The advancement in extraterrestrial exploration has highlighted the crucial need for studying how the human cardiovascular system adapts to space conditions.Human development occurs under the influence of gravity,shie...The advancement in extraterrestrial exploration has highlighted the crucial need for studying how the human cardiovascular system adapts to space conditions.Human development occurs under the influence of gravity,shielded from space radiation by Earth’s magnetic field,and within an environment characterized by 24-hour day-night cycles resulting from Earth’s rotation,thus deviating from these conditions necessitates adaptive responses for survival.With upcoming manned lunar and Martian missions approaching rapidly,it is essential to understand the impact of various stressors induced by outer-space environments on cardiovascular health.This comprehensive review integrates insights from both actual space missions and simulated experiments on Earth,to analyze how microgravity,space radiation,and disrupted circadian affect cardiovascular well-being.Prolonged exposure to microgravity induces myocardial atrophy and endothelial dysfunction,which may be exacerbated by space radiation.Mitochondrial dysfunction and oxidative stress emerge as key underlying mechanisms along with disturbances in ion channel perturbations,cytoskeletal damage,and myofibril changes.Disruptions in circadian rhythms caused by factors such as microgravity,light exposure,and irregular work schedules,could further exacerbate cardiovascular issues.However,current research tends to predominantly focus on disruptions in the core clock gene,overlooking the multifactorial nature of circadian rhythm disturbances in space.Future space missions should prioritize targeted prevention strategies and early detection methods for identifying cardiovascular risks,to preserve astronaut health and ensure mission success.展开更多
Spaceflight and ground-based microgravity analog experiments have suggested that microgravity can affect microbial growth and metabolism. Although the effects of microgravity and its analogs on microorganisms have bee...Spaceflight and ground-based microgravity analog experiments have suggested that microgravity can affect microbial growth and metabolism. Although the effects of microgravity and its analogs on microorganisms have been studied for more than 50 years, plausible conflicting and diverse results have frequently been reported in different experiments, especially regarding microbial growth and secondary metabolism. Until now, only the responses of a few typical microbes to microgravity have been investigated; systematic studies of the genetic and phenotypic responses of these microorganisms to microgravity in space are still insufficient due to technological and logistical hurdles. The use of different test strains and secondary metabolites in these studies appears to have caused diverse and conflicting results. Moreover, subtle changes in the extracellular microenvironments around microbial cells play a key role in the diverse responses of microbial growth and secondary metabolisms. Therefore, "indirect" effects represent a reasonable pathway to explain the occurrence of these phenomena in microorganisms. This review summarizes current knowledge on the changes in microbial growth and secondary metabolism in response to spaceflight and its analogs and discusses the diverse and conflicting results. In addition, recommendations are given for future studies on the effects of microgravity in space on microbial growth and secondary metabolism.展开更多
When analyze the uncertainty of the cost and the schedule of the spaceflight project, it is needed to know the value of the schedule-cost correlation coefficient. This paper deduces the schedule distribution, consider...When analyze the uncertainty of the cost and the schedule of the spaceflight project, it is needed to know the value of the schedule-cost correlation coefficient. This paper deduces the schedule distribution, considering the effect of the cost, and proposes the estimation formula of the correlation coefficient between the in（schedule） and the cost. On the basis of the fact and Taylor expansion, the relation expression between the schedule-cost correlation coefficient and the in-schedule-cost correlation coefficient is put forward. By analyzing the value features of the estimation formula of the in-schedule-cost correlation coefficient, the general rules are proposed to ascertain the value of the schedule-cost correlation coefficient. An example is given to demonstrate how to approximately amend the schedule-cost correlation coefficient based on the historical statistics, which reveals the traditional assigned value is inaccurate. The universality of this estimation method is analyzed.展开更多
