With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and disadvantages.Due to the fact that requirements to MTT algorithms vary from the...With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and disadvantages.Due to the fact that requirements to MTT algorithms vary from the application scenarios,performance evaluation is significant to select an appropriate MTT algorithm for the specific application scenario.In this paper,we propose a performance evaluation method on the sets of trajectories with temporal dimension specifics to compare the estimated trajectories with the true trajectories.The proposed method evaluates the estimate results of an MTT algorithm in terms of tracking accuracy,continuity and clarity.Furthermore,its computation is based on a multi-dimensional assignment problem,which is formulated as a computable form using linear programming.To enhance the influence of recent estimated states of the trajectories in the evaluation,an attention function is used to reweight the trajectory errors at different time steps.Finally,simulation results show that the proposed performance evaluation method is able to evaluate many aspects of the MTT algorithms.These evaluations are worthy for selecting suitable MTT algorithms in different application scenarios.展开更多
Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrins...Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrinsic mechanisms underlying the decision of a stem cell to proliferate,enter a dormant quiescent state or differentiate into a specific cell type remains incompletely understood.展开更多
Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other...Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.展开更多
Supercapacitors are gaining popularity due to their high cycling stability,power density,and fast charge and discharge rates.Researchers are ex-ploring electrode materials,electrolytes,and separat-ors for cost-effecti...Supercapacitors are gaining popularity due to their high cycling stability,power density,and fast charge and discharge rates.Researchers are ex-ploring electrode materials,electrolytes,and separat-ors for cost-effective energy storage systems.Ad-vances in materials science have led to the develop-ment of hybrid nanomaterials,such as combining fil-amentous carbon forms with inorganic nanoparticles,to create new charge and energy transfer processes.Notable materials for electrochemical energy-stor-age applications include MXenes,2D transition met-al carbides,and nitrides,carbon black,carbon aerogels,activated carbon,carbon nanotubes,conducting polymers,carbon fibers,and nanofibers,and graphene,because of their thermal,electrical,and mechanical properties.Carbon materials mixed with conducting polymers,ceramics,metal oxides,transition metal oxides,metal hydroxides,transition metal sulfides,trans-ition metal dichalcogenide,metal sulfides,carbides,nitrides,and biomass materials have received widespread attention due to their remarkable performance,eco-friendliness,cost-effectiveness,and renewability.This article explores the development of carbon-based hybrid materials for future supercapacitors,including electric double-layer capacitors,pseudocapacitors,and hy-brid supercapacitors.It investigates the difficulties that influence structural design,manufacturing(electrospinning,hydro-thermal/solvothermal,template-assisted synthesis,electrodeposition,electrospray,3D printing)techniques and the latest car-bon-based hybrid materials research offer practical solutions for producing high-performance,next-generation supercapacitors.展开更多
Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmenta...Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.展开更多
The microstructural evolution,phase stability,and mechanical properties of Al-Li-Mg-Ti-M(M=Zn,Zr,V)lightweight high-entropy alloys(LW-HEAs)were investigated.The LW-HEAs with three components,Al_(20)Li_(20)Mg_(10)-Ti_(...The microstructural evolution,phase stability,and mechanical properties of Al-Li-Mg-Ti-M(M=Zn,Zr,V)lightweight high-entropy alloys(LW-HEAs)were investigated.The LW-HEAs with three components,Al_(20)Li_(20)Mg_(10)-Ti_(40)Zn_(10)(#Zn),Al_(20)Li_(20)Mg_(10)Ti_(30)Zr_(20)(#Zr),and Al_(20)Li_(20)Mg_(10)Ti_(30)V_(20)(#V),were designed according to the thermo-dynamic design criteria of HEA,and prepared via a combination process of mechanical alloying and cold-press sintering.The effects of alloy composition and sintering temperature on the microstructure and mechanical properties of the LW-HEAs were studied.The results show that the as-milled Al-Li-Mg-Ti-M(M=Zn,Zr,V)LW-HEAs form a simple structure with HCP-type solid solution as the primary phase,a dual-HCP type solid solution phase,and a BCC phase,respectively.After cold-press sintering,the#Zn and#V alloys undergo obvious phase transformation;while the#Zr alloy with dual-HCP phases exhibits the best phase stability during heat treatment.The#V-750°C alloy demonstrates the maximum hardness and specific strength of HV 595.2 and 625 MPa∙cm3/g,respectively,under the combined effect of solid solution strengthening of BCC phase and precipitation strengthening ofβ-AlTi_(3).Moreover,the#Zr-650°C,#Zr-750°C,and#Zn-650°C alloys are expected to have excellent plasticity.展开更多
Fully implanted brain-computer interfaces(BCIs)are preferred as they eliminate signal degradation caused by interference and absorption in external tissues,a common issue in non-fully implanted systems.To optimize the...Fully implanted brain-computer interfaces(BCIs)are preferred as they eliminate signal degradation caused by interference and absorption in external tissues,a common issue in non-fully implanted systems.To optimize the design of electroencephalography electrodes in fully implanted BCI systems,this study investigates the penetration and absorption characteristics of microwave signals in human brain tissue at different frequencies.Electromagnetic simulations are used to analyze the power density distribution and specific absorption rate(SAR)of signals at various frequen-cies.The results indicate that lower-frequency signals offer advantages in terms of power density and attenuation coeffi-cients.However,SAR-normalized analysis,which considers both power density and electromagnetic radiation hazards,shows that higher-frequency signals perform better at superficial to intermediate depths.Specifically,at a depth of 2 mm beneath the cortex,the power density of a 6.5 GHz signal is 247.83%higher than that of a 0.4 GHz signal.At a depth of 5 mm,the power density of a 3.5 GHz signal exceeds that of a 0.4 GHz signal by 224.16%.The findings suggest that 6.5 GHz is optimal for electrodes at a depth of 2 mm,3.5 GHz for 5 mm,2.45 GHz for depths of 15-20 mm,and 1.8 GHz for 25 mm.展开更多
