A new endophytic antagonistic fungus, Chaetomium spirale ND35 from Populus tomentosa, was reported. The bio-control trials of C. spirale ND35 against the Valsa Canker of apple were preliminarily investigated. The resu...A new endophytic antagonistic fungus, Chaetomium spirale ND35 from Populus tomentosa, was reported. The bio-control trials of C. spirale ND35 against the Valsa Canker of apple were preliminarily investigated. The results of dual culture on PDA plate showed that C. spirale ND35 was capable of strong antagonism against Valsa ceratosperma, and for inhibiting the mycelial growth of V. ceratosperma,.the crude extract of liquid culture of corn steep powder broth was more effective than that one of malt extract broth (MEB). The results of bio-control in greenhouse and field indicated that the disease incidence of apple tree treated with C. spirale ND35 was lower significantly than that treated by other methods. The re-isolation experiment suggested that C. spirale ND35 could colonize in stems and branches of apple trees successfully, and the ND35 colonization rate of the treatment with solid wheat bran culture was higher than that of corn steep powder broth, but the field experiment result the control effect of liquid culture of C. spirale ND35 was better than that of solid culture.展开更多
Three new C_(27)-steroidal glycoalkaloids,spiralosides A–C(1–3),were obtained from the total alkaloids of Solanum spirale by chromatographic methods.On the basis of spectroscopic evidence,spiralosides A–C were eluc...Three new C_(27)-steroidal glycoalkaloids,spiralosides A–C(1–3),were obtained from the total alkaloids of Solanum spirale by chromatographic methods.On the basis of spectroscopic evidence,spiralosides A–C were elucidated as(22R,25S)-22,26-epiminocholest-5-ene-3β,16a-diol-N-acetyl-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl(1),(22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl(2),(22R,25S)-22,26-epiminocholest-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl(3),respectively.The total alkaloids of S.spirale have been screened for their antitussive and expectorant effects in intact animal model.展开更多
Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance....Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance.The results show that when the equivalent diameter of the spiral tube increased from 16.68 to 21.23 mm,its surface heat transfer coefficient decreased from 22,040 to 17,230 W/m^(2)⋅K,and the outlet air temperature dropped from 822.3 to 807.3 K.However,the pressure loss decreased from 2.692 to 0.958 kPa.which reveals the contradiction between the heat transfer efficiency and the flow resistance.By adding a baffle to enhance the turbulent disturbance,the wall heat flux density is increased by 21.17%,the surface heat transfer coefficient is increased by 12.1%,and the outlet temperature is optimized,which verifies the significant improvement of the heat transfer performance by the countercurrent design.Comprehensive research shows that the collaborative optimization of spiral tube equivalent diameter parameters and baffle flow control is the key to improve the comprehensive performance of heat exchanger.Theresearch results provide a theoretical basis for energy-saving design of industrial heat exchangers.展开更多
Early fault detection for spiral bevel gears is crucial to ensure normal operation and prevent accidents.The harmonic components,excited by the time-varying mesh stiffness,always appear in measured vibration signal.Ho...Early fault detection for spiral bevel gears is crucial to ensure normal operation and prevent accidents.The harmonic components,excited by the time-varying mesh stiffness,always appear in measured vibration signal.How to extract the periodical impulses that indicate gear localized fault buried in the intensive noise and interfered by harmonics is a challenging task.In this paper,a novel Periodical Sparse-Assisted Decoupling(PSAD)method is proposed as an optimization problem to extract fault feature from noisy vibration signal.The PSAD method decouples the impulsive fault feature and harmonic components based on the sparse representation method.The sparsity within and across groups property and the periodicity of the fault feature are incorporated into the regularizer as the prior information.The nonconvex penalty is employed to highlight the sparsity of fault features.Meanwhile,the weight factor based on2norm of each group is constructed to strengthen the amplitude of fault feature.An iterative algorithm with Majorization-Minimization(MM)is derived to solve the optimization problem.Simulation study and experimental analysis confirm the performance of the proposed PSAD method in extracting and enhancing defect impulses from noisy signal.The suggested method surpasses other comparative methods in extracting and enhancing fault features.展开更多
Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target.In addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon exposure.To investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with kanamycin.We found that the mice exhibited auditory deficits following the acute loss of outer hair cells.Spiral ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over time.Transcriptomic profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 inflammasome.Activation of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory cytokines.Pharmacological intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury model.These findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron degeneration.Inhibition of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.展开更多