[ Objective] To explore the effects of spaceflight on the second-generation seeds of alfalfa and provide a theoretical basis for mutation breeding. [Method] The seeds of Medicago stavia L. lines no. 1, no. 2 and no. 4...[ Objective] To explore the effects of spaceflight on the second-generation seeds of alfalfa and provide a theoretical basis for mutation breeding. [Method] The seeds of Medicago stavia L. lines no. 1, no. 2 and no. 4 were carried into space by the Shijian-8 seed breeding satellite for a 15-d spaceflight treatment. After returning to the ground, seedlings were transplanted to field. Traits of the second-generation seeds of alfalfa were evaluated. [Result] The 1 000-grain weight of the second-generation seeds were 5% -9% significantly higher than that the control （P 〈 0.05）. The germination rate, seedling weight, shoot length and root length were significantly increased （P 〈 0.05）. The hard seed rate and the rate of moldy seeds were significantly decreased （ P 〈 0.05）. However, the rate of dead seeds was increased. [ Conclusion] Spaceflight treatment has positive mutagenic effects on the second-generation seeds of alfalfa.展开更多
Highly relativistic speeds are desirable for interstellar travel. Relativistic time dilation would reduce the subjective duration of the trip for the travelers, so that they can cover galaxy-scale distances in a reaso...Highly relativistic speeds are desirable for interstellar travel. Relativistic time dilation would reduce the subjective duration of the trip for the travelers, so that they can cover galaxy-scale distances in a reasonable amount of personal time. Unfortunately, as spaceship velocities approach the speed of light, interstellar hydrogen H, although only present at a density of approximately 1.8 atoms/cm3, turns into intense radiation that would quickly kill passengers and destroy electronic instrumentation. In addition, the energy loss of ionizing radiation passing through the ship’s hull represents an increasing heat load that necessitates large expenditures of energy to cool the ship. Stopping or diverting this flux, either with material or electromagnetic shields, is a daunting problem. Going slow to avoid severe H irradiation sets an upper speed limit of v ~ 0.5 c. This velocity only gives a time dilation factor of about 15%, which would not substantially assist galaxy-scale voyages. Diffuse interstellar H atoms are the ultimate cosmic space mines and represent a formidable obstacle to interstellar travel.展开更多
To evaluate the cost risk and the schedule risk of the spaceflight project,the schedule-cost(S-C) correlation coefficient is directly appointed according to the experts' experience usually.This paper deduces SDMCU...To evaluate the cost risk and the schedule risk of the spaceflight project,the schedule-cost(S-C) correlation coefficient is directly appointed according to the experts' experience usually.This paper deduces SDMCU(the schedule distribution model considering the effect of the cost uncertainty),and then proposes the approximate formula to estimate the ln(S)-C correlation coefficient based on the models of SDMCU and CDMSU(the cost distribution model considering the effect of the schedule uncertainty).Furthermore,an approximate relationship expression of the S-C and the ln(S)-C correlation coefficients is put forward according to general facts and the Taylor expansion,and advanced by means of mass numerical validation is the general rule of obtaining the estimation value of the schedule-cost correlation coefficient based on the historical data.展开更多
On September 21,1992, the feasibility report on implementing China's Manned Spaceflight Project was approved and a three-step development strategy was also determined. From then on, China's Manned Spaceflight ...On September 21,1992, the feasibility report on implementing China's Manned Spaceflight Project was approved and a three-step development strategy was also determined. From then on, China's Manned Spaceflight Project has developed rapidly.展开更多
The LM-2F launch vehicle is China's first launch carrier developed for China's Manned Space Program,which is one of the most important parts of the Program.It is developed from the LM-2E launch vehicle,with ad...The LM-2F launch vehicle is China's first launch carrier developed for China's Manned Space Program,which is one of the most important parts of the Program.It is developed from the LM-2E launch vehicle,with addition of two new systems,an escape system and a fault detection system.展开更多
Intergenerational inheritance of stress memory plays a crucial role in plant adaptation to environmental changes,particularly in the context of spaceflight,where plants may serve as a food source for humans on long-du...Intergenerational inheritance of stress memory plays a crucial role in plant adaptation to environmental changes,particularly in the context of spaceflight,where plants may serve as a food source for humans on long-duration missions.However,the intergenerational genetic effects of spaceflight-induced stress memory in plants remain unclear.In this study,we assessed the cross-generational genetic effects of spaceflight stress memory using the rice mutant B10,identified during the SJ-10 return satellite mission.Our results showed that the oxidative stress effects induced by spaceflight persisted until the M5 generation in rice.We found that the rice genome remained unstable post-spaceflight,leading to alterations in genome methylation levels.Additionally,we observed significant changes in the methylation levels of transposons,suggesting their involvement in the intergenerational inheritance of