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A target imaging simulation method for ground-based system based on signal-to-noise ratio
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作者 Chunxu Ren Yun Li +3 位作者 Yanzhao Li Weihua Gao Wenlong Niu Xiaodong Peng 《Astronomical Techniques and Instruments》 2025年第5期288-298,共11页
Space target imaging simulation technology is an important tool for space target detection and identification,with advantages that include high flexibility and low cost.However,existing space target imaging simulation... Space target imaging simulation technology is an important tool for space target detection and identification,with advantages that include high flexibility and low cost.However,existing space target imaging simulation technologies are mostly based on target magnitudes for simulations,making it difficult to meet image simulation requirements for different signal-to-noise ratio(SNR)needs.Therefore,design of a simulation method that generates target image sequences with various SNRs based on the optical detection system parameters will be important for faint space target detection research.Addressing the SNR calculation issue in optical observation systems,this paper proposes a ground-based detection image SNR calculation method using the optical system parameters.This method calculates the SNR of an observed image precisely using radiative transfer theory,the optical system parameters,and the observation environment parameters.An SNR-based target sequence image simulation method for ground-based detection scenarios is proposed.This method calculates the imaging SNR using the optical system parameters and establishes a model for conversion between the target’s apparent magnitude and image grayscale values,thereby enabling generation of target sequence simulation images with corresponding SNRs for different system parameters.Experiments show that the SNR obtained using this calculation method has an average calculation error of<1 dB when compared with the theoretical SNR of the actual optical system.Additionally,the simulation images generated by the imaging simulation method show high consistency with real images,which meets the requirements of faint space target detection algorithm research and provides reliable data support for development of related technologies. 展开更多
关键词 Image SNR calculation Imaging simulation Ground-based optical detection system Space target image sequence
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Application of a relief-optimized method for target space exteriorization sampling in landslide susceptibility assessment
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作者 CUI Yulong DENG Qining MIAO Haibo 《Journal of Mountain Science》 2025年第9期3391-3407,共17页
Selection of negative samples significantly influences landslide susceptibility assessment,especially when establishing the relationship between landslides and environmental factors in regions with complex geological ... Selection of negative samples significantly influences landslide susceptibility assessment,especially when establishing the relationship between landslides and environmental factors in regions with complex geological conditions.Traditional sampling strategies commonly used in landslide susceptibility models can lead to a misrepresentation of the distribution of negative samples,causing a deviation from actual geological conditions.This,in turn,negatively affects the discriminative ability and generalization performance of the models.To address this issue,we propose a novel approach for selecting negative samples to enhance the quality of machine learning models.We choose the Liangshan Yi Autonomous Prefecture,located in southwestern Sichuan,China,as the case study.This area,characterized by complex terrain,frequent tectonic activities,and steep slope erosion,experiences recurrent landslides,making it an ideal setting for validating our proposed method.We calculate the contribution values of environmental factors using the relief algorithm to construct the feature space,apply the Target Space Exteriorization Sampling(TSES)method to select negative samples,calculate landslide probability values by Random Forest(RF)modeling,and then create regional landslide susceptibility maps.We evaluate the performance of the RF model optimized by the Environmental Factor Selection-based TSES(EFSTSES)method using standard performance metrics.The results indicated that the model achieved an accuracy(ACC)of 0.962,precision(PRE)of 0.961,and an area under the curve(AUC)of 0.962.These findings demonstrate that the EFSTSES-based model effectively mitigates the negative sample imbalance issue,enhances the differentiation between landslide and non-landslide samples,and reduces misclassification,particularly in geologically complex areas.These improvements offer valuable insights for disaster prevention,land use planning,and risk mitigation strategies. 展开更多
关键词 Non-landslide sample selection Relief algorithm target Space Exteriorization Sampling Landslide Susceptibility Assessment
