Dear Editor,In the accompanying Comment,Bratchenko et al.raised two concerns about the spectral data analysis pipeline employed for the Surface-enhanced Raman scattering and Artificial Intelligence for Cancer Screenin...Dear Editor,In the accompanying Comment,Bratchenko et al.raised two concerns about the spectral data analysis pipeline employed for the Surface-enhanced Raman scattering and Artificial Intelligence for Cancer Screening(SERS-AICS)technique in our original paper:(1)inappropriate accuracy presentation and(2)the use of a single data split for model evaluation.As a promising technique for molecular fingerprinting,SERS-basedearlycancerdetection approaches using biofluids and liquid biopsy are typically evaluated base stricty on theiracuray and elaility.展开更多
Dear Editor,In their recent publication,Dong et al.l demonstrated high performance of SERS-based liquid biopsy of human serum analysis for earlier cancer detection.Moreover,this study was highlighted in News&Vies ...Dear Editor,In their recent publication,Dong et al.l demonstrated high performance of SERS-based liquid biopsy of human serum analysis for earlier cancer detection.Moreover,this study was highlighted in News&Vies section of Light Science and Applications journal by Shi et al.?.No doubt,different optical techniques nowadays are widely used for the analysis of biofluids and liquid biopsy33-10 and demonstrate high accuracy in possible clinical applications.At the same time,the paper by Dong et al.may be treated incorrectly due to the drawbacks in spectral data analysis.展开更多
文摘Dear Editor,In the accompanying Comment,Bratchenko et al.raised two concerns about the spectral data analysis pipeline employed for the Surface-enhanced Raman scattering and Artificial Intelligence for Cancer Screening(SERS-AICS)technique in our original paper:(1)inappropriate accuracy presentation and(2)the use of a single data split for model evaluation.As a promising technique for molecular fingerprinting,SERS-basedearlycancerdetection approaches using biofluids and liquid biopsy are typically evaluated base stricty on theiracuray and elaility.
基金findings of this paper were supported by the Russian Science Foundation ProjectNo.21-75-10097.
文摘Dear Editor,In their recent publication,Dong et al.l demonstrated high performance of SERS-based liquid biopsy of human serum analysis for earlier cancer detection.Moreover,this study was highlighted in News&Vies section of Light Science and Applications journal by Shi et al.?.No doubt,different optical techniques nowadays are widely used for the analysis of biofluids and liquid biopsy33-10 and demonstrate high accuracy in possible clinical applications.At the same time,the paper by Dong et al.may be treated incorrectly due to the drawbacks in spectral data analysis.
