The melt onset dates(MOD)over Arctic sea ice plays an important role in the seasonal cycle of sea ice surface properties,which impacts Arctic surface solar radiation absorbed by the ice-ocean system.Monitoring interan...The melt onset dates(MOD)over Arctic sea ice plays an important role in the seasonal cycle of sea ice surface properties,which impacts Arctic surface solar radiation absorbed by the ice-ocean system.Monitoring interannual variations in MOD is valuable for understanding climate change.In this study,we investigated the spatio-temporal variability of MOD over Arctic sea ice and 14 Arctic sub-regions in the period of 1979 to 2017 from passive microwave satellite data.A set of mathematical and statistical methods,including the Sen’s slope and Mann-Kendall mutation tests,were used to comprehensively assess the variation trend and abrupt points of MOD during the past 39 years for different Arctic sub-regions.Additionally,the correlation between Arctic Oscillation(AO)and MOD was analyzed.The results indicate that:(1)all Arctic sub-regions show a trend toward earlier MOD except the Bering Sea and St.Lawrence Gulf.The East Siberian Sea exhibits a significantly earlier trend,with the highest rate of-9.45 d/decade;(2)the temporal variability and statistical significance of MOD trend exhibit large interannual differences with different time windows for most regions in the Arctic;(3)during the past 39 years,the MOD changed abruptly in different years for different sub-regions;(4)the seasonal AO has more influence on MOD than monthly AO.The findings in this study can improve our knowledge of MOD changes and are beneficial for further Arctic climate change study.展开更多
Spatio-temporal analysis of drought provides valuable information for drought management and damage mitigation. In this study, the Standardized Precipitation Index at the time scale of 6 months (SPI-6) is selected to ...Spatio-temporal analysis of drought provides valuable information for drought management and damage mitigation. In this study, the Standardized Precipitation Index at the time scale of 6 months (SPI-6) is selected to reflect drought conditions in the North-Eastern coastal region of Vietnam. The drought events and their characteristics from 1981 to 2019 are detected at 9 meteorological stations and 10 Chirps rainfall stations. The spatio-temporal variation of drought in the study region is analyzed on the basis of the number, duration, severity, intensity, and peak of the detected drought events at the 19 stations. The results show that from 1981 to 2019 the drought events mainly occurred with 1-season duration and moderate intensity and peak. The number, duration, severity, and peak of the drought events were the greatest in the period 2001-2010 and were the smallest in the period 2011-2019. Among the 19 stations, the drought duration tends to decrease at 11 stations, increase at 7 stations, and has a slight variant at 1 station;the drought severity tends to decrease at 14 stations, increase at 4 stations, and has not a significant trend at 1 station;the drought intensity tends to decrease at 17 stations, increase at 1 station, and has a slight variant at 1 station;and the drought peak tends to decrease at 18 stations and increase at 1 station.展开更多
This paper examines the spatial pattern of land and water resources as well as urbanization and their interactions in the Tarim River Basin, Xinjiang, China. In order to do so, we extract the data associated with effi...This paper examines the spatial pattern of land and water resources as well as urbanization and their interactions in the Tarim River Basin, Xinjiang, China. In order to do so, we extract the data associated with efficiency of land and water resources and urbanization for the years of 1995, 2000, 2005 and 2008. Specifically the paper investigates the extent to which agglomeration of population and economic activities varies geographically and inter- plays with spatial pattern of resources efficiency through computation of Global Moran＇s I index, Getis-Ord Gi＊ index and a coordinated development model. The method used provides clear evidence that urbanization, land and water resources efficiency have shown uneven spatial pattern due to oasis distribution, climate, and initial phase of urban development. Some conclusions can be drawn as follows. （1） Agglomeration and dispersion of urbanization are not consistent with those of land and water resources efficiency. （2） Evolution of the hot and cold spots of urbanization, and land and water resources efficiency, in different trajecto- ries, indicate that there are no significant interactions between them. （3） The evidence that numbers of hot and cold spots of the three factors present varying structures reveals the dominance of unequal urban development in the study area. （4） Significant differences are also found between sub-river basins in terms of the three factors, which is a reflection of the complex physical geography of the area. （5） The degree of coordinated development of cities in the Tarim River Basin is generally low in part as a reflection of difference in spatial patterns of the three factors. It is also shown that the pattern of the degree of coordinated development is relatively stable compared with evolution of hot and cold spots of the three factors.展开更多
Most forest fires in the Margalla Hills are related to human activities and socioeconomic factors are essential to assess their likelihood of occurrence.This study considers both environmental(altitude,precipitation,f...Most forest fires in the Margalla Hills are related to human activities and socioeconomic factors are essential to assess their likelihood of occurrence.This study considers both environmental(altitude,precipitation,forest type,terrain and humidity index)and socioeconomic(population density,distance from roads and urban areas)factors to analyze how human behavior affects the risk of forest fires.Maximum entropy(Maxent)modelling and random forest(RF)machine learning methods were used to predict the probability and spatial diffusion patterns of forest fires in the Margalla Hills.The receiver operating characteristic(ROC)curve and the area under the ROC curve(AUC)were used to compare the models.We studied the fire history from 1990 to 2019 to establish the relationship between the probability of forest fire and environmental and socioeconomic changes.Using Maxent,the AUC fire probability values for the 1999 s,2009 s,and 2019 s were 0.532,0.569,and 0.518,respectively;using RF,they were 0.782,0.825,and 0.789,respectively.Fires were mainly distributed in urban areas and their probability of occurrence was related to accessibility and human behaviour/activity.AUC principles for validation were greater in the random forest models than in the Maxent models.Our results can be used to establish preventive measures to reduce risks of forest fires by considering socio-economic and environmental conditions.展开更多
Introduction: Colorectal cancer(CRC) is a common type of neoplasm. This study examined the spatio?temporal distribution of the CRC incidence in Guangzhou during 2010–2014.Methods: Colorectal cancer incidence data wer...Introduction: Colorectal cancer(CRC) is a common type of neoplasm. This study examined the spatio?temporal distribution of the CRC incidence in Guangzhou during 2010–2014.Methods: Colorectal cancer incidence data were obtained from the Guangzhou Cancer Registry System. Spatial autocorrelation analysis and a retrospective spatio?temporal scan were used to assess the spatio?temporal cluster distribution of CRC cases.Results: A total of 14,618 CRC cases were registered in Guangzhou during 2010–2014, with a crude incidence of 35.56/100,000 and an age?standardized rate of incidence by the world standard population(ASRIW) of 23.58/100,000. The crude incidence increased by 19.70% from 2010(32.88/100,000) to 2014(39.36/100,000) with an average annual percentage change(AAPC) of 4.33%. The AAPC of ASRIW was not statistically significant. The spatial autocorrelation analysis revealed a CRC incidence hot spot in central urban areas in Guangzhou City, which included 25 streets in southwestern Baiyun District, northwestern Haizhu District, and the border region between Liwan and Yuexiu Dis?tricts. Three high? and five low?incidence clusters were identified according to spatio?temporal scan of CRC incidence clusters. The high?incidence clusters were located in central urban areas including the border regions between Bai?yun, Haizhu, Liwan, and Yuexiu Districts.Conclusions: This study revealed the spatio?temporal cluster pattern of the incidence of CRC in Guangzhou. This information can inform allocation of health resources for CRC screening.展开更多