spaceflight-induced stress memory.Furthermore,we identified thousands of differentially expressed genes(DEGs)and differentially alternatively spliced(DAS)genes induced by spaceflight stress memory across multiple rice generations.Notably,differentially methylated cytosines were more abundant in non-expressed genes than in DEGs or DAS genes.A substantial number of DEGs and DASs related to oxidative stress were identified,primarily involved in the generation and scavenging of reactive oxygen species.This study also presented report on the response of alternative splicing events in rice to spaceflight stress.Moreover,our findings revealed that genome methylation was associated with gene expression but not with DAS.In conclusion,our study provides comprehensive insights into the intergenerational inheritance of spaceflight-induced stress in rice and may contribute to uncovering novel mechanisms of oxidative stress-induced genomic instability and epigenetic regulation in plant stress inheritance.展开更多
Sufficient sleep duration and good sleep quality are crucial to ensure normal physical and mental health, cognition and work performance for the common people, as well as astronauts. On-orbit sleep problem is very com...Sufficient sleep duration and good sleep quality are crucial to ensure normal physical and mental health, cognition and work performance for the common people, as well as astronauts. On-orbit sleep problem is very common among astronauts and has potential detrimental influences on the health of crewmembers and the safety of flight missions. Sleep in space is becoming a new medical research frontier. In this review we summarized on-orbit sleep problems of astronauts and six kinds of causes, and we presented the effects of lack of sleep on performance as well as mental and physical health, then we proposed seven kinds of countermeasures for sleep disturbance in spaceflight, including pharmacologic interventions, light treatment, crew selection and training, Traditional Chinese Medicine and so on. Furthermore, we discussed and oriented the prospect of researches on sleep in space.展开更多
As one of the seven scientific payloads on board the Tianwen-1 orbiter,the Mars Orbiter Magnetometer(MOMAG)will measure the magnetic fields of and surrounding Mars to study its space environment and the interaction wi...As one of the seven scientific payloads on board the Tianwen-1 orbiter,the Mars Orbiter Magnetometer(MOMAG)will measure the magnetic fields of and surrounding Mars to study its space environment and the interaction with the solar wind.The instrument consists of two identical triaxial fluxgate magnetometer sensors,mounted on a 3.19 meter-long boom with a seperation of about 90 cm.The dual-magnetometers configuration will help eliminate the magnetic field interference generated by the spacecraft platform and payloads.The sensors are controlled by an electric box mounted inside the orbiter.Each magnetometer measures the ambient vector magnetic field over a wide dynamic range(to 10,000 nT per axis)with a resolution of 1.19 pT.Both magnetometers sample the ambient magnetic field at an intrinsic frequency of 128 Hz,but will operate in a model with alternating frequency between 1 and 32 Hz to meet telemetry allocations.展开更多
To further improve upland rice varieties Huhan 3 and Huhan 7, seed samples were sent to outer space with two recoverable spaceships for approximately 1 and 5 d and were propagated for 7 and 5 generations, respectively...To further improve upland rice varieties Huhan 3 and Huhan 7, seed samples were sent to outer space with two recoverable spaceships for approximately 1 and 5 d and were propagated for 7 and 5 generations, respectively. Phenotypic analysis revealed that the morphological traits and the protein and amylose contents of grains changed. Characterization of genomic mutations by the gene-associated simple sequence repeat （SSR） and insertion-delete （InDel） markers indicated that the mutation pattern was very complex. Most of the mutations occurred at the 3＇- or 5＇-end of the fragments in the simple sequence repeat fragment. Reverse transcription-polymerase chain reaction （RT-PCR） assay showed that mutations in those parts of the SSR affected their gene expression, indicating that gene associated markers would be helpful to isolate functional genes. Field survey for breeding also revealed that more lines with high yield, high quality and drought-tolerance could be selected through aerospace breeding. The results indicate that aerospace mutagenesis resulted in molecular variation, as well as physiological and morphological changes for rice breeding.展开更多
AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term spaceflights.METHODS:Breath tests based on the oral administration of 13 C-la...AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term spaceflights.METHODS:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 Project.In particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid meals.In addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal inflammation.Because no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the experiment.RESULTS:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external assistance.No evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy subjects.In contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same subject.This variability suggested that the H 2-breath test was strongly affected by external factors,which may have been related to the diet of the crewmembers or to environmental conditions(e.g.,the accumulation of hydrogen in the simulator microenvironment).At least in closed microenvironments such as the MARS-500 simulator,13 C-breath tests should therefore be preferred to H 2-breath tests.Finally,the fecal calprotectin test showed significant alterations during the mission simulation:all of the crewmembers were negative for the test at the beginning of the simulation but showed various degrees of positivity in at least one of the subsequent tests,thus indicating the onset of an intestinal inflammation.CONCLUSION:Breath tests,especially those 13 Cbased,proved suitable for monitoring gastrointestinal motility in the 520-d isolation experiment withinMARS-500 project and can be applied in long-term spaceflights.展开更多
The application of manned spaceflight makes a great impetus on the development of space medicine. With the deep growth of Chinese manned space, our national space medicine has attained great achievements. In this pape...The application of manned spaceflight makes a great impetus on the development of space medicine. With the deep growth of Chinese manned space, our national space medicine has attained great achievements. In this paper, the basic research of Space Medicine and its application in China during 2012–2014 were briefly reviewed.展开更多
Accompanying the flourishing developments of China's manned spaceflight,space medicine has achieved great development during the past two years in China.In this paper,scientific research of space medicine and its ...Accompanying the flourishing developments of China's manned spaceflight,space medicine has achieved great development during the past two years in China.In this paper,scientific research of space medicine and its application in China during 2010-2012 have been briefly introduced.展开更多
A typical man-machine-environment system is composed of astronaut, vehicle and space environment in the course of manned spaceflight. In this paper, the important role played by man and the factors on his capability i...A typical man-machine-environment system is composed of astronaut, vehicle and space environment in the course of manned spaceflight. In this paper, the important role played by man and the factors on his capability in vehicle system have been described, and a stress-strength human reliability model is also put forward. In the end, it must be systematically considered to raise the astronaut's reliability.展开更多
Zhai Zhigang, taikonaut of China’s Shenzhou-13 manned spaceflight mission, exits the return capsule on April 16.Zhai and two other taikonauts, Wang Yaping and Ye Guangfu, touched down at the Dongfeng landing site in ...Zhai Zhigang, taikonaut of China’s Shenzhou-13 manned spaceflight mission, exits the return capsule on April 16.Zhai and two other taikonauts, Wang Yaping and Ye Guangfu, touched down at the Dongfeng landing site in Inner Mongolia Autonomous Region in north China after a six-month mission. They are the second crew sent to orbit for space station construction.展开更多
Based on the requirements of manned spaceships,this paper introduces the characteristics of the propulsion system from the perspectives of design scheme,basic composition,safety and reliability measures,and also intro...Based on the requirements of manned spaceships,this paper introduces the characteristics of the propulsion system from the perspectives of design scheme,basic composition,safety and reliability measures,and also introduces the ground test verification and on-orbit flight characteristics of the Shenzhou 13 propulsion system.According to the flight results,it was seen that the performance of the Shenzhou 13 propulsion system fully met the engineering requirements for the manned space mission.展开更多
With the development of manned spaceflight, more and more researches are involved in the area of gravitation physiology. When astronauts are exposed to microgravity, a series of special physiological or pathological c...With the development of manned spaceflight, more and more researches are involved in the area of gravitation physiology. When astronauts are exposed to microgravity, a series of special physiological or pathological changes will occur, which will start self-regulation mechanisms to reduce abnormalities and help the organism to better adapt to microgravity. However, these adaptive changes may also induce degradation or damage to physiological functions. This paper summarizes the physiological effects of microgravity on the human body from the aspects of skeletal and mineral metabolism, muscle structure and function, vestibular functions, cardiovascular function and pulmonary function, as well as expounds some commonly used ground-based space analogies. The paper will provide a reference for further study on the physiological effects of microgravity.展开更多
基金supported by the National Natural Science Fund for Distinguished Young Scholars of China(82125004).