Spiral pile foundations,as a promising type of foundation,are of significant importance for the development of offshore wind energy,particularly as it moves toward deeper waters.This study conducted a physical experim...Spiral pile foundations,as a promising type of foundation,are of significant importance for the development of offshore wind energy,particularly as it moves toward deeper waters.This study conducted a physical experiment on a three-spiral-pile jacket foundation under deep-buried sandy soil conditions.During the experiment,horizontal displacement was applied to the structure to thoroughly investigate the bearing characteristics of the three-spiral-pile jacket foundation.This study also focused on analyzing the bearing mechanisms of conventional piles compared with spiral piles with different numbers of blades.Three different working conditions were set up and compared,and key data,such as the horizontal bearing capacity,pile shaft axial force,and spiral blade soil pressure,were measured and analyzed.The results show the distinct impacts of the spiral blades on the compressed and tensioned sides of the foundation.Specifically,on the compressed side,the spiral blades effectively enhance the restraint of the soil on the pile foundation,whereas on the tensioned side,an excessive number of spiral blades can negatively affect the structural tensile performance to some extent.This study also emphasizes that the addition of blades to the side of a single pile is the most effective method for increasing the bearing capacity of the foundation.This research aims to provide design insights into improving the bearing capacity of the foundation.展开更多
Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF ...Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF envelope forming principle of spiral bevel gears is proposed.Secondly,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement relationships.Thirdly,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel gear.Fourthly,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their interference.Finally,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming equipment.The simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.展开更多
Photoinduced[2+2]cycloaddition of biomass-derived cycloolefin is a promising approach to synthesize high-energy bio-fuels,however,the conversion efficiency and selectivity are still low.Herein,we provide an acid-promo...Photoinduced[2+2]cycloaddition of biomass-derived cycloolefin is a promising approach to synthesize high-energy bio-fuels,however,the conversion efficiency and selectivity are still low.Herein,we provide an acid-promoted photocycloaddition approach to synthesize a new kind of spiral fuel from biomass-derived cyclohexanone (CHOE) and camphene (CPE).BrΦnsted acids show higher catalytic activity than Lewis acids,and acetic acid (HOAc) possesses the best catalytic performance,with CHOE conversion up to 99.1%.Meanwhile,the HOAc-catalytic effect has been confirmed for[2+2]photocycloaddition of other biomass-derived ketenes and olefins.The catalytic mechanism and dynamics have been investigated,and show that HOAc can bond with C=O groups of CHOE to form H–CHOE complex,which leads to higher light adsorption and longer triplet lifetime.Meanwhile,H–CHOE complex reduces the energy gap between CHOE LUMO and CPE HOMO,shortens the distance of ring-forming atoms,and then decreases the energy barrier (from 103.3 kcal mol^(-1)to 95.8 kcal mol^(-1)) of rate-limiting step.After hydrodeoxygenation,the targeted bio-spiral fuel shows high density of 0.992 g cm^(-3),high neat heat of combustion of 41.89 MJ L^(-1),low kinetic viscosity of 5.69 mm^(2)s^(-1)at 20℃,which is very promising to serve as high-performance aerospace fuel.展开更多
During high-speed rotation,the surface of aeronautic spiral bevel gears will generate significant pressure and viscous forces,which will cause a certain amount of windage power loss and reduce the efficiency of the tr...During high-speed rotation,the surface of aeronautic spiral bevel gears will generate significant pressure and viscous forces,which will cause a certain amount of windage power loss and reduce the efficiency of the transmission system.Based on the computational fluid dynamics,this paper analyzes the windage power loss of a single spiral bevel gear and a spiral bevel gear pair under oil injection lubrication.In addition,the shroud is used to suppress gear windage loss,and the clearance size and opening angle of the designed shroud are optimized.Finally,by comparing and analyzing the experimental results,the following conclusions were obtained:(1)For a single gear,the speed is the most important factor affecting windage loss,followed by the hand of spiral,and rotation direction;(2)For gear pairs,under oil injection lubrication,the input speed has the greatest impact on windage power loss,followed by the influence of oil injection port speed,temperature and oil injection port pressure;(3)Installing a shroud is an effective method to reduce windage power loss;(4)In the pure air phase,the smaller the clearance between the shroud and the gear surface,and the smaller the radial direction between the shroud and the shaft,the better the effect of reducing windage;(5)In the two-phase flow of oil and gas,it is necessary to design oil drainage holes on the shroud to ensure the smooth discharge of lubricating oil and improve the drag reduction effect.展开更多
1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出...1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出。行为测听:左侧听力正常,右侧极重度感音神经性听力下降。耳声发射(OAE):左侧正常,右侧全频未引出。展开更多
Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of curr...Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.展开更多
Spiral galaxies are the most common type of galaxies in the universe,and most spiral galaxies contain a supermassive black hole in their center.However,thus far,the formation of spiral galaxies is still not fully unde...Spiral galaxies are the most common type of galaxies in the universe,and most spiral galaxies contain a supermassive black hole in their center.However,thus far,the formation of spiral galaxies is still not fully understood,and especially,what determines the number of spiral arms is still an open question as well.Here,inspired by fascinating spiral galaxies,we demonstrate that such a spiral-galaxy-shaped optical field can be generated by interference of a vortex wave and a trumpet wave.Interestingly,we show it is the topological charge of the vortex wave that determines the number of spiral arms in our model.展开更多