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Ultra-lightweight CNN design based on neural architecture search and knowledge distillation: A novel method to build the automatic recognition model of space target ISAR images 被引量:7
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作者 Hong Yang Ya-sheng Zhang +1 位作者 Can-bin Yin Wen-zhe Ding 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2022年第6期1073-1095,共23页
In this paper,a novel method of ultra-lightweight convolution neural network(CNN)design based on neural architecture search(NAS)and knowledge distillation(KD)is proposed.It can realize the automatic construction of th... In this paper,a novel method of ultra-lightweight convolution neural network(CNN)design based on neural architecture search(NAS)and knowledge distillation(KD)is proposed.It can realize the automatic construction of the space target inverse synthetic aperture radar(ISAR)image recognition model with ultra-lightweight and high accuracy.This method introduces the NAS method into the radar image recognition for the first time,which solves the time-consuming and labor-consuming problems in the artificial design of the space target ISAR image automatic recognition model(STIIARM).On this basis,the NAS model’s knowledge is transferred to the student model with lower computational complexity by the flow of the solution procedure(FSP)distillation method.Thus,the decline of recognition accuracy caused by the direct compression of model structural parameters can be effectively avoided,and the ultralightweight STIIARM can be obtained.In the method,the Inverted Linear Bottleneck(ILB)and Inverted Residual Block(IRB)are firstly taken as each block’s basic structure in CNN.And the expansion ratio,output filter size,number of IRBs,and convolution kernel size are set as the search parameters to construct a hierarchical decomposition search space.Then,the recognition accuracy and computational complexity are taken as the objective function and constraint conditions,respectively,and the global optimization model of the CNN architecture search is established.Next,the simulated annealing(SA)algorithm is used as the search strategy to search out the lightweight and high accuracy STIIARM directly.After that,based on the three principles of similar block structure,the same corresponding channel number,and the minimum computational complexity,the more lightweight student model is designed,and the FSP matrix pairing between the NAS model and student model is completed.Finally,by minimizing the loss between the FSP matrix pairs of the NAS model and student model,the student model’s weight adjustment is completed.Thus the ultra-lightweight and high accuracy STIIARM is obtained.The proposed method’s effectiveness is verified by the simulation experiments on the ISAR image dataset of five types of space targets. 展开更多
关键词 Space target ISAR image Neural architecture search Knowledge distillation Lightweight model
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Research on spatial-variant property of bistatic ISAR imaging plane of space target 被引量:5
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作者 郭宝锋 王俊岭 +2 位作者 高梅国 尚朝轩 傅雄军 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第4期507-520,共14页
The imaging plane of inverse synthetic aperture radar (ISAR) is the projection plane of the target. When taking an image using the range-Doppler theory, the imaging plane may have a spatial-variant property, which c... The imaging plane of inverse synthetic aperture radar (ISAR) is the projection plane of the target. When taking an image using the range-Doppler theory, the imaging plane may have a spatial-variant property, which causes the change of scatter's projection position and results in migration through resolution cells, In this study, we focus on the spatial-variant property of the imaging plane of a three-axis-stabilized space target. The innovative contributions are as follows. 1) The target motion model in orbit is provided based on a two-body model. 2) The instantaneous imaging plane is determined by the method of vector analysis. 3) Three Euler angles are introduced to describe the spatial-variant property of the imaging plane, and the image quality is analyzed. The simulation results confirm the analysis of the spatial-variant property. The research in this study is significant for the selection of the imaging segment, and provides the evidence for the following data processing and compensation algorithm. 展开更多
关键词 space target bistatic ISAR imaging plane spatial-variant property
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A modified OMP method for multi-orbit three dimensional ISAR imaging of the space target 被引量:3
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作者 JIANG Libing ZHENG Shuyu +2 位作者 YANG Qingwei YANG Peng WANG Zhuang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2023年第4期879-893,共15页
