In this work,a novel MXene-copolymeric molecularly imprinted hydrogel(FMMIH)with temperature/pH dual response and photothermal conversion performance for selective recognition of cis-diol compounds is successfully pre...In this work,a novel MXene-copolymeric molecularly imprinted hydrogel(FMMIH)with temperature/pH dual response and photothermal conversion performance for selective recognition of cis-diol compounds is successfully prepared.Functionalized MXene becomes an important part of the hydrogel’s skeleton by participating in the free radical polymerization reaction.Therefore,FMMIH exhibits improved mechanical properties and great photothermal conversion performance.Furthermore,based on the temperature/pH dual response,FMMIH can realize the controllable capture and release of ginsenoside Rb1 with cis diol structures through dual recognitions of functional groups and geometric space.Under the conditions of pH 8.5 and 25℃,the adsorption capacity of FMMIH is 26.3 mg·g^(-1) and the imprinting factor is 16.4,showing a good imprinting effect.It is worth noting that the volume shrinkage caused by photothermal conversion of the hydrogel is conducive to the elution of template molecules and greatly saves the time of desorption(the desorption efficiency is as high as 89.4%under light conditions for 30 min,which is 3.7 times in dark conditions).These excellent properties make it possible to have broad prospects in many fields such as separation of cis-diol compounds,drug delivery systems,and biosensors.展开更多
In this work,a novel electrochemical sensor based on covalent organic framework@carbon black@molecularly imprinted polydopamine(COF@CB@MPDA)was developed for selective recognition and determination of ciprofloxacin(CF...In this work,a novel electrochemical sensor based on covalent organic framework@carbon black@molecularly imprinted polydopamine(COF@CB@MPDA)was developed for selective recognition and determination of ciprofloxacin(CF).COF@CB@MPDA possessed good water dispersibility and was synthesized by the selfpolymerization of dopamine under alkaline conditions in the presence of the COF,CB and CF.The high surface area COF enhanced the adsorption of CF,whilst CB gave the composites high electrical conductivity to improve the sensitivity of the proposed COF@CB@MPDA/glassy carbon electrode(GCE)sensor.The specific recognition of CF by COF@CB@MPDA involved hydrogen bonding and van der Waals interactions.Under optimized conditions,the sensor showed a good linear relationship with CF concentration over the range of 5.0×10^(–7)and 1.0×10^(–4)mol/L,with a limit of detection(LOD)of 9.53×10^(–8)mol/L.Further,the developed sensor exhibited high selectivity,repeatability and stability for CF detection in milk and milk powders.The method used to fabricate the COF@CB@MPDA/GCE sensor could be easily adapted for the selective recognition and detection of other antibacterial agents and organic pollutants in the environment.展开更多
To effectively treat pollution and overcome the lack of selectivity of TiO_(2)-based photocatalysts,a 1D structure and molecular imprinting technology have been combined to produce TiO_(2)/SiO_(2) hybrid fibers by a s...To effectively treat pollution and overcome the lack of selectivity of TiO_(2)-based photocatalysts,a 1D structure and molecular imprinting technology have been combined to produce TiO_(2)/SiO_(2) hybrid fibers by a simple electrospinning method by directly adding templates into the precursor solution.In our design,TBOT acts as a titanium source and a functional monomer to combine with RhB and generate specific recognition sites,and SiO_(2) plays a role in inhibiting phase transition.The calcination process can not only remove the template and form an imprinting cavity but also enhance the crystallinity of photoca-talysts.The inorganic framework also overcomes the shortcomings of the instability of traditional organic molecularly imprinted layers.In contrast to a nonimprinted sample,imprinted fibers exhibit higher adsorp-tion capacity and selectivity,attributed to the specific combination through hydrogen bonds and space matching effect.The photocatalytic efficiency of the imprinted sample reached 100%within only 15 min,showing excellent photocatalytic performance and high selectivity.This work not only provides a novel,simple method to fabricate TiO_(2) fiber photocatalysts with high selectivity for the first time but also offers new strategies for the effective and selective treatment of pollutants in wastewater.展开更多
Molecular imaging has emerged as a transformative tool in cancer diagnosis,enabling the visualization of biological processes at the cellular and molecular levels.Aptamers,single-stranded oligonucleotides with high af...Molecular imaging has emerged as a transformative tool in cancer diagnosis,enabling the visualization of biological processes at the cellular and molecular levels.Aptamers,single-stranded oligonucleotides with high affinity and specificity for target molecules,have gained significant attention as versatile probes for molecular imaging due to their unique properties,including small size,ease of modification,low immunogenicity,and rapid tissue penetration.This review explores the integration of aptamers with various imaging agents to enhance cancer diagnosis and therapy.Aptamer-based imaging probes offer high sensitivity and real-time visualization of tumor markers.Aptamer-based fluorescence probes and aptamer-conjugated magnetic resonance imaging(MRI)probes,including gadolinium-based contrast agents,improve tumor targeting and imaging resolution.Additionally,aptamers have been utilized in single-photon emission computed tomography(SPECT)and positron emission tomography(PET)imaging to enhance the specificity of radiotracers for cancer detection.Furthermore,aptamer-targeted ultrasound and computed tomography(CT)imaging demonstrate the potential for noninvasive and precise tumor localization.By leveraging the unique advantages of aptamers,these imaging strategies not only improve diagnostic accuracy but also pave the way for image-guided cancer therapies.This review highlights the significant role of aptamers in advancing molecular imaging and their potential to revolutionize cancer diagnosis and treatment.展开更多
基金the National Natural Science Foundation of China(No.21978024)Beijing Natural Science Foundation(No.2202034)the National Key R&D Program of China(No.2019YFB1309703).