Introduction:Breast cancer is a leading tumor with a high mortality in women.This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012.Methods:The ...Introduction:Breast cancer is a leading tumor with a high mortality in women.This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012.Methods:The data on breast cancer incidence were obtained from the Shenzhen Cancer Registry System.To describe the temporal trend,the average annual percentage change(AAPC) was analyzed using a pinpoint regression model.Spatial autocorrelation and a retrospective spatio-temporal scan approach were used to detect the spatio-temporal cluster distribution of breast cancer cases.Results:Breast cancer ranked first among different types of cancer in women in Shenzhen between 2007 and 2012 with a crude incidence of 20.0/100,000 population.The age-standardized rate according to the world standard population was 21.1/100,000 in 2012,with an AAPC of 11.3%.The spatial autocorrelation analysis showed a spatial correlation characterized by the presence of a hotspot in south-central Shenzhen,which included the eastern part of Luohu District(Donghu and Liantang Streets) and Yantian District(Shatoujiao,Haishan,and Yantian Streets).Five spatio-temporal cluster areas were detected between 2010 and 2012,one of which was a Class 1 cluster located in southwestern Shenzhen in 2010,which included Yuehai,Nantou,Shahe,Shekou,and Nanshan Streets in Nanshan District with an incidence of 54.1/100,000 and a relative risk of 2.41;the other four were Class 2 clusters located in Yantian,Luohu,Futian,and Longhua Districts with a relative risk ranging from 1.70 to 3.25.Conclusions:This study revealed the spatio-temporal cluster pattern for the incidence of female breast cancer in Shenzhen,which will be useful for a better allocation of health resources in Shenzhen.展开更多
Urban air quality degradation from rising CO_(2) is acute in rapidly developing tropical cities such as Makassar,Indonesia.We deploy a drone-based Internet of Things(IoT)platform for real-time CO_(2) monitoring,integr...Urban air quality degradation from rising CO_(2) is acute in rapidly developing tropical cities such as Makassar,Indonesia.We deploy a drone-based Internet of Things(IoT)platform for real-time CO_(2) monitoring,integrating low-cost sensors(NDIR,MQ135,MG811)on a DJI Phantom 4 with cloud streaming to Firebase.Measurements were collected at five sites,namely Jl.AP.Pettarani,Jl.Ahmad Yani,Jl.Sultan Hasanuddin,Jl.Nusantara,and KIMA at 08:00,12:00,and 16:00 in September 2024 while vertically profiling 1-20 m with three repeat flights per site and time.Descriptive statistics and one-way ANOVA with Tukey HSD assessed spatio-temporal differences;Pearson correlation quantified cross-sensor agreement.Results show marked spatial and diurnal variability:Jl.AP.Pettarani exhibits the highest mean concentration(442.5 ppm),likely due to flyover-induced trapping,whereas Jl.Ahmad Yani records the lowest(390.0 ppm).Vertical profiles reveal mid-altitude peaks in street-canyon and industrial settings,and dilution with height in greener areas,indicating ventilation contrasts.Preprocessing removed outliers and applied temperature-humidity corrections to low-cost sensors.Differences across locations and times are statistically significant(p<0.05),and cross-sensor correlations are strong(r≈0.88-0.96)after correction.Compared with fixed ground stations,the system provides fine-scale three-dimensional coverage and real-time visualization useful for field decisions.Limitations include payload-constrained endurance and intermittent data loss in obstructed areas.Findings support targeted interventions,improving canyon ventilation around flyovers and expanding urban greenery relevant to Makassar and similar tropical cities.展开更多
Objective To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis(TB)in the Guangdong Province between 2010 and 2019.Method Spatial and temporal variations in TB ...Objective To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis(TB)in the Guangdong Province between 2010 and 2019.Method Spatial and temporal variations in TB incidence were mapped using heat maps and hierarchical clustering.Socioenvironmental influencing factors were evaluated using a Bayesian spatiotemporal conditional autoregressive(ST-CAR)model.Results Annual incidence of TB in Guangdong decreased from 91.85/100,000 in 2010 to 53.06/100,000in 2019.Spatial hotspots were found in northeastern Guangdong,particularly in Heyuan,Shanwei,and Shantou,while Shenzhen,Dongguan,and Foshan had the lowest rates in the Pearl River Delta.The STCAR model showed that the TB risk was lower with higher per capita Gross Domestic Product(GDP)[Relative Risk(RR),0.91;95%Confidence Interval(CI):0.86–0.98],more the ratio of licensed physicians and physician(RR,0.94;95%CI:0.90-0.98),and higher per capita public expenditure(RR,0.94;95%CI:0.90–0.97),with a marginal effect of population density(RR,0.86;95%CI:0.86–1.00).Conclusion The incidence of TB in Guangdong varies spatially and temporally.Areas with poor economic conditions and insufficient healthcare resources are at an increased risk of TB infection.Strategies focusing on equitable health resource distribution and economic development are the key to TB control.展开更多
Escalating anthropogenic pressures are profoundly transforming natural landscapes,resulting in significant declines in vegetation cover and rising habitat fragmentation.These disruptions,driven by increasing human act...Escalating anthropogenic pressures are profoundly transforming natural landscapes,resulting in significant declines in vegetation cover and rising habitat fragmentation.These disruptions,driven by increasing human activities such as mining,agriculture,industrialization,and urbanization,confine numerous species to fragmented and degraded environments.This study quantitatively assesses spatio-temporal changes in forest cover and fragmentation in the Sundargarh and Keonjhar districts of Odisha,India,from 2000 to 2024,employing landscape metrics based on Landsat TM and OLI satellite imagery.Our findings reveal a notable decline in forest coverage,which decreased from 30.69%in 2000 to 24.55%in 2024,while non-forest areas expanded from 69.31%to 75.45%.Fragmentation analysis indicates a significant deterioration in forest health,characterized by increasing edge effects and shrinking core habitats-both of which serve as indicators of substantial disturbances within forest ecosystems.Notably,while the number of forest patches increased by 18.6%(rising from 2736 to 3239),the total forest area continues to diminish.The Largest Patch Index(LPl)experienced a substantial reduction of 41.2%,declining from 7.37 to 4.33.Nearly 107654 ha of the core area were lost over 24 years,and the Core Area Percentage of Landscape(CPLAND)decreased from 25.1%to 19.1%.This trend suggests that larger,contiguous forest landscapes are fragmenting into smaller,isolated patches,which impedes wildlife movement and ecological processes.The analysis particularly highlights the Joda and Koida blocks,which are heavily impacted by mining activities and exhibit the most significant alterations in land use and land cover.Additionally,a trend analysis map generated using the Mann-Kendall test visually corroborates these findings,illustrating that the lowest values are concentrated in the most fragmented areas.It underscores the urgent need for stricter regulations governing anthropogenic activities.The implementation of effective forest conservation strategies aimed at preserving the ecological integrity of the region's forests is recommended to enhance the resilience and sustainability of these vital ecosystems.展开更多
