A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera （Vahl.） Boergesen. The structures, identified using chemical and spectroscopic methods in...A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera （Vahl.） Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were： （1） 22-hydroxy-5α-eholest-3,6-dione, （2） 6-hydroxycholest-4-ene-3-one, （3） cholest-4-ene-3,6-dione, （4） cholest-5-ene-3β-ol, （5） 5u-cholestane-3,6-dione, （6） β-Sitosterol and （7） Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines.展开更多
基金Supported by the National Major Research Program of China "The Creation for Significant Innovative Drugs" (No. 2009ZX09103-148)the Research and Development Program of Shinan District of Qingdao (No. 2009-2-14-HY)
文摘A new ketosteroid, along with six known steroids, was isolated from the ethanolic extracts of red alga Acanthophora spicifera （Vahl.） Boergesen. The structures, identified using chemical and spectroscopic methods including 2D NMR, were： （1） 22-hydroxy-5α-eholest-3,6-dione, （2） 6-hydroxycholest-4-ene-3-one, （3） cholest-4-ene-3,6-dione, （4） cholest-5-ene-3β-ol, （5） 5u-cholestane-3,6-dione, （6） β-Sitosterol and （7） Saringosterol. The MTT method was used to test the cytotoxicity of the compounds against the human cancer cell lines, HCT-8, Bel-7402, BGC-823, A549 and HELA. Compounds 1, 2, 3 and 5 showed moderate cytotoxic activity against human cancer cell lines.