The conventional two dimensional(2D)inverse synthetic aperture radar(ISAR)imaging fails to provide the targets'three dimensional(3D)information.In this paper,a 3D ISAR imaging method for the space target is propos... The conventional two dimensional(2D)inverse synthetic aperture radar(ISAR)imaging fails to provide the targets'three dimensional(3D)information.In this paper,a 3D ISAR imaging method for the space target is proposed based on mutliorbit observation data and an improved orthogonal matching pursuit(OMP)algorithm.Firstly,the 3D scattered field data is converted into a set of 2D matrix by stacking slices of the 3D data along the elevation direction dimension.Then,an improved OMP algorithm is applied to recover the space target's amplitude information via the 2D matrix data.Finally,scattering centers can be reconstructed with specific three dimensional locations.Numerical simulations are provided to demonstrate the effectiveness and superiority of the proposed 3D imaging method. 展开更多
关键词 three dimensional inverse synthetic aperture radar(3D ISAR)imaging space target improved orthogonal matching pursuit(OMP)algorithm scattering centers
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High resolution inverse synthetic aperture radar imaging of three-axis-stabilized space target by exploiting orbital and sparse priors 被引量:2
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作者 马俊涛 高梅国 +3 位作者 郭宝锋 董健 熊娣 冯祺 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第10期459-471,共13页
The development of inverse synthetic aperture radar (ISAR) imaging techniques is of notable significance for moni- toring, tracking and identifying space targets in orbit. Usually, a well-focused ISAR image of a spa... The development of inverse synthetic aperture radar (ISAR) imaging techniques is of notable significance for moni- toring, tracking and identifying space targets in orbit. Usually, a well-focused ISAR image of a space target can be obtained in a deliberately selected imaging segment in which the target moves with only uniform planar rotation. However, in some imaging segments, the nonlinear range migration through resolution cells (MTRCs) and time-varying Doppler caused by the three-dimensional rotation of the target would degrade the ISAR imaging performance, and it is troublesome to realize accurate motion compensation with conventional methods. Especially in the case of low signal-to-noise ratio (SNR), the estimation of motion parameters is more difficult. In this paper, a novel algorithm for high-resolution ISAR imaging of a space target by using its precise ephemeris and orbital motion model is proposed. The innovative contributions are as follows. 1) The change of a scatterer projection position is described with the spatial-variant angles of imaging plane calculated based on the orbital motion model of the three-axis-stabilized space target. 2) A correction method of MTRC in slant- and cross-range dimensions for arbitrarily imaging segment is proposed. 3) Coarse compensation for translational motion using the precise ephemeris and the fine compensation for residual phase errors by using sparsity-driven autofo- cus method are introduced to achieve a high-resolution ISAR image. Simulation results confirm the effectiveness of the proposed method. 展开更多
关键词 space target ISAR imaging MTRC correction SPARSITY
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Test research on IR radiation characteristics control of space target using cryogenic vacuum multilayer insulation film structure 被引量:1
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作者 卢春莲 周彦平 付森 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2011年第4期119-122,共4页
In order to achieve the objective of controlling IR radiation characteristics of space target,we design multilayer insulation film structure to cover the target.In space environment the structure comes to cryogenic va... In order to achieve the objective of controlling IR radiation characteristics of space target,we design multilayer insulation film structure to cover the target.In space environment the structure comes to cryogenic vacuum multilayer insulation film structure.It can quickly lower the surface temperature of space target,approaching to the ultra-low temperature of the space environment.A vacuum simulation verification test was designed and performed.Through the analysis of test results,we can see that the surface temperature of space target covered by the structure changes with the ambient temperature,having no direct relationship with internal temperature of the target.Therefore,the designed cryogenic vacuum multilayer insulation film structure has excellent IR radiation control performance.It can reduce the target’s IR radiation intensity so as to reduce the probability of detection by IR detectors. 展开更多
关键词 IR radiation CRYOGENIC VACUUM insulation film space target
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GS-orthogonalization OMP method for space target detection via bistatic space-based radar 被引量:1
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作者 Shuyu ZHENG Libing JIANG +2 位作者 Qingwei YANG Yingjian ZHAO Zhuang WANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第7期333-351,共19页
