Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sw...Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity.展开更多
As NPC performances surge in popularity,destinations are recruiting actors and building story-driven scenes to reinvent traditional tourism Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin’s w...As NPC performances surge in popularity,destinations are recruiting actors and building story-driven scenes to reinvent traditional tourism Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin’s work schedule during the National Day holiday a month ago.From 1 to 8 October,he maintained a relentless pace,not just logging miles but also switching between roles.展开更多
Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe...Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.展开更多
Economic shale gas production requires hydraulic fracture stimulation to increase the formation permeability. Hydraulic fracturing strongly depends on geomechanical parameters such as Young＇s modulus and Poisson＇s r...Economic shale gas production requires hydraulic fracture stimulation to increase the formation permeability. Hydraulic fracturing strongly depends on geomechanical parameters such as Young＇s modulus and Poisson＇s ratio. Fracture-prone sweet spots can be predicted by prestack inversion, which is an ill-posed problem; thus, regularization is needed to obtain unique and stable solutions. To characterize gas-bearing shale sedimentary bodies, elastic parameter variations are regarded as an anisotropic Markov random field. Bayesian statistics are adopted for transforming prestack inversion to the maximum posterior probability. Two energy functions for the lateral and vertical directions are used to describe the distribution, and the expectation-maximization algorithm is used to estimate the hyperparameters of the prior probability of elastic parameters. Finally, the inversion yields clear geological boundaries, high vertical resolution, and reasonable lateral continuity using the conjugate gradient method to minimize the objective function. Antinoise and imaging ability of the method were tested using synthetic and real data.展开更多
After analysis of connotation of low-carbon scenic spots,the paper considered that a perfect low-carbon scenic spot is a comprehensive integrity with satisfying tourists' lowest tourist experience effect as the pr...After analysis of connotation of low-carbon scenic spots,the paper considered that a perfect low-carbon scenic spot is a comprehensive integrity with satisfying tourists' lowest tourist experience effect as the premise and with low energy consumption,low pollution and low emission as the foundation.Low-carbon tourist scenic spots had been classified into three types which are ecological type,cultural type and coupling type of ecology and culture.Representatives of each type of tourist scenic spot were illustrated.It proposed that government should play the leading role in cultivation of low-carbon scenic spot;tourism industry should enhance self supervision;tourism development mode should be transformed and upgrading of tourist products should be realized.By taking Yuntai Mountain Scenic Area of Henan Province for example,based on low-carbon tourist resources,low-carbon development of management,following measures realizing low-carbon economy were put forward:① purifying air quality and beautifying environment of scenic area;② sifting laggard productivity and protecting ecological resources in the scenic area by many means;③ sticking to low-carbon environmental protection concept and completing infrastructure service;④ developing tourist native products and souvenirs based on local resources;⑤ applying electronic access control ticket system,intelligent monitor system and LED information and communication platform,so as to achieve low-carbon management.展开更多
Barn swallows Hirundo rustica have white spots on their tail feathers, and they have been hypothe-sized to be a handicap because white spots are prone to feather breakage, ectoparasites are dispro-portionately common ...Barn swallows Hirundo rustica have white spots on their tail feathers, and they have been hypothe-sized to be a handicap because white spots are prone to feather breakage, ectoparasites are dispro-portionately common in white spots, and size of white spots increases with tail length. Here I testfor attractiveness of narrow and long tail spots by manipulation of their shape while using com-plete painting of spots and an absence of treatment as a control. Female barn swallows are knownto differentially invest in reproduction when mated to attractive males. Spot manipulation tookplace during laying of the first clutch, and there were no effects of treatment on clutch size or broodsize of first or second broods. In contrast, the incidence of second clutches and the total number ofeggs and fledglings produced during the breeding season was larger in males with painting of theside of tail spots rather than painting of the tip of spots, painting of entire spots, or no treatment.These findings are consistent with the hypothesis that it is the shape rather than the size of tailspots that affects differential reproductive effort by female barn swallows.展开更多
Turbulent spots play a key role in the formation of the turbulence and the transition. The generation and evolution of turbulent spots using the wall impulse model in the plane Couette flow are studied by direct numer...Turbulent spots play a key role in the formation of the turbulence and the transition. The generation and evolution of turbulent spots using the wall impulse model in the plane Couette flow are studied by direct numerical simulation of Navier-Stokes equations. A group of three-dimensional coupling compact difference schemes with high accuracy and high resolution is used in the numerical calculation. The important characteristics of turbulent spots based on the results of examples are analyzed, including the formation of random pulse, the generation of Reynolds stress, the growth of disturbance amplitude, and the continuous change of spot shape, especially the complex evolution process of the streamwise vortices. Computational results confirm that basic properties of turbulent spots in the laminar flow are similar to those in the turbulent flow.展开更多