Aqueous zinc-ion batteries(AZIBs)are gaining attention owing to their affordability,high safety,and high energy density,making them a promising solution for large-scale energy storage.However,their performance is hamp...Aqueous zinc-ion batteries(AZIBs)are gaining attention owing to their affordability,high safety,and high energy density,making them a promising solution for large-scale energy storage.However,their performance is hampered by the instability of both the anode-electrolyte interface and the cathode-electrolyte interface.The use of sodium gluconate(SG),an organic sodium salt with multiple hydroxyl groups,as an electrolyte additive is suggested.Experimental and theoretical analyses demonstrate that Na^(+)from SG can intercalate and deintercalate within the associated V_(2)O_(5) cathode during in situ electrochemical processes.This action supports the layered structure of V_(2)O_(5),prevents structural collapse and phase transitions,and enhances Zn^(2+)diffusion kinetics.Additionally,the gluconate anion disrupts the original Zn^(2+)solvation structure,mitigates water-induced side reactions,and suppresses Zn dendrite growth.The synchronous regulation of both the V_(2)O_(5) cathode and Zn anode by the SG additive leads to considerable performance improvements.Zn‖Zn symmetric batteries demonstrate a cycle life exceeding 2800 h at 0.5 mA cm^(-2)and 1 mAh cm^(-2).In Zn‖V_(2)O_(5) full batteries,a high specific capacity of 288.92 mAh g^(-1)and capacity retention of 82.29%are maintained over 1000 cycles at a current density of 2 A g^(-1).This multifunctional additive strategy offers a new pathway for the practical application of AZIBs.展开更多
In this study,two wheat-derived cadmium(Cd)-immobilizing endophytic Pseudomonas paralactis M14 and Priestia megaterium R27 were evaluated for their effects on wheat tissue Cd uptake under hydroponic conditions.Then,th...In this study,two wheat-derived cadmium(Cd)-immobilizing endophytic Pseudomonas paralactis M14 and Priestia megaterium R27 were evaluated for their effects on wheat tissue Cd uptake under hydroponic conditions.Then,the impacts of the biochar(BC),M14+R27(MR),and BC+MR treatments on wheat Cd uptake and the mechanisms involved were investigated at the jointing,heading,and mature stages of wheat plants under field-plot conditions.A hydroponic experiment showed that the MR treatment significantly decreased the above-ground tissue Cd content compared with theM14 or R27 treatment.The BC+MRtreatment reduced the grain Cd content by 51.5%-67.7%and Cd translocation factor at the mature stage of wheat plants and increased the organic matter-bound Cd content by 31%-75%in the rhizosphere soils compared with the BC or MR treatment.Compared with the BC or MR treatment,the relative abundances of the biomarkers associated with Gemmatimonas,Altererythrobacter,Gammaproteobacteria,Xanthomonadaceae,Phenylobacterium,and Nocardioides in the BC+MR-treated rhizosphere microbiome decreased and negatively correlated with the organic matter-bound Cd contents.In the BC+MR-treated root interior microbiome,the relative abundance of the biomarker belonging to Exiguobacterium increased and negatively correlated with the Cd translocation factor,while the relative abundance of the biomarker belonging to Pseudonocardiaceae decreased and positively correlated with the Cd translocation factor.Our findings suggested that the BC+MR treatment reduced Cd availability and Cd transfer through affecting the abundances of these specific biomarkers in the rhizosphere soil and root interior microbiomes,leading to decreased wheat grain Cd uptake in the contaminated soil.展开更多
Influenza,a highly contagious respiratory infectious disease caused by an influenza virus,is a threat to public health worldwide.Avian influenza viruses(AIVs)have the potential to cause the next pandemic by crossing t...Influenza,a highly contagious respiratory infectious disease caused by an influenza virus,is a threat to public health worldwide.Avian influenza viruses(AIVs)have the potential to cause the next pandemic by crossing the species barrier through mutation of viral genome.Here,we investigated the pathogenicity of AIVs obtained from South Korea and Mongolia during 2018–2019 by measuring viral titers in the lungs and extrapulmonary organs of mouse models.In addition,we assessed the pathogenicity of AIVs in ferret models.Moreover,we compared the ability of viruses to replicate in mammalian cells,as well as the receptor-binding preferences of AIV isolates.Genetic analyses were finally performed to identify the genetic relationships and amino acid substitutions between viral proteins during mammalian adaptation.Of the 24 AIV isolates tested,A/Mallard/South Korea/KNU2019-34/2019(KNU19-34;H1N1)caused severe bodyweight loss and high mortality in mice.The virus replicated in the lungs,kidneys,and heart.Importantly,KNU19-34-infected ferrets showed high viral loads in both nasal washes and lungs.KNU19-34 replicated rapidly in A549 and bound preferentially to human likeα2,6-linked sialic acids rather than to avian-likeα2,3-linked sialic acids,similar to the pandemic A/California/04/2009(H1N1)strain.Gene segments of KNU19-34 were distributed in Egypt and Asia lineages from 2015 to 2018,and the virus had several amino acid substitutions compared to H1N1 AIV isolates that were non-pathogenic in mice.Collectively,the data suggest that KNU19-34 has zoonotic potential and the possibility of new mutations responsible for mammalian adaptation.展开更多
Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s disease.This method differs from pharmacological approaches...Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s disease.This method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of function.Recently,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological conditions.Addressing open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.展开更多
Evaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy Taylan Tugrul1(1.Department of Radiation Oncology,Medicine Faculty of Van Yüzü...Evaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy Taylan Tugrul1(1.Department of Radiation Oncology,Medicine Faculty of Van YüzüncüYıl University,Van,Turkey)Abstract:Quality assurance practices performed before treatment are believed to identify various potential errors.In this study,2-dimensional(2D)dosimetric results were analyzed by making some intentional mistakes in six different treatment plans.In this way,the detectability of errors was investigated.In all segments of all treatment plans,one of the multileaf collimators was kept fixed at different positions on the central axis.In addition to multileaf collimators error,gantry error was also examined in the study.The dose distribution results obtained by Treatment Planning System(TPS)were compared with those obtained by the 2D array device,both as local calculation and global calculation methods,using the gamma analysis method.When the results are examined in the case where the Multi-leaf collimators(MLC)is fixed at the 1 cm position.展开更多
BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an e...BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell therapies.Stem cells have yielded so far mixed results in clinical trials,and at patient level the results varied from impressive to no improvement.In this context we have administered autologous cord blood(ACB)and a non-placebo,material intervention repre-sented by an individualized combination of supplements(ICS)to ASD children.METHODS CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children;ACB was infused as an inpatient procedure.Treatment efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist,Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score,after interviewing the children’s parents and therapists.Before and after each intervention participants had a set of blood tests including inflammatory,metabolic and oxidative markers,and the neuronal specific enolase.RESULTS No serious adverse reactions were noted during and after cord blood or supplement administration.ACB improved evaluation scores in 78%of children with age 3–7-years(n=28),but was much less effective in kids older than 8 years or with body weight of more than 35 kg(n=28;only 11%of children improved scores).ICS yielded better results than ACB in 5 cases out of 28,while in 23 kids ACB brought more improvement than ICS(P<0.05);high initial levels of inflammation and ferritin were associated with no improvement.Ample individual differences were noted in children's progress,and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction,but not on irritability or aggressive behavior.CONCLUSION ACB has superior efficacy to ICS in ASD;high inflammation,ferritin,age and body weight predict less improvement;more clinical studies are needed for studying ACB efficacy in ASD.展开更多
To meet the demand for air-breathing power for wide-range vehicles at Mach 0–10,two thermal cycles with ammonia as the fuel and coolant were analyzed,namely the precooled rocket-turbine cycle(PC-RT)and the precooled ...To meet the demand for air-breathing power for wide-range vehicles at Mach 0–10,two thermal cycles with ammonia as the fuel and coolant were analyzed,namely the precooled rocket-turbine cycle(PC-RT)and the precooled gas-turbine cycle.Firstly,the operating modes of the precooled cycle engines were divided into turbine mode,precooling mode,and ramjet mode.Secondly,a fluid-structure coupling heat transfer program was used to evaluate the cooling effects of different fuels on the incoming high-temperature air.The result shows that the equivalent heat sink of ammonia is higher than that of other fuels and can meet the cooling requirement of at least Mach 4 in the precooling mode.Thirdly,the performance of the PC-RT in the turbine and precooling modes was compared at Mach 2.5.The result shows that air precooling alleviates the restriction of the pumping pressure on the minimum requiredβand improves the specific thrust within a reasonable range ofβ.Fourthly,the performance of the precooled cycle engines was compared when using different fuels.The result shows that the specific thrust of ammonia is greater than that of other fuels,and the performance advantages of ammonia are the most obvious in the precooling mode due to its highest equivalent heat sink.To sum up,the precooled cycle engines with ammonia as the fuel and coolant presented in this study have the advantages of no carbon emissions,low cost,high specific thrust,and no clogging of the cooling channels by cracking products.They are suitable for applications such as the first-stage power of the two-stage vehicle,and high Mach numbers air-breathing flight.展开更多
Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely ...Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely used“generic”(absolute intensity)cut-point approach has limited generalisability to population-level free-living data.Further,current methods generally fail to account for differences in people's physical capacity.展开更多
Conventional gas sensing materials(e.g.,metal oxides)suffer from deficient sensitivity and serve cross-sensitivity issues due to the lack of efficient adsorption sites.Herein,the heteroatom atomically doping strategy ...Conventional gas sensing materials(e.g.,metal oxides)suffer from deficient sensitivity and serve cross-sensitivity issues due to the lack of efficient adsorption sites.Herein,the heteroatom atomically doping strategy is demonstrated to significantly enhance the sensing performance of metal oxides-based gas sensing materials.Specifically,the Sn atoms were incorporated into porous Fe_(2)O_(3)in the form of atomically dispersed sites.As revealed by X-ray absorption spectroscopy and atomic-resolution scanning transmission electron microscopy,these Sn atoms successfully occupy the Fe sites in the Fe_(2)O_(3)lattice,forming the unique Sn-O-Fe sites.Compared to Fe-O-Fe sites(from bare Fe_(2)O_(3))and Sn-O-Sn sites(from SnO_(2)/Fe_(2)O_(3)with high Sn loading),the Sn-O-Fe sites on porous Fe_(2)O_(3)exhibit a superior sensitivity(Rg/Ra=2646.6)to 1 ppm NO_(2),along with dramatically increased selectivity and ultra-low limits of detection(10 ppb).Further theoretical calculations suggest that the strong adsorption of NO_(2)on Sn-O-Fe sites(N atom on Sn site,O atom on Fe site)contributes a more efficient gas response,compared to NO_(2)on Fe-O-Fe sites and other gases on Sn-O-Fe sites.Moreover,the incorporated Sn atoms reduce the bandgap of Fe_(2)O_(3),not only facilitating the electron release but also increasing the NO_(2)adsorption at a low working temperature(150°C).This work introduces an effective strategy to construct effective adsorption sites that show a unique response to specific gas molecules,potentially promoting the rational design of atomically modified gas sensing materials with high sensitivity and high selectivity.展开更多
Objective:To assess aptamer-based assays for diagnosing latent tuberculosis infection(LTBI).Methods:Literature from Medline,ScienceDirect,and Scopus,covering publications from January 1,2012,to December 31,2023,was ex...Objective:To assess aptamer-based assays for diagnosing latent tuberculosis infection(LTBI).Methods:Literature from Medline,ScienceDirect,and Scopus,covering publications from January 1,2012,to December 31,2023,was examined.This review evaluates different aptamers,biomarkers,sample types,sample sizes,reference assays,and the assays'sensitivity and specificity.By using the Quality Assessment of Diagnostic Accuracy Studies 2,the risk of bias in each study was evaluated.Results:Aptamer-based assays generally showed a sensitivity of 90%(95%CI:75%-100%)and specificity of 90%(95%CI:50%-100%),where optical aptasensor showed the highest sensitivity and specificity at 100%.Serum samples were frequently used to enhance antigen detectability,improving the assay’s performance.Meanwhile,HspX was the most studied biomarker,followed by MPT64,and IFN-γ.Conclusions:Aptamer-based assays could be reliable alternatives to current LTBI detection methods,but further research is needed to validate their clinical efficacy.展开更多