A space-based bistatic radar system composed of two space-based radars as the transmitter and the receiver respectively has a wider surveillance region and a better early warning capability for high-speed targets,and ... A space-based bistatic radar system composed of two space-based radars as the transmitter and the receiver respectively has a wider surveillance region and a better early warning capability for high-speed targets,and it can detect focused space targets more flexibly than the monostatic radar system or the ground-based radar system.However,the target echo signal is more difficult to process due to the high-speed motion of both space-based radars and space targets.To be specific,it will encounter the problems of Range Cell Migration(RCM)and Doppler Frequency Migration(DFM),which degrade the long-time coherent integration performance for target detection and localization inevitably.To solve this problem,a novel target detection method based on an improved Gram Schmidt(GS)-orthogonalization Orthogonal Matching Pursuit(OMP)algorithm is proposed in this paper.First,the echo model for bistatic space-based radar is constructed and the conditions for RCM and DFM are analyzed.Then,the proposed GS-orthogonalization OMP method is applied to estimate the equivalent motion parameters of space targets.Thereafter,the RCM and DFM are corrected by the compensation function correlated with the estimated motion parameters.Finally,coherent integration can be achieved by performing the Fast Fourier Transform(FFT)operation along the slow time direction on compensated echo signal.Numerical simulations and real raw data results validate that the proposed GS-orthogonalization OMP algorithm achieves better motion parameter estimation performance and higher detection probability for space targets detection. 展开更多
关键词 Bistatic space-based radar High-speed maneuvering space targets detection Range Cell Migration(RCM) Doppler Frequency Migration(DFM) Gram Schmidt(GS)-orthogonalization Orthogonal Matching Pursuit(OMP)algorithm
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A grasp planning algorithm under uneven contact point distribution scenario for space non-cooperative target capture 被引量:2
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作者 Bicheng CAI Chengfei YUE +2 位作者 Fan WU Xueqin CHEN Yunhai GENG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第11期452-464,共13页
The contact point configuration should be carefully chosen to ensure a stable capture,especially for the non-cooperative target capture mission using multi-armed spacecraft.In this work scenario,the contact points on ... The contact point configuration should be carefully chosen to ensure a stable capture,especially for the non-cooperative target capture mission using multi-armed spacecraft.In this work scenario,the contact points on the base and on the arms are distributed on the opposite side of the target.Otherwise,large forces will be needed.To cope with this problem,an uneven-oriented distribution union criterion is proposed.The union criterion contains a virtual symmetrical criterion and a geometry criterion.The virtual symmetrical contact point criterion is derived from the proof of the force closure principle using computational geometry to ensure a stable grasp,and the geometry criterion is calculated by the volume of the minimum polyhedron formed by the contact points to get a wide-range distribution.To further accelerate the optimization rate and enhance the global search ability,a line array modeling method and a continuous-discrete global search algorithm are proposed.The line array modeling method reduces the workload of calculating the descent direction and the gradient available,while the continuous-discrete global search algorithm reducing the optimization dimension.Then a highly efficient grasping is achieved and the corresponding contact point is calculated.Finally,an exhaustive verification is conducted to numerically analyze the disturbance resistance ability,and simulation results demonstrate the effectiveness of the proposed algorithms. 展开更多
关键词 Grasp planning Line array modeling Space debris removal Space non-cooperative target capture Virtual symmetrical contact point method
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Analytic optimal pose tracking control in close-range proximity operations with a non-cooperative target 被引量:1
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作者 Caisheng WEI Guanhua HUANG +1 位作者 Zeyang YIN Qifeng CHEN 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2024年第5期410-425,共16页
This paper investigates an analytical optimal pose tracking control problem for chaser spacecraft during the close-range proximity operations with a non-cooperative space target subject to attitude tumbling and unknow... This paper investigates an analytical optimal pose tracking control problem for chaser spacecraft during the close-range proximity operations with a non-cooperative space target subject to attitude tumbling and unknown orbital maneuvering.Firstly,the relative translational motion between the orbital target and the chaser spacecraft is described in the Line-of-Sight(LOS)coordinate frame along with attitude quaternion dynamics.Then,based on the coupled 6-Degree of Freedom(DOF)pose dynamic model,an analytical optimal control action consisting of constrained optimal control value,application time and its duration are proposed via exploring the iterative sequential action control algorithm.Meanwhile,the global closed-loop asymptotic stability of the proposed predictive control action is presented and discussed.Compared with traditional proximity control schemes,the highlighting advantages are that the application time and duration of the devised controller is applied discretely in light of the influence of the instantaneous pose configuration on the pose tracking performance with less energy consumptions rather than at each sample time.Finally,three groups of illustrative examples are organized to validate the effectiveness of the proposed analytical optimal pose tracking control scheme. 展开更多