A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and adva...A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and advancing tourism. We systematically analyzed the accessibility of 56 scenic spots in Xi’an City, China, via car and public transport travel modes using the real-time travel function of the Baidu Maps API(Application Programming Interface) along with spatial analysis methods and the modal accessibility gap index of scenic spots. We obtained the following results. First, maximum and minimum travel times using public transport exceeded those using cars. Moreover, the accessibility of scenic spots via cars and public transport presented a circular spatial pattern of increasing travel time from the center to the periphery. Contrasting with travel by public transport, car travel showed a clear time-space compression effect. Second, accessibility of the scenic spots via cars and public transport showed some spatial heterogeneity, with no clear advantages of car accessibility in the central urban area. However, advantages of car accessibility were increasingly evident moving from the center to the periphery. Third, whereas the correlation of the modal accessibility gap index of scenic spots in Xi’an with global space was significantly positive, local spatial interdependence was only evident in some inner city areas and in marginal areas. Moreover, spatial heterogeneity was evident in two regions but was insignificant in other areas, indicating that the spatial interdependence of the modal accessibility gap index in most scenic spots was not apparent in terms of the overall effect of public transport routes, road networks, and the distribution of scenic spots. The improvement of public transport coverage in marginal areas and the optimization of public transport routes in central urban areas are essential tasks for improving travel using public transport in the future.展开更多
Direct infusion mass spectrometry(DIMS) is a powerful technique in clinical diagnosis for screening neonatal amino acid metabolic disorders from dried blood spots(DBS).However,DIMS sometimes generated false-positive r...Direct infusion mass spectrometry(DIMS) is a powerful technique in clinical diagnosis for screening neonatal amino acid metabolic disorders from dried blood spots(DBS).However,DIMS sometimes generated false-positive results for analysis of amino acids.In this work,we utilized a stable isotope derivatization method,combining with liquid chromatography tandem mass spectrometry(SID-LC-MS),to improve the specificity for screening amino acids in DBS specimens.A pair of isotope reagents,p-(dimethylamino)phenyl isothiocyanate(DMAP-NCS) and 4-isothiocyanato-N,N-bis(methyl-[2H2])aniline([2H4]DMAP-NCS),was synthesized and used to label amino acids in DBS specimens.The [2H4]DMAP-NCS labelled amino acid standards were used as internal standards to compensate the matrix effect.This method was validated by measuring linearity,recovery and accuracy.The results showed that the developed SID-LC-MS method can be used for sensitive and selective determination of 12 diagnostically important amino acids in DBS specimens.展开更多
Shale reservoirs are characterized by low porosity and strong anisotropy. Conventional geophysical methods are far from perfect when it comes to the prediction of shale sweet spot locations, and even less reliable whe...Shale reservoirs are characterized by low porosity and strong anisotropy. Conventional geophysical methods are far from perfect when it comes to the prediction of shale sweet spot locations, and even less reliable when attempting to delineate unconventional features of shale oil and gas. Based on some mathematical algorithms such as fuzzy mathematics, machine learning and multiple regression analysis, an effective workflow is proposed to allow intelligent prediction of sweet spots and comprehensive quantitative characterization of shale oil and gas reservoirs. This workflow can effectively combine multi-scale and multi-disciplinary data such as geology, well drilling, logging and seismic data. Following the maximum subordination and attribute optimization principle, we establish a machine learning model by adopting the support vector machine method to arrive at multi-attribute prediction of reservoir sweet spot location. Additionally, multiple regression analysis technology is applied to quantitatively predict a number of sweet spot attributes. The practical application of these methods to areas of interest shows high accuracy of sweet spot prediction, indicating that it is a good approach for describing the distribution of high-quality regions within shale reservoirs. Based on these sweet spot attributes, quantitative characterization of unconventional reservoirs can provide a reliable evaluation of shale reservoir potential.展开更多
Bicycle-sharing system is considered as a green option to provide a better connection between scenic spots and nearby metro/bus stations. Allocating and optimizing the layout of bicycle-sharing system inside the sceni...Bicycle-sharing system is considered as a green option to provide a better connection between scenic spots and nearby metro/bus stations. Allocating and optimizing the layout of bicycle-sharing system inside the scenic spot and around its influencing area are focused on. It is found that the terrain, land use, nearby transport network and scenery point distribution have significant impact on the allocation of bicycle-sharing system. While the candidate bicycle-sharing stations installed at the inner scenic points, entrances/exits and metro stations are fixed, the ones installed at bus-stations and other passenger concentration buildings are adjustable. Aiming at minimizing the total cycling distance and overlapping rate, an optimization model is proposed and solved based on the idea of cluster concept and greedy heuristic. A revealed preference/stated preference （RP/SP） combined survey was conducted at Xuanwu Lake in Nanjing, China, to get an insight into the touring trip characteristics and bicycle-sharing tendency. The results reveal that 39.81% visitors accept a cycling distance of 1-3 km and 62.50% respondents think that the bicycle-sharing system should charge an appropriate fee. The sttrvey indicates that there is high possibility to carry out a bicycle-sharing system at Xuanwu Lake. Optimizing the allocation problem cluster by cluster rather than using an exhaustive search method significantly reduces the computing amount from O（2^43） to O（43 2）. The 500 m-radius-coverage rate for the alternative optimized by 500 m-radius-cluster and 800 m-radius-cluster is 89.2% and 68.5%, respectively. The final layout scheme will provide decision makers engineering guidelines and theoretical support.展开更多
