In recent years,posttranscriptional cellular processes such as alternative splicing,messenger RNA(mRNA)decay and translational control have emerged as important regulatory layers required for fine-tuning the inflammat...In recent years,posttranscriptional cellular processes such as alternative splicing,messenger RNA(mRNA)decay and translational control have emerged as important regulatory layers required for fine-tuning the inflammatory response in coordination with transcriptional regulation.However,among these posttranscriptional mechanisms,very little is known regarding the role of alternative polyadenylation(APA),a process that generates transcripts with different 3'ends,in modulating gene expression during inflammation.In a paper published on this topic,Chen and coworkers provided evidence indicating that alternative polyadenylation promotes macrophage inflammatory functions by modulating the expression of genes involved in the autophagy pathway[1].展开更多
文摘In recent years,posttranscriptional cellular processes such as alternative splicing,messenger RNA(mRNA)decay and translational control have emerged as important regulatory layers required for fine-tuning the inflammatory response in coordination with transcriptional regulation.However,among these posttranscriptional mechanisms,very little is known regarding the role of alternative polyadenylation(APA),a process that generates transcripts with different 3'ends,in modulating gene expression during inflammation.In a paper published on this topic,Chen and coworkers provided evidence indicating that alternative polyadenylation promotes macrophage inflammatory functions by modulating the expression of genes involved in the autophagy pathway[1].