This study aims to enhance the digital drilling process monitoring(DPM)or monitoring while drilling(MWD)technique,which is a widely recognized method in geological exploration for evaluating rock mass quality.First,ro...This study aims to enhance the digital drilling process monitoring(DPM)or monitoring while drilling(MWD)technique,which is a widely recognized method in geological exploration for evaluating rock mass quality.First,robust displacement and torque measurement facilities for rotary-core drilling are discussed.The conventional cable encoder for displacement measurement is replaced with a magnetostrictive displacement sensor,which is more reliable in harsh field drilling environments.This enables the measurement of the bit position with an accuracy of<1 mm.Most importantly,this new instrument is proven to be successful in improving the detection of structural discontinuities with thicknesses>1 mm.In addition,by measuring the electric current of the driving motor,the torque applied to the bit is conveniently and accurately converted.These innovations ensure high-quality data collection for DPM practices.Second,two indices derived from DPM are proposed to quantitatively describe rock mass quality.The specific energy index(SEI)and specific penetration index(SPI)are based on the principles of energy conservation and Mohr-Coulomb failure criterion,respectively.Extensive field tests conducted in a dam grouting area confirm a linear relationship between the thrust force and penetration per rotation,and between the torque and penetration per rotation.The correlation ratios of the related regressions are typically>0.9.These two indices allow for the quantitative interpretation of DPM data into rock mechanics characteristics,such as uniaxial compressive strength,rock quality designation(RQD),and rock mass permeability,eliminating the need for subjective judgment normally involved in the currently used rock mass quality rating approaches.展开更多
Nanozymes,characterized by their stability,cost-effectiveness,and tunable catalytic activity,are promising alternatives to natural enzymes.However,specifically mimicking a single natural enzyme's activity presents...Nanozymes,characterized by their stability,cost-effectiveness,and tunable catalytic activity,are promising alternatives to natural enzymes.However,specifically mimicking a single natural enzyme's activity presents a challenge.By exploiting the catalytic selectivity derived from the valence-band hybridization of noble metal nanoalloys,we introduce an alloying strategy to modulate the reaction specificity of metallic nanozymes.Ag Pd nanoalloy exhibits enhanced peroxidase-like activity and eliminated oxidase-like activity by adjusting the Ag content.The introduction of Ag changes the hybrid d band energy of the alloyed metal and inhibits the O_(2)adsorption and decomposition on Pd,while improving the peroxidase mimicry by allowing for the H_(2)O_(2)activation.By exemplifying the construction of a highly sensitive and selective colorimetric glucose detection platform with its practicality validated in serum samples,this strategy pioneers a multi-noble metal nanozyme with tailored peroxidase activity based on the chemical structure engineering and would advance the development of single-catalytic function nanozymes for building exclusively specific biosensors through reducing substrate competition.展开更多
Iron disulfide(FeS_(2))has been widely used in thermal batteries because of its high theoretical specific capacity and voltage plateau.However,low thermal decomposition temperature,poor conductivity and inferior actua...Iron disulfide(FeS_(2))has been widely used in thermal batteries because of its high theoretical specific capacity and voltage plateau.However,low thermal decomposition temperature,poor conductivity and inferior actual specific capacity limit its wide applications.Herein,we report a gold-doped FeS_(2)(FeS_(2)-Au),which not only reduces the band gap of the FeS_(2)crystals but also enriches the electron transport path of FeS_(2)by the formation of Au nanoparticles.First-principles calculation shows that the diffusion energy barrier of lithium-ion is reduced after the Au-doped FeS_(2).In addition,Au increases the electron cloud density around sulfur atoms,which helps to enhance the stability of Fe-S covalent bonds and thus results in better thermal stability of FeS_(2).When the Au content is 130μg·g^(-1)(FeS_(2)-Au_(4)),the thermal decomposition temperature(TG5%)of FeS_(2)-Au is 72.2℃ higher than that of pristine FeS_(2).At a discharge temperature of 500℃,a current density of 200 mA·cm^(-2) and a cutoff voltage of 1.4 V,FeS_(2)-Au_(4)demonstrates superior specific capacity and high specific energy compared to FeS_(2).More precisely,the specific capacity of FeS_(2)-Au_(4)attains a value of 379 mAh·g^(-1),with a corresponding specific energy of 714 Wh·kg^(-1).In contrast,the discharge specific capacity and specific energy of FeS_(2)are lower,amounting to 348 mAh·g^(-1)and 656 Wh·kg^(-1),respectively.This study offers a novel approach to enhancing the electrochemical performance of FeS_(2)in high-temperature molten salt electrochemical systems(thermal batteries),thereby laying a solid foundation for its potential practical application.展开更多
基金supported by the National Natural Science Foundation of China(No.62276204,No.62306222)the Natural Science Basic Research Program of Shaanxi,China(No.2023-JC-QN-0710)。
文摘With the great development of Multi-Target Tracking(MTT)technologies,many MTT algorithms have been proposed with their own advantages and disadvantages.Due to the fact that requirements to MTT algorithms vary from the application scenarios,performance evaluation is significant to select an appropriate MTT algorithm for the specific application scenario.In this paper,we propose a performance evaluation method on the sets of trajectories with temporal dimension specifics to compare the estimated trajectories with the true trajectories.The proposed method evaluates the estimate results of an MTT algorithm in terms of tracking accuracy,continuity and clarity.Furthermore,its computation is based on a multi-dimensional assignment problem,which is formulated as a computable form using linear programming.To enhance the influence of recent estimated states of the trajectories in the evaluation,an attention function is used to reweight the trajectory errors at different time steps.Finally,simulation results show that the proposed performance evaluation method is able to evaluate many aspects of the MTT algorithms.These evaluations are worthy for selecting suitable MTT algorithms in different application scenarios.