Microwave heating can rapidly and uniformly raise the temperature and accelerate the reaction rate.In this paper,microwave heating was used to improve the acid leaching,and the mechanism was investigated via microscop...Microwave heating can rapidly and uniformly raise the temperature and accelerate the reaction rate.In this paper,microwave heating was used to improve the acid leaching,and the mechanism was investigated via microscopic morphology analysis and numerical simulation by COMSOL Multiphysics software.The effects of the microwave power,leaching temperature,CaF_(2) dosage,H_(2)SO_(4) concentration,and leaching time on the vanadium recovery were investigated.A vanadium recovery of 80.66%is obtained at a microwave power of 550 W,leaching temperature of 95℃,CaF_(2) dosage of 5wt%,H_(2)SO_(4) concentration of 20vol%,and leaching time of 2.5 h.Compared with conventional leaching technology,the vanadium recovery increases by 6.18%,and the leaching time shortens by 79.17%.More obvious pulverization of shale particles and delamination of mica minerals happen in the microwave-assisted leaching process.Numerical simulation results show that the temperature of vanadium shales increases with an increase in electric field(E-field).The distributions of E-field and temperature among vanadium shale particles are relatively uniform,except for the higher content at the contact position of the particles.The analysis results of scaleup experiments and leaching experiments indicate high-temperature hot spots in the process of microwave-assisted leaching,and the local high temperature destroys the mineral structure and accelerates the reaction rate.展开更多
With the increasing effects of global climate change and fishing activities,the spatial distribution of the neon flying squid(Ommastrephes bartramii) is changing in the traditional fishing ground of 150°-160°...With the increasing effects of global climate change and fishing activities,the spatial distribution of the neon flying squid(Ommastrephes bartramii) is changing in the traditional fishing ground of 150°-160°E and 38°-45°N in the northwest Pacific Ocean.This research aims to identify the spatial hot and cold spots(i.e.spatial clusters) of O.bartramii to reveal its spatial structure using commercial fishery data from2007 to 2010 collected by Chinese mainland squid-j igging fleets.A relatively strongly-clustered distribution for O.bartramii was observed using an exploratory spatial data analysis(ESDA) method.The results show two hot spots and one cold spot in 2007 while only one hot and one cold spots were identified each year from2008 to 2010.The hot and cold spots in 2007 occupied 8.2%and 5.6%of the study area,respectively;these percentages for hot and cold spot areas were 5.8%and 3.1%in 2008,10.2%and 2.9%in 2009,and 16.4%and 11.9%in 2010,respectively.Nearly half(>45%) of the squid from 2007 to 2009 reported by Chinese fleets were caught in hot spot areas while this percentage reached its peak at 68.8%in 2010,indicating that the hot spot areas are central fishing grounds.A further change analysis shows the area centered at156°E/43.5°N was persistent as a hot spot over the whole period from 2007 to 2010.Furthermore,the hot spots were mainly identified in areas with sea surface temperature(SST) in the range of 15-20℃ around warm Kuroshio Currents as well as with the chlorophyll-a(chl-a) concentration above 0.3 mg/m^3.The outcome of this research improves our understanding of spatiotemporal hotspots and its variation for O.bartramii and is useful for sustainable exploitation,assessment,and management of this squid.展开更多
Mongolian spots(MS) are congenital birthmarks seen most commonly over the lumbosacral area. They are bluish-green to black in color and oval to irregular in shape. They are most commonly found in individuals of Africa...Mongolian spots(MS) are congenital birthmarks seen most commonly over the lumbosacral area. They are bluish-green to black in color and oval to irregular in shape. They are most commonly found in individuals of African or Asian ethnic background. Although these lesions resolve by one to two years of age, widespread, extrasacral and dark colored MS sometimes persist into adulthood. Aberrant MS over occiput, temple, mandibular area, shoulders and limbs may be confused with other dermal melanocytoses and bruises secondary to child abuse, thus necessitating documentation at birth. Although traditionally believed to be benign in nature, they have now been shown to co-exist with inborn errors of metabolism, most commonly GM1 gangliosidosis and mucopolysaccharidosis type Ⅰ(Hurler's disease), followed by mucopolysaccharidosis type Ⅱ(Hunter's syndrome), mucolipidosis, Niemann-Pick disease and mannosidosis. They have also been seen to co-exist with various vascular or other pigmented birthmarks like café-au-lait macules. Co-existing Mongolian spots and vascular birthmarks like nevus flammeus, nevus anemicus or nevus spilus is termed as phakomatosis pigmentovascularis. This review focuses on the important associations of Mongolian spots and stresses upon the importance of screening babies with extensive MS.展开更多