In this paper,the Taixin Integrated Economic Zone in Shanxi Province is taken as the research object,and the coupling coordination degree model and bivariate spatial autocorrelation model are used to judge the couplin...In this paper,the Taixin Integrated Economic Zone in Shanxi Province is taken as the research object,and the coupling coordination degree model and bivariate spatial autocorrelation model are used to judge the coupling coordination and spatial-temporal correlation between urbanization and ecosystem service,and the hotspot analysis is used to judge the spatial-temporal trend of urbanization and ecosystem service.The results show that:(1)The urbanization level from 2000 to 2020 continued to rise,the areas with relatively high urbanization were concentrated in the central part of the study area,and the relatively high terrain areas on both sides of the study area,the urbanization was relatively slow,and the hotspot areas with highly significant and significant urbanization level from 2000 to 2020 were distributed as bands in the central part of the study area and the area was rising,and there was no Cold spot area distribution;between 2000 and 2020,the ecosystem service value in the study area increased by 2.6800×10^(8) yuan.Over these two decades,it exhibited a development trend that first rose and then declined.The woodland and grassland agglomeration areas were located on the two sides of the study area,forming highly significant and significant hotspots.Conversely,the central and northeastern parts of the study area were characterized by concentrated man-made land surfaces and croplands,resulting in the formation of highly significant and significant cold spots.(2)In the central part of the study area where man-made land surface and cultivated land are concentrated,the coupling coordination between urbanization and ecosystem service is in the intermediate dislocation and mild dislocation interval;the woodland and grassland concentration areas on both sides of the study area are ecologically fragile,and the coupling coordination between the two is in the level of less than intermediate dislocation.(3)From 2000 to 2020,urbanization and the value of ecosystem services were both negatively correlated,although the correlation coefficient was low.In the central and northeastern parts,urbanization and ecosystem service exhibited patterns of high-low,high-high,and low-low clustering.Conversely,on both sides of the study area,most of the clusters showed a low-high pattern.展开更多
Background: Although visceral leishmaniasis(VL),a disease caused by parasites,is controlled in most provinces in China,it is still a serious public health problem and remains fundamentally uncontrolled in some northwe...Background: Although visceral leishmaniasis(VL),a disease caused by parasites,is controlled in most provinces in China,it is still a serious public health problem and remains fundamentally uncontrolled in some northwest provinces and autonomous regions.The objective of this study is to explore the spatial and temporal characteristics of VL in Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region in China from 2004 to 2018 and to identify the risk areas for VL transmission.Methods:: Spatiotemporal models were applied to explore the spatio-temporal distribution characteristics of VL and the association between VL and meteorological factors in western China from 2004 to 2018.Geographic information of patients from the National Diseases Reporting Information System operated by the Chinese Center for Disease Control and Prevention was defined according to the address code from the surveillance data.Results: During our study period,nearly 90%of cases occurred in some counties in three western regions(Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region),and a significant spatial clustering pattern was observed.With our spatiotemporal model,the transmission risk,autoregressive risk and epidemic risk of these counties during our study period were also well predicted.The number of VL cases in three regions of western China concentrated on a few of counties.VL in Kashi Prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic areas.Conclusions: The number of VL cases in three regions of western China concentrated on a few of counties.VL in Kashi Prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic areas.Our findings will strengthen the VL control programme in China.展开更多
In the process of logistics distribution of manufacturing enterprises, the automatic scheduling method based on the algorithm model has the advantages of accurate calculation and stable operation, but it excessively r...In the process of logistics distribution of manufacturing enterprises, the automatic scheduling method based on the algorithm model has the advantages of accurate calculation and stable operation, but it excessively relies on the results of data calculation, ignores historical information and empirical data in the solving process, and has the bottleneck of low processing dimension and small processing scale. Therefore, in the digital twin(DT) system based on virtual and real fusion, a modeling and analysis method of production logistics spatio-temporal graph network model is proposed, considering the characteristics of road network topology and time-varying data. In the DT system, the temporal graph network model of the production logistics task is established and combined with the network topology, and the historical scheduling information about logistics elements is stored in the nodes. When the dynamic task arrives, a multi-stage links probability prediction method is adopted to predict the possibility of loading, driving, and other link relationships between task-related entity nodes at each stage. Several experiments are carried out, and the prediction accuracy of the digital twin-based temporal graph network(DTGN) model trained by historical scheduling information reaches 99.2% when the appropriate batch size is selected. Through logistics simulation experiments, the feasibility and the effectiveness of production logistics spatio-temporal graph network analysis methods based on historical scheduling information are verified.展开更多
Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy neonate.Some algorithms have been used to assess the ploidy status ...Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy neonate.Some algorithms have been used to assess the ploidy status of embryos derived from couples with normal chromosome,who subjected to preimplantation genetic testing for aneuploidy(PGT-A)treatment.However,it is currently unknown whether artificial intelligence model can be used to assess the euploidy status of blastocyst derived from populations with chromosomal rearrangement.Methods:From February 2020 to May 2021,we collected the whole raw time-lapse videos at multiple focal planes from in vitro cultured embryos,the clinical information of couples,and the comprehensive chromosome screening results of those blastocysts that had received PGT treatment.Initially,we developed a novel deep learning model called the Attentive Multi-Focus Selection Network(AMSNet)to analyze time-lapse videos in real time and predict blastocyst formation.Building upon AMSNet,we integrated additional clinically predictive variables and created a second deep learning model,the Attentive Multi-Focus Video and Clinical Information Fusion Network(AMCFNet),to assess the euploidy status of embryos.The efficacy of the AMCFNet was further tested in embryos with parental chromosomal rearrangements.The receiver operating characteristic curve(ROC)was used to evaluate the superiority of the model.Results:A total of 4112 embryos with complete time-lapse videos were enrolled for the blastocyst formation prediction task,and 1422 qualified blastocysts received PGT-A(n=589)or PGT for chromosomal structural rearrangement(PGT-SR,n=833)were enrolled for the euploidy assessment task in this study.The AMSNet model using seven focal raw time-lapse videos has the best real-time accuracy.The real-time accuracy for AMSNet to predict blastocyst formation reached above 70%on the day 2 of embryo culture,and then increased to 80%on the day 4 of embryo culture.Combing with 4 clinical features of couples,the AUC of AMCFNet with 7 focal points increased to 0.729 in blastocysts derived from couples with chromosomal rearrangement.Conclusion:Integrating seven focal raw time-lapse images of embryos and parental clinical information,AMCFNet model have the capability of assessing euploidy status in blastocysts derived from couples with chromosomal rearrangement.展开更多
