Dear Editor,The intervertebral disc(IVD)is a crucial fibrocartilaginous structure that connects adjacent vertebrae.It plays a fundamental role in maintaining spinal stability and absorbing mechanical stress.Each disc ...Dear Editor,The intervertebral disc(IVD)is a crucial fibrocartilaginous structure that connects adjacent vertebrae.It plays a fundamental role in maintaining spinal stability and absorbing mechanical stress.Each disc is composed of three parts:the inner nucleus pulposus(NP),the outer annulus fibrosus(AF),and the superior and inferior cartilage endplates(CEPs).Degeneration of IVDs is a primary contributor to various spinal disorders,such as cervical spondylosis,low back pain,and lumbar disc herniation,all of which lead to a significant reduction in the quality of life of patients and impose a substantial economic burden.In China,IVD degeneration(IVDD)is the third most common chronic disease following hypertension and diabetes,highlighting the widespread impact of IVDD on public health.1 Non-degenerated adult IVDs are devoid of a vascular system within。展开更多
基金supported by the National Natural Science Foundation of China,China(82472505,82472498,82272549,82072488,82102620,and 82170255)the National Key Research and Development plan,Ministry of Science and Technology of the People’s Republic of China(2022YFC2407203)+2 种基金the Young Health Talents of Shanghai Municipal Health Commission,China(2022YQ011)the China Medical Education Association(2023-020)and the Youth Talent Project of Huashan Hospital(30302164006).
文摘Dear Editor,The intervertebral disc(IVD)is a crucial fibrocartilaginous structure that connects adjacent vertebrae.It plays a fundamental role in maintaining spinal stability and absorbing mechanical stress.Each disc is composed of three parts:the inner nucleus pulposus(NP),the outer annulus fibrosus(AF),and the superior and inferior cartilage endplates(CEPs).Degeneration of IVDs is a primary contributor to various spinal disorders,such as cervical spondylosis,low back pain,and lumbar disc herniation,all of which lead to a significant reduction in the quality of life of patients and impose a substantial economic burden.In China,IVD degeneration(IVDD)is the third most common chronic disease following hypertension and diabetes,highlighting the widespread impact of IVDD on public health.1 Non-degenerated adult IVDs are devoid of a vascular system within。