The surface profile of laser peened stainless steel was researched in this paper,a special lens was used to convert circle laser spot to square spot,the difference of surface profile obtained by laser peening with cir...The surface profile of laser peened stainless steel was researched in this paper,a special lens was used to convert circle laser spot to square spot,the difference of surface profile obtained by laser peening with circle laser spot was compared with that with square laser spot.Laser peened zone showed steep depression at the edge with square spot,but the surface in the shocked zone was very smooth.With suitable overlapped rate,square spot can produce smoother surface profile than circle spot,and laser peening with square spot is more effective than circle spot.展开更多
By taking the twelve scenic spots in Ancient Lotus Pond Garden as study objects, they have been introduced and their names have been classified in accordance with allege and symbol nomenclature, linguistic rhetoric no...By taking the twelve scenic spots in Ancient Lotus Pond Garden as study objects, they have been introduced and their names have been classified in accordance with allege and symbol nomenclature, linguistic rhetoric nomenclature, narration and description nomenclature, and emotion-endowing and ambition-expressing nomenclature adopted in related articles. Then, the cultural connotations of these scenic spots have been summarized, and Confucian thought and Taoist thought contained in "Surge Including Pavilion" and "High Principle Tower" have been analyzed. The research is aimed at enlightening modern garden workers through illustrating the connotation of the names of scenic spots, so that they can be inspired in the naming process.展开更多
Cereal crops, including wheat, barley, oats, rye, etc., are the major sources of calories and proteins for most of the people in the world as well as in China. Cereal rusts and powdery mildews are very important disea...Cereal crops, including wheat, barley, oats, rye, etc., are the major sources of calories and proteins for most of the people in the world as well as in China. Cereal rusts and powdery mildews are very important diseases occurred on the cereal crops, which caused yield losses at 5-10% in general and even more than 30% while severe epidemics occurred. In recent years, with the global climate change, change of cultivation system and evolution of the pathogens, the world is facing great challenges caused by cereal diseases.展开更多
The Chang-63 reservoir in the Huaqing area has widely developed tight sandstone ＂thick sand layers, but not reservoirs characterized by rich in oil＂, and it is thus necessary to further study its oil and gas enrichm...The Chang-63 reservoir in the Huaqing area has widely developed tight sandstone ＂thick sand layers, but not reservoirs characterized by rich in oil＂, and it is thus necessary to further study its oil and gas enrichment law. This study builds porosity and fracture development and evolution models in different deposition environments, through core observation, casting thin section, SEM, porosity and permeability analysis, burial history analysis, and ＂four-property-relationships＂ analysis.展开更多
In China, many scenic and tourism areas are suffering from the urbanization that results from physical development of tourism projects, leading to the removal of the vegetative cover, the creation of areas impermeable...In China, many scenic and tourism areas are suffering from the urbanization that results from physical development of tourism projects, leading to the removal of the vegetative cover, the creation of areas impermeable to water, in-stream modifications, and other problems. In this paper, the risk of soil erosion and its ecological risks in the West Lake Scenic Spots （WLSS） area were quantitatively evaluated by integrating the revised universal soil loss equation （RUSLE） with a digital elevation model （DEM） and geographical information system （GIS） software. The standard RUSLE factors were modified to account for local climatic and topographic characteristics reflected in the DEM maps, and for the soil types and vegetation cover types. An interface was created between the Areinfo software and RUSLE so that the level of soil erosion and its ecological risk in the WLSS area could be mapped immediately once the model factors were defined for the area. The results from an analysis using the Areinfo-RUSLE interface showed that the risk value in 93 % of the expanding western part of the WLSS area was moderate or more severe and the soil erosion risk in this area was thus large compared with that in the rest of the area. This paper mainly aimed to increase the awareness of the soil erosion risk in urbanizing areas and suggest that the local governments should consider the probable ecological risk resulting from soil erosion when enlarging and developing tourism areas.展开更多
BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related death.Over the past two decades,numerous researchers have provided important evidence regarding...BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related death.Over the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of CRC.The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed.Despite the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.AIM To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research directions.METHODS We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023.We used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and references.Co-authorship,co-citation,and co-occurrence analyses were the main methods of analysis.CiteSpace and VOSviewer were used to visualize the results.RESULTS A total of 205 studies were ultimately identified.The number of publications on this topic has steadily increased since 2007.China and the United States have made the largest contributions to this field.Anticancer Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this field.Co-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this field.CONCLUSION This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between the two.It is recommended to focus on emerging research hotspots,such as the correlations among intestinal microbiota,inflammatory bowel disease,TJ protein expression,and CRC.展开更多
文摘Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity.
