Based on experiments of low cycle fatigue for 5083-H112 aluminum alloy, two energybased predictive models have been introduced to predict the fatigue crack growth behaviors of traditional Compact Tension（CT） and sma...Based on experiments of low cycle fatigue for 5083-H112 aluminum alloy, two energybased predictive models have been introduced to predict the fatigue crack growth behaviors of traditional Compact Tension（CT） and small-sized C-shaped Inside Edge-notched Tension（CIET）specimens with different thicknesses and load ratios. Different values of the effective stress ratio U are employed in the theoretical fatigue crack growth models to correct the effect of crack closure.Results indicate that the two predictive models show different capacities of predicting the fatigue crack growth behaviors of CIET and CT specimens with different thicknesses and load ratios.The accuracy of predicted results of the two models is strongly affected by the method for determination of the effective stress ratio U. Finally, the energy-based Shi＆Cai model with crack closure correction by means of Newman＇s method is highly recommended in prediction of fatigue crack growth of CIET specimens via low cycle fatigue properties.展开更多
Numerical calculations of creep damage development and life behavior of circular notched specimens of nickel-base single crystal had been performed. The creep stress distributions depend on the specimen geometry. For ...Numerical calculations of creep damage development and life behavior of circular notched specimens of nickel-base single crystal had been performed. The creep stress distributions depend on the specimen geometry. For a small notch radius, von Mises stress has an especial distribution. The damage distribution is greatly influenced by the notch depth, notch radius as well as notch type. The creep crack initiation place is different for each notched specimen. The characteristics of notch strengthening and notch weakening depend on the notch radius and notch type. For the same notch type, the creep rupture lives decrease with the decreasing of notch radius. A creep life model has been presented for the multiaxial stress states based on the crystallographic slip system theory.展开更多
Liquid-based microbiology (LBM) is the future for the technological development of microbiology laboratories. In particular, the Eswab system (by Copan) simplifies and streamlines specimen collection and represents th...Liquid-based microbiology (LBM) is the future for the technological development of microbiology laboratories. In particular, the Eswab system (by Copan) simplifies and streamlines specimen collection and represents the only liquid system supporting the recovery of all types of bacteria (aerobic, anaerobic, and fastidious bacteria). In addition, LBM offers advantages in the efficiency of microorganism recovery and ease of sampling, transport, and storage. LBM also allows the introduction of true automation in the laboratory: either by using Copan ? (Walk-Away Specimen Processor) or any other commercially available specimen processor that utilizes LBM. In this paper, we illustrate how LBM can positively change laboratory workflow by illustrating several years of our experience with LBM. LBM allows clinical specimen optimization and has several important advantages: cost reduction (due to the smaller number of different devices used), time savings for medical or nursing staff (less confusion in collection device selection and fewer samples being collected), time savings for laboratory staff (fewer samples to access and handle for individual investigations), and patient comfort improvement (multiple sample collection can be avoided). A unique collection device for several investigations also guarantees quality due to the uniformity of the sample and standardization of procedures.展开更多