文摘The advancement in extraterrestrial exploration has highlighted the crucial need for studying how the human cardiovascular system adapts to space conditions.Human development occurs under the influence of gravity,shielded from space radiation by Earth’s magnetic field,and within an environment characterized by 24-hour day-night cycles resulting from Earth’s rotation,thus deviating from these conditions necessitates adaptive responses for survival.With upcoming manned lunar and Martian missions approaching rapidly,it is essential to understand the impact of various stressors induced by outer-space environments on cardiovascular health.This comprehensive review integrates insights from both actual space missions and simulated experiments on Earth,to analyze how microgravity,space radiation,and disrupted circadian affect cardiovascular well-being.Prolonged exposure to microgravity induces myocardial atrophy and endothelial dysfunction,which may be exacerbated by space radiation.Mitochondrial dysfunction and oxidative stress emerge as key underlying mechanisms along with disturbances in ion channel perturbations,cytoskeletal damage,and myofibril changes.Disruptions in circadian rhythms caused by factors such as microgravity,light exposure,and irregular work schedules,could further exacerbate cardiovascular issues.However,current research tends to predominantly focus on disruptions in the core clock gene,overlooking the multifactorial nature of circadian rhythm disturbances in space.Future space missions should prioritize targeted prevention strategies and early detection methods for identifying cardiovascular risks,to preserve astronaut health and ensure mission success.
基金supported by the China Manned Space Engineering Program(CMSE,921–2)the National Program on Key Basic Research Project(973 Program,No.2014CB744400)the General Financial Grant from the China Postdoctoral Science Foundation(No.2016 M602971)
文摘Spaceflight and ground-based microgravity analog experiments have suggested that microgravity can affect microbial growth and metabolism. Although the effects of microgravity and its analogs on microorganisms have been studied for more than 50 years, plausible conflicting and diverse results have frequently been reported in different experiments, especially regarding microbial growth and secondary metabolism. Until now, only the responses of a few typical microbes to microgravity have been investigated; systematic studies of the genetic and phenotypic responses of these microorganisms to microgravity in space are still insufficient due to technological and logistical hurdles. The use of different test strains and secondary metabolites in these studies appears to have caused diverse and conflicting results. Moreover, subtle changes in the extracellular microenvironments around microbial cells play a key role in the diverse responses of microbial growth and secondary metabolisms. Therefore, "indirect" effects represent a reasonable pathway to explain the occurrence of these phenomena in microorganisms. This review summarizes current knowledge on the changes in microbial growth and secondary metabolism in response to spaceflight and its analogs and discusses the diverse and conflicting results. In addition, recommendations are given for future studies on the effects of microgravity in space on microbial growth and secondary metabolism.
基金This project was supported by Weapon System Advanced Research Foundation(51419010204KG01) and National ScienceFoundation of China(70272002).