文摘As NPC performances surge in popularity,destinations are recruiting actors and building story-driven scenes to reinvent traditional tourism Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin’s work schedule during the National Day holiday a month ago.From 1 to 8 October,he maintained a relentless pace,not just logging miles but also switching between roles.
基金supported by the Guangdong High Level Innovation Research Institute(Grant No.2021B0909050006)the National Grand Instrument Project(Grant No.2019YFF01014402)+1 种基金the National Natural Science Foundation of China(Grant No.12205008)support from the National Science Fund for Distinguished Young Scholars(Grant No.12225501)。
文摘Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.
基金supported by CNPC fundamental research project(No.2014E-3204)
文摘Economic shale gas production requires hydraulic fracture stimulation to increase the formation permeability. Hydraulic fracturing strongly depends on geomechanical parameters such as Young＇s modulus and Poisson＇s ratio. Fracture-prone sweet spots can be predicted by prestack inversion, which is an ill-posed problem; thus, regularization is needed to obtain unique and stable solutions. To characterize gas-bearing shale sedimentary bodies, elastic parameter variations are regarded as an anisotropic Markov random field. Bayesian statistics are adopted for transforming prestack inversion to the maximum posterior probability. Two energy functions for the lateral and vertical directions are used to describe the distribution, and the expectation-maximization algorithm is used to estimate the hyperparameters of the prior probability of elastic parameters. Finally, the inversion yields clear geological boundaries, high vertical resolution, and reasonable lateral continuity using the conjugate gradient method to minimize the objective function. Antinoise and imaging ability of the method were tested using synthetic and real data.
基金Supported by Scientific and Technological Research and Development Planning Project of Hebei Province in2010(10457204D-14)~~
文摘After analysis of connotation of low-carbon scenic spots,the paper considered that a perfect low-carbon scenic spot is a comprehensive integrity with satisfying tourists' lowest tourist experience effect as the premise and with low energy consumption,low pollution and low emission as the foundation.Low-carbon tourist scenic spots had been classified into three types which are ecological type,cultural type and coupling type of ecology and culture.Representatives of each type of tourist scenic spot were illustrated.It proposed that government should play the leading role in cultivation of low-carbon scenic spot;tourism industry should enhance self supervision;tourism development mode should be transformed and upgrading of tourist products should be realized.By taking Yuntai Mountain Scenic Area of Henan Province for example,based on low-carbon tourist resources,low-carbon development of management,following measures realizing low-carbon economy were put forward:① purifying air quality and beautifying environment of scenic area;② sifting laggard productivity and protecting ecological resources in the scenic area by many means;③ sticking to low-carbon environmental protection concept and completing infrastructure service;④ developing tourist native products and souvenirs based on local resources;⑤ applying electronic access control ticket system,intelligent monitor system and LED information and communication platform,so as to achieve low-carbon management.
文摘Barn swallows Hirundo rustica have white spots on their tail feathers, and they have been hypothe-sized to be a handicap because white spots are prone to feather breakage, ectoparasites are dispro-portionately common in white spots, and size of white spots increases with tail length. Here I testfor attractiveness of narrow and long tail spots by manipulation of their shape while using com-plete painting of spots and an absence of treatment as a control. Female barn swallows are knownto differentially invest in reproduction when mated to attractive males. Spot manipulation tookplace during laying of the first clutch, and there were no effects of treatment on clutch size or broodsize of first or second broods. In contrast, the incidence of second clutches and the total number ofeggs and fledglings produced during the breeding season was larger in males with painting of theside of tail spots rather than painting of the tip of spots, painting of entire spots, or no treatment.These findings are consistent with the hypothesis that it is the shape rather than the size of tailspots that affects differential reproductive effort by female barn swallows.
文摘Turbulent spots play a key role in the formation of the turbulence and the transition. The generation and evolution of turbulent spots using the wall impulse model in the plane Couette flow are studied by direct numerical simulation of Navier-Stokes equations. A group of three-dimensional coupling compact difference schemes with high accuracy and high resolution is used in the numerical calculation. The important characteristics of turbulent spots based on the results of examples are analyzed, including the formation of random pulse, the generation of Reynolds stress, the growth of disturbance amplitude, and the continuous change of spot shape, especially the complex evolution process of the streamwise vortices. Computational results confirm that basic properties of turbulent spots in the laminar flow are similar to those in the turbulent flow.