基金supported by the Argentine Agency for the Promotion of Science and Technology ANPCyT(PICT2019-1472 to GP,PICT2019-4597 to FL,PICT2020-1524 to GP,and PICT2021-00627 to FL)supported by an Independent Career Position from CONICETsupported by a postdoctoral fellowship from ANPCyT。
文摘Stem cell proliferation is tightly regulated in developing and adult tissues through the coordinated action of cell-intrinsic and extracellular signals.Although many extracellular cues were identified,the cell-intrinsic mechanisms underlying the decision of a stem cell to proliferate,enter a dormant quiescent state or differentiate into a specific cell type remains incompletely understood.
文摘Alzheimer’s disease(AD)is the most common form of dementia.In addition to the lack of effective treatments,there are limitations in diagnostic capabilities.The complexity of AD itself,together with a variety of other diseases often observed in a patient’s history in addition to their AD diagnosis,make deciphering the molecular mechanisms that underlie AD,even more important.Large datasets of single-cell RNA sequencing,single-nucleus RNA-sequencing(snRNA-seq),and spatial transcriptomics(ST)have become essential in guiding and supporting new investigations into the cellular and regional susceptibility of AD.However,with unique technology,software,and larger databases emerging;a lack of integration of these data can contribute to ineffective use of valuable knowledge.Importantly,there was no specialized database that concentrates on ST in AD that offers comprehensive differential analyses under various conditions,such as sex-specific,region-specific,and comparisons between AD and control groups until the new Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease(ssREAD)database(Wang et al.,2024)was introduced to meet the scientific community’s growing demand for comprehensive,integrated,and accessible data analysis.
文摘Supercapacitors are gaining popularity due to their high cycling stability,power density,and fast charge and discharge rates.Researchers are ex-ploring electrode materials,electrolytes,and separat-ors for cost-effective energy storage systems.Ad-vances in materials science have led to the develop-ment of hybrid nanomaterials,such as combining fil-amentous carbon forms with inorganic nanoparticles,to create new charge and energy transfer processes.Notable materials for electrochemical energy-stor-age applications include MXenes,2D transition met-al carbides,and nitrides,carbon black,carbon aerogels,activated carbon,carbon nanotubes,conducting polymers,carbon fibers,and nanofibers,and graphene,because of their thermal,electrical,and mechanical properties.Carbon materials mixed with conducting polymers,ceramics,metal oxides,transition metal oxides,metal hydroxides,transition metal sulfides,trans-ition metal dichalcogenide,metal sulfides,carbides,nitrides,and biomass materials have received widespread attention due to their remarkable performance,eco-friendliness,cost-effectiveness,and renewability.This article explores the development of carbon-based hybrid materials for future supercapacitors,including electric double-layer capacitors,pseudocapacitors,and hy-brid supercapacitors.It investigates the difficulties that influence structural design,manufacturing(electrospinning,hydro-thermal/solvothermal,template-assisted synthesis,electrodeposition,electrospray,3D printing)techniques and the latest car-bon-based hybrid materials research offer practical solutions for producing high-performance,next-generation supercapacitors.
基金supported by the National Natural Science Foundation of China(Nos.42077299,and U21A20290)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750400)the Ordos Key Research and Development Program(No.YF20240037).
文摘Persistent toxic substances(PTS)represent a paramount environmental issue in the 21st century.Understanding the concentrations and forms of PTS in the environment is crucial for accurately assessing their environmental health impacts.This article presents a concise overview of the components of PTS,pertinent environmental regulations,and conventional detection methodologies.Additionally,we offer an in-depth review of the principles,development,and practical applications of surface-enhanced Raman scattering(SERS)in environmental monitoring,emphasizing the advancements in detecting trace amounts of PTS in complex environmental matrices.Recent progress in enhancing SERS sensitivity,improving selectivity,and practical implementations are detailed,showcasing innovative materials and methods.Integrating SERS with advanced algorithms are highlighted as pivotal areas for future research.
基金financially supported by China Aeronautical Science Foundation (No.2023Z0530Q9002)the Program for Chongqing Talents,China (No.cstc2024ycjh-bgzxm0066)。
文摘The microstructural evolution,phase stability,and mechanical properties of Al-Li-Mg-Ti-M(M=Zn,Zr,V)lightweight high-entropy alloys(LW-HEAs)were investigated.The LW-HEAs with three components,Al_(20)Li_(20)Mg_(10)-Ti_(40)Zn_(10)(#Zn),Al_(20)Li_(20)Mg_(10)Ti_(30)Zr_(20)(#Zr),and Al_(20)Li_(20)Mg_(10)Ti_(30)V_(20)(#V),were designed according to the thermo-dynamic design criteria of HEA,and prepared via a combination process of mechanical alloying and cold-press sintering.The effects of alloy composition and sintering temperature on the microstructure and mechanical properties of the LW-HEAs were studied.The results show that the as-milled Al-Li-Mg-Ti-M(M=Zn,Zr,V)LW-HEAs form a simple structure with HCP-type solid solution as the primary phase,a dual-HCP type solid solution phase,and a BCC phase,respectively.After cold-press sintering,the#Zn and#V alloys undergo obvious phase transformation;while the#Zr alloy with dual-HCP phases exhibits the best phase stability during heat treatment.The#V-750°C alloy demonstrates the maximum hardness and specific strength of HV 595.2 and 625 MPa∙cm3/g,respectively,under the combined effect of solid solution strengthening of BCC phase and precipitation strengthening ofβ-AlTi_(3).Moreover,the#Zr-650°C,#Zr-750°C,and#Zn-650°C alloys are expected to have excellent plasticity.
基金The Open Project of State Key Laboratory of Smart Grid Protection and Operation Control in 2022(No.SGNR0000KJJS2302150).
