The contrast agent concentration, the time of repetition (TR) and magnetic field strength are significant parameters that influence for the accurate signal intensity (SI) in quantitative Magnetic Resonance Imaging (MR...The contrast agent concentration, the time of repetition (TR) and magnetic field strength are significant parameters that influence for the accurate signal intensity (SI) in quantitative Magnetic Resonance Imaging (MRI). Therefore, this study was conducted to investigate and refine the dependence and the optimal effect of Time of Repetition (TR) on the relationship between signal intensity and Gd-DTPA (Gadolinium-diethylene-triaminepenta-acetic acid) concentration, after applying two-dimensional (2D) Spin Echo (SE) pulse sequence under low-field MRI. In addition to that, the optimal concentration of Gd-DTPA at given sequence parameters at low-field MRI was also evaluated. A water-filled phantom was constructed for a range of Gd-DTPA concentrations (0 - 6 mmol/L) and the mean signal intensities (SIs) were assessed in the defined region of interest on T1-weighted images with different TR values (40 - 2000 ms). The generated signal-concentration curves for Gd-DTPA revealed that increasing TR was associated with the increase of the overall SIs and the maximum relationship between SI to concentration. Moreover, the required Gd-DTPA concentration to produce the maximum SI was associated to decrease with the increase of TR. In addition to this, the application of beyond 100 ms TR values in this study with relatively higher concentrations (beyond 1 - 2 mmol/L) has resulted predominantly non-linear patterns in the signal-concentration curves and it appears the saturation or decay of the SIs due to T2 effect. From these results, it can be suggested that the selection of relatively lower Gd-DTPA concentration ( mmol/L) with less than 800 ms (<800 ms) TR values can produce a better linear relationship between the concertation and SIs in T1-weighted SE low field contrast-enhanced MRI. Furthermore, this study also outlined the significance and necessity of the optimization of TR in SE sequence in low field MRI prior to a particular examination.展开更多
Objective To investigate the clinical value of different magnetic resonance (MR) pulse sequences in diagnosis of spinal metastatic tumor. Methods Fifteen patients with clinically suspected spinal metastatic tumor were...Objective To investigate the clinical value of different magnetic resonance (MR) pulse sequences in diagnosis of spinal metastatic tumor. Methods Fifteen patients with clinically suspected spinal metastatic tumor were included in this study. These patients were with documented primary tumors. Four MR pulse sequences, T1-weighted spin echo (T1WI SE), T2-weighted fast spin echo (T2WI FSE), short time inversion recovery (STIR), and gradient echo 2-D multi echo data imaging combination (GE Me-2D) were used to detect spinal metastasis. Results Fifteen vertebral bodies were entire involvement, 38 vertebral bodies were section involvement, and totally 53 vertebral bodies were involved. There were 19 focal infections in pedicle of vertebral arch, 15 metastases in spinous process and transverse process. Fifty-three vertebral bodies were abnormal in T1WI SE and GE Me-2D, 35 vertebral bodies were found abnormal in T2WI FSE, and 50 vertebral bodies were found abnormal in STIR. The verges of focal signal of involved vertebral bodies were comparatively clear in T1WI SE, comparatively clear or vague in T2WI FSE, vague in STIR, and clear in GE Me-2D.Conclusions GE Me-2D may be the most sensitive technique to detect metastases. So three sequences (T1WI SE, T2WI FSE, GE Me-2D) can demonstrate the early changes of spinal metastasis roundly.展开更多
Nuclear magnetic resonance(NMR)spectroscopy is a powerful tool for analyzing molecular structure and composition.However,traditional NMR experiments suffer from long acquisition times,especially in multidimensional NM...Nuclear magnetic resonance(NMR)spectroscopy is a powerful tool for analyzing molecular structure and composition.However,traditional NMR experiments suffer from long acquisition times,especially in multidimensional NMR spectroscopy.This problem,to some extent,limits broader applications of NMR techniques.Various methods have been proposed to accelerate sampling,including non-uniform sampling(NUS),multi-FID acquisition(MFA),Hadamard encoding,Fourier encoding,spatial encoding Ultrafast 2D NMR(UF2DNMR),and so on.The review focuses on rapid sampling methods developed in contemporary China,introducing their fundamental principles and applications while discussing their respective advantages and disadvantages.展开更多
