Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX.The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma,and it has thus been commonly...Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX.The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma,and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma,but emerging evidence suggests that upon depletion of SS18-SSX,an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival.In this article,we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of synovial sarcoma cells to SS18-SSX targeted therapeutics.展开更多
Rotary friction welding is a highly effective solid-state technique for joining dissimilar materials,which offers the potential for significant weight reduction without compromising strength.Traditionally,during rotar...Rotary friction welding is a highly effective solid-state technique for joining dissimilar materials,which offers the potential for significant weight reduction without compromising strength.Traditionally,during rotary friction welding,the severely deformed material,or flash,is expelled from the interface and machined away to achieve the desired joint geometry.However,this work introduces a novel approach:trapping the flash within the joint to improve joint properties.The study investigates two different interface geometry combinationsdflat-flat and flat-taper interfaces.Previous research shows that Ni interlayer between steel and titanium can enhance the joint strength.This study builds on the existing knowledge(effect of Ni interlayer)by examining the influence of interface geometry to further improve the dissimilar joint performance.The experimental results,including tensile testing and microstructural characterization,highlight the superior performance of the flat-taper interface.The modified geometry minimizes flash loss,providing a cavity that retains both the flash and the Ni interlayer within the joint.This retention promotes dynamic recrystallization,resulting in refined grain structures near the interface.Moreover,the trapped Ni interlayer effectively prevents the formation of brittle Fe-Ti intermetallic compounds at the dissimilar material interface.The findings reveal that the flat-taper interface improved joint strength by an impressive 105%compared to the flat-flat interface.This innovative geometry modification demonstrates the potential to enhance mechanical properties of dissimilar joints through better flash and interlayer management.展开更多
Aimed at the problem of the low computational efficiency of the existing urethral-valve reliability analysis,an efficient reliability analysis method of the wireless energy-transmitting urethral-valve(WETUV)was propos...Aimed at the problem of the low computational efficiency of the existing urethral-valve reliability analysis,an efficient reliability analysis method of the wireless energy-transmitting urethral-valve(WETUV)was proposed.The method is called FTA-AK-SS,based on the active learning Kriging(AK)model,subset simulation(SS)algorithm,and fault tree analysis(FTA).According to the principle of FTA,we established the fault tree model of the WETUV to determine its minimum cut set and bottom events.Then we defined the random variables affecting its reliability.The U learning function was used to selectively add the sample points of random variables to update the initial Kriging surrogate model.At the same time,combined with the SS algorithm,the reliability and sensitivity analyses of the WETUV were realized.The result shows that compared with the traditional Monte Carlo simulation and FTA-Kriging-SS methods,the proposed method significantly improves the calculation efficiency of the WETUV under the premise of ensuring calculation accuracy.The reliability of the WETUV is greatly affected by the rubber pad’s aging,the receiver coil’s corrosion,and the position deviation.This study can provide a new way to realize a high-efficiency reliability calculation and analysis for urethral valves.展开更多
文摘Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX.The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma,and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma,but emerging evidence suggests that upon depletion of SS18-SSX,an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival.In this article,we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of synovial sarcoma cells to SS18-SSX targeted therapeutics.
文摘Rotary friction welding is a highly effective solid-state technique for joining dissimilar materials,which offers the potential for significant weight reduction without compromising strength.Traditionally,during rotary friction welding,the severely deformed material,or flash,is expelled from the interface and machined away to achieve the desired joint geometry.However,this work introduces a novel approach:trapping the flash within the joint to improve joint properties.The study investigates two different interface geometry combinationsdflat-flat and flat-taper interfaces.Previous research shows that Ni interlayer between steel and titanium can enhance the joint strength.This study builds on the existing knowledge(effect of Ni interlayer)by examining the influence of interface geometry to further improve the dissimilar joint performance.The experimental results,including tensile testing and microstructural characterization,highlight the superior performance of the flat-taper interface.The modified geometry minimizes flash loss,providing a cavity that retains both the flash and the Ni interlayer within the joint.This retention promotes dynamic recrystallization,resulting in refined grain structures near the interface.Moreover,the trapped Ni interlayer effectively prevents the formation of brittle Fe-Ti intermetallic compounds at the dissimilar material interface.The findings reveal that the flat-taper interface improved joint strength by an impressive 105%compared to the flat-flat interface.This innovative geometry modification demonstrates the potential to enhance mechanical properties of dissimilar joints through better flash and interlayer management.
基金Foundation item:the National Natural Science Foundation of China(No.52075101)the Natural Science Foundation of Guangdong Province(No.2017A030313265)Guangzhou Scientific Research Plan(No.201904010184)。
文摘Aimed at the problem of the low computational efficiency of the existing urethral-valve reliability analysis,an efficient reliability analysis method of the wireless energy-transmitting urethral-valve(WETUV)was proposed.The method is called FTA-AK-SS,based on the active learning Kriging(AK)model,subset simulation(SS)algorithm,and fault tree analysis(FTA).According to the principle of FTA,we established the fault tree model of the WETUV to determine its minimum cut set and bottom events.Then we defined the random variables affecting its reliability.The U learning function was used to selectively add the sample points of random variables to update the initial Kriging surrogate model.At the same time,combined with the SS algorithm,the reliability and sensitivity analyses of the WETUV were realized.The result shows that compared with the traditional Monte Carlo simulation and FTA-Kriging-SS methods,the proposed method significantly improves the calculation efficiency of the WETUV under the premise of ensuring calculation accuracy.The reliability of the WETUV is greatly affected by the rubber pad’s aging,the receiver coil’s corrosion,and the position deviation.This study can provide a new way to realize a high-efficiency reliability calculation and analysis for urethral valves.