文摘Fully implanted brain-computer interfaces(BCIs)are preferred as they eliminate signal degradation caused by interference and absorption in external tissues,a common issue in non-fully implanted systems.To optimize the design of electroencephalography electrodes in fully implanted BCI systems,this study investigates the penetration and absorption characteristics of microwave signals in human brain tissue at different frequencies.Electromagnetic simulations are used to analyze the power density distribution and specific absorption rate(SAR)of signals at various frequen-cies.The results indicate that lower-frequency signals offer advantages in terms of power density and attenuation coeffi-cients.However,SAR-normalized analysis,which considers both power density and electromagnetic radiation hazards,shows that higher-frequency signals perform better at superficial to intermediate depths.Specifically,at a depth of 2 mm beneath the cortex,the power density of a 6.5 GHz signal is 247.83%higher than that of a 0.4 GHz signal.At a depth of 5 mm,the power density of a 3.5 GHz signal exceeds that of a 0.4 GHz signal by 224.16%.The findings suggest that 6.5 GHz is optimal for electrodes at a depth of 2 mm,3.5 GHz for 5 mm,2.45 GHz for depths of 15-20 mm,and 1.8 GHz for 25 mm.
基金supported by the Battery Energy Storage Testing Center of Chongqing through their provision of testing support and technical assistance。
文摘Aqueous zinc-ion batteries(AZIBs)are gaining attention owing to their affordability,high safety,and high energy density,making them a promising solution for large-scale energy storage.However,their performance is hampered by the instability of both the anode-electrolyte interface and the cathode-electrolyte interface.The use of sodium gluconate(SG),an organic sodium salt with multiple hydroxyl groups,as an electrolyte additive is suggested.Experimental and theoretical analyses demonstrate that Na^(+)from SG can intercalate and deintercalate within the associated V_(2)O_(5) cathode during in situ electrochemical processes.This action supports the layered structure of V_(2)O_(5),prevents structural collapse and phase transitions,and enhances Zn^(2+)diffusion kinetics.Additionally,the gluconate anion disrupts the original Zn^(2+)solvation structure,mitigates water-induced side reactions,and suppresses Zn dendrite growth.The synchronous regulation of both the V_(2)O_(5) cathode and Zn anode by the SG additive leads to considerable performance improvements.Zn‖Zn symmetric batteries demonstrate a cycle life exceeding 2800 h at 0.5 mA cm^(-2)and 1 mAh cm^(-2).In Zn‖V_(2)O_(5) full batteries,a high specific capacity of 288.92 mAh g^(-1)and capacity retention of 82.29%are maintained over 1000 cycles at a current density of 2 A g^(-1).This multifunctional additive strategy offers a new pathway for the practical application of AZIBs.
基金supported by the National Natural Science Foundation of China(No.41977199).
文摘In this study,two wheat-derived cadmium(Cd)-immobilizing endophytic Pseudomonas paralactis M14 and Priestia megaterium R27 were evaluated for their effects on wheat tissue Cd uptake under hydroponic conditions.Then,the impacts of the biochar(BC),M14+R27(MR),and BC+MR treatments on wheat Cd uptake and the mechanisms involved were investigated at the jointing,heading,and mature stages of wheat plants under field-plot conditions.A hydroponic experiment showed that the MR treatment significantly decreased the above-ground tissue Cd content compared with theM14 or R27 treatment.The BC+MRtreatment reduced the grain Cd content by 51.5%-67.7%and Cd translocation factor at the mature stage of wheat plants and increased the organic matter-bound Cd content by 31%-75%in the rhizosphere soils compared with the BC or MR treatment.Compared with the BC or MR treatment,the relative abundances of the biomarkers associated with Gemmatimonas,Altererythrobacter,Gammaproteobacteria,Xanthomonadaceae,Phenylobacterium,and Nocardioides in the BC+MR-treated rhizosphere microbiome decreased and negatively correlated with the organic matter-bound Cd contents.In the BC+MR-treated root interior microbiome,the relative abundance of the biomarker belonging to Exiguobacterium increased and negatively correlated with the Cd translocation factor,while the relative abundance of the biomarker belonging to Pseudonocardiaceae decreased and positively correlated with the Cd translocation factor.Our findings suggested that the BC+MR treatment reduced Cd availability and Cd transfer through affecting the abundances of these specific biomarkers in the rhizosphere soil and root interior microbiomes,leading to decreased wheat grain Cd uptake in the contaminated soil.
基金funded by grants from the National Research Foundation of Korea(NRF)grant funded by the Korea government(2018M3A9H4055203 and 2023R1A2C2003679)from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(HV23C1857)from KRIBB Research Initiative Program(KGM9942421).
文摘Influenza,a highly contagious respiratory infectious disease caused by an influenza virus,is a threat to public health worldwide.Avian influenza viruses(AIVs)have the potential to cause the next pandemic by crossing the species barrier through mutation of viral genome.Here,we investigated the pathogenicity of AIVs obtained from South Korea and Mongolia during 2018–2019 by measuring viral titers in the lungs and extrapulmonary organs of mouse models.In addition,we assessed the pathogenicity of AIVs in ferret models.Moreover,we compared the ability of viruses to replicate in mammalian cells,as well as the receptor-binding preferences of AIV isolates.Genetic analyses were finally performed to identify the genetic relationships and amino acid substitutions between viral proteins during mammalian adaptation.Of the 24 AIV isolates tested,A/Mallard/South Korea/KNU2019-34/2019(KNU19-34;H1N1)caused severe bodyweight loss and high mortality in mice.The virus replicated in the lungs,kidneys,and heart.Importantly,KNU19-34-infected ferrets showed high viral loads in both nasal washes and lungs.KNU19-34 replicated rapidly in A549 and bound preferentially to human likeα2,6-linked sialic acids rather than to avian-likeα2,3-linked sialic acids,similar to the pandemic A/California/04/2009(H1N1)strain.Gene segments of KNU19-34 were distributed in Egypt and Asia lineages from 2015 to 2018,and the virus had several amino acid substitutions compared to H1N1 AIV isolates that were non-pathogenic in mice.Collectively,the data suggest that KNU19-34 has zoonotic potential and the possibility of new mutations responsible for mammalian adaptation.
基金supported by the Brazil Family Program for Neurology(to MB),Alastair Rushworth Research Fund(to MS),Australian Government Research Training Program Scholarship(to MS),the National Natural Science Foundation of China(82202787)(to CW).