基金Under the auspices of National Natural Science Foundation of China(No.41831284,41501120)Special Scientific Research Project of Education Department of Shaanxi Provincial Government(No.18JK0649)Scientific Research Project of Xi’an International Studies University(No.18XWC24)
文摘A study of the accessibility of a city’s scenic spots via different travel modes can contribute to optimization of tourism-related transportation while improving tourists’ travel-related satisfaction levels and advancing tourism. We systematically analyzed the accessibility of 56 scenic spots in Xi’an City, China, via car and public transport travel modes using the real-time travel function of the Baidu Maps API(Application Programming Interface) along with spatial analysis methods and the modal accessibility gap index of scenic spots. We obtained the following results. First, maximum and minimum travel times using public transport exceeded those using cars. Moreover, the accessibility of scenic spots via cars and public transport presented a circular spatial pattern of increasing travel time from the center to the periphery. Contrasting with travel by public transport, car travel showed a clear time-space compression effect. Second, accessibility of the scenic spots via cars and public transport showed some spatial heterogeneity, with no clear advantages of car accessibility in the central urban area. However, advantages of car accessibility were increasingly evident moving from the center to the periphery. Third, whereas the correlation of the modal accessibility gap index of scenic spots in Xi’an with global space was significantly positive, local spatial interdependence was only evident in some inner city areas and in marginal areas. Moreover, spatial heterogeneity was evident in two regions but was insignificant in other areas, indicating that the spatial interdependence of the modal accessibility gap index in most scenic spots was not apparent in terms of the overall effect of public transport routes, road networks, and the distribution of scenic spots. The improvement of public transport coverage in marginal areas and the optimization of public transport routes in central urban areas are essential tasks for improving travel using public transport in the future.
基金supported by the National Key R&D Program of China(No.2018YFA0900400)the National Natural ScienceFoundation of China(Nos.21635006,31670373,21721005,21904099)the Postdoctoral Science Foundation of China(No.2018M642893)。
文摘Direct infusion mass spectrometry(DIMS) is a powerful technique in clinical diagnosis for screening neonatal amino acid metabolic disorders from dried blood spots(DBS).However,DIMS sometimes generated false-positive results for analysis of amino acids.In this work,we utilized a stable isotope derivatization method,combining with liquid chromatography tandem mass spectrometry(SID-LC-MS),to improve the specificity for screening amino acids in DBS specimens.A pair of isotope reagents,p-(dimethylamino)phenyl isothiocyanate(DMAP-NCS) and 4-isothiocyanato-N,N-bis(methyl-[2H2])aniline([2H4]DMAP-NCS),was synthesized and used to label amino acids in DBS specimens.The [2H4]DMAP-NCS labelled amino acid standards were used as internal standards to compensate the matrix effect.This method was validated by measuring linearity,recovery and accuracy.The results showed that the developed SID-LC-MS method can be used for sensitive and selective determination of 12 diagnostically important amino acids in DBS specimens.
基金supported by National Science and Technology Major Project (No. 2017ZX05049002)NSFC and Sinopec Joint Key Project (U1663207)the National Key Basic Research Program of China (973 Program No. 2014CB239104)
文摘Shale reservoirs are characterized by low porosity and strong anisotropy. Conventional geophysical methods are far from perfect when it comes to the prediction of shale sweet spot locations, and even less reliable when attempting to delineate unconventional features of shale oil and gas. Based on some mathematical algorithms such as fuzzy mathematics, machine learning and multiple regression analysis, an effective workflow is proposed to allow intelligent prediction of sweet spots and comprehensive quantitative characterization of shale oil and gas reservoirs. This workflow can effectively combine multi-scale and multi-disciplinary data such as geology, well drilling, logging and seismic data. Following the maximum subordination and attribute optimization principle, we establish a machine learning model by adopting the support vector machine method to arrive at multi-attribute prediction of reservoir sweet spot location. Additionally, multiple regression analysis technology is applied to quantitatively predict a number of sweet spot attributes. The practical application of these methods to areas of interest shows high accuracy of sweet spot prediction, indicating that it is a good approach for describing the distribution of high-quality regions within shale reservoirs. Based on these sweet spot attributes, quantitative characterization of unconventional reservoirs can provide a reliable evaluation of shale reservoir potential.
基金Project(51208261)supported by the National Natural Science Foundation of ChinaProject(12YJCZH062)supported by the Ministry of Education of Humanities and Social Science of ChinaProject(30920140132033)supported by the Fundamental Research Funds for the Central Universities,China
文摘Bicycle-sharing system is considered as a green option to provide a better connection between scenic spots and nearby metro/bus stations. Allocating and optimizing the layout of bicycle-sharing system inside the scenic spot and around its influencing area are focused on. It is found that the terrain, land use, nearby transport network and scenery point distribution have significant impact on the allocation of bicycle-sharing system. While the candidate bicycle-sharing stations installed at the inner scenic points, entrances/exits and metro stations are fixed, the ones installed at bus-stations and other passenger concentration buildings are adjustable. Aiming at minimizing the total cycling distance and overlapping rate, an optimization model is proposed and solved based on the idea of cluster concept and greedy heuristic. A revealed preference/stated preference （RP/SP） combined survey was conducted at Xuanwu Lake in Nanjing, China, to get an insight into the touring trip characteristics and bicycle-sharing tendency. The results reveal that 39.81% visitors accept a cycling distance of 1-3 km and 62.50% respondents think that the bicycle-sharing system should charge an appropriate fee. The sttrvey indicates that there is high possibility to carry out a bicycle-sharing system at Xuanwu Lake. Optimizing the allocation problem cluster by cluster rather than using an exhaustive search method significantly reduces the computing amount from O（2^43） to O（43 2）. The 500 m-radius-coverage rate for the alternative optimized by 500 m-radius-cluster and 800 m-radius-cluster is 89.2% and 68.5%, respectively. The final layout scheme will provide decision makers engineering guidelines and theoretical support.