Heating,ventilation,and air conditioning(HVAC)systems contribute substantially to global energy consumption,while rejecting significant amounts of low-grade heat into the environment.This paper presents a nonintrusive...Heating,ventilation,and air conditioning(HVAC)systems contribute substantially to global energy consumption,while rejecting significant amounts of low-grade heat into the environment.This paper presents a nonintrusive spiral-coil heat exchanger designed to recover waste heat from the outdoor condenser of a split-type air conditioner.The system operates externally without altering the existing HVAC configuration,thereby rendering it suitable for retrofitting.Water was circulated as the working fluid at flow rates of 0.028–0.052 kg/s to assess thermal performance.Performance indicators,including the outlet water temperature,heat transfer rate,convective coefficient,and efficiency,were systematically evaluated.The system achieved a maximum outlet water temperature of 67℃and a peak thermal efficiency of 91.07%at the highest flow rate.The uncertainty analysis confirmed reliable measurements within±3.45%.The monthly energy savings were estimated at 178.35 kWh,accompanied by a reduction in CO_(2)emissions of up to 187.26 kg,yielding a short payback period of 1.06 years.These results demonstrate the feasibility of spiral-coil heat exchangers as cost-effective and eco-friendly alternatives to conventional electric water heaters.The proposed approach not only enhances the overall energy utilization but also contributes to energy conservation and climate mitigation objectives.展开更多
In this paper,a 4×4 wideband linearly po-larization(LP)antenna array is proposed by using pla-nar dual-arm spiral structures.Wideband balun struc-tures,composed of microstrip line-fed coupling slots,are adopted t...In this paper,a 4×4 wideband linearly po-larization(LP)antenna array is proposed by using pla-nar dual-arm spiral structures.Wideband balun struc-tures,composed of microstrip line-fed coupling slots,are adopted to feed two dual-arms spiral structures with opposite phases.Then,by combining the left-and right-hand circular polarizations,a linearly polar-ization is achieved.The proposed antenna has a wide operating bandwidth due to the wideband nature of the spiral structure.Simulated results show that the an-tenna element can achieve a 68.73%impedance band-width and a maximum gain of 6.64 dBi within 19.44–38.83 GHz.A 4×4 array prototype is designed to verify the concept.Measured results show that an impedance bandwidth of 63.73%is obtained.The pro-posed array has the merits of a wide bandwidth,a low profile,a low cost,and a small size,which is promis-ing for the application in millimeter wave wireless sys-tems.展开更多
Objective:This study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses(AAVs)carrying Ch R2(H134R)to explore...Objective:This study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses(AAVs)carrying Ch R2(H134R)to explore the potential of cochlear optogenetics as a hearing restoration technology.Methods:Healthy adult guinea pigs were used in the experiments.The viral vector AAV2/8-Ch R2(H134R)-h Syn-e YFP was administered to the right cochlea via the round window membrane.The confocal microscopy and reverse transcription polymerase chain reaction(RT-PCR)were utilized to analyze the Ch R2(H134R)expression localized to spiral ganglion neurons(SGNs).The auditory pathway activation was assessed by recording the optical compound action potential(oCAP)and acoustic compound action potential(a CAP)at various laser intensities.Results:The Ch R2(H134R)-e YFP expression was confirmed in 90%of the tested animals,localized to the SGNs of the injected ear.Higher m RNA levels of Ch R2(H134R)and e YFP were observed in the injected ear compared to the non-injected ear,while actin(Actb)m RNA levels were not significantly different.The o CAP was successfully elicited by a 470 nm blue light laser stimulus,with similar amplitudes and latency periods to those of a CAPs when the o CAP was evoked by 5.80 m W blue light and the a CAP was evoked by a 40 d B SPL click.The amplitudes of o CAPs increased with increasing laser intensity.Conclusion:This study demonstrates the viability of optogenetic activation of the auditory system in adult guinea pigs through the transduction of AAV-Ch R2(H134R)in SGNs.Cochlear optogenetics demonstrates potential as a hearing restoration technology,providing a basis for further clinical research and opening new avenues for investigation.展开更多
BACKGROUND In postsurgical upper gastrointestinal anatomy,motorized spiral enteroscopy(MSE)assisted endoscopic retrograde cholangiopancreaticography(ERCP)was shown feasible and has the advantage that standard ERCP ins...BACKGROUND In postsurgical upper gastrointestinal anatomy,motorized spiral enteroscopy(MSE)assisted endoscopic retrograde cholangiopancreaticography(ERCP)was shown feasible and has the advantage that standard ERCP instruments can be used.Therefore,MSE-ERCP appears to be the optimal solution for postsurgical patients,especially with Roux-en-Y anatomy.AIM To show feasibility and safety of MSE-ERCP in patients with Roux-en-Y anatomy.METHODS We retrospectively analyzed all consecutive MSE-ERCP procedures in patients with Roux-en-Y anatomy between September 2021 and May 2023 in an endoscopic tertiary referral center.RESULTS We identified 26 MSE-ERCPs:(1)18 MSE-ERCPs in 13 patients with Roux-en-Y anatomy after liver transplantation(n=11)or gastrectomy(n=2);and(2)Another 8 MSE-ERCP interventions in 5 patients with very long Roux-en-Y situation after gastric bypass.Overall success of reaching the biliary entry was 88%and further interventions were successful in 83%of patients.In very long alimentary limb situations,success of reaching the biliary entry was not-significantly lower compared to“standard”Roux-en-Y(75%vs 94%,P=0.215).ERCP-interventions were not-significantly less successful in patients with native papilla compared to hepaticojejunostomy(63%vs 93%,P=0.103).Mean intervention time was 105 minutes.Intervention times were longer in very long limb situations(133 minutes vs 91 minutes;P=0.032).Overall,we observed three adverse events(n=1 caused by enteroscopy,n=1 caused by the biliary intervention,n=1 unrelated to the procedure).In 15/26 cases(58%)MSE-ERCP was carried out on an outpatient basis.CONCLUSION MSE-ERCP has been a promising technique for patients with Roux-en-Y reconstruction requiring biliary interventions.However,MSE was recently withdrawn from the market due to severe safety concerns,which were not observed in this study.展开更多