文摘Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s disease.This method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of function.Recently,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological conditions.Addressing open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.
文摘Evaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy Taylan Tugrul1(1.Department of Radiation Oncology,Medicine Faculty of Van YüzüncüYıl University,Van,Turkey)Abstract:Quality assurance practices performed before treatment are believed to identify various potential errors.In this study,2-dimensional(2D)dosimetric results were analyzed by making some intentional mistakes in six different treatment plans.In this way,the detectability of errors was investigated.In all segments of all treatment plans,one of the multileaf collimators was kept fixed at different positions on the central axis.In addition to multileaf collimators error,gantry error was also examined in the study.The dose distribution results obtained by Treatment Planning System(TPS)were compared with those obtained by the 2D array device,both as local calculation and global calculation methods,using the gamma analysis method.When the results are examined in the case where the Multi-leaf collimators(MLC)is fixed at the 1 cm position.
文摘BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell therapies.Stem cells have yielded so far mixed results in clinical trials,and at patient level the results varied from impressive to no improvement.In this context we have administered autologous cord blood(ACB)and a non-placebo,material intervention repre-sented by an individualized combination of supplements(ICS)to ASD children.METHODS CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children;ACB was infused as an inpatient procedure.Treatment efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist,Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score,after interviewing the children’s parents and therapists.Before and after each intervention participants had a set of blood tests including inflammatory,metabolic and oxidative markers,and the neuronal specific enolase.RESULTS No serious adverse reactions were noted during and after cord blood or supplement administration.ACB improved evaluation scores in 78%of children with age 3–7-years(n=28),but was much less effective in kids older than 8 years or with body weight of more than 35 kg(n=28;only 11%of children improved scores).ICS yielded better results than ACB in 5 cases out of 28,while in 23 kids ACB brought more improvement than ICS(P<0.05);high initial levels of inflammation and ferritin were associated with no improvement.Ample individual differences were noted in children's progress,and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction,but not on irritability or aggressive behavior.CONCLUSION ACB has superior efficacy to ICS in ASD;high inflammation,ferritin,age and body weight predict less improvement;more clinical studies are needed for studying ACB efficacy in ASD.
基金This work was supported by the High-level Innovative Research Institute from the Department of Science and Technology of Guangdong Province(Grant No.2020B0909010003)the Ministry of Education of China(Grant No.8091B02052401).
文摘To meet the demand for air-breathing power for wide-range vehicles at Mach 0–10,two thermal cycles with ammonia as the fuel and coolant were analyzed,namely the precooled rocket-turbine cycle(PC-RT)and the precooled gas-turbine cycle.Firstly,the operating modes of the precooled cycle engines were divided into turbine mode,precooling mode,and ramjet mode.Secondly,a fluid-structure coupling heat transfer program was used to evaluate the cooling effects of different fuels on the incoming high-temperature air.The result shows that the equivalent heat sink of ammonia is higher than that of other fuels and can meet the cooling requirement of at least Mach 4 in the precooling mode.Thirdly,the performance of the PC-RT in the turbine and precooling modes was compared at Mach 2.5.The result shows that air precooling alleviates the restriction of the pumping pressure on the minimum requiredβand improves the specific thrust within a reasonable range ofβ.Fourthly,the performance of the precooled cycle engines was compared when using different fuels.The result shows that the specific thrust of ammonia is greater than that of other fuels,and the performance advantages of ammonia are the most obvious in the precooling mode due to its highest equivalent heat sink.To sum up,the precooled cycle engines with ammonia as the fuel and coolant presented in this study have the advantages of no carbon emissions,low cost,high specific thrust,and no clogging of the cooling channels by cracking products.They are suitable for applications such as the first-stage power of the two-stage vehicle,and high Mach numbers air-breathing flight.
文摘Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely used“generic”(absolute intensity)cut-point approach has limited generalisability to population-level free-living data.Further,current methods generally fail to account for differences in people's physical capacity.
基金supported by the National Key Research and Development Project of China(Grant No.2022YFB3205500)the National Natural Science Foundation of China(Grant No.12275190,12105201)+2 种基金Jiangsu Funding Program for Excellent Postdoctoral Talent(Grant No.2024ZB723)the Shenzhen Research Funding Program(JCYJ20230807154402004)supported by the Collaborative Innovation Center of Suzhou Nano Science&Technology,the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),the 111 Project,the Joint International Research Laboratory of Carbon-Based Functional Materials and Devices,and the Suzhou Key Laboratory of Functional Nano&Soft Materials and Soochow University-Western University Centre for Synchrotron Radiation Research.
文摘Conventional gas sensing materials(e.g.,metal oxides)suffer from deficient sensitivity and serve cross-sensitivity issues due to the lack of efficient adsorption sites.Herein,the heteroatom atomically doping strategy is demonstrated to significantly enhance the sensing performance of metal oxides-based gas sensing materials.Specifically,the Sn atoms were incorporated into porous Fe_(2)O_(3)in the form of atomically dispersed sites.As revealed by X-ray absorption spectroscopy and atomic-resolution scanning transmission electron microscopy,these Sn atoms successfully occupy the Fe sites in the Fe_(2)O_(3)lattice,forming the unique Sn-O-Fe sites.Compared to Fe-O-Fe sites(from bare Fe_(2)O_(3))and Sn-O-Sn sites(from SnO_(2)/Fe_(2)O_(3)with high Sn loading),the Sn-O-Fe sites on porous Fe_(2)O_(3)exhibit a superior sensitivity(Rg/Ra=2646.6)to 1 ppm NO_(2),along with dramatically increased selectivity and ultra-low limits of detection(10 ppb).Further theoretical calculations suggest that the strong adsorption of NO_(2)on Sn-O-Fe sites(N atom on Sn site,O atom on Fe site)contributes a more efficient gas response,compared to NO_(2)on Fe-O-Fe sites and other gases on Sn-O-Fe sites.Moreover,the incorporated Sn atoms reduce the bandgap of Fe_(2)O_(3),not only facilitating the electron release but also increasing the NO_(2)adsorption at a low working temperature(150°C).This work introduces an effective strategy to construct effective adsorption sites that show a unique response to specific gas molecules,potentially promoting the rational design of atomically modified gas sensing materials with high sensitivity and high selectivity.