基金supported by the National Natural Science Foundation of China(No.51904211)the National Natural Science Foundation of China(No.52004187)。
文摘Microwave heating can rapidly and uniformly raise the temperature and accelerate the reaction rate.In this paper,microwave heating was used to improve the acid leaching,and the mechanism was investigated via microscopic morphology analysis and numerical simulation by COMSOL Multiphysics software.The effects of the microwave power,leaching temperature,CaF_(2) dosage,H_(2)SO_(4) concentration,and leaching time on the vanadium recovery were investigated.A vanadium recovery of 80.66%is obtained at a microwave power of 550 W,leaching temperature of 95℃,CaF_(2) dosage of 5wt%,H_(2)SO_(4) concentration of 20vol%,and leaching time of 2.5 h.Compared with conventional leaching technology,the vanadium recovery increases by 6.18%,and the leaching time shortens by 79.17%.More obvious pulverization of shale particles and delamination of mica minerals happen in the microwave-assisted leaching process.Numerical simulation results show that the temperature of vanadium shales increases with an increase in electric field(E-field).The distributions of E-field and temperature among vanadium shale particles are relatively uniform,except for the higher content at the contact position of the particles.The analysis results of scaleup experiments and leaching experiments indicate high-temperature hot spots in the process of microwave-assisted leaching,and the local high temperature destroys the mineral structure and accelerates the reaction rate.
基金Supported by the National Natural Science Foundation of China(Nos.41406146,41476129)the Natural Science Foundation of Shanghai Municipality(No.13ZR1419300)+1 种基金the Research Fund for the Doctoral Program of Higher Education of China(No.20123104120002)the Shanghai Universities First-Class Disciplines Project-Fisheries(A)
文摘With the increasing effects of global climate change and fishing activities,the spatial distribution of the neon flying squid(Ommastrephes bartramii) is changing in the traditional fishing ground of 150°-160°E and 38°-45°N in the northwest Pacific Ocean.This research aims to identify the spatial hot and cold spots(i.e.spatial clusters) of O.bartramii to reveal its spatial structure using commercial fishery data from2007 to 2010 collected by Chinese mainland squid-j igging fleets.A relatively strongly-clustered distribution for O.bartramii was observed using an exploratory spatial data analysis(ESDA) method.The results show two hot spots and one cold spot in 2007 while only one hot and one cold spots were identified each year from2008 to 2010.The hot and cold spots in 2007 occupied 8.2%and 5.6%of the study area,respectively;these percentages for hot and cold spot areas were 5.8%and 3.1%in 2008,10.2%and 2.9%in 2009,and 16.4%and 11.9%in 2010,respectively.Nearly half(>45%) of the squid from 2007 to 2009 reported by Chinese fleets were caught in hot spot areas while this percentage reached its peak at 68.8%in 2010,indicating that the hot spot areas are central fishing grounds.A further change analysis shows the area centered at156°E/43.5°N was persistent as a hot spot over the whole period from 2007 to 2010.Furthermore,the hot spots were mainly identified in areas with sea surface temperature(SST) in the range of 15-20℃ around warm Kuroshio Currents as well as with the chlorophyll-a(chl-a) concentration above 0.3 mg/m^3.The outcome of this research improves our understanding of spatiotemporal hotspots and its variation for O.bartramii and is useful for sustainable exploitation,assessment,and management of this squid.
文摘Mongolian spots(MS) are congenital birthmarks seen most commonly over the lumbosacral area. They are bluish-green to black in color and oval to irregular in shape. They are most commonly found in individuals of African or Asian ethnic background. Although these lesions resolve by one to two years of age, widespread, extrasacral and dark colored MS sometimes persist into adulthood. Aberrant MS over occiput, temple, mandibular area, shoulders and limbs may be confused with other dermal melanocytoses and bruises secondary to child abuse, thus necessitating documentation at birth. Although traditionally believed to be benign in nature, they have now been shown to co-exist with inborn errors of metabolism, most commonly GM1 gangliosidosis and mucopolysaccharidosis type Ⅰ(Hurler's disease), followed by mucopolysaccharidosis type Ⅱ(Hunter's syndrome), mucolipidosis, Niemann-Pick disease and mannosidosis. They have also been seen to co-exist with various vascular or other pigmented birthmarks like café-au-lait macules. Co-existing Mongolian spots and vascular birthmarks like nevus flammeus, nevus anemicus or nevus spilus is termed as phakomatosis pigmentovascularis. This review focuses on the important associations of Mongolian spots and stresses upon the importance of screening babies with extensive MS.
