Establishing a Regional Marine Innovation Ecosystem(RMIE)is crucial for advancing China’s maritime power strategy.Concurrently,developing a competitive RMIE serves as a strategic lever to enhance the global competiti...Establishing a Regional Marine Innovation Ecosystem(RMIE)is crucial for advancing China’s maritime power strategy.Concurrently,developing a competitive RMIE serves as a strategic lever to enhance the global competitiveness of China’s marine science sector.However,research on the competitiveness of RMIE is limited.To this end,this study constructs an evaluation index system based on ecological niche theory to assess the competitiveness of RMIE in China from 2008 to 2020.The findings indicate generally fluctuating upward trends in RMIE’s competitiveness,with Shandong,Jiangsu,and Guangdong showing relatively strong positions.Notably,there are significant intra-regional imbalances and inter-regional asynchrony in RMIE’s competitiveness across China’s three major marine economic circles.Recognizing that forecasting RMIE competitiveness can inform policy formulation,this paper proposes a systematic multivariate grey interval prediction model that incorporates spatial proximity effects.This model effectively captures the interval and uncertainty characteristics of RMIE’s competitiveness while considering spatial relationships among regions.Results from comparative analysis,robustness tests,and sensitivity analysis demonstrate its superior applicability and forecasting accuracy.Additionally,interval forecasts and scenario analyses suggest that RMIE competitiveness will maintain stable growth,although unbalanced and unsynchronized development is likely to persist.Overall,the approach developed for evaluating and forecasting RMIE competitiveness offers valuable insights for effective policy formulation.展开更多
Place attachment has been a research focus in the fields of park and recreation management.Place attachment plays an important role in promoting sustainable development of parks and mountain tourism destination,howeve...Place attachment has been a research focus in the fields of park and recreation management.Place attachment plays an important role in promoting sustainable development of parks and mountain tourism destination,however,there are limited studies that identified the spatial patterns of place attachment,especially in the context of mountain tourism destinations in China.Also,the geospatial spectrum of visitors is usually broad,examining the multivariate relationships among spatial proximity,perceived authenticity,and place attachment are essential for mountain tourism destinations to promote destination image and strengthen emotional bonding with targeted visitor groups.In this study,we selected an iconic and highly visited park,Jiuzhai Valley National Park in China,as our study site and conducted an on-site visitor survey to collect 557 samples.Study uses factor analysis and the structure equation model to analyze the relationship among spatial proximity,perceived authenticity,and place attachment.Results validate the two-dimension structure of place attachment and perceived authenticity.Study findings suggest that spatial proximity has significant impacts on existential authenticity and place identity,but has no significant impacts on place dependence.Perceived authenticity has a positive impact on place attachment.Study results advance the theories of place attachment and provide effective strategies to enhance emotional attachment between visitors and mountain tourism destinations.展开更多
Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago.Chromosomal translocations,a type of particular structural changes involving heterologous chromo...Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago.Chromosomal translocations,a type of particular structural changes involving heterologous chromosomes,have made a critical impact on diagnosis,prognosis and treatment of cancers.For example,the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia.In the past few decades,tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations.This review focuses on the basic mechanisms underlying the generation of chromosomal translocations.In particular,the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.展开更多
基金National Social Science Fund of China,No.24BTJ037Significant Project of the National Social Science Foundation of China,No.23&ZD102+1 种基金The Key Research Base for Philosophy and Social Sciences in Hangzhou:ESG and Sustainable Development Research Center,No.25JD053Zhejiang Provincial Statistical Scientific Research Project,No.25TJZZ12。
文摘Establishing a Regional Marine Innovation Ecosystem(RMIE)is crucial for advancing China’s maritime power strategy.Concurrently,developing a competitive RMIE serves as a strategic lever to enhance the global competitiveness of China’s marine science sector.However,research on the competitiveness of RMIE is limited.To this end,this study constructs an evaluation index system based on ecological niche theory to assess the competitiveness of RMIE in China from 2008 to 2020.The findings indicate generally fluctuating upward trends in RMIE’s competitiveness,with Shandong,Jiangsu,and Guangdong showing relatively strong positions.Notably,there are significant intra-regional imbalances and inter-regional asynchrony in RMIE’s competitiveness across China’s three major marine economic circles.Recognizing that forecasting RMIE competitiveness can inform policy formulation,this paper proposes a systematic multivariate grey interval prediction model that incorporates spatial proximity effects.This model effectively captures the interval and uncertainty characteristics of RMIE’s competitiveness while considering spatial relationships among regions.Results from comparative analysis,robustness tests,and sensitivity analysis demonstrate its superior applicability and forecasting accuracy.Additionally,interval forecasts and scenario analyses suggest that RMIE competitiveness will maintain stable growth,although unbalanced and unsynchronized development is likely to persist.Overall,the approach developed for evaluating and forecasting RMIE competitiveness offers valuable insights for effective policy formulation.
基金funded by Hainan University Social Science Innovative Researchgrant(HDSKTD202013)Hainan Provincial Natural Science Foundation of China(420QN218)。
文摘Place attachment has been a research focus in the fields of park and recreation management.Place attachment plays an important role in promoting sustainable development of parks and mountain tourism destination,however,there are limited studies that identified the spatial patterns of place attachment,especially in the context of mountain tourism destinations in China.Also,the geospatial spectrum of visitors is usually broad,examining the multivariate relationships among spatial proximity,perceived authenticity,and place attachment are essential for mountain tourism destinations to promote destination image and strengthen emotional bonding with targeted visitor groups.In this study,we selected an iconic and highly visited park,Jiuzhai Valley National Park in China,as our study site and conducted an on-site visitor survey to collect 557 samples.Study uses factor analysis and the structure equation model to analyze the relationship among spatial proximity,perceived authenticity,and place attachment.Results validate the two-dimension structure of place attachment and perceived authenticity.Study findings suggest that spatial proximity has significant impacts on existential authenticity and place identity,but has no significant impacts on place dependence.Perceived authenticity has a positive impact on place attachment.Study results advance the theories of place attachment and provide effective strategies to enhance emotional attachment between visitors and mountain tourism destinations.
基金supported by University of Colorado School of Medicine start-up fundLeukemia Research FoundationBoettcher Foundation for J.H.W.J.H.W.is a recipient of Boettcher Foundation Webb-Waring Biomedical Research Award.
文摘Chromosomal aberrations have been associated with cancer development since their discovery more than a hundred years ago.Chromosomal translocations,a type of particular structural changes involving heterologous chromosomes,have made a critical impact on diagnosis,prognosis and treatment of cancers.For example,the discovery of translocation between chromosomes 9 and 22 and the subsequent success of targeting the fusion product BCR-ABL transformed the therapy for chronic myelogenous leukemia.In the past few decades,tremendous progress has been achieved towards elucidating the mechanism causing chromosomal translocations.This review focuses on the basic mechanisms underlying the generation of chromosomal translocations.In particular,the contribution of frequency of DNA double strand breaks and spatial proximity of translocating loci is discussed.