The cloud-to-ground lightning data between 2007 and 2008 were collected by lightning detection and location system,which was composed of four lightning detectors in four different sites of Dalian area.The spatio-tempo...The cloud-to-ground lightning data between 2007 and 2008 were collected by lightning detection and location system,which was composed of four lightning detectors in four different sites of Dalian area.The spatio-temporal distribution of cloud-to-ground lightning in surrounding areas of Dalian was analyzed from several aspects of polarity distribution,diurnal variation,lightning intensity and lightning density.The results showed that the number of negative lightning accounted for 93.9% of the total number of lightning,and its average lightning intensity was 27.99 kA.The number of positive lightning accounted for 6.1% of the total number of lightning,and its average lightning intensity was 35.56 kA.The diurnal variation of lightning frequency showed an obvious structure of two peaks (17:00-18:00 and 04:00-05:00) and two valleys (09:00-10:00 and 00:00-01:00).The number of lightning between May and September was 91.5% of the annual number,and the lightning occurred the most frequently between June and August.Most of positive and negative lightning was at the intensity of 15-35 kA,80.0% lower than 40 kA,and 99.3% lower than 100 kA.The lightning density had obvious regional differences in distribution,high in the Liaodong Bay and the Dalian Bay and low in inland areas.Therefore,coastal areas should attract more attention in lightning disaster defense in the surrounding areas of Dalian.展开更多
Understanding the tectono-magmatic evolution history of the Tengchong block is crucial for elucidating the formation of the Eastern Tethys tectonic domain.However,the correlation and evolution of the Tengchong block w...Understanding the tectono-magmatic evolution history of the Tengchong block is crucial for elucidating the formation of the Eastern Tethys tectonic domain.However,the correlation and evolution of the Tengchong block with the Sibumasu and Lhasa blocks is controversial during the Permian and Cretaceous.This study explores the information contained within magmatic rocks using big data and spatio-temporal analysis,providing quantitative constraints for the discussion of the tectonomagmatic evolution of the Tengchong block.To more accurately assess true magma activities and reduce errors caused by preservation and sampling processes,we utilized local singularity analysis to obtain the singularity index time-series.Correlation analysis of zircon ages and eHf(t)(correlation coefficient0.5)values indicates that the Tengchong block is more similar to the Sibumasu block.Results from timelagged cross-correlation analysis indicate that the Tengchong block and Sibumasu block exhibit a shorter lag in magmatic activities(3 Myr).Wavelet analysis reveals similar periods of collision-related magmatic activities(57 Myr and 43 Myr).Integrating evidence from paleontology and ophiolite belts,we propose that the Tengchong block co-evolved more closely with the Sibumasu block than with the Lhasa block,suggesting similar tectonic processes during the Early Permian to Early Cretaceous.Approximately 250–236 Ma,in the western Tengchong block,partial melting of the lower crust occurs due to crustal thickening.Around 219–213 Ma and 198–180 Ma,after the Tengchong block collided with the Eurasian continent,the subduction of the Meso-Tethys Ocean commenced.Around 130–111 Ma,the overall tectonic feature was a scissor-like closure of the Meso-Tethys Ocean from north to south.展开更多
In Canada,Gonorrhea infection ranks as the second most prevalent sexually transmitted infection.In 2018,Manitoba reported an incidence rate three times greater than the national average.This study aims to investigate ...In Canada,Gonorrhea infection ranks as the second most prevalent sexually transmitted infection.In 2018,Manitoba reported an incidence rate three times greater than the national average.This study aims to investigate the spatial,temporal,and spatio-temporal patterns of Gonorrhea infection in Manitoba,using individual-level laboratory-confirmed administrative data provided by Manitoba Health from 2000 to 2016.Age and sex patterns indicate that females are affected by infections at younger ages compared to males.Moreover,there is an increase in repeated infections in 2016,accounting for 16%of the total infections.Spatial analysis at the 96 Manitoba regional health authority districts highlights significant positive spatial autocorrelation,demonstrating a clustered distribution of the infection.Northern districts of Manitoba and central Winnipeg were identified as significant clusters.Temporal analysis shows seasonal patterns,with higher infections in late summer and fall.Additionally,spatio-temporal analysis reveals clusters during high-risk periods,with the most likely cluster in the northern districts of Manitoba from January 2006 to June 2014,and a secondary cluster in central Winnipeg from June 2004 to November 2012.This study identifies that Gonorrhea infection transmission in Manitoba has temporal,spatial,and spatio-temporal variations.The findings provide vital insights for public health and Manitoba Health by revealing high-risk clusters and emphasizing the need for focused and localized prevention,control measures,and resource allocation.展开更多
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations...Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.展开更多
The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.A...The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
基金The National Key Research and Development Program of China under contract No.2018YFA0605403the National Natural Science Foundation of China under contract No.42071084Jiangyuan Zeng was supported by the Youth Innovation Promotion Association CAS under contract No.2018082。
文摘The melt onset dates(MOD)over Arctic sea ice plays an important role in the seasonal cycle of sea ice surface properties,which impacts Arctic surface solar radiation absorbed by the ice-ocean system.Monitoring interannual variations in MOD is valuable for understanding climate change.In this study,we investigated the spatio-temporal variability of MOD over Arctic sea ice and 14 Arctic sub-regions in the period of 1979 to 2017 from passive microwave satellite data.A set of mathematical and statistical methods,including the Sen’s slope and Mann-Kendall mutation tests,were used to comprehensively assess the variation trend and abrupt points of MOD during the past 39 years for different Arctic sub-regions.Additionally,the correlation between Arctic Oscillation(AO)and MOD was analyzed.The results indicate that:(1)all Arctic sub-regions show a trend toward earlier MOD except the Bering Sea and St.Lawrence Gulf.The East Siberian Sea exhibits a significantly earlier trend,with the highest rate of-9.45 d/decade;(2)the temporal variability and statistical significance of MOD trend exhibit large interannual differences with different time windows for most regions in the Arctic;(3)during the past 39 years,the MOD changed abruptly in different years for different sub-regions;(4)the seasonal AO has more influence on MOD than monthly AO.The findings in this study can improve our knowledge of MOD changes and are beneficial for further Arctic climate change study.