文摘In this work,a novel MXene-copolymeric molecularly imprinted hydrogel(FMMIH)with temperature/pH dual response and photothermal conversion performance for selective recognition of cis-diol compounds is successfully prepared.Functionalized MXene becomes an important part of the hydrogel’s skeleton by participating in the free radical polymerization reaction.Therefore,FMMIH exhibits improved mechanical properties and great photothermal conversion performance.Furthermore,based on the temperature/pH dual response,FMMIH can realize the controllable capture and release of ginsenoside Rb1 with cis diol structures through dual recognitions of functional groups and geometric space.Under the conditions of pH 8.5 and 25℃,the adsorption capacity of FMMIH is 26.3 mg·g^(-1) and the imprinting factor is 16.4,showing a good imprinting effect.It is worth noting that the volume shrinkage caused by photothermal conversion of the hydrogel is conducive to the elution of template molecules and greatly saves the time of desorption(the desorption efficiency is as high as 89.4%under light conditions for 30 min,which is 3.7 times in dark conditions).These excellent properties make it possible to have broad prospects in many fields such as separation of cis-diol compounds,drug delivery systems,and biosensors.
基金supported by the Project of Key R&D Program of Shandong Province(2023CXGC010712).Geoffrey I.N.
文摘In this work,a novel electrochemical sensor based on covalent organic framework@carbon black@molecularly imprinted polydopamine(COF@CB@MPDA)was developed for selective recognition and determination of ciprofloxacin(CF).COF@CB@MPDA possessed good water dispersibility and was synthesized by the selfpolymerization of dopamine under alkaline conditions in the presence of the COF,CB and CF.The high surface area COF enhanced the adsorption of CF,whilst CB gave the composites high electrical conductivity to improve the sensitivity of the proposed COF@CB@MPDA/glassy carbon electrode(GCE)sensor.The specific recognition of CF by COF@CB@MPDA involved hydrogen bonding and van der Waals interactions.Under optimized conditions,the sensor showed a good linear relationship with CF concentration over the range of 5.0×10^(–7)and 1.0×10^(–4)mol/L,with a limit of detection(LOD)of 9.53×10^(–8)mol/L.Further,the developed sensor exhibited high selectivity,repeatability and stability for CF detection in milk and milk powders.The method used to fabricate the COF@CB@MPDA/GCE sensor could be easily adapted for the selective recognition and detection of other antibacterial agents and organic pollutants in the environment.
基金supported by the National Natural Science Foundation of China(52073120).
文摘To effectively treat pollution and overcome the lack of selectivity of TiO_(2)-based photocatalysts,a 1D structure and molecular imprinting technology have been combined to produce TiO_(2)/SiO_(2) hybrid fibers by a simple electrospinning method by directly adding templates into the precursor solution.In our design,TBOT acts as a titanium source and a functional monomer to combine with RhB and generate specific recognition sites,and SiO_(2) plays a role in inhibiting phase transition.The calcination process can not only remove the template and form an imprinting cavity but also enhance the crystallinity of photoca-talysts.The inorganic framework also overcomes the shortcomings of the instability of traditional organic molecularly imprinted layers.In contrast to a nonimprinted sample,imprinted fibers exhibit higher adsorp-tion capacity and selectivity,attributed to the specific combination through hydrogen bonds and space matching effect.The photocatalytic efficiency of the imprinted sample reached 100%within only 15 min,showing excellent photocatalytic performance and high selectivity.This work not only provides a novel,simple method to fabricate TiO_(2) fiber photocatalysts with high selectivity for the first time but also offers new strategies for the effective and selective treatment of pollutants in wastewater.
基金support by the National Natural Science Foundation of China(32171429)the Natural Science Foundation of Hunan Province(2022JJ30672,2024JJ9218).
文摘Molecular imaging has emerged as a transformative tool in cancer diagnosis,enabling the visualization of biological processes at the cellular and molecular levels.Aptamers,single-stranded oligonucleotides with high affinity and specificity for target molecules,have gained significant attention as versatile probes for molecular imaging due to their unique properties,including small size,ease of modification,low immunogenicity,and rapid tissue penetration.This review explores the integration of aptamers with various imaging agents to enhance cancer diagnosis and therapy.Aptamer-based imaging probes offer high sensitivity and real-time visualization of tumor markers.Aptamer-based fluorescence probes and aptamer-conjugated magnetic resonance imaging(MRI)probes,including gadolinium-based contrast agents,improve tumor targeting and imaging resolution.Additionally,aptamers have been utilized in single-photon emission computed tomography(SPECT)and positron emission tomography(PET)imaging to enhance the specificity of radiotracers for cancer detection.Furthermore,aptamer-targeted ultrasound and computed tomography(CT)imaging demonstrate the potential for noninvasive and precise tumor localization.By leveraging the unique advantages of aptamers,these imaging strategies not only improve diagnostic accuracy but also pave the way for image-guided cancer therapies.This review highlights the significant role of aptamers in advancing molecular imaging and their potential to revolutionize cancer diagnosis and treatment.