关键词 Optimal control Close-range proximity operation Non-cooperative space target Coupled attitude and orbit control Iterative sequential action control
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Coordinated target localization base on pseudo measurement for clustered space robot 被引量:5
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作者 Zhai Guang Zhang Jingrui Zhou Zhicheng 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2013年第6期1524-1533,共10页
This paper presents a coordinated target localization method for clustered space robot.According to the different measuring capabilities of cluster members,the master-slave coordinated relative navigation strategy for... This paper presents a coordinated target localization method for clustered space robot.According to the different measuring capabilities of cluster members,the master-slave coordinated relative navigation strategy for target localization with respect to slavery space robots is proposed;then the basic mathematical models,including coordinated relative measurement model and cluster centralized dynamics,are established respectively.By employing the linear Kalman flter theorem,the centralized estimator based on truth measurements is developed and analyzed frstly,and with an intention to inhabit the initial uncertainties related to target localization,the globally stabilized estimator is designed through introduction of pseudo measurements.Furthermore,the observability and controllability of stochastic system are also analyzed to qualitatively evaluate the convergence performance of pseudo measurement estimator.Finally,on-orbit target approaching scenario is simulated by using semi-physical simulation system,which is used to verify the convergence performance of proposed estimator.During the simulation,both the known and unknown maneuvering acceleration cases are considered to demonstrate the robustness of coordinated localization strategy. 展开更多
关键词 Clustered space robot Coordinated target localization On-orbit servicing Pseudo measurements
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A parallel pipeline connected-component labeling method for on-orbit space target monitoring
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作者 LI Zongling ZHANG Qingjun +1 位作者 LONG Teng ZHAO Baojun 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2022年第5期1095-1107,共13页
The paper designs a peripheral maximum gray differ-ence(PMGD)image segmentation method,a connected-compo-nent labeling(CCL)algorithm based on dynamic run length(DRL),and a real-time implementation streaming processor ... The paper designs a peripheral maximum gray differ-ence(PMGD)image segmentation method,a connected-compo-nent labeling(CCL)algorithm based on dynamic run length(DRL),and a real-time implementation streaming processor for DRL-CCL.And it verifies the function and performance in space target monitoring scene by the carrying experiment of Tianzhou-3 cargo spacecraft(TZ-3).The PMGD image segmentation method can segment the image into highly discrete and simple point tar-gets quickly,which reduces the generation of equivalences greatly and improves the real-time performance for DRL-CCL.Through parallel pipeline design,the storage of the streaming processor is optimized by 55%with no need for external me-mory,the logic is optimized by 60%,and the energy efficiency ratio is 12 times than that of the graphics processing unit,62 times than that of the digital signal proccessing,and 147 times than that of personal computers.Analyzing the results of 8756 images completed on-orbit,the speed is up to 5.88 FPS and the target detection rate is 100%.Our algorithm and implementation method meet the requirements of lightweight,high real-time,strong robustness,full-time,and stable operation in space irradia-tion environment. 展开更多
关键词 Tianzhou-3 cargo spacecraft(TZ-3) connected-component labeling(CCL)algorithms parallel pipeline processing on-orbit space target detection streaming processor
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Space moving target detection using time domain feature
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作者 王敏 陈金勇 +1 位作者 高峰 赵金宇 《Optoelectronics Letters》 EI 2018年第1期67-70,共4页