文摘Spatio-temporal analysis of drought provides valuable information for drought management and damage mitigation. In this study, the Standardized Precipitation Index at the time scale of 6 months (SPI-6) is selected to reflect drought conditions in the North-Eastern coastal region of Vietnam. The drought events and their characteristics from 1981 to 2019 are detected at 9 meteorological stations and 10 Chirps rainfall stations. The spatio-temporal variation of drought in the study region is analyzed on the basis of the number, duration, severity, intensity, and peak of the detected drought events at the 19 stations. The results show that from 1981 to 2019 the drought events mainly occurred with 1-season duration and moderate intensity and peak. The number, duration, severity, and peak of the drought events were the greatest in the period 2001-2010 and were the smallest in the period 2011-2019. Among the 19 stations, the drought duration tends to decrease at 11 stations, increase at 7 stations, and has a slight variant at 1 station;the drought severity tends to decrease at 14 stations, increase at 4 stations, and has not a significant trend at 1 station;the drought intensity tends to decrease at 17 stations, increase at 1 station, and has a slight variant at 1 station;and the drought peak tends to decrease at 18 stations and increase at 1 station.
基金Foundation： National Natural Science Foundation of China, No.40901092
文摘This paper examines the spatial pattern of land and water resources as well as urbanization and their interactions in the Tarim River Basin, Xinjiang, China. In order to do so, we extract the data associated with efficiency of land and water resources and urbanization for the years of 1995, 2000, 2005 and 2008. Specifically the paper investigates the extent to which agglomeration of population and economic activities varies geographically and inter- plays with spatial pattern of resources efficiency through computation of Global Moran＇s I index, Getis-Ord Gi＊ index and a coordinated development model. The method used provides clear evidence that urbanization, land and water resources efficiency have shown uneven spatial pattern due to oasis distribution, climate, and initial phase of urban development. Some conclusions can be drawn as follows. （1） Agglomeration and dispersion of urbanization are not consistent with those of land and water resources efficiency. （2） Evolution of the hot and cold spots of urbanization, and land and water resources efficiency, in different trajecto- ries, indicate that there are no significant interactions between them. （3） The evidence that numbers of hot and cold spots of the three factors present varying structures reveals the dominance of unequal urban development in the study area. （4） Significant differences are also found between sub-river basins in terms of the three factors, which is a reflection of the complex physical geography of the area. （5） The degree of coordinated development of cities in the Tarim River Basin is generally low in part as a reflection of difference in spatial patterns of the three factors. It is also shown that the pattern of the degree of coordinated development is relatively stable compared with evolution of hot and cold spots of the three factors.
基金supported by the National Key Research and Development Program of China(Grant No.2019YFE0127700)。
文摘Most forest fires in the Margalla Hills are related to human activities and socioeconomic factors are essential to assess their likelihood of occurrence.This study considers both environmental(altitude,precipitation,forest type,terrain and humidity index)and socioeconomic(population density,distance from roads and urban areas)factors to analyze how human behavior affects the risk of forest fires.Maximum entropy(Maxent)modelling and random forest(RF)machine learning methods were used to predict the probability and spatial diffusion patterns of forest fires in the Margalla Hills.The receiver operating characteristic(ROC)curve and the area under the ROC curve(AUC)were used to compare the models.We studied the fire history from 1990 to 2019 to establish the relationship between the probability of forest fire and environmental and socioeconomic changes.Using Maxent,the AUC fire probability values for the 1999 s,2009 s,and 2019 s were 0.532,0.569,and 0.518,respectively;using RF,they were 0.782,0.825,and 0.789,respectively.Fires were mainly distributed in urban areas and their probability of occurrence was related to accessibility and human behaviour/activity.AUC principles for validation were greater in the random forest models than in the Maxent models.Our results can be used to establish preventive measures to reduce risks of forest fires by considering socio-economic and environmental conditions.
文摘Introduction: Colorectal cancer(CRC) is a common type of neoplasm. This study examined the spatio?temporal distribution of the CRC incidence in Guangzhou during 2010–2014.Methods: Colorectal cancer incidence data were obtained from the Guangzhou Cancer Registry System. Spatial autocorrelation analysis and a retrospective spatio?temporal scan were used to assess the spatio?temporal cluster distribution of CRC cases.Results: A total of 14,618 CRC cases were registered in Guangzhou during 2010–2014, with a crude incidence of 35.56/100,000 and an age?standardized rate of incidence by the world standard population(ASRIW) of 23.58/100,000. The crude incidence increased by 19.70% from 2010(32.88/100,000) to 2014(39.36/100,000) with an average annual percentage change(AAPC) of 4.33%. The AAPC of ASRIW was not statistically significant. The spatial autocorrelation analysis revealed a CRC incidence hot spot in central urban areas in Guangzhou City, which included 25 streets in southwestern Baiyun District, northwestern Haizhu District, and the border region between Liwan and Yuexiu Dis?tricts. Three high? and five low?incidence clusters were identified according to spatio?temporal scan of CRC incidence clusters. The high?incidence clusters were located in central urban areas including the border regions between Bai?yun, Haizhu, Liwan, and Yuexiu Districts.Conclusions: This study revealed the spatio?temporal cluster pattern of the incidence of CRC in Guangzhou. This information can inform allocation of health resources for CRC screening.
文摘Introduction:Breast cancer is a leading tumor with a high mortality in women.This study examined the spatio-temporal distribution of the incidence of female breast cancer in Shenzhen between 2007 and 2012.Methods:The data on breast cancer incidence were obtained from the Shenzhen Cancer Registry System.To describe the temporal trend,the average annual percentage change(AAPC) was analyzed using a pinpoint regression model.Spatial autocorrelation and a retrospective spatio-temporal scan approach were used to detect the spatio-temporal cluster distribution of breast cancer cases.Results:Breast cancer ranked first among different types of cancer in women in Shenzhen between 2007 and 2012 with a crude incidence of 20.0/100,000 population.The age-standardized rate according to the world standard population was 21.1/100,000 in 2012,with an AAPC of 11.3%.The spatial autocorrelation analysis showed a spatial correlation characterized by the presence of a hotspot in south-central Shenzhen,which included the eastern part of Luohu District(Donghu and Liantang Streets) and Yantian District(Shatoujiao,Haishan,and Yantian Streets).Five spatio-temporal cluster areas were detected between 2010 and 2012,one of which was a Class 1 cluster located in southwestern Shenzhen in 2010,which included Yuehai,Nantou,Shahe,Shekou,and Nanshan Streets in Nanshan District with an incidence of 54.1/100,000 and a relative risk of 2.41;the other four were Class 2 clusters located in Yantian,Luohu,Futian,and Longhua Districts with a relative risk ranging from 1.70 to 3.25.Conclusions:This study revealed the spatio-temporal cluster pattern for the incidence of female breast cancer in Shenzhen,which will be useful for a better allocation of health resources in Shenzhen.