文摘When analyze the uncertainty of the cost and the schedule of the spaceflight project, it is needed to know the value of the schedule-cost correlation coefficient. This paper deduces the schedule distribution, considering the effect of the cost, and proposes the estimation formula of the correlation coefficient between the in（schedule） and the cost. On the basis of the fact and Taylor expansion, the relation expression between the schedule-cost correlation coefficient and the in-schedule-cost correlation coefficient is put forward. By analyzing the value features of the estimation formula of the in-schedule-cost correlation coefficient, the general rules are proposed to ascertain the value of the schedule-cost correlation coefficient. An example is given to demonstrate how to approximately amend the schedule-cost correlation coefficient based on the historical statistics, which reveals the traditional assigned value is inaccurate. The universality of this estimation method is analyzed.
基金supported by the grants of the National Key Technology R&D Program (2008BADB3B04 )Basic Science and Research Special Fund for the State Level and Public Scientific Research Institute (Grassland Research Institute,Chinese Academy of Agricultural Sciences) (2007-1-02)
文摘[ Objective] To explore the effects of spaceflight on the second-generation seeds of alfalfa and provide a theoretical basis for mutation breeding. [Method] The seeds of Medicago stavia L. lines no. 1, no. 2 and no. 4 were carried into space by the Shijian-8 seed breeding satellite for a 15-d spaceflight treatment. After returning to the ground, seedlings were transplanted to field. Traits of the second-generation seeds of alfalfa were evaluated. [Result] The 1 000-grain weight of the second-generation seeds were 5% -9% significantly higher than that the control （P 〈 0.05）. The germination rate, seedling weight, shoot length and root length were significantly increased （P 〈 0.05）. The hard seed rate and the rate of moldy seeds were significantly decreased （ P 〈 0.05）. However, the rate of dead seeds was increased. [ Conclusion] Spaceflight treatment has positive mutagenic effects on the second-generation seeds of alfalfa.
文摘Highly relativistic speeds are desirable for interstellar travel. Relativistic time dilation would reduce the subjective duration of the trip for the travelers, so that they can cover galaxy-scale distances in a reasonable amount of personal time. Unfortunately, as spaceship velocities approach the speed of light, interstellar hydrogen H, although only present at a density of approximately 1.8 atoms/cm3, turns into intense radiation that would quickly kill passengers and destroy electronic instrumentation. In addition, the energy loss of ionizing radiation passing through the ship’s hull represents an increasing heat load that necessitates large expenditures of energy to cool the ship. Stopping or diverting this flux, either with material or electromagnetic shields, is a daunting problem. Going slow to avoid severe H irradiation sets an upper speed limit of v ~ 0.5 c. This velocity only gives a time dilation factor of about 15%, which would not substantially assist galaxy-scale voyages. Diffuse interstellar H atoms are the ultimate cosmic space mines and represent a formidable obstacle to interstellar travel.
文摘To evaluate the cost risk and the schedule risk of the spaceflight project,the schedule-cost(S-C) correlation coefficient is directly appointed according to the experts' experience usually.This paper deduces SDMCU(the schedule distribution model considering the effect of the cost uncertainty),and then proposes the approximate formula to estimate the ln(S)-C correlation coefficient based on the models of SDMCU and CDMSU(the cost distribution model considering the effect of the schedule uncertainty).Furthermore,an approximate relationship expression of the S-C and the ln(S)-C correlation coefficients is put forward according to general facts and the Taylor expansion,and advanced by means of mass numerical validation is the general rule of obtaining the estimation value of the schedule-cost correlation coefficient based on the historical data.
文摘On September 21,1992, the feasibility report on implementing China's Manned Spaceflight Project was approved and a three-step development strategy was also determined. From then on, China's Manned Spaceflight Project has developed rapidly.
文摘The LM-2F launch vehicle is China's first launch carrier developed for China's Manned Space Program,which is one of the most important parts of the Program.It is developed from the LM-2E launch vehicle,with addition of two new systems,an escape system and a fault detection system.
基金supported by the Natural Science Foundation of Chongqing,China(Grant No.CSTB2024NSCQ-MSX0462)the Postdoctoral Fellowship Program of CPSF,China(Grant No.GZC20242211)+1 种基金the Heilongjiang Touyan Team,China(Grant No.HITTY-20190034)the Project of the Aerospace Science and Technology Collaborative Innovation Center,China(Grant No.BSAUEA5740600223).