Correction:One Health Adv 3,12(2025)https://doi.org/10.1186/s44280-025-00078-y Following the publication of the original article[1],it is reported that the first sentence in Abstract section contains an error due to i...Correction:One Health Adv 3,12(2025)https://doi.org/10.1186/s44280-025-00078-y Following the publication of the original article[1],it is reported that the first sentence in Abstract section contains an error due to inadvertent typesetting mistake when performing proof corrections.The sentence has been corrected from:Staphylococcus aureus is a Gram significant pathogen in clinical settings and community.展开更多
目的通过检测痰液脱落细胞FHIT基因微卫星不稳定性(microsatellite instability,MSI)和杂合性缺失(loss of heterozygosity,LOH),评价FHIT基因检测在肺癌早期诊断中的敏感性,探讨肺癌筛查的有效方法。方法以液基细胞学为基础,采集并分...目的通过检测痰液脱落细胞FHIT基因微卫星不稳定性(microsatellite instability,MSI)和杂合性缺失(loss of heterozygosity,LOH),评价FHIT基因检测在肺癌早期诊断中的敏感性,探讨肺癌筛查的有效方法。方法以液基细胞学为基础,采集并分离高危人群痰液脱落细胞,提取DNA,检测FHIT基因MSI和LOH。结果在肺癌患者中出现MSI或LOH异常的阳性率在41.6%～49.5%之间,以D3S1300最高,达到49.5%,3个位点中至少1个位点出现微卫星异常为72.3%(n=73),至少2个位点出现微卫星异常为45.5%(n=46)。统计学分析表明,FHIT基因出现MSI或LOH在肺癌和非肺癌患者中的差异有统计学意义(P<0.05)。结论以液基细胞学为基础,检测痰液脱落细胞FHIT基因的MSI和LOH可以作为肺癌早期诊断的新途径。不同微卫星位点出现异常表现的具体形式有所不同,多位点联合检测可以提高诊断的敏感性和特异性。展开更多
目的:检索、评价和总结国内外成人静脉血液标本管理的最佳证据,为提高成人静脉血液标本合格率提供证据支持。方法:检索Up To Date、the Cochrane Library、BMJ、护理和联合卫生文献累积索引数据库、PubMed、WHO、加拿大安大略注册护士...目的:检索、评价和总结国内外成人静脉血液标本管理的最佳证据,为提高成人静脉血液标本合格率提供证据支持。方法:检索Up To Date、the Cochrane Library、BMJ、护理和联合卫生文献累积索引数据库、PubMed、WHO、加拿大安大略注册护士协会、美国国家临床诊疗指南数据库、荷兰医学文摘数据库、苏格兰学院间指南网络、英国国家临床优化研究所指南库、中国生物医学文献数据库、万方数据库、中国知网、医脉通和迈特思创等数据库内关于成人静脉血液标本管理的证据,包括指南、专家共识、证据总结等。检索时限为从建库至2021年1月31日。由2名研究人员对文献质量进行评价,对符合质量标准的文献进行证据提取。应用临床指南研究与评价系统、系统评价评估工具、JBI证据预分级及证据推荐级别系统进行文献质量评价及证据级别评定。结果:共纳入6篇文献,包括4篇指南、1篇专家共识和1篇证据总结。最佳证据从采血部位、采血途径、压脉带、采血装置、采血工具、采血量、标本混合、标本运输和采血人员9个方面共提取了14条证据。结论:现有证据可为临床医护人员开展成人静脉血液标本管理实践提供依据。在临床应用时,需要充分考虑临床情景,结合专业人士的判断及病人的意愿,遵循个体化原则,分析证据应用的障碍因素及促进因素,审慎地将证据应用于临床实践中。展开更多
基金financially supported by the National Natural Science Foundation of China (Nos. 11202174 and 11472228)
文摘Based on experiments of low cycle fatigue for 5083-H112 aluminum alloy, two energybased predictive models have been introduced to predict the fatigue crack growth behaviors of traditional Compact Tension（CT） and small-sized C-shaped Inside Edge-notched Tension（CIET）specimens with different thicknesses and load ratios. Different values of the effective stress ratio U are employed in the theoretical fatigue crack growth models to correct the effect of crack closure.Results indicate that the two predictive models show different capacities of predicting the fatigue crack growth behaviors of CIET and CT specimens with different thicknesses and load ratios.The accuracy of predicted results of the two models is strongly affected by the method for determination of the effective stress ratio U. Finally, the energy-based Shi＆Cai model with crack closure correction by means of Newman＇s method is highly recommended in prediction of fatigue crack growth of CIET specimens via low cycle fatigue properties.
基金supported by the National Natural Science Foundation of China(50005016,50375124)Natural Science Foundation of Shaanxi Province and China Aviation Foundation(02C53011,03B53003)as well as the Yangtze River Foundation
文摘Numerical calculations of creep damage development and life behavior of circular notched specimens of nickel-base single crystal had been performed. The creep stress distributions depend on the specimen geometry. For a small notch radius, von Mises stress has an especial distribution. The damage distribution is greatly influenced by the notch depth, notch radius as well as notch type. The creep crack initiation place is different for each notched specimen. The characteristics of notch strengthening and notch weakening depend on the notch radius and notch type. For the same notch type, the creep rupture lives decrease with the decreasing of notch radius. A creep life model has been presented for the multiaxial stress states based on the crystallographic slip system theory.