基金supported by the Directorate of Research,Technology,and Community Service(DRTPM),Ministry of Education,Culture,Research,and Technology,grant number 2817/UN36.11/LP2M/2024.
文摘Urban air quality degradation from rising CO_(2) is acute in rapidly developing tropical cities such as Makassar,Indonesia.We deploy a drone-based Internet of Things(IoT)platform for real-time CO_(2) monitoring,integrating low-cost sensors(NDIR,MQ135,MG811)on a DJI Phantom 4 with cloud streaming to Firebase.Measurements were collected at five sites,namely Jl.AP.Pettarani,Jl.Ahmad Yani,Jl.Sultan Hasanuddin,Jl.Nusantara,and KIMA at 08:00,12:00,and 16:00 in September 2024 while vertically profiling 1-20 m with three repeat flights per site and time.Descriptive statistics and one-way ANOVA with Tukey HSD assessed spatio-temporal differences;Pearson correlation quantified cross-sensor agreement.Results show marked spatial and diurnal variability:Jl.AP.Pettarani exhibits the highest mean concentration(442.5 ppm),likely due to flyover-induced trapping,whereas Jl.Ahmad Yani records the lowest(390.0 ppm).Vertical profiles reveal mid-altitude peaks in street-canyon and industrial settings,and dilution with height in greener areas,indicating ventilation contrasts.Preprocessing removed outliers and applied temperature-humidity corrections to low-cost sensors.Differences across locations and times are statistically significant(p<0.05),and cross-sensor correlations are strong(r≈0.88-0.96)after correction.Compared with fixed ground stations,the system provides fine-scale three-dimensional coverage and real-time visualization useful for field decisions.Limitations include payload-constrained endurance and intermittent data loss in obstructed areas.Findings support targeted interventions,improving canyon ventilation around flyovers and expanding urban greenery relevant to Makassar and similar tropical cities.
基金supported by the Guangdong Provincial Clinical Research Center for Tuberculosis(No.2020B1111170014)。
文摘Objective To investigate the spatiotemporal patterns and socioeconomic factors influencing the incidence of tuberculosis(TB)in the Guangdong Province between 2010 and 2019.Method Spatial and temporal variations in TB incidence were mapped using heat maps and hierarchical clustering.Socioenvironmental influencing factors were evaluated using a Bayesian spatiotemporal conditional autoregressive(ST-CAR)model.Results Annual incidence of TB in Guangdong decreased from 91.85/100,000 in 2010 to 53.06/100,000in 2019.Spatial hotspots were found in northeastern Guangdong,particularly in Heyuan,Shanwei,and Shantou,while Shenzhen,Dongguan,and Foshan had the lowest rates in the Pearl River Delta.The STCAR model showed that the TB risk was lower with higher per capita Gross Domestic Product(GDP)[Relative Risk(RR),0.91;95%Confidence Interval(CI):0.86–0.98],more the ratio of licensed physicians and physician(RR,0.94;95%CI:0.90-0.98),and higher per capita public expenditure(RR,0.94;95%CI:0.90–0.97),with a marginal effect of population density(RR,0.86;95%CI:0.86–1.00).Conclusion The incidence of TB in Guangdong varies spatially and temporally.Areas with poor economic conditions and insufficient healthcare resources are at an increased risk of TB infection.Strategies focusing on equitable health resource distribution and economic development are the key to TB control.
基金the Department of Science and Technology(DST-INSPIRE),Government of India,for their financial support。
文摘Escalating anthropogenic pressures are profoundly transforming natural landscapes,resulting in significant declines in vegetation cover and rising habitat fragmentation.These disruptions,driven by increasing human activities such as mining,agriculture,industrialization,and urbanization,confine numerous species to fragmented and degraded environments.This study quantitatively assesses spatio-temporal changes in forest cover and fragmentation in the Sundargarh and Keonjhar districts of Odisha,India,from 2000 to 2024,employing landscape metrics based on Landsat TM and OLI satellite imagery.Our findings reveal a notable decline in forest coverage,which decreased from 30.69%in 2000 to 24.55%in 2024,while non-forest areas expanded from 69.31%to 75.45%.Fragmentation analysis indicates a significant deterioration in forest health,characterized by increasing edge effects and shrinking core habitats-both of which serve as indicators of substantial disturbances within forest ecosystems.Notably,while the number of forest patches increased by 18.6%(rising from 2736 to 3239),the total forest area continues to diminish.The Largest Patch Index(LPl)experienced a substantial reduction of 41.2%,declining from 7.37 to 4.33.Nearly 107654 ha of the core area were lost over 24 years,and the Core Area Percentage of Landscape(CPLAND)decreased from 25.1%to 19.1%.This trend suggests that larger,contiguous forest landscapes are fragmenting into smaller,isolated patches,which impedes wildlife movement and ecological processes.The analysis particularly highlights the Joda and Koida blocks,which are heavily impacted by mining activities and exhibit the most significant alterations in land use and land cover.Additionally,a trend analysis map generated using the Mann-Kendall test visually corroborates these findings,illustrating that the lowest values are concentrated in the most fragmented areas.It underscores the urgent need for stricter regulations governing anthropogenic activities.The implementation of effective forest conservation strategies aimed at preserving the ecological integrity of the region's forests is recommended to enhance the resilience and sustainability of these vital ecosystems.
基金supported by the Natural Science Foundation of Shanxi Province(Grant No.20210302124437)the Graduate Student Research and Innovation Project of Shanxi Province(Grant No.2023KY551).