文摘Intergenerational inheritance of stress memory plays a crucial role in plant adaptation to environmental changes,particularly in the context of spaceflight,where plants may serve as a food source for humans on long-duration missions.However,the intergenerational genetic effects of spaceflight-induced stress memory in plants remain unclear.In this study,we assessed the cross-generational genetic effects of spaceflight stress memory using the rice mutant B10,identified during the SJ-10 return satellite mission.Our results showed that the oxidative stress effects induced by spaceflight persisted until the M5 generation in rice.We found that the rice genome remained unstable post-spaceflight,leading to alterations in genome methylation levels.Additionally,we observed significant changes in the methylation levels of transposons,suggesting their involvement in the intergenerational inheritance of spaceflight-induced stress memory.Furthermore,we identified thousands of differentially expressed genes(DEGs)and differentially alternatively spliced(DAS)genes induced by spaceflight stress memory across multiple rice generations.Notably,differentially methylated cytosines were more abundant in non-expressed genes than in DEGs or DAS genes.A substantial number of DEGs and DASs related to oxidative stress were identified,primarily involved in the generation and scavenging of reactive oxygen species.This study also presented report on the response of alternative splicing events in rice to spaceflight stress.Moreover,our findings revealed that genome methylation was associated with gene expression but not with DAS.In conclusion,our study provides comprehensive insights into the intergenerational inheritance of spaceflight-induced stress in rice and may contribute to uncovering novel mechanisms of oxidative stress-induced genomic instability and epigenetic regulation in plant stress inheritance.
基金supported by the Manned Spaceflight Program of China,the Advanced Space Medio-Engineering Research Project of China(2014SY54A0001)
文摘Sufficient sleep duration and good sleep quality are crucial to ensure normal physical and mental health, cognition and work performance for the common people, as well as astronauts. On-orbit sleep problem is very common among astronauts and has potential detrimental influences on the health of crewmembers and the safety of flight missions. Sleep in space is becoming a new medical research frontier. In this review we summarized on-orbit sleep problems of astronauts and six kinds of causes, and we presented the effects of lack of sleep on performance as well as mental and physical health, then we proposed seven kinds of countermeasures for sleep disturbance in spaceflight, including pharmacologic interventions, light treatment, crew selection and training, Traditional Chinese Medicine and so on. Furthermore, we discussed and oriented the prospect of researches on sleep in space.
基金supported by the Chinese National Space Administration,and the science team of MOMAG is supported by the Strategic Priority Program(Grant No.XDB41000000)the key Research Program of Frontier Sciences(No.QYZDB-SSW-DQC015)of the Chinese Academy of Sciences.
文摘As one of the seven scientific payloads on board the Tianwen-1 orbiter,the Mars Orbiter Magnetometer(MOMAG)will measure the magnetic fields of and surrounding Mars to study its space environment and the interaction with the solar wind.The instrument consists of two identical triaxial fluxgate magnetometer sensors,mounted on a 3.19 meter-long boom with a seperation of about 90 cm.The dual-magnetometers configuration will help eliminate the magnetic field interference generated by the spacecraft platform and payloads.The sensors are controlled by an electric box mounted inside the orbiter.Each magnetometer measures the ambient vector magnetic field over a wide dynamic range(to 10,000 nT per axis)with a resolution of 1.19 pT.Both magnetometers sample the ambient magnetic field at an intrinsic frequency of 128 Hz,but will operate in a model with alternating frequency between 1 and 32 Hz to meet telemetry allocations.
