Ultrasonic neuromodulation has gained recognition as a promising therapeutic approach.A miniature transducer capable of generating suitable-strength and broadband ultrasound is of great significance for achieving high...Ultrasonic neuromodulation has gained recognition as a promising therapeutic approach.A miniature transducer capable of generating suitable-strength and broadband ultrasound is of great significance for achieving high spatial precision ultrasonic neural stimulation.However,the ultrasound transducer with the above integrated is yet to be challenged.Here,we developed a fiber-optic photoacoustic emitter(FPE)with a diameter of 200μm,featuring controllable sound intensity and a broadband response(−6 dB bandwidth:162%).The device integrates MXene(Ti_(3)C_(2)Tx),known for its exceptional photothermal properties,and polydimethylsiloxane,which offers a high thermal expansion coefficient.This FPE,exhibiting high spatial precision(lateral:163.3μm,axial:207μm),is capable of selectively activating neurons in targeted regions.Using the TetTagging method to selectively express a cfos-promoter-inducible mCHERRY gene within the medial prefrontal cortex(mPFC),we found that photoacoustic stimulation significantly and temporarily activated the neurons.In vivo fiber photometry demonstrated that photoacoustic stimulation induced substantial calcium transients in mPFC neurons.Furthermore,we confirmed that photoacoustic stimulation of the mPFC using FPE markedly alleviates acute social defeat stress-induced emotional stress in mice.This work demonstrates the potential of FPEs for clinical applications,with a particular focus on modulating neural activity to regulate emotions.展开更多
We propose a new ion-trap geometry to carry out accurate measurements of the quadrupole shifts in the （171）Yb ion.This trap will minimize the quadrupole shift due to the harmonic component of the confining potential...We propose a new ion-trap geometry to carry out accurate measurements of the quadrupole shifts in the （171）Yb ion.This trap will minimize the quadrupole shift due to the harmonic component of the confining potential by an order of magnitude.This will be useful to reduce the uncertainties in the clock frequency measurements of the 6s 2S（1/2）→4f（13）6s2 2F（7/2）and 6s 2S（1/2）→5d2D（3/2） transitions,from which we can deduce the precise values of the quadrupole moments（0s） of the 4f（13）6s2 2F（7/2） and 5d2D（3/2） states.Moreover,it may be able to affirm the validity of the measured 0 value of the4f（13）6s22F（7/2） state,for which three independent theoretical studies defer almost by one order of magnitude from the measurement.We also calculate 0s using the relativistic coupled-cluster（RCC） method.We use these 0 values to estimate the quadrupole shift that can be measured in our proposed ion trap experiment.展开更多
Precise spatial doping has long been fundamental to modern silicon-based electronics,enabling the creation of high-performance devices with complex architectures and fine control over charge transport.In contrast,orga...Precise spatial doping has long been fundamental to modern silicon-based electronics,enabling the creation of high-performance devices with complex architectures and fine control over charge transport.In contrast,organic semiconductors(OSCs),despite their potential for flexible,lightweight,and solution-processable electronics,have struggled to achieve such precise doping.Traditional doping approaches in OSCs often rely on spontaneous chemical reactions that lack spatial selectivity,severely limiting the resolution and reproducibility of doping patterns.展开更多
基金supported by the National Nature Science Foundation of China(Grant Number:U24A20306,12102140,6227031087,62035006,and 6207030117).
文摘Ultrasonic neuromodulation has gained recognition as a promising therapeutic approach.A miniature transducer capable of generating suitable-strength and broadband ultrasound is of great significance for achieving high spatial precision ultrasonic neural stimulation.However,the ultrasound transducer with the above integrated is yet to be challenged.Here,we developed a fiber-optic photoacoustic emitter(FPE)with a diameter of 200μm,featuring controllable sound intensity and a broadband response(−6 dB bandwidth:162%).The device integrates MXene(Ti_(3)C_(2)Tx),known for its exceptional photothermal properties,and polydimethylsiloxane,which offers a high thermal expansion coefficient.This FPE,exhibiting high spatial precision(lateral:163.3μm,axial:207μm),is capable of selectively activating neurons in targeted regions.Using the TetTagging method to selectively express a cfos-promoter-inducible mCHERRY gene within the medial prefrontal cortex(mPFC),we found that photoacoustic stimulation significantly and temporarily activated the neurons.In vivo fiber photometry demonstrated that photoacoustic stimulation induced substantial calcium transients in mPFC neurons.Furthermore,we confirmed that photoacoustic stimulation of the mPFC using FPE markedly alleviates acute social defeat stress-induced emotional stress in mice.This work demonstrates the potential of FPEs for clinical applications,with a particular focus on modulating neural activity to regulate emotions.
基金CSIR-National Physical Laboratory,Depaitment of Science and Technology(Grant No.SB/S2/LOP/033/2013)the Board of Research in Nuclear Sciences(Grant No. 34/14/ 19/2014-BRNS/0309) for supporting
文摘We propose a new ion-trap geometry to carry out accurate measurements of the quadrupole shifts in the （171）Yb ion.This trap will minimize the quadrupole shift due to the harmonic component of the confining potential by an order of magnitude.This will be useful to reduce the uncertainties in the clock frequency measurements of the 6s 2S（1/2）→4f（13）6s2 2F（7/2）and 6s 2S（1/2）→5d2D（3/2） transitions,from which we can deduce the precise values of the quadrupole moments（0s） of the 4f（13）6s2 2F（7/2） and 5d2D（3/2） states.Moreover,it may be able to affirm the validity of the measured 0 value of the4f（13）6s22F（7/2） state,for which three independent theoretical studies defer almost by one order of magnitude from the measurement.We also calculate 0s using the relativistic coupled-cluster（RCC） method.We use these 0 values to estimate the quadrupole shift that can be measured in our proposed ion trap experiment.
基金supported by Beijing Natural Science Foundation(JQ22006).
文摘Precise spatial doping has long been fundamental to modern silicon-based electronics,enabling the creation of high-performance devices with complex architectures and fine control over charge transport.In contrast,organic semiconductors(OSCs),despite their potential for flexible,lightweight,and solution-processable electronics,have struggled to achieve such precise doping.Traditional doping approaches in OSCs often rely on spontaneous chemical reactions that lack spatial selectivity,severely limiting the resolution and reproducibility of doping patterns.