文摘In this paper,the Taixin Integrated Economic Zone in Shanxi Province is taken as the research object,and the coupling coordination degree model and bivariate spatial autocorrelation model are used to judge the coupling coordination and spatial-temporal correlation between urbanization and ecosystem service,and the hotspot analysis is used to judge the spatial-temporal trend of urbanization and ecosystem service.The results show that:(1)The urbanization level from 2000 to 2020 continued to rise,the areas with relatively high urbanization were concentrated in the central part of the study area,and the relatively high terrain areas on both sides of the study area,the urbanization was relatively slow,and the hotspot areas with highly significant and significant urbanization level from 2000 to 2020 were distributed as bands in the central part of the study area and the area was rising,and there was no Cold spot area distribution;between 2000 and 2020,the ecosystem service value in the study area increased by 2.6800×10^(8) yuan.Over these two decades,it exhibited a development trend that first rose and then declined.The woodland and grassland agglomeration areas were located on the two sides of the study area,forming highly significant and significant hotspots.Conversely,the central and northeastern parts of the study area were characterized by concentrated man-made land surfaces and croplands,resulting in the formation of highly significant and significant cold spots.(2)In the central part of the study area where man-made land surface and cultivated land are concentrated,the coupling coordination between urbanization and ecosystem service is in the intermediate dislocation and mild dislocation interval;the woodland and grassland concentration areas on both sides of the study area are ecologically fragile,and the coupling coordination between the two is in the level of less than intermediate dislocation.(3)From 2000 to 2020,urbanization and the value of ecosystem services were both negatively correlated,although the correlation coefficient was low.In the central and northeastern parts,urbanization and ecosystem service exhibited patterns of high-low,high-high,and low-low clustering.Conversely,on both sides of the study area,most of the clusters showed a low-high pattern.
基金This work was financially supported by grants from the China Mega-Project on Infectious Disease Prevention(No.2018ZX10713001).
文摘Background: Although visceral leishmaniasis(VL),a disease caused by parasites,is controlled in most provinces in China,it is still a serious public health problem and remains fundamentally uncontrolled in some northwest provinces and autonomous regions.The objective of this study is to explore the spatial and temporal characteristics of VL in Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region in China from 2004 to 2018 and to identify the risk areas for VL transmission.Methods:: Spatiotemporal models were applied to explore the spatio-temporal distribution characteristics of VL and the association between VL and meteorological factors in western China from 2004 to 2018.Geographic information of patients from the National Diseases Reporting Information System operated by the Chinese Center for Disease Control and Prevention was defined according to the address code from the surveillance data.Results: During our study period,nearly 90%of cases occurred in some counties in three western regions(Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region),and a significant spatial clustering pattern was observed.With our spatiotemporal model,the transmission risk,autoregressive risk and epidemic risk of these counties during our study period were also well predicted.The number of VL cases in three regions of western China concentrated on a few of counties.VL in Kashi Prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic areas.Conclusions: The number of VL cases in three regions of western China concentrated on a few of counties.VL in Kashi Prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic areas.Our findings will strengthen the VL control programme in China.
基金National Key Research and Development Plan of China (No.2019YFB1706300)Shanghai Frontier Science Research Center for Modern Textiles (Donghua University),China。
文摘In the process of logistics distribution of manufacturing enterprises, the automatic scheduling method based on the algorithm model has the advantages of accurate calculation and stable operation, but it excessively relies on the results of data calculation, ignores historical information and empirical data in the solving process, and has the bottleneck of low processing dimension and small processing scale. Therefore, in the digital twin(DT) system based on virtual and real fusion, a modeling and analysis method of production logistics spatio-temporal graph network model is proposed, considering the characteristics of road network topology and time-varying data. In the DT system, the temporal graph network model of the production logistics task is established and combined with the network topology, and the historical scheduling information about logistics elements is stored in the nodes. When the dynamic task arrives, a multi-stage links probability prediction method is adopted to predict the possibility of loading, driving, and other link relationships between task-related entity nodes at each stage. Several experiments are carried out, and the prediction accuracy of the digital twin-based temporal graph network(DTGN) model trained by historical scheduling information reaches 99.2% when the appropriate batch size is selected. Through logistics simulation experiments, the feasibility and the effectiveness of production logistics spatio-temporal graph network analysis methods based on historical scheduling information are verified.
基金supported by grants from the National Natural Science Found of China(No.81270750)Natural Science Found of Guangdong China(No.2019A1515011845)+1 种基金Stem Cell Research Founding from Chinese Medical Association(No.19020010780)Sun Yat-sen University 5010 Clinical Research Project(No.2023003).
文摘Background:The goal of the assisted reproductive treatment is to transfer one euploid blastocyst and to help infertile women giving birth one healthy neonate.Some algorithms have been used to assess the ploidy status of embryos derived from couples with normal chromosome,who subjected to preimplantation genetic testing for aneuploidy(PGT-A)treatment.However,it is currently unknown whether artificial intelligence model can be used to assess the euploidy status of blastocyst derived from populations with chromosomal rearrangement.Methods:From February 2020 to May 2021,we collected the whole raw time-lapse videos at multiple focal planes from in vitro cultured embryos,the clinical information of couples,and the comprehensive chromosome screening results of those blastocysts that had received PGT treatment.Initially,we developed a novel deep learning model called the Attentive Multi-Focus Selection Network(AMSNet)to analyze time-lapse videos in real time and predict blastocyst formation.Building upon AMSNet,we integrated additional clinically predictive variables and created a second deep learning model,the Attentive Multi-Focus Video and Clinical Information Fusion Network(AMCFNet),to assess the euploidy status of embryos.The efficacy of the AMCFNet was further tested in embryos with parental chromosomal rearrangements.The receiver operating characteristic curve(ROC)was used to evaluate the superiority of the model.Results:A total of 4112 embryos with complete time-lapse videos were enrolled for the blastocyst formation prediction task,and 1422 qualified blastocysts received PGT-A(n=589)or PGT for chromosomal structural rearrangement(PGT-SR,n=833)were enrolled for the euploidy assessment task in this study.The AMSNet model using seven focal raw time-lapse videos has the best real-time accuracy.The real-time accuracy for AMSNet to predict blastocyst formation reached above 70%on the day 2 of embryo culture,and then increased to 80%on the day 4 of embryo culture.Combing with 4 clinical features of couples,the AUC of AMCFNet with 7 focal points increased to 0.729 in blastocysts derived from couples with chromosomal rearrangement.Conclusion:Integrating seven focal raw time-lapse images of embryos and parental clinical information,AMCFNet model have the capability of assessing euploidy status in blastocysts derived from couples with chromosomal rearrangement.
文摘The cloud-to-ground lightning data between 2007 and 2008 were collected by lightning detection and location system,which was composed of four lightning detectors in four different sites of Dalian area.The spatio-temporal distribution of cloud-to-ground lightning in surrounding areas of Dalian was analyzed from several aspects of polarity distribution,diurnal variation,lightning intensity and lightning density.The results showed that the number of negative lightning accounted for 93.9% of the total number of lightning,and its average lightning intensity was 27.99 kA.The number of positive lightning accounted for 6.1% of the total number of lightning,and its average lightning intensity was 35.56 kA.The diurnal variation of lightning frequency showed an obvious structure of two peaks (17:00-18:00 and 04:00-05:00) and two valleys (09:00-10:00 and 00:00-01:00).The number of lightning between May and September was 91.5% of the annual number,and the lightning occurred the most frequently between June and August.Most of positive and negative lightning was at the intensity of 15-35 kA,80.0% lower than 40 kA,and 99.3% lower than 100 kA.The lightning density had obvious regional differences in distribution,high in the Liaodong Bay and the Dalian Bay and low in inland areas.Therefore,coastal areas should attract more attention in lightning disaster defense in the surrounding areas of Dalian.