In this article,we propose that superradiant echoes can be achieved at room temperature by applying a laser illumination and a microwave Hahn echo sequence to a diamond with a high concentration of nitrogen-vacancy(NV...In this article,we propose that superradiant echoes can be achieved at room temperature by applying a laser illumination and a microwave Hahn echo sequence to a diamond with a high concentration of nitrogen-vacancy(NV)centers placed in a dielectric microwave cavity.We identify that the combined action of two microwave driving pulses and a free evolution imprints a frequency grating among NV spin sub-ensembles,and the multiple re-phasing of the grated spin sub-ensembles leads to multiple superradiant echoes through a collective coupling with the cavity.Furthermore,we show that the superradiant echoes can be actively tailored through the microwave pulses and the laser illumination by adjusting the grating parameters,and the multiple re-phasing dynamics is analogous to the one leading to superradiant beats in atomic optical clock systems.In the future,the spin sub-ensembles grating and the resulting echoes can be further optimized with dynamical decoupling,which might pave the way for applications in quantum sensing.展开更多
The field of diffusion micro structural magnetic resonance(MR)aims to probe timedependent diffusion,i.e.,an ensemble-averaged mean-squared displacement that is not linear in time.This time-dependence contains rich inf...The field of diffusion micro structural magnetic resonance(MR)aims to probe timedependent diffusion,i.e.,an ensemble-averaged mean-squared displacement that is not linear in time.This time-dependence contains rich information about the surrounding microenvironment.MR methods to measure time-dependent diffusion quantitatively,however,require either non-standard pulse sequences,such as oscillating gradients,or make non-physical assumptions,such as infinitely narrow gradient pulses.Here,we argue that standard spin echo and stimulated echo MR sequences can be used to probe directly.In particular,we propose a framework in which the log-signal ratio obtained from a pair of measurements with different inter-pulse spacingΔis proportional to the MSD between these twoΔvalues along the gradient direction x:-.The framework is quantitative for short,finite-duration gradient pulses and under the Gaussian phase approximation(GPA).To validate the framework,we consider onedimensional diffusion between impermeable,parallel planes,as well as periodicallyspaced,permeable planes.Excellent agreement is obtained between the estimation and the ground truth in the regime where the GPA is expected to hold.Importantly,the GPA can be made to hold for any underlying microstructure,making the proposed framework widely applicable.展开更多
The Gaussian phase distribution approximation enables analysis of restricted diffusion encoded by general gradient waveforms but fails to account for the diffraction-like features that may occur for simple pore geomet...The Gaussian phase distribution approximation enables analysis of restricted diffusion encoded by general gradient waveforms but fails to account for the diffraction-like features that may occur for simple pore geometries.We investigate the range of validity of the approximation by random walk simulations of restricted diffusion in a cylinder using isotropic diffusion encoding sequences as well as conventional single gradient pulse pairs and oscillating gradient waveforms.The results show that clear deviations from the approximation may be observed at relative signal attenuations below 0.1 for onedimensional sequences with few oscillation periods.Increasing the encoding dimensionality and/or number of oscillations while extending the total duration of the waveform diminishes the non-Gaussian effects while preserving the low apparent diffusivities characteristic of restriction.展开更多
文摘The contrast agent concentration, the time of repetition (TR) and magnetic field strength are significant parameters that influence for the accurate signal intensity (SI) in quantitative Magnetic Resonance Imaging (MRI). Therefore, this study was conducted to investigate and refine the dependence and the optimal effect of Time of Repetition (TR) on the relationship between signal intensity and Gd-DTPA (Gadolinium-diethylene-triaminepenta-acetic acid) concentration, after applying two-dimensional (2D) Spin Echo (SE) pulse sequence under low-field MRI. In addition to that, the optimal concentration of Gd-DTPA at given sequence parameters at low-field MRI was also evaluated. A water-filled phantom was constructed for a range of Gd-DTPA concentrations (0 - 6 mmol/L) and the mean signal intensities (SIs) were assessed in the defined region of interest on T1-weighted images with different TR values (40 - 2000 ms). The generated signal-concentration curves for Gd-DTPA revealed that increasing TR was associated with the increase of the overall SIs and the maximum relationship between SI to concentration. Moreover, the required Gd-DTPA concentration to produce the maximum SI was associated to decrease with the increase of TR. In addition to this, the application of beyond 100 ms TR values in this study with relatively higher concentrations (beyond 1 - 2 mmol/L) has resulted predominantly non-linear patterns in the signal-concentration curves and it appears the saturation or decay of the SIs due to T2 effect. From these results, it can be suggested that the selection of relatively lower Gd-DTPA concentration ( mmol/L) with less than 800 ms (<800 ms) TR values can produce a better linear relationship between the concertation and SIs in T1-weighted SE low field contrast-enhanced MRI. Furthermore, this study also outlined the significance and necessity of the optimization of TR in SE sequence in low field MRI prior to a particular examination.
