The basis of life-long spermatogenesis is spermatogonial stem cells (SSCs) located at the basal membrane of the seminiferous tubules in the testis. After several rounds of proliferation and spermatogonial differentiat...The basis of life-long spermatogenesis is spermatogonial stem cells (SSCs) located at the basal membrane of the seminiferous tubules in the testis. After several rounds of proliferation and spermatogonial differentiation, the male germ cells will eventually undergo meiosis to form haploid spermatids. Disturbance of the molecular regulation of spermatogenesis can lead to spermatogenic arrest, in humans often during meiosis,1,2 and subsequent azoospermia. Unfortunately, no treatment option enabling conception of a genetically own child is currently available for men suffering from spermatogenic arrest before spermatids are formed.展开更多
Tripterygium hypoglaucum (Level.) Hutch (THH) is aChinese herb which block mitosis and inhibit germinalcell developing in human and rat.The experimentemployed a test system in which mouse spermatocyteswere analyzed fo...Tripterygium hypoglaucum (Level.) Hutch (THH) is aChinese herb which block mitosis and inhibit germinalcell developing in human and rat.The experimentemployed a test system in which mouse spermatocyteswere analyzed for the aneuploid induction after micewere treated by THH (crude water-extracts).展开更多
文摘The basis of life-long spermatogenesis is spermatogonial stem cells (SSCs) located at the basal membrane of the seminiferous tubules in the testis. After several rounds of proliferation and spermatogonial differentiation, the male germ cells will eventually undergo meiosis to form haploid spermatids. Disturbance of the molecular regulation of spermatogenesis can lead to spermatogenic arrest, in humans often during meiosis,1,2 and subsequent azoospermia. Unfortunately, no treatment option enabling conception of a genetically own child is currently available for men suffering from spermatogenic arrest before spermatids are formed.
基金Supported by the National Nature Science Foundation of China(39070504)the Yunnan Science Committee(90C046)
文摘Tripterygium hypoglaucum (Level.) Hutch (THH) is aChinese herb which block mitosis and inhibit germinalcell developing in human and rat.The experimentemployed a test system in which mouse spermatocyteswere analyzed for the aneuploid induction after micewere treated by THH (crude water-extracts).