文摘Understanding the tectono-magmatic evolution history of the Tengchong block is crucial for elucidating the formation of the Eastern Tethys tectonic domain.However,the correlation and evolution of the Tengchong block with the Sibumasu and Lhasa blocks is controversial during the Permian and Cretaceous.This study explores the information contained within magmatic rocks using big data and spatio-temporal analysis,providing quantitative constraints for the discussion of the tectonomagmatic evolution of the Tengchong block.To more accurately assess true magma activities and reduce errors caused by preservation and sampling processes,we utilized local singularity analysis to obtain the singularity index time-series.Correlation analysis of zircon ages and eHf(t)(correlation coefficient0.5)values indicates that the Tengchong block is more similar to the Sibumasu block.Results from timelagged cross-correlation analysis indicate that the Tengchong block and Sibumasu block exhibit a shorter lag in magmatic activities(3 Myr).Wavelet analysis reveals similar periods of collision-related magmatic activities(57 Myr and 43 Myr).Integrating evidence from paleontology and ophiolite belts,we propose that the Tengchong block co-evolved more closely with the Sibumasu block than with the Lhasa block,suggesting similar tectonic processes during the Early Permian to Early Cretaceous.Approximately 250–236 Ma,in the western Tengchong block,partial melting of the lower crust occurs due to crustal thickening.Around 219–213 Ma and 198–180 Ma,after the Tengchong block collided with the Eurasian continent,the subduction of the Meso-Tethys Ocean commenced.Around 130–111 Ma,the overall tectonic feature was a scissor-like closure of the Meso-Tethys Ocean from north to south.
文摘In Canada,Gonorrhea infection ranks as the second most prevalent sexually transmitted infection.In 2018,Manitoba reported an incidence rate three times greater than the national average.This study aims to investigate the spatial,temporal,and spatio-temporal patterns of Gonorrhea infection in Manitoba,using individual-level laboratory-confirmed administrative data provided by Manitoba Health from 2000 to 2016.Age and sex patterns indicate that females are affected by infections at younger ages compared to males.Moreover,there is an increase in repeated infections in 2016,accounting for 16%of the total infections.Spatial analysis at the 96 Manitoba regional health authority districts highlights significant positive spatial autocorrelation,demonstrating a clustered distribution of the infection.Northern districts of Manitoba and central Winnipeg were identified as significant clusters.Temporal analysis shows seasonal patterns,with higher infections in late summer and fall.Additionally,spatio-temporal analysis reveals clusters during high-risk periods,with the most likely cluster in the northern districts of Manitoba from January 2006 to June 2014,and a secondary cluster in central Winnipeg from June 2004 to November 2012.This study identifies that Gonorrhea infection transmission in Manitoba has temporal,spatial,and spatio-temporal variations.The findings provide vital insights for public health and Manitoba Health by revealing high-risk clusters and emphasizing the need for focused and localized prevention,control measures,and resource allocation.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:Receptor-interacting protein kinases(RIPKs)regulate cell death,inflammation,and immune responses,yet their roles in cancer are not fully understood.This study investigates the expression,genomic alterations,and functional implications of RIPK family members across various cancers.Methods:We collected multi-omics data from The Cancer Genome Atlas and other public databases,including gene expression,copy number variation(CNV),mutation,methylation,tumor mutation burden(TMB),and microsatellite instability(MSI).Differential expression and survival analyses were performed using DESeq2 and Cox proportional hazards models.CNV and mutation data were analyzed with GISTIC2 and Mutect2,and methylation data with the ChAMP package.Correlations with TMB and MSI were assessed using Pearson coefficients,and gene set enrichment analysis was conducted with the MSigDB Hallmark gene sets.Results:RIPK family members show significant differential expression in various cancers,with RIPK1 and RIPK4 frequently altered.Survival analysis reveals heterogeneous impacts on overall survival.CNV and mutation analyses identify high alteration frequencies for RIPK2 and RIPK7,affecting gene expression.RIPK1 and RIPK7 are hypermethylated in several cancers,inversely correlating with RIPK3 expression.RIPK1,RIPK2,RIPK5,RIPK6,and RIPK7 correlate positively with TMB,while RIPK3 shows negative correlations in some cancers.MSI analysis indicates associations with DNA mismatch repair.G ene set enrichment analysis highlights immune-related pathway enrichment for RIPK1,RIPK2,RIPK3,and RIPK6,and cell proliferation and DNA repair pathways for RIPK4 and RIPK5.RIPK family members showed heterogeneous alterations across cancers:for example,RIPK7 was mutated in up to~15%of u terine c orpus e ndometrial c arcinoma and l ung s quamous c ell c arcinoma cases,and RIPK1 and RIPK7 exhibited frequent promoter hypermethylation in multiple tumor types.Several genes displayed context-dependent associations with overall survival and with TMB/MSI.Conclusion:This pan-cancer analysis of the RIPK family reveals their diverse roles and potential as biomarkers and therapeutic targets.The findings emphasize the importance of RIPK genes in tumorigenesis and suggest context-dependent functions across cancer types.Further studies are needed to explore their mechanisms in cancer development and clinical applications.
基金financially supported by the National Natural Science Foundation of China(Nos.52034002 and U2202254)the Fundamental Research Funds for the Central Universities,China(No.FRF-TT-19-001)。
文摘The sulfation and decomposition process has proven effective in selectively extracting lithium from lepidolite.It is essential to clarify the thermochemical behavior and kinetic parameters of decomposition reactions.Accordingly,comprehensive kinetic study by employing thermalgravimetric analysis at various heating rates was presented in this paper.Two main weight loss regions were observed during heating.The initial region corresponded to the dehydration of crystal water,whereas the subsequent region with overlapping peaks involved complex decomposition reactions.The overlapping peaks were separated into two individual reaction peaks and the activation energy of each peak was calculated using isoconversional kinetics methods.The activation energy of peak 1 exhibited a continual increase as the reaction conversion progressed,while that of peak 2 steadily decreased.The optimal kinetic models,identified as belonging to the random nucleation and subsequent growth category,provided valuable insights into the mechanism of the decomposition reactions.Furthermore,the adjustment factor was introduced to reconstruct the kinetic mechanism models,and the reconstructed models described the kinetic mechanism model more accurately for the decomposition reactions.This study enhanced the understanding of the thermochemical behavior and kinetic parameters of the lepidolite sulfation product decomposition reactions,further providing theoretical basis for promoting the selective extraction of lithium.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
