Objective:To more rapidly and accurately obtain minimal erythema dose(MED)and minimal persistent pigment dose(MPPD)values in sun protection testing,we conducted a retrospective exploration of previous test data.Method...Objective:To more rapidly and accurately obtain minimal erythema dose(MED)and minimal persistent pigment dose(MPPD)values in sun protection testing,we conducted a retrospective exploration of previous test data.Methods:This retrospective study analyzed sunscreen test data collected from January 1,2021,to September 1,2024,among long-term East Asian residents in Shenzhen,China.We investigated correlations between skin color characteristics,age,seasonal variations,and UV sensitivity indicators(MED and MPPD).Results:The results indicate that in the population tested,there is a significant negative correlation between ITA°and the unprotected MED of participants(P<0.05),but no statistical correlation with the unprotected MPPD(P>0.05).There was a minimal correlation between participant age and both unprotected MED and MPPD.When compared to the other seasons,participants in winter exhibited significantly higher unprotected MED(P<0.05),and the unprotected MPPD was significantly higher in the autumn and winter than in spring and summer(P<0.05).Conclusion:In conclusion,defining proprietary predictive MED and MPPD values based on laboratory test population data in sunscreen efficacy testing enhances the probability of actual values conforming to preset gradients,thereby improving test success rates and overall efficiency.Moreover,while the impact of age is relatively minor,differences in skin color,population,and season do affect the results of MED and MPPD,which in turn influence the outcomes of sun protection product testing.Therefore,it may be necessary to conduct customized sun protection capability tests tailored to the product's target demographic and environmental context.展开更多
Background:Long-term exposure to sunlight can lead to inflammatory responses,skin photoaging and cancers.Plant extracts can serve as effective biological UV(ultraviolet)filters for their UV absorption capacity.Red ric...Background:Long-term exposure to sunlight can lead to inflammatory responses,skin photoaging and cancers.Plant extracts can serve as effective biological UV(ultraviolet)filters for their UV absorption capacity.Red rice extract is rich in phenolic acids,flavonoids,anthocyanins and procyanins has the potential as a biological UV filter.Aims:This study aims to evaluate the potential of red rice extract as a biological UV filter.Forthurmore,exploring the ability of red rice extract to enhance SPF performance and serve as a potential substitute for chemical UV filters.Methods:Using UV absorption spectroscopy,the UV absorption performance of red rice extract was compared with that of three known UV filters.Additionally,using the Folin-Ciocalteu reagent to test the total phenolic acids content of red rice extract and the antioxidant capacity of red rice extract was verified through a 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical clearance assay,confirming its potential as a biological UV filter.Subsequently,the photoprotective enhancement effects of red rice extract in sunscreen formulations were explored by testing the SPF value with UV2000S.Results:Experiments conducted by adding different concentrations of red rice extract to sunscreen formulations demonstrated that its photoprotective enhancement effects were positively correlated with its concentration.The addition of 1%red rice extract to both oil-in-water(O/W)and water-in-oil(W/O)sunscreen formulations demonstrated good photoprotective enhancement effects,with SPF values increasing by over 10%.Further experiments showed that 1%,3%,and 5%red rice extract could replace approximately 12.82%,19.05%,and 26.09%of traditional UV filters in sunscreen formulations,achieving similar SPF values.Conclusions:These findings suggest that red rice extract is a promising biological UV filter,capable of enhancing SPF values and serving as a viable alternative for traditional UV filters.Red rice extract can be used in sunscreen products and provide photoprotection benefit.展开更多
文摘Objective:To more rapidly and accurately obtain minimal erythema dose(MED)and minimal persistent pigment dose(MPPD)values in sun protection testing,we conducted a retrospective exploration of previous test data.Methods:This retrospective study analyzed sunscreen test data collected from January 1,2021,to September 1,2024,among long-term East Asian residents in Shenzhen,China.We investigated correlations between skin color characteristics,age,seasonal variations,and UV sensitivity indicators(MED and MPPD).Results:The results indicate that in the population tested,there is a significant negative correlation between ITA°and the unprotected MED of participants(P<0.05),but no statistical correlation with the unprotected MPPD(P>0.05).There was a minimal correlation between participant age and both unprotected MED and MPPD.When compared to the other seasons,participants in winter exhibited significantly higher unprotected MED(P<0.05),and the unprotected MPPD was significantly higher in the autumn and winter than in spring and summer(P<0.05).Conclusion:In conclusion,defining proprietary predictive MED and MPPD values based on laboratory test population data in sunscreen efficacy testing enhances the probability of actual values conforming to preset gradients,thereby improving test success rates and overall efficiency.Moreover,while the impact of age is relatively minor,differences in skin color,population,and season do affect the results of MED and MPPD,which in turn influence the outcomes of sun protection product testing.Therefore,it may be necessary to conduct customized sun protection capability tests tailored to the product's target demographic and environmental context.
基金support from Guangdong S&T programme[2024A0505050001].
文摘Background:Long-term exposure to sunlight can lead to inflammatory responses,skin photoaging and cancers.Plant extracts can serve as effective biological UV(ultraviolet)filters for their UV absorption capacity.Red rice extract is rich in phenolic acids,flavonoids,anthocyanins and procyanins has the potential as a biological UV filter.Aims:This study aims to evaluate the potential of red rice extract as a biological UV filter.Forthurmore,exploring the ability of red rice extract to enhance SPF performance and serve as a potential substitute for chemical UV filters.Methods:Using UV absorption spectroscopy,the UV absorption performance of red rice extract was compared with that of three known UV filters.Additionally,using the Folin-Ciocalteu reagent to test the total phenolic acids content of red rice extract and the antioxidant capacity of red rice extract was verified through a 2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical clearance assay,confirming its potential as a biological UV filter.Subsequently,the photoprotective enhancement effects of red rice extract in sunscreen formulations were explored by testing the SPF value with UV2000S.Results:Experiments conducted by adding different concentrations of red rice extract to sunscreen formulations demonstrated that its photoprotective enhancement effects were positively correlated with its concentration.The addition of 1%red rice extract to both oil-in-water(O/W)and water-in-oil(W/O)sunscreen formulations demonstrated good photoprotective enhancement effects,with SPF values increasing by over 10%.Further experiments showed that 1%,3%,and 5%red rice extract could replace approximately 12.82%,19.05%,and 26.09%of traditional UV filters in sunscreen formulations,achieving similar SPF values.Conclusions:These findings suggest that red rice extract is a promising biological UV filter,capable of enhancing SPF values and serving as a viable alternative for traditional UV filters.Red rice extract can be used in sunscreen products and provide photoprotection benefit.