基金supported by Higher Institution Centre of Excellence(HICoE)Grant(A305-KR-AKH002-0000000278-K134)from the Ministry of Higher Education,Malaysia.
文摘Objective:To assess aptamer-based assays for diagnosing latent tuberculosis infection(LTBI).Methods:Literature from Medline,ScienceDirect,and Scopus,covering publications from January 1,2012,to December 31,2023,was examined.This review evaluates different aptamers,biomarkers,sample types,sample sizes,reference assays,and the assays'sensitivity and specificity.By using the Quality Assessment of Diagnostic Accuracy Studies 2,the risk of bias in each study was evaluated.Results:Aptamer-based assays generally showed a sensitivity of 90%(95%CI:75%-100%)and specificity of 90%(95%CI:50%-100%),where optical aptasensor showed the highest sensitivity and specificity at 100%.Serum samples were frequently used to enhance antigen detectability,improving the assay’s performance.Meanwhile,HspX was the most studied biomarker,followed by MPT64,and IFN-γ.Conclusions:Aptamer-based assays could be reliable alternatives to current LTBI detection methods,but further research is needed to validate their clinical efficacy.
基金financially supported by the National Natural Science Foundation of China(Grant No.52079150)Science and Technology Major Project of the Xizang Autonomous Region of China(XZ202201ZD0003G)Water Conservancy Technology Demonstration Project(SF-202404).
文摘This study aims to enhance the digital drilling process monitoring(DPM)or monitoring while drilling(MWD)technique,which is a widely recognized method in geological exploration for evaluating rock mass quality.First,robust displacement and torque measurement facilities for rotary-core drilling are discussed.The conventional cable encoder for displacement measurement is replaced with a magnetostrictive displacement sensor,which is more reliable in harsh field drilling environments.This enables the measurement of the bit position with an accuracy of<1 mm.Most importantly,this new instrument is proven to be successful in improving the detection of structural discontinuities with thicknesses>1 mm.In addition,by measuring the electric current of the driving motor,the torque applied to the bit is conveniently and accurately converted.These innovations ensure high-quality data collection for DPM practices.Second,two indices derived from DPM are proposed to quantitatively describe rock mass quality.The specific energy index(SEI)and specific penetration index(SPI)are based on the principles of energy conservation and Mohr-Coulomb failure criterion,respectively.Extensive field tests conducted in a dam grouting area confirm a linear relationship between the thrust force and penetration per rotation,and between the torque and penetration per rotation.The correlation ratios of the related regressions are typically>0.9.These two indices allow for the quantitative interpretation of DPM data into rock mechanics characteristics,such as uniaxial compressive strength,rock quality designation(RQD),and rock mass permeability,eliminating the need for subjective judgment normally involved in the currently used rock mass quality rating approaches.
基金financially supported by the National Natural Science Foundation of China(No.22074038)the Luoyang Institute of Science and Technology Natural Science General Project(No.21010905)+1 种基金the Fundamental Research Funds for the Central Universitiessponsored by the Domestic Visiting Scholar Program of Shandong University of Science and Technology。
文摘Nanozymes,characterized by their stability,cost-effectiveness,and tunable catalytic activity,are promising alternatives to natural enzymes.However,specifically mimicking a single natural enzyme's activity presents a challenge.By exploiting the catalytic selectivity derived from the valence-band hybridization of noble metal nanoalloys,we introduce an alloying strategy to modulate the reaction specificity of metallic nanozymes.Ag Pd nanoalloy exhibits enhanced peroxidase-like activity and eliminated oxidase-like activity by adjusting the Ag content.The introduction of Ag changes the hybrid d band energy of the alloyed metal and inhibits the O_(2)adsorption and decomposition on Pd,while improving the peroxidase mimicry by allowing for the H_(2)O_(2)activation.By exemplifying the construction of a highly sensitive and selective colorimetric glucose detection platform with its practicality validated in serum samples,this strategy pioneers a multi-noble metal nanozyme with tailored peroxidase activity based on the chemical structure engineering and would advance the development of single-catalytic function nanozymes for building exclusively specific biosensors through reducing substrate competition.
基金supported by the Central South University Innovation-Driven Research Programme(No.2023CXQD009).
文摘Iron disulfide(FeS_(2))has been widely used in thermal batteries because of its high theoretical specific capacity and voltage plateau.However,low thermal decomposition temperature,poor conductivity and inferior actual specific capacity limit its wide applications.Herein,we report a gold-doped FeS_(2)(FeS_(2)-Au),which not only reduces the band gap of the FeS_(2)crystals but also enriches the electron transport path of FeS_(2)by the formation of Au nanoparticles.First-principles calculation shows that the diffusion energy barrier of lithium-ion is reduced after the Au-doped FeS_(2).In addition,Au increases the electron cloud density around sulfur atoms,which helps to enhance the stability of Fe-S covalent bonds and thus results in better thermal stability of FeS_(2).When the Au content is 130μg·g^(-1)(FeS_(2)-Au_(4)),the thermal decomposition temperature(TG5%)of FeS_(2)-Au is 72.2℃ higher than that of pristine FeS_(2).At a discharge temperature of 500℃,a current density of 200 mA·cm^(-2) and a cutoff voltage of 1.4 V,FeS_(2)-Au_(4)demonstrates superior specific capacity and high specific energy compared to FeS_(2).More precisely,the specific capacity of FeS_(2)-Au_(4)attains a value of 379 mAh·g^(-1),with a corresponding specific energy of 714 Wh·kg^(-1).In contrast,the discharge specific capacity and specific energy of FeS_(2)are lower,amounting to 348 mAh·g^(-1)and 656 Wh·kg^(-1),respectively.This study offers a novel approach to enhancing the electrochemical performance of FeS_(2)in high-temperature molten salt electrochemical systems(thermal batteries),thereby laying a solid foundation for its potential practical application.
