Mitochondria,the cellular powerhouses,are dynamic organelles whose quality control is essential for maintaining cellular homeostasis,particularly under stress conditions such as oxidative damage or metabolic imbalance...Mitochondria,the cellular powerhouses,are dynamic organelles whose quality control is essential for maintaining cellular homeostasis,particularly under stress conditions such as oxidative damage or metabolic imbalance[1].Among the mechanisms ensuring mitochondrial integrity,mitochondrial-derived vesicles(MDVs)have emerged as a critical pathway for shuttling damaged components to lysosomes or the extracellular space,distinct from the more widely studied mitophagy[2,3].展开更多
基金supported by the National Key Research and Development Program of China(2022YFE0210100)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000)+6 种基金the National Natural Science Foundation projects of China(32371007,32025010,32488301,92254301,92357302,92157202,32241002,32261160376,and 32370782)the Major Project of Guangzhou National Laboratory(GZNL2024A03006)the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003,YSBR-075 and 188GJHZ2024048GC)Guangdong Province Science and Technology Program(2023B0303000023,2023B1111050005,2023B1212060050,2023B1212120009,2024B1515040020,and 2024A1515030120)Guangzhou Science and Technology Program(202206060002 and 2025A04J5485)Health@InnoHK funding support from the Innovation Technology Commission of the Hong Kong SAR,and Major Research Project(GIBHMRP25-01)Basic Research Project of Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences.
文摘Mitochondria,the cellular powerhouses,are dynamic organelles whose quality control is essential for maintaining cellular homeostasis,particularly under stress conditions such as oxidative damage or metabolic imbalance[1].Among the mechanisms ensuring mitochondrial integrity,mitochondrial-derived vesicles(MDVs)have emerged as a critical pathway for shuttling damaged components to lysosomes or the extracellular space,distinct from the more widely studied mitophagy[2,3].