To achieve high-precision trajectory following during helicopter maneuver tasks and reduce the disruptive influences of unknown variabilities,this study introduces a cascaded-loop helicopter trajectory tracking contro...To achieve high-precision trajectory following during helicopter maneuver tasks and reduce the disruptive influences of unknown variabilities,this study introduces a cascaded-loop helicopter trajectory tracking controller,whose parameters are set using an Ant Colony OptimizationSlime Mould Algorithm(ACO-SMA).Initially,a nonlinear flight dynamics model of the helicopter is constructed.Observer gain functions and nonlinear feedback from a vibrational suppression function to improve the tracking performance of the controller,addressing issues in disturbance estimation and compensation of the Active Disturbance Rejection Control(ADRC).Simultaneously,a cascaded loop system,comprising an internal attitude loop and an external position loop,is created,and the ant colony-slime mold hybrid algorithm optimizes the system parameters of the trajectory tracking controller.Finally,helicopter trajectory tracking simulation experiments are conducted,including spiral ascending and“8”shape climbing maneuvers.The findings indicate that the ADRC employed for helicopter trajectory tracking exhibits outstanding performance in rejecting disturbances caused by gusts and accurately tracking trajectories.The trajectory tracking controller,whose parameters are optimized by the ACO-SMA,shows higher tracking precision compared to the conventional PID and ADRC,thereby substantially improving the precision of maneuver tasks.展开更多
Spiral waves,as a typical self-organized structure with chiral characteristics,are widely found in excitable media such as cardiac tissues,chemical reactions,and neural networks.Based on the Fitz Hugh–Nagumo model,we...Spiral waves,as a typical self-organized structure with chiral characteristics,are widely found in excitable media such as cardiac tissues,chemical reactions,and neural networks.Based on the Fitz Hugh–Nagumo model,we investigated the mechanisms underlying the effects of direct current electric fields(DCEF),alternating current electric fields(ACEF),and polarized electric fields(PEF)on the interaction and annihilation processes of counter-rotating spiral waves.We found that in a direct current electric field,the drift direction of the spiral wave is determined jointly by its chirality and the electric field direction,which allows selective attraction or repulsion.In an alternating current electric field,the annihilation behavior of spiral waves can be influenced by the phase and intensity of the electric field,where a specific range of parameters induces resonance drift and eventual annihilation.On the other hand,the polarized electric field exhibits a more complex modulation capability on spiral waves:the trajectory and annihilation efficiency of spiral waves can be regulated by both the intensity and phase of the polarized electric field.These results reveal the potential feasibility of regulating multichiral spiral waves through multiple electric fields,providing theoretical insight for the control of spiral waves in relevant systems.展开更多
Under the dual-carbon background,the technological updating of traditional high-energy-consuming equipment should not be delayed,and the problem of reactor energy consumption should not be ignored.Therefore,this study...Under the dual-carbon background,the technological updating of traditional high-energy-consuming equipment should not be delayed,and the problem of reactor energy consumption should not be ignored.Therefore,this study is based on computational fluid dynamics(CFD)theory to simulate the spiral stirred reactor with different design parameters(distance of paddle from bottom surface to reactor height ratio h1/H,diameter of stirring paddle to reactor diameter ratio Ds/D,length of blade section to reactor height ratio Ls/H).It was found that the reactor designed with lower Ls/H values and higher h1/H,Ds/D values would have smaller power number(Np)values and smaller flow field average velocity.In addition,this study also fitted the correlation equation of Np concerning Reynolds number and h1/H,Ds/D,and Ls/H,and the conclusions of the study can be used as a reference for the design of industrial equipment.展开更多
We have analyzed magnetic order in the one-dimensional Kondo lattice with classical localized spins.To identify relevant low-energy configurations,we combine the exact diagonalization of the electronic system with a d...We have analyzed magnetic order in the one-dimensional Kondo lattice with classical localized spins.To identify relevant low-energy configurations,we combine the exact diagonalization of the electronic system with a dissipative evolution,described by the Landau–Lifshitz-Gilbert equation.We find that spiral states always relax into a more complex form of noncollinear order,characterized by a periodic modulation of the relative angles between neighboring spins.A finite-size scaling analysis shows that the amplitude of the modulation and the gain in free energy remain finite in the thermodynamic limit.Importantly,the wavelength of the modulation is determined by the Fermi wavevector of the unperturbed spiral.This suggests that complex noncollinear order originates from an instability of the unperturbed spirals,which,in the presence of a weak pairing term,may hinder topological superconductivity.Our final phase diagram is obtained by comparing the modulated spiral states with various complex collinear configurations proposed in the literature.展开更多
基金This research was supported by National Natural Science Foundation of China (Grant No. 30100143)
文摘A new endophytic antagonistic fungus, Chaetomium spirale ND35 from Populus tomentosa, was reported. The bio-control trials of C. spirale ND35 against the Valsa Canker of apple were preliminarily investigated. The results of dual culture on PDA plate showed that C. spirale ND35 was capable of strong antagonism against Valsa ceratosperma, and for inhibiting the mycelial growth of V. ceratosperma,.the crude extract of liquid culture of corn steep powder broth was more effective than that one of malt extract broth (MEB). The results of bio-control in greenhouse and field indicated that the disease incidence of apple tree treated with C. spirale ND35 was lower significantly than that treated by other methods. The re-isolation experiment suggested that C. spirale ND35 could colonize in stems and branches of apple trees successfully, and the ND35 colonization rate of the treatment with solid wheat bran culture was higher than that of corn steep powder broth, but the field experiment result the control effect of liquid culture of C. spirale ND35 was better than that of solid culture.
基金The authors are grateful to the Natural Science Foundation of China(81225024)to the analytical group of the Laboratory of Phytochemistry,Kunming Institute of Botany for spectral measurements.