文摘Liquid-based microbiology (LBM) is the future for the technological development of microbiology laboratories. In particular, the Eswab system (by Copan) simplifies and streamlines specimen collection and represents the only liquid system supporting the recovery of all types of bacteria (aerobic, anaerobic, and fastidious bacteria). In addition, LBM offers advantages in the efficiency of microorganism recovery and ease of sampling, transport, and storage. LBM also allows the introduction of true automation in the laboratory: either by using Copan ? (Walk-Away Specimen Processor) or any other commercially available specimen processor that utilizes LBM. In this paper, we illustrate how LBM can positively change laboratory workflow by illustrating several years of our experience with LBM. LBM allows clinical specimen optimization and has several important advantages: cost reduction (due to the smaller number of different devices used), time savings for medical or nursing staff (less confusion in collection device selection and fewer samples being collected), time savings for laboratory staff (fewer samples to access and handle for individual investigations), and patient comfort improvement (multiple sample collection can be avoided). A unique collection device for several investigations also guarantees quality due to the uniformity of the sample and standardization of procedures.
文摘Correction:One Health Adv 3,12(2025)https://doi.org/10.1186/s44280-025-00078-y Following the publication of the original article[1],it is reported that the first sentence in Abstract section contains an error due to inadvertent typesetting mistake when performing proof corrections.The sentence has been corrected from:Staphylococcus aureus is a Gram significant pathogen in clinical settings and community.
文摘目的通过检测痰液脱落细胞FHIT基因微卫星不稳定性(microsatellite instability,MSI)和杂合性缺失(loss of heterozygosity,LOH),评价FHIT基因检测在肺癌早期诊断中的敏感性,探讨肺癌筛查的有效方法。方法以液基细胞学为基础,采集并分离高危人群痰液脱落细胞,提取DNA,检测FHIT基因MSI和LOH。结果在肺癌患者中出现MSI或LOH异常的阳性率在41.6%～49.5%之间,以D3S1300最高,达到49.5%,3个位点中至少1个位点出现微卫星异常为72.3%(n=73),至少2个位点出现微卫星异常为45.5%(n=46)。统计学分析表明,FHIT基因出现MSI或LOH在肺癌和非肺癌患者中的差异有统计学意义(P<0.05)。结论以液基细胞学为基础,检测痰液脱落细胞FHIT基因的MSI和LOH可以作为肺癌早期诊断的新途径。不同微卫星位点出现异常表现的具体形式有所不同,多位点联合检测可以提高诊断的敏感性和特异性。
文摘目的:检索、评价和总结国内外成人静脉血液标本管理的最佳证据,为提高成人静脉血液标本合格率提供证据支持。方法:检索Up To Date、the Cochrane Library、BMJ、护理和联合卫生文献累积索引数据库、PubMed、WHO、加拿大安大略注册护士协会、美国国家临床诊疗指南数据库、荷兰医学文摘数据库、苏格兰学院间指南网络、英国国家临床优化研究所指南库、中国生物医学文献数据库、万方数据库、中国知网、医脉通和迈特思创等数据库内关于成人静脉血液标本管理的证据,包括指南、专家共识、证据总结等。检索时限为从建库至2021年1月31日。由2名研究人员对文献质量进行评价,对符合质量标准的文献进行证据提取。应用临床指南研究与评价系统、系统评价评估工具、JBI证据预分级及证据推荐级别系统进行文献质量评价及证据级别评定。结果:共纳入6篇文献,包括4篇指南、1篇专家共识和1篇证据总结。最佳证据从采血部位、采血途径、压脉带、采血装置、采血工具、采血量、标本混合、标本运输和采血人员9个方面共提取了14条证据。结论:现有证据可为临床医护人员开展成人静脉血液标本管理实践提供依据。在临床应用时,需要充分考虑临床情景,结合专业人士的判断及病人的意愿,遵循个体化原则,分析证据应用的障碍因素及促进因素,审慎地将证据应用于临床实践中。