文摘Objective To investigate the clinical value of different magnetic resonance (MR) pulse sequences in diagnosis of spinal metastatic tumor. Methods Fifteen patients with clinically suspected spinal metastatic tumor were included in this study. These patients were with documented primary tumors. Four MR pulse sequences, T1-weighted spin echo (T1WI SE), T2-weighted fast spin echo (T2WI FSE), short time inversion recovery (STIR), and gradient echo 2-D multi echo data imaging combination (GE Me-2D) were used to detect spinal metastasis. Results Fifteen vertebral bodies were entire involvement, 38 vertebral bodies were section involvement, and totally 53 vertebral bodies were involved. There were 19 focal infections in pedicle of vertebral arch, 15 metastases in spinous process and transverse process. Fifty-three vertebral bodies were abnormal in T1WI SE and GE Me-2D, 35 vertebral bodies were found abnormal in T2WI FSE, and 50 vertebral bodies were found abnormal in STIR. The verges of focal signal of involved vertebral bodies were comparatively clear in T1WI SE, comparatively clear or vague in T2WI FSE, vague in STIR, and clear in GE Me-2D.Conclusions GE Me-2D may be the most sensitive technique to detect metastases. So three sequences (T1WI SE, T2WI FSE, GE Me-2D) can demonstrate the early changes of spinal metastasis roundly.
基金financially supported by the National Natural Science Foundation of China(grant numbers 22174118,12411530077,and 22374124).
文摘Nuclear magnetic resonance(NMR)spectroscopy is a powerful tool for analyzing molecular structure and composition.However,traditional NMR experiments suffer from long acquisition times,especially in multidimensional NMR spectroscopy.This problem,to some extent,limits broader applications of NMR techniques.Various methods have been proposed to accelerate sampling,including non-uniform sampling(NUS),multi-FID acquisition(MFA),Hadamard encoding,Fourier encoding,spatial encoding Ultrafast 2D NMR(UF2DNMR),and so on.The review focuses on rapid sampling methods developed in contemporary China,introducing their fundamental principles and applications while discussing their respective advantages and disadvantages.
基金supported by the National Key R&D Program of China(Grant No.2024YFE0105200)the National Natural Science Foundation of China(Grant Nos.12422413,62475242,and U25A20192)+4 种基金the Scientific Research Innovation Capability Support Project for Young Faculty(Grant No.SRICSPYF-BS2025008)the Joint Fund of Henan Province Science and Technology R&D Program(Grant No.245200810005)the Crossdisciplinary Innovative Research Group Project of Henan Province(Grant No.232300421004)the Postgraduate Education Reform and Quality Improvement Project of Henan Province(Grant No.YJS2025GZZ04)the Carlsberg Foundation through the“Semper Ardens”Research Project QCoo L.
文摘In this article,we propose that superradiant echoes can be achieved at room temperature by applying a laser illumination and a microwave Hahn echo sequence to a diamond with a high concentration of nitrogen-vacancy(NV)centers placed in a dielectric microwave cavity.We identify that the combined action of two microwave driving pulses and a free evolution imprints a frequency grating among NV spin sub-ensembles,and the multiple re-phasing of the grated spin sub-ensembles leads to multiple superradiant echoes through a collective coupling with the cavity.Furthermore,we show that the superradiant echoes can be actively tailored through the microwave pulses and the laser illumination by adjusting the grating parameters,and the multiple re-phasing dynamics is analogous to the one leading to superradiant beats in atomic optical clock systems.In the future,the spin sub-ensembles grating and the resulting echoes can be further optimized with dynamical decoupling,which might pave the way for applications in quantum sensing.
基金supported by the intramural research program(IRP)of the Eunice Kennedy Shriver National Institute of Child Health and Human Development。
文摘The field of diffusion micro structural magnetic resonance(MR)aims to probe timedependent diffusion,i.e.,an ensemble-averaged mean-squared displacement that is not linear in time.This time-dependence contains rich information about the surrounding microenvironment.MR methods to measure time-dependent diffusion quantitatively,however,require either non-standard pulse sequences,such as oscillating gradients,or make non-physical assumptions,such as infinitely narrow gradient pulses.Here,we argue that standard spin echo and stimulated echo MR sequences can be used to probe directly.In particular,we propose a framework in which the log-signal ratio obtained from a pair of measurements with different inter-pulse spacingΔis proportional to the MSD between these twoΔvalues along the gradient direction x:-.The framework is quantitative for short,finite-duration gradient pulses and under the Gaussian phase approximation(GPA).To validate the framework,we consider onedimensional diffusion between impermeable,parallel planes,as well as periodicallyspaced,permeable planes.Excellent agreement is obtained between the estimation and the ground truth in the regime where the GPA is expected to hold.Importantly,the GPA can be made to hold for any underlying microstructure,making the proposed framework widely applicable.
基金financially supported by the Swedish Research Council(2022-04422_VR)。
文摘The Gaussian phase distribution approximation enables analysis of restricted diffusion encoded by general gradient waveforms but fails to account for the diffraction-like features that may occur for simple pore geometries.We investigate the range of validity of the approximation by random walk simulations of restricted diffusion in a cylinder using isotropic diffusion encoding sequences as well as conventional single gradient pulse pairs and oscillating gradient waveforms.The results show that clear deviations from the approximation may be observed at relative signal attenuations below 0.1 for onedimensional sequences with few oscillation periods.Increasing the encoding dimensionality and/or number of oscillations while extending the total duration of the waveform diminishes the non-Gaussian effects while preserving the low apparent diffusivities characteristic of restriction.
