multi-scale wavelet entropy features of wavelet coefficients from different received signals were combined with calculating uneven weight factor and stability weight factor of the extracted multi-dimensional characteristics. Radar emitter signals of different modulation types and different parameters modulated were recognized through feature weighting and feature fusion. Theoretical analysis and simulation results show that the presented algorithm has a high recognition rate. Additionally, when the SNR is greater than-4 d B, the correct recognition rate is higher than 93%. Hence, the proposed algorithm has great application value.展开更多
The surface finish quality is critical to the service performance of a machined part,and single-point diamond ultra-precision machining can achieve excellent surface quality for many engineering materials.This study s...The surface finish quality is critical to the service performance of a machined part,and single-point diamond ultra-precision machining can achieve excellent surface quality for many engineering materials.This study studied the problem of predicting the surface roughness for titanium alloy workpieces in ultra-precision machining.Process data and surface roughness measurement results were obtained during end-face machining experiments.A deep learning neural network model was built based on the ResNet-50 architecture to predict surface roughness.We propose increasing prediction accuracy by using the energy ratio difference(ERD)as a stability feature that can be extracted using fast iterative variational mode decomposition(FI-VMD).The roughness value obtained with an analytic model was also used as an input feature of the prediction model.The prediction accuracy of the proposed approach was depicted to be improved by 8.7%with the two newly introduced roughness predictors.The influence of the tool parameters on the prediction accuracy was investigated,and the proposed hybrid-driven model exhibited higher robustness to errors of the tool parameters than the analytic roughness model.展开更多
文摘Background:Gene expression profiling plays a key role in cancer research,but its high dimensionality and redundancy pose challenges for effective analysis.Feature selection and robust classification are critical for improving predictive performance,while explainable machine learning techniques support transparency and biomarker discovery.Methods:To propose a hybrid explainable machine learning framework that combines stability-guided multi-source(SGMS)feature selection with classification models for gene expression-based cancer prediction and biomarker identification.SGMS integrates Mutual Information,F-statistic,and random forest(RF)importance to select informative genes.These features are used to train classifiers,including novel elasticnet logistic regression(NEN-LR),RF,and Support Vector Machine(SVM).Performance is evaluated using accuracy,precision,recall,F1-score,and Matthews correlation coefficient(MCC).SHapley Additive exPlanations(SHAP)values are used to interpret gene-level contributions,and co-expression networks help identify functional gene modules.Results:The proposed NEN-LR classifier achieved the highest performance with 99.8%accuracy,99.9%precision,and 0.997 MCC using the top 200 SGMS-selected genes.Biomarker discovery identified both class-specific and shared genes across five cancer types,with top genes like gene_230,gene_5380,and gene_18570 consistently appearing across multiple classes.Visualization tools,including heatmaps,Venn diagrams,and co-expression networks,were used to interpret expression dynamics and regulatory patterns,enhancing the biological relevance of findings.SHAP analysis revealed top biomarkers with strong predictive influence,while co-expression clustering uncovered biologically meaningful gene modules.Other models also showed marked improvement using SGMS-selected features.Conclusion:The proposed framework successfully integrates feature selection,interpretable classification,and biomarker discovery,providing a powerful tool for precision oncology and molecular diagnostics.
基金Project(61301095)supported by the National Natural Science Foundation of ChinaProject(QC2012C070)supported by Heilongjiang Provincial Natural Science Foundation for the Youth,ChinaProjects(HEUCF130807,HEUCFZ1129)supported by the Fundamental Research Funds for the Central Universities of China
文摘In modern electromagnetic environment, radar emitter signal recognition is an important research topic. On the basis of multi-resolution wavelet analysis, an adaptive radar emitter signal recognition method based on multi-scale wavelet entropy feature extraction and feature weighting was proposed. With the only priori knowledge of signal to noise ratio(SNR), the method of extracting multi-scale wavelet entropy features of wavelet coefficients from different received signals were combined with calculating uneven weight factor and stability weight factor of the extracted multi-dimensional characteristics. Radar emitter signals of different modulation types and different parameters modulated were recognized through feature weighting and feature fusion. Theoretical analysis and simulation results show that the presented algorithm has a high recognition rate. Additionally, when the SNR is greater than-4 d B, the correct recognition rate is higher than 93%. Hence, the proposed algorithm has great application value.
基金supported by the National Key Research and Development Project of China(Grant No.2020YFB1710400)the National Natural Science Foundation of China(Grant No.52005205)the National Science Fund for Distinguished Young Scholars(Grant No.52225506)。
文摘The surface finish quality is critical to the service performance of a machined part,and single-point diamond ultra-precision machining can achieve excellent surface quality for many engineering materials.This study studied the problem of predicting the surface roughness for titanium alloy workpieces in ultra-precision machining.Process data and surface roughness measurement results were obtained during end-face machining experiments.A deep learning neural network model was built based on the ResNet-50 architecture to predict surface roughness.We propose increasing prediction accuracy by using the energy ratio difference(ERD)as a stability feature that can be extracted using fast iterative variational mode decomposition(FI-VMD).The roughness value obtained with an analytic model was also used as an input feature of the prediction model.The prediction accuracy of the proposed approach was depicted to be improved by 8.7%with the two newly introduced roughness predictors.The influence of the tool parameters on the prediction accuracy was investigated,and the proposed hybrid-driven model exhibited higher robustness to errors of the tool parameters than the analytic roughness model.