文摘Three new C_(27)-steroidal glycoalkaloids,spiralosides A–C(1–3),were obtained from the total alkaloids of Solanum spirale by chromatographic methods.On the basis of spectroscopic evidence,spiralosides A–C were elucidated as(22R,25S)-22,26-epiminocholest-5-ene-3β,16a-diol-N-acetyl-3-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl(1),(22R,25S)-22,26-epiminocholest-5-ene-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl(2),(22R,25S)-22,26-epiminocholest-3β,16α-diol-N-acetyl-3-O-β-D-glucopyranosyl(3),respectively.The total alkaloids of S.spirale have been screened for their antitussive and expectorant effects in intact animal model.
基金supported by the Jing-Jin-Ji Regional Integrated Environmental Improvement-National Science and Technology Major Project(No.2024ZD1200400).
文摘Based on the Fluent numerical simulation method,this study systematically analyzed the structural parameters of the spiral tube heat exchanger and the influence of the external baffle on its heat transfer performance.The results show that when the equivalent diameter of the spiral tube increased from 16.68 to 21.23 mm,its surface heat transfer coefficient decreased from 22,040 to 17,230 W/m^(2)⋅K,and the outlet air temperature dropped from 822.3 to 807.3 K.However,the pressure loss decreased from 2.692 to 0.958 kPa.which reveals the contradiction between the heat transfer efficiency and the flow resistance.By adding a baffle to enhance the turbulent disturbance,the wall heat flux density is increased by 21.17%,the surface heat transfer coefficient is increased by 12.1%,and the outlet temperature is optimized,which verifies the significant improvement of the heat transfer performance by the countercurrent design.Comprehensive research shows that the collaborative optimization of spiral tube equivalent diameter parameters and baffle flow control is the key to improve the comprehensive performance of heat exchanger.Theresearch results provide a theoretical basis for energy-saving design of industrial heat exchangers.
基金supported by the National Science Foundationof China(Nos.52305127 and 52475130)。
文摘Early fault detection for spiral bevel gears is crucial to ensure normal operation and prevent accidents.The harmonic components,excited by the time-varying mesh stiffness,always appear in measured vibration signal.How to extract the periodical impulses that indicate gear localized fault buried in the intensive noise and interfered by harmonics is a challenging task.In this paper,a novel Periodical Sparse-Assisted Decoupling(PSAD)method is proposed as an optimization problem to extract fault feature from noisy vibration signal.The PSAD method decouples the impulsive fault feature and harmonic components based on the sparse representation method.The sparsity within and across groups property and the periodicity of the fault feature are incorporated into the regularizer as the prior information.The nonconvex penalty is employed to highlight the sparsity of fault features.Meanwhile,the weight factor based on2norm of each group is constructed to strengthen the amplitude of fault feature.An iterative algorithm with Majorization-Minimization(MM)is derived to solve the optimization problem.Simulation study and experimental analysis confirm the performance of the proposed PSAD method in extracting and enhancing defect impulses from noisy signal.The suggested method surpasses other comparative methods in extracting and enhancing fault features.
基金supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW)the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).
文摘Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target.In addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon exposure.To investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with kanamycin.We found that the mice exhibited auditory deficits following the acute loss of outer hair cells.Spiral ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over time.Transcriptomic profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 inflammasome.Activation of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory cytokines.Pharmacological intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury model.These findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron degeneration.Inhibition of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.
基金The National Natural Science Foundation of China(No.52171274).
文摘Spiral pile foundations,as a promising type of foundation,are of significant importance for the development of offshore wind energy,particularly as it moves toward deeper waters.This study conducted a physical experiment on a three-spiral-pile jacket foundation under deep-buried sandy soil conditions.During the experiment,horizontal displacement was applied to the structure to thoroughly investigate the bearing characteristics of the three-spiral-pile jacket foundation.This study also focused on analyzing the bearing mechanisms of conventional piles compared with spiral piles with different numbers of blades.Three different working conditions were set up and compared,and key data,such as the horizontal bearing capacity,pile shaft axial force,and spiral blade soil pressure,were measured and analyzed.The results show the distinct impacts of the spiral blades on the compressed and tensioned sides of the foundation.Specifically,on the compressed side,the spiral blades effectively enhance the restraint of the soil on the pile foundation,whereas on the tensioned side,an excessive number of spiral blades can negatively affect the structural tensile performance to some extent.This study also emphasizes that the addition of blades to the side of a single pile is the most effective method for increasing the bearing capacity of the foundation.This research aims to provide design insights into improving the bearing capacity of the foundation.
基金the National Science and Technology Major Project of China(No.2019-VII0017e0158)the National Natural Science Foundation of China(No.U21A20131)+1 种基金the Industry-University Research Cooperation Project,China(No.HFZL2020CXY025)the National Key Laboratory of Science and Technology on Helicopter Transmission,China(No.HTL-O-21G05).
文摘Spiral bevel gears are critical transmission components,and are widely used in the aerospace field.This paper proposes a new multi-DOF envelope forming process for fabricating spiral bevel gears.Firstly,the multi-DOF envelope forming principle of spiral bevel gears is proposed.Secondly,the design methods for the envelope tool geometry and movement are proposed based on the envelope geometry and movement relationships.Thirdly,the metal flow and tooth filling laws are revealed through 3D FE simulation of the multi-DOF envelope forming process of a typical spiral bevel gear.Fourthly,a new method for separating the envelope tool and the formed spiral bevel gear with back taper tooth is proposed to avoid their interference.Finally,experiments on multi-DOF envelope forming of this typical spiral bevel gear are conducted using new heavy load multi-DOF envelope forming equipment.The simulation and experimental results show the feasibility of the proposed multi-DOF envelope forming process for fabricating spiral bevel gears with back taper tooth and the corresponding process design methods.