文摘The surface profile of laser peened stainless steel was researched in this paper,a special lens was used to convert circle laser spot to square spot,the difference of surface profile obtained by laser peening with circle laser spot was compared with that with square laser spot.Laser peened zone showed steep depression at the edge with square spot,but the surface in the shocked zone was very smooth.With suitable overlapped rate,square spot can produce smoother surface profile than circle spot,and laser peening with square spot is more effective than circle spot.
文摘By taking the twelve scenic spots in Ancient Lotus Pond Garden as study objects, they have been introduced and their names have been classified in accordance with allege and symbol nomenclature, linguistic rhetoric nomenclature, narration and description nomenclature, and emotion-endowing and ambition-expressing nomenclature adopted in related articles. Then, the cultural connotations of these scenic spots have been summarized, and Confucian thought and Taoist thought contained in "Surge Including Pavilion" and "High Principle Tower" have been analyzed. The research is aimed at enlightening modern garden workers through illustrating the connotation of the names of scenic spots, so that they can be inspired in the naming process.
文摘Cereal crops, including wheat, barley, oats, rye, etc., are the major sources of calories and proteins for most of the people in the world as well as in China. Cereal rusts and powdery mildews are very important diseases occurred on the cereal crops, which caused yield losses at 5-10% in general and even more than 30% while severe epidemics occurred. In recent years, with the global climate change, change of cultivation system and evolution of the pathogens, the world is facing great challenges caused by cereal diseases.
文摘The Chang-63 reservoir in the Huaqing area has widely developed tight sandstone ＂thick sand layers, but not reservoirs characterized by rich in oil＂, and it is thus necessary to further study its oil and gas enrichment law. This study builds porosity and fracture development and evolution models in different deposition environments, through core observation, casting thin section, SEM, porosity and permeability analysis, burial history analysis, and ＂four-property-relationships＂ analysis.
基金financial support from the National Natural Science Foundation of China(No.40201021)the Zhejiang Natural Science Foundation of China(M403040).
文摘In China, many scenic and tourism areas are suffering from the urbanization that results from physical development of tourism projects, leading to the removal of the vegetative cover, the creation of areas impermeable to water, in-stream modifications, and other problems. In this paper, the risk of soil erosion and its ecological risks in the West Lake Scenic Spots （WLSS） area were quantitatively evaluated by integrating the revised universal soil loss equation （RUSLE） with a digital elevation model （DEM） and geographical information system （GIS） software. The standard RUSLE factors were modified to account for local climatic and topographic characteristics reflected in the DEM maps, and for the soil types and vegetation cover types. An interface was created between the Areinfo software and RUSLE so that the level of soil erosion and its ecological risk in the WLSS area could be mapped immediately once the model factors were defined for the area. The results from an analysis using the Areinfo-RUSLE interface showed that the risk value in 93 % of the expanding western part of the WLSS area was moderate or more severe and the soil erosion risk in this area was thus large compared with that in the rest of the area. This paper mainly aimed to increase the awareness of the soil erosion risk in urbanizing areas and suggest that the local governments should consider the probable ecological risk resulting from soil erosion when enlarging and developing tourism areas.
基金Supported by the National Natural Science Foundation of China,No.82170525Beijing Shijitan Hospital Professionals Training Program,No.2023 LJRCDL.
文摘BACKGROUND Colorectal cancer(CRC)is the third most common cancer worldwide and the second leading cause of cancer-related death.Over the past two decades,numerous researchers have provided important evidence regarding the role of tight junction(TJ)proteins in the occurrence and progression of CRC.The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed.Despite the large number of publications in this field,a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed.AIM To analyze research on TJs and CRC,summarize the field’s history and current status,and predict future research directions.METHODS We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023.We used bibliometrics to analyze the data of these papers,such as the authors,countries,institutions,and references.Co-authorship,co-citation,and co-occurrence analyses were the main methods of analysis.CiteSpace and VOSviewer were used to visualize the results.RESULTS A total of 205 studies were ultimately identified.The number of publications on this topic has steadily increased since 2007.China and the United States have made the largest contributions to this field.Anticancer Research was the most prolific journal,publishing 8 articles,while the journal Oncogene had the highest average citation rate(68.33).Professor Dhawan P was the most prolific and cited author in this field.Co-occurrence analysis of keywords revealed that“tight junction protein expression”,“colorectal cancer”,“intestinal microbiota”,and“inflammatory bowel disease”had the highest frequency of occurrence,revealing the research hotspots and trends in this field.CONCLUSION This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC,providing valuable research perspectives and future directions for studying the connection between the two.It is recommended to focus on emerging research hotspots,such as the correlations among intestinal microbiota,inflammatory bowel disease,TJ protein expression,and CRC.