基金supported by the National High-Technology Research and Development Program of China(Grant No.2010AA101805)National Key Technology R&D Program of China(Grant No.2013ZX08001-003)Shanghai Agricultural Science and Technology Key Projects,China(Grant No.2009-6-4-2)
文摘To further improve upland rice varieties Huhan 3 and Huhan 7, seed samples were sent to outer space with two recoverable spaceships for approximately 1 and 5 d and were propagated for 7 and 5 generations, respectively. Phenotypic analysis revealed that the morphological traits and the protein and amylose contents of grains changed. Characterization of genomic mutations by the gene-associated simple sequence repeat （SSR） and insertion-delete （InDel） markers indicated that the mutation pattern was very complex. Most of the mutations occurred at the 3＇- or 5＇-end of the fragments in the simple sequence repeat fragment. Reverse transcription-polymerase chain reaction （RT-PCR） assay showed that mutations in those parts of the SSR affected their gene expression, indicating that gene associated markers would be helpful to isolate functional genes. Field survey for breeding also revealed that more lines with high yield, high quality and drought-tolerance could be selected through aerospace breeding. The results indicate that aerospace mutagenesis resulted in molecular variation, as well as physiological and morphological changes for rice breeding.
文摘AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term spaceflights.METHODS:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 Project.In particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid meals.In addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal inflammation.Because no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the experiment.RESULTS:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external assistance.No evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy subjects.In contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same subject.This variability suggested that the H 2-breath test was strongly affected by external factors,which may have been related to the diet of the crewmembers or to environmental conditions(e.g.,the accumulation of hydrogen in the simulator microenvironment).At least in closed microenvironments such as the MARS-500 simulator,13 C-breath tests should therefore be preferred to H 2-breath tests.Finally,the fecal calprotectin test showed significant alterations during the mission simulation:all of the crewmembers were negative for the test at the beginning of the simulation but showed various degrees of positivity in at least one of the subsequent tests,thus indicating the onset of an intestinal inflammation.CONCLUSION:Breath tests,especially those 13 Cbased,proved suitable for monitoring gastrointestinal motility in the 520-d isolation experiment withinMARS-500 project and can be applied in long-term spaceflights.
文摘The application of manned spaceflight makes a great impetus on the development of space medicine. With the deep growth of Chinese manned space, our national space medicine has attained great achievements. In this paper, the basic research of Space Medicine and its application in China during 2012–2014 were briefly reviewed.
文摘Accompanying the flourishing developments of China's manned spaceflight,space medicine has achieved great development during the past two years in China.In this paper,scientific research of space medicine and its application in China during 2010-2012 have been briefly introduced.
文摘A typical man-machine-environment system is composed of astronaut, vehicle and space environment in the course of manned spaceflight. In this paper, the important role played by man and the factors on his capability in vehicle system have been described, and a stress-strength human reliability model is also put forward. In the end, it must be systematically considered to raise the astronaut's reliability.
文摘Zhai Zhigang, taikonaut of China’s Shenzhou-13 manned spaceflight mission, exits the return capsule on April 16.Zhai and two other taikonauts, Wang Yaping and Ye Guangfu, touched down at the Dongfeng landing site in Inner Mongolia Autonomous Region in north China after a six-month mission. They are the second crew sent to orbit for space station construction.
文摘Based on the requirements of manned spaceships,this paper introduces the characteristics of the propulsion system from the perspectives of design scheme,basic composition,safety and reliability measures,and also introduces the ground test verification and on-orbit flight characteristics of the Shenzhou 13 propulsion system.According to the flight results,it was seen that the performance of the Shenzhou 13 propulsion system fully met the engineering requirements for the manned space mission.
文摘With the development of manned spaceflight, more and more researches are involved in the area of gravitation physiology. When astronauts are exposed to microgravity, a series of special physiological or pathological changes will occur, which will start self-regulation mechanisms to reduce abnormalities and help the organism to better adapt to microgravity. However, these adaptive changes may also induce degradation or damage to physiological functions. This paper summarizes the physiological effects of microgravity on the human body from the aspects of skeletal and mineral metabolism, muscle structure and function, vestibular functions, cardiovascular function and pulmonary function, as well as expounds some commonly used ground-based space analogies. The paper will provide a reference for further study on the physiological effects of microgravity.