基金the support from National Key R&D Program of China (2021YFC2103704)the National Natural Science Foundation of China (22222808)+4 种基金the Natural Science Foundation of Shandong Province (ZR2023QB152)the Youth Innovation Team Plan of Shandong Province (2022KJ270)the China National Postdoctoral Program for Innovative Talents (BX20240251)the Aeronautical Science Foundation of China (2023Z073048003)the Haihe Laboratory of Sustainable Chemical Transformations。
文摘Photoinduced[2+2]cycloaddition of biomass-derived cycloolefin is a promising approach to synthesize high-energy bio-fuels,however,the conversion efficiency and selectivity are still low.Herein,we provide an acid-promoted photocycloaddition approach to synthesize a new kind of spiral fuel from biomass-derived cyclohexanone (CHOE) and camphene (CPE).BrΦnsted acids show higher catalytic activity than Lewis acids,and acetic acid (HOAc) possesses the best catalytic performance,with CHOE conversion up to 99.1%.Meanwhile,the HOAc-catalytic effect has been confirmed for[2+2]photocycloaddition of other biomass-derived ketenes and olefins.The catalytic mechanism and dynamics have been investigated,and show that HOAc can bond with C=O groups of CHOE to form H–CHOE complex,which leads to higher light adsorption and longer triplet lifetime.Meanwhile,H–CHOE complex reduces the energy gap between CHOE LUMO and CPE HOMO,shortens the distance of ring-forming atoms,and then decreases the energy barrier (from 103.3 kcal mol^(-1)to 95.8 kcal mol^(-1)) of rate-limiting step.After hydrodeoxygenation,the targeted bio-spiral fuel shows high density of 0.992 g cm^(-3),high neat heat of combustion of 41.89 MJ L^(-1),low kinetic viscosity of 5.69 mm^(2)s^(-1)at 20℃,which is very promising to serve as high-performance aerospace fuel.
基金Supported by National Natural Science Foundation of China(Grant Nos.51175422,61973011)Shaanxi Provincial Natural Science Basic Research Plan of China(Grant No.2022JM-195)+1 种基金Fundamental Research Funds for the Central Universities of Chinathe Research Start-up Funds of Hangzhou International Innovation Institute of Beihang University(Grant No.2024KQ036)。
文摘During high-speed rotation,the surface of aeronautic spiral bevel gears will generate significant pressure and viscous forces,which will cause a certain amount of windage power loss and reduce the efficiency of the transmission system.Based on the computational fluid dynamics,this paper analyzes the windage power loss of a single spiral bevel gear and a spiral bevel gear pair under oil injection lubrication.In addition,the shroud is used to suppress gear windage loss,and the clearance size and opening angle of the designed shroud are optimized.Finally,by comparing and analyzing the experimental results,the following conclusions were obtained:(1)For a single gear,the speed is the most important factor affecting windage loss,followed by the hand of spiral,and rotation direction;(2)For gear pairs,under oil injection lubrication,the input speed has the greatest impact on windage power loss,followed by the influence of oil injection port speed,temperature and oil injection port pressure;(3)Installing a shroud is an effective method to reduce windage power loss;(4)In the pure air phase,the smaller the clearance between the shroud and the gear surface,and the smaller the radial direction between the shroud and the shaft,the better the effect of reducing windage;(5)In the two-phase flow of oil and gas,it is necessary to design oil drainage holes on the shroud to ensure the smooth discharge of lubricating oil and improve the drag reduction effect.
文摘1临床资料患儿,女,3岁,主因“发现右耳听力差3年”就诊。家长3年前发现患儿右耳听力差,站于右侧呼唤患儿反应迟钝,说话发声及面部表情正常。体格检查:双侧耳廓及外耳道未见明显异常。声导抗:双耳A型。声反射:左侧90 dB SPL,右侧未引出。行为测听:左侧听力正常,右侧极重度感音神经性听力下降。耳声发射(OAE):左侧正常,右侧全频未引出。
文摘Optical field manipulation,an emerging frontier in photonics,demonstrates significant potential in biomedical microscopy,quantum state engineering,and micro-nano fabrication.To address the critical limitations of current optical modulation technologies in achieving full-parameter precision control,we proposed a novel approach for dynamic azimuthal optical field modulation based on dual-spiral arrays.By designing spatially interleaved spiral structures with different initial radii while maintaining identical periodic parameters,we achieved continuous optical modulation spanning the full 0-2πrange in azimuthal field distribution.Through rigorous numerical simulations,we systematically established a quantitative correlation between the structural parameters and azimuthal optical field patterns,revealing,for the first time,a quasi-linear relationship between the radius difference and the resultant optical distribution.This theoretical framework advances our fundamental understanding of structured optical field manipulation as well as provides a new paradigm for programmable photonic device design,with distinct technical advantages in super-resolution imaging and optical tweezer systems.
