Objective To investigate the correlation between serum plasmamembranevesicle-associated protein(PLVAP)levels and metabolism-associated fatty liver disease(MAFLD)in patients with T2DM.Methods A total of 255 patients wi...Objective To investigate the correlation between serum plasmamembranevesicle-associated protein(PLVAP)levels and metabolism-associated fatty liver disease(MAFLD)in patients with T2DM.Methods A total of 255 patients with type 2 diabetes mellitus(T2DM)treated in Gansu Provincial Hospital from September 2023 to March 2024 were selected in this study,and were divided into T2DM alone group(n=141)and the T2DM combined with MAFLD group(n=114)according to whether they were combined with MAFLD or not.Spearman correlation analysis was used to analyze the correlation between serum PLVAP and other indexes,multiple linear regression analysis was used to analyze the influencing factors of serum PLVAP,and Logistic regression analysis was used to analyze the influencing factors of MAFLD in T2DM patients.The early diagnostic value of serum PLVAP on MAFLD in patients with T2DM by analyzing the receiver's operating characteristics(ROC)curve.Results Compared with the MAFLD group,BMI,WC,FPG,C-P,HOMA-IR,TG,AST,ALT,GGT,hepatic steatosis index(HSI)and phytohaemagglutinin-like oxidized low-density lipoprotein receptor 1(LOX-1)were decreased in the T2DM group(P<0.05).DM duration,,HDL-C,AST/ALT and PLVAP were elevated(P<0.05).Spearman correlation analysis showed that PLVAP was positively correlated with AST/ALT(P<0.05)and negatively correlated with WC,DBP,C-P,ALT,GGT and HSI(P<0.05).Multiple linear regression analysis showed that WC was an influencing factor for PLVAP.Logistic regression analysis showed that DM duration,WC,TG,PLVAP,LOX-1 were influencing factors for MAFLD.Analysis of the subjects'work characteristics(ROC)curve showed that the area under the ROC curve was 0.785,with a sensitivity of 81.6%and a specificity of 67.4%.Conclusion Reduced PLVAP is a risk factor for comorbid MAFLD in patients with T2DM and is important for predicting the co-existence of MAFLD in patients with T2DM.展开更多
Agriculture green development(AGD)has become an unavoidable choice to address the unique national circumstances of China.This study established a county-level AGD evaluation index system,comprised three dimensions,foo...Agriculture green development(AGD)has become an unavoidable choice to address the unique national circumstances of China.This study established a county-level AGD evaluation index system,comprised three dimensions,food production,ecological environment and socioeconomic development,using 20 indicators.The assessment delved into historical trend and current situation,utilizing Spearman rank correlation analysis to analyze trade-off and synergy relationships,using Quzhou County,Hebei Province as a case study.The main findings were in four areas.Firstly,the index for AGD in Quzhou County increased by 58.9%from 1978 to 2019.The major contribution were the social economy(65.8%)and food production(53.5%),whereas the ecological environment was found to have had a negative impact.Secondly,in 2019,the AGD index was only 56.4,indicating substantial potential for improvement relative to the target value.A notable difference in scores existed between the three dimensions,with the order being ecological environment(66.3)>food production(61.7)>socioeconomic(41.3).Also,90%of the indicators did not reach the target value.Thirdly,relationship analysis of the indicators revealed that the synergistic effect exceeded the trade-off effect.Specifically,46.3%of the indicators had no significant relationship,35.3%had a synergistic relationship,and 18.4%had a trade-off relationship.Finally,interdimensional indicator relationships exhibited a trade-off effect between the ecological environment and both food production and socioeconomic dimensions.However,a positive trend of synergy between production and ecology has emerged since 2015.In conclusion,the quantitative evaluation index system exposed the unbalanced development and significant potential relative to the target value of AGD in Quzhou County,despite notable progress.展开更多
文摘Objective To investigate the correlation between serum plasmamembranevesicle-associated protein(PLVAP)levels and metabolism-associated fatty liver disease(MAFLD)in patients with T2DM.Methods A total of 255 patients with type 2 diabetes mellitus(T2DM)treated in Gansu Provincial Hospital from September 2023 to March 2024 were selected in this study,and were divided into T2DM alone group(n=141)and the T2DM combined with MAFLD group(n=114)according to whether they were combined with MAFLD or not.Spearman correlation analysis was used to analyze the correlation between serum PLVAP and other indexes,multiple linear regression analysis was used to analyze the influencing factors of serum PLVAP,and Logistic regression analysis was used to analyze the influencing factors of MAFLD in T2DM patients.The early diagnostic value of serum PLVAP on MAFLD in patients with T2DM by analyzing the receiver's operating characteristics(ROC)curve.Results Compared with the MAFLD group,BMI,WC,FPG,C-P,HOMA-IR,TG,AST,ALT,GGT,hepatic steatosis index(HSI)and phytohaemagglutinin-like oxidized low-density lipoprotein receptor 1(LOX-1)were decreased in the T2DM group(P<0.05).DM duration,,HDL-C,AST/ALT and PLVAP were elevated(P<0.05).Spearman correlation analysis showed that PLVAP was positively correlated with AST/ALT(P<0.05)and negatively correlated with WC,DBP,C-P,ALT,GGT and HSI(P<0.05).Multiple linear regression analysis showed that WC was an influencing factor for PLVAP.Logistic regression analysis showed that DM duration,WC,TG,PLVAP,LOX-1 were influencing factors for MAFLD.Analysis of the subjects'work characteristics(ROC)curve showed that the area under the ROC curve was 0.785,with a sensitivity of 81.6%and a specificity of 67.4%.Conclusion Reduced PLVAP is a risk factor for comorbid MAFLD in patients with T2DM and is important for predicting the co-existence of MAFLD in patients with T2DM.
基金supported by the National Key Research and Development Program of China(2021YFD1700400)the Yunnan Fundamental Research Projects(202201AU070001)the Startup Fund for Young Faculty at SJTU(22X010500256)。
文摘Agriculture green development(AGD)has become an unavoidable choice to address the unique national circumstances of China.This study established a county-level AGD evaluation index system,comprised three dimensions,food production,ecological environment and socioeconomic development,using 20 indicators.The assessment delved into historical trend and current situation,utilizing Spearman rank correlation analysis to analyze trade-off and synergy relationships,using Quzhou County,Hebei Province as a case study.The main findings were in four areas.Firstly,the index for AGD in Quzhou County increased by 58.9%from 1978 to 2019.The major contribution were the social economy(65.8%)and food production(53.5%),whereas the ecological environment was found to have had a negative impact.Secondly,in 2019,the AGD index was only 56.4,indicating substantial potential for improvement relative to the target value.A notable difference in scores existed between the three dimensions,with the order being ecological environment(66.3)>food production(61.7)>socioeconomic(41.3).Also,90%of the indicators did not reach the target value.Thirdly,relationship analysis of the indicators revealed that the synergistic effect exceeded the trade-off effect.Specifically,46.3%of the indicators had no significant relationship,35.3%had a synergistic relationship,and 18.4%had a trade-off relationship.Finally,interdimensional indicator relationships exhibited a trade-off effect between the ecological environment and both food production and socioeconomic dimensions.However,a positive trend of synergy between production and ecology has emerged since 2015.In conclusion,the quantitative evaluation index system exposed the unbalanced development and significant potential relative to the target value of AGD in Quzhou County,despite notable progress.