基金National Natural Science Foundation of China(12174047,12574353)。
文摘Spiral galaxies are the most common type of galaxies in the universe,and most spiral galaxies contain a supermassive black hole in their center.However,thus far,the formation of spiral galaxies is still not fully understood,and especially,what determines the number of spiral arms is still an open question as well.Here,inspired by fascinating spiral galaxies,we demonstrate that such a spiral-galaxy-shaped optical field can be generated by interference of a vortex wave and a trumpet wave.Interestingly,we show it is the topological charge of the vortex wave that determines the number of spiral arms in our model.
文摘Heating,ventilation,and air conditioning(HVAC)systems contribute substantially to global energy consumption,while rejecting significant amounts of low-grade heat into the environment.This paper presents a nonintrusive spiral-coil heat exchanger designed to recover waste heat from the outdoor condenser of a split-type air conditioner.The system operates externally without altering the existing HVAC configuration,thereby rendering it suitable for retrofitting.Water was circulated as the working fluid at flow rates of 0.028–0.052 kg/s to assess thermal performance.Performance indicators,including the outlet water temperature,heat transfer rate,convective coefficient,and efficiency,were systematically evaluated.The system achieved a maximum outlet water temperature of 67℃and a peak thermal efficiency of 91.07%at the highest flow rate.The uncertainty analysis confirmed reliable measurements within±3.45%.The monthly energy savings were estimated at 178.35 kWh,accompanied by a reduction in CO_(2)emissions of up to 187.26 kg,yielding a short payback period of 1.06 years.These results demonstrate the feasibility of spiral-coil heat exchangers as cost-effective and eco-friendly alternatives to conventional electric water heaters.The proposed approach not only enhances the overall energy utilization but also contributes to energy conservation and climate mitigation objectives.
基金supported in part by the National Natural Science Foundation of China under Grant 62131008the Fundamental Research Funds for the Central Universities 2242022k60003.
文摘In this paper,a 4×4 wideband linearly po-larization(LP)antenna array is proposed by using pla-nar dual-arm spiral structures.Wideband balun struc-tures,composed of microstrip line-fed coupling slots,are adopted to feed two dual-arms spiral structures with opposite phases.Then,by combining the left-and right-hand circular polarizations,a linearly polar-ization is achieved.The proposed antenna has a wide operating bandwidth due to the wideband nature of the spiral structure.Simulated results show that the an-tenna element can achieve a 68.73%impedance band-width and a maximum gain of 6.64 dBi within 19.44–38.83 GHz.A 4×4 array prototype is designed to verify the concept.Measured results show that an impedance bandwidth of 63.73%is obtained.The pro-posed array has the merits of a wide bandwidth,a low profile,a low cost,and a small size,which is promis-ing for the application in millimeter wave wireless sys-tems.
基金supported by the Beijing Natural Science Foundation of China under Grant 7222185。
文摘Objective:This study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses(AAVs)carrying Ch R2(H134R)to explore the potential of cochlear optogenetics as a hearing restoration technology.Methods:Healthy adult guinea pigs were used in the experiments.The viral vector AAV2/8-Ch R2(H134R)-h Syn-e YFP was administered to the right cochlea via the round window membrane.The confocal microscopy and reverse transcription polymerase chain reaction(RT-PCR)were utilized to analyze the Ch R2(H134R)expression localized to spiral ganglion neurons(SGNs).The auditory pathway activation was assessed by recording the optical compound action potential(oCAP)and acoustic compound action potential(a CAP)at various laser intensities.Results:The Ch R2(H134R)-e YFP expression was confirmed in 90%of the tested animals,localized to the SGNs of the injected ear.Higher m RNA levels of Ch R2(H134R)and e YFP were observed in the injected ear compared to the non-injected ear,while actin(Actb)m RNA levels were not significantly different.The o CAP was successfully elicited by a 470 nm blue light laser stimulus,with similar amplitudes and latency periods to those of a CAPs when the o CAP was evoked by 5.80 m W blue light and the a CAP was evoked by a 40 d B SPL click.The amplitudes of o CAPs increased with increasing laser intensity.Conclusion:This study demonstrates the viability of optogenetic activation of the auditory system in adult guinea pigs through the transduction of AAV-Ch R2(H134R)in SGNs.Cochlear optogenetics demonstrates potential as a hearing restoration technology,providing a basis for further clinical research and opening new avenues for investigation.
文摘BACKGROUND In postsurgical upper gastrointestinal anatomy,motorized spiral enteroscopy(MSE)assisted endoscopic retrograde cholangiopancreaticography(ERCP)was shown feasible and has the advantage that standard ERCP instruments can be used.Therefore,MSE-ERCP appears to be the optimal solution for postsurgical patients,especially with Roux-en-Y anatomy.AIM To show feasibility and safety of MSE-ERCP in patients with Roux-en-Y anatomy.METHODS We retrospectively analyzed all consecutive MSE-ERCP procedures in patients with Roux-en-Y anatomy between September 2021 and May 2023 in an endoscopic tertiary referral center.RESULTS We identified 26 MSE-ERCPs:(1)18 MSE-ERCPs in 13 patients with Roux-en-Y anatomy after liver transplantation(n=11)or gastrectomy(n=2);and(2)Another 8 MSE-ERCP interventions in 5 patients with very long Roux-en-Y situation after gastric bypass.Overall success of reaching the biliary entry was 88%and further interventions were successful in 83%of patients.In very long alimentary limb situations,success of reaching the biliary entry was not-significantly lower compared to“standard”Roux-en-Y(75%vs 94%,P=0.215).ERCP-interventions were not-significantly less successful in patients with native papilla compared to hepaticojejunostomy(63%vs 93%,P=0.103).Mean intervention time was 105 minutes.Intervention times were longer in very long limb situations(133 minutes vs 91 minutes;P=0.032).Overall,we observed three adverse events(n=1 caused by enteroscopy,n=1 caused by the biliary intervention,n=1 unrelated to the procedure).In 15/26 cases(58%)MSE-ERCP was carried out on an outpatient basis.CONCLUSION MSE-ERCP has been a promising technique for patients with Roux-en-Y reconstruction requiring biliary interventions.However,MSE was recently withdrawn from the market due to severe safety concerns,which were not observed in this study.
基金support of the National Natural Science Foundation of China(No.12032012)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China。
文摘To achieve high-precision trajectory following during helicopter maneuver tasks and reduce the disruptive influences of unknown variabilities,this study introduces a cascaded-loop helicopter trajectory tracking controller,whose parameters are set using an Ant Colony OptimizationSlime Mould Algorithm(ACO-SMA).Initially,a nonlinear flight dynamics model of the helicopter is constructed.Observer gain functions and nonlinear feedback from a vibrational suppression function to improve the tracking performance of the controller,addressing issues in disturbance estimation and compensation of the Active Disturbance Rejection Control(ADRC).Simultaneously,a cascaded loop system,comprising an internal attitude loop and an external position loop,is created,and the ant colony-slime mold hybrid algorithm optimizes the system parameters of the trajectory tracking controller.Finally,helicopter trajectory tracking simulation experiments are conducted,including spiral ascending and“8”shape climbing maneuvers.The findings indicate that the ADRC employed for helicopter trajectory tracking exhibits outstanding performance in rejecting disturbances caused by gusts and accurately tracking trajectories.The trajectory tracking controller,whose parameters are optimized by the ACO-SMA,shows higher tracking precision compared to the conventional PID and ADRC,thereby substantially improving the precision of maneuver tasks.
基金supported by the National Natural Science Foundation of China(Grant No.12175080)by Self-Determined Research Funds of Central China Normal University from the Colleges’Basic Research and Operation of MOE(Grant No.CCNU25JC012)。
文摘Spiral waves,as a typical self-organized structure with chiral characteristics,are widely found in excitable media such as cardiac tissues,chemical reactions,and neural networks.Based on the Fitz Hugh–Nagumo model,we investigated the mechanisms underlying the effects of direct current electric fields(DCEF),alternating current electric fields(ACEF),and polarized electric fields(PEF)on the interaction and annihilation processes of counter-rotating spiral waves.We found that in a direct current electric field,the drift direction of the spiral wave is determined jointly by its chirality and the electric field direction,which allows selective attraction or repulsion.In an alternating current electric field,the annihilation behavior of spiral waves can be influenced by the phase and intensity of the electric field,where a specific range of parameters induces resonance drift and eventual annihilation.On the other hand,the polarized electric field exhibits a more complex modulation capability on spiral waves:the trajectory and annihilation efficiency of spiral waves can be regulated by both the intensity and phase of the polarized electric field.These results reveal the potential feasibility of regulating multichiral spiral waves through multiple electric fields,providing theoretical insight for the control of spiral waves in relevant systems.
基金supported by the Natural Science Foundation of Shandong Province(ZR2023ZD22)the Major Research and Development Program of Shandong Province(2023CXGC010601).
文摘Under the dual-carbon background,the technological updating of traditional high-energy-consuming equipment should not be delayed,and the problem of reactor energy consumption should not be ignored.Therefore,this study is based on computational fluid dynamics(CFD)theory to simulate the spiral stirred reactor with different design parameters(distance of paddle from bottom surface to reactor height ratio h1/H,diameter of stirring paddle to reactor diameter ratio Ds/D,length of blade section to reactor height ratio Ls/H).It was found that the reactor designed with lower Ls/H values and higher h1/H,Ds/D values would have smaller power number(Np)values and smaller flow field average velocity.In addition,this study also fitted the correlation equation of Np concerning Reynolds number and h1/H,Ds/D,and Ls/H,and the conclusions of the study can be used as a reference for the design of industrial equipment.
基金support from the Innovation Program for Quantum Science and Technology under Grant No.2021ZD0301602the National Science Association Funds under Grant No.U2230402+2 种基金supported by FCT-Portugal(PR)the Quant ERA II project‘DQUANT:A Dissipative Quantum Chaos perspective on Near-Term Quantum Computing’via Grant Agreement No.101017733support from FCTPortugal through Grant No.UID/CTM/04540/2020。
文摘We have analyzed magnetic order in the one-dimensional Kondo lattice with classical localized spins.To identify relevant low-energy configurations,we combine the exact diagonalization of the electronic system with a dissipative evolution,described by the Landau–Lifshitz-Gilbert equation.We find that spiral states always relax into a more complex form of noncollinear order,characterized by a periodic modulation of the relative angles between neighboring spins.A finite-size scaling analysis shows that the amplitude of the modulation and the gain in free energy remain finite in the thermodynamic limit.Importantly,the wavelength of the modulation is determined by the Fermi wavevector of the unperturbed spiral.This suggests that complex noncollinear order originates from an instability of the unperturbed spirals,which,in the presence of a weak pairing term,may hinder topological superconductivity.Our final phase diagram is obtained by comparing the modulated spiral states with various complex collinear configurations proposed in the literature.