The traditional space target detection methods mainly use the spatial characteristics of the star map to detect the targets, which can not make full use of the time domain information. This paper presents a new space ... The traditional space target detection methods mainly use the spatial characteristics of the star map to detect the targets, which can not make full use of the time domain information. This paper presents a new space moving target detection method based on time domain features. We firstly construct the time spectral data of star map, then analyze the time domain features of the main objects(target, stars and the background) in star maps, finally detect the moving targets using single pulse feature of the time domain signal. The real star map target detection experimental results show that the proposed method can effectively detect the trajectory of moving targets in the star map sequence, and the detection probability achieves 99% when the false alarm rate is about 8×10^(-5), which outperforms those of compared algorithms. 展开更多
关键词 AS Space moving target detection using time domain feature
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Data matching and association based on the arc-segment difference method
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作者 Jiannan Sun Zhe Kang +1 位作者 Zhenwei Li Cunbo Fan 《Astronomical Techniques and Instruments》 2025年第5期299-309,共11页
In response to the issue of fuzzy matching and association when optical observation data are matched with the orbital elements in a catalog database,this paper proposes a matching and association strategy based on the... In response to the issue of fuzzy matching and association when optical observation data are matched with the orbital elements in a catalog database,this paper proposes a matching and association strategy based on the arcsegment difference method.First,a matching error threshold is set to match the observation data with the known catalog database.Second,the matching results for the same day are sorted on the basis of target identity and observation residuals.Different matching error thresholds and arc-segment dynamic association thresholds are then applied to categorize the observation residuals of the same target across different arc-segments,yielding matching results under various thresholds.Finally,the orbital residual is computed through orbit determination(OD),and the positional error is derived by comparing the OD results with the orbit track from the catalog database.The appropriate matching error threshold is then selected on the basis of these results,leading to the final matching and association of the fuzzy correlation data.Experimental results showed that the correct matching rate for data arc-segments is 92.34% when the matching error threshold is set to 720″,with the arc-segment difference method processing the results of an average matching rate of 97.62% within 8 days.The remaining 5.28% of the fuzzy correlation data are correctly matched and associated,enabling identification of orbital maneuver targets through further processing and analysis.This method substantially enhances the efficiency and accuracy of space target cataloging,offering robust technical support for dynamic maintenance of the space target database. 展开更多
关键词 Optical data processing Space target identification Fuzzy correlation Arc-segment difference method Orbit determination
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Bayesian track-before-detect algorithm for nonstationary sea clutter 被引量:2
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作者 XU Cong HE Zishu +1 位作者 LIU Haicheng LI Yadan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第6期1338-1344,共7页
Radar detection of small targets in sea clutter is a particularly demanding task because of the nonstationary characteristic of sea clutter.The track-before-detect(TBD)filter is an effective way to increase the signal... Radar detection of small targets in sea clutter is a particularly demanding task because of the nonstationary characteristic of sea clutter.The track-before-detect(TBD)filter is an effective way to increase the signal-to-clutter ratio(SCR),thus improving the detection performance of small targets in sea clutter.To cope with the nonstationary characteristic of sea clutter,an easily-implemented Bayesian TBD filter with adaptive detection threshold is proposed and a new parameter estimation method is devised which is integrated into the detection process.The detection threshold is set according to the parameter estimation result under the framework of information theory.For detection of closely spaced targets,those within the same range cell as the one under test are treated as contribution to sea clutter,and a successive elimination method is adopted to detect them.Simulation results prove the effectiveness of the proposed algorithm in detecting small targets in nonstationary sea clutter,especially closely spaced ones. 展开更多
关键词 small target track-before-detect(TBD) nonstationary sea clutter closely spaced target
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A Normalizing Flow-Based Bidirectional Mapping Residual Network for Unsupervised Defect Detection 被引量:1
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作者 Lanyao Zhang Shichao Kan +3 位作者 Yigang Cen Xiaoling Chen Linna Zhang Yansen Huang 《Computers, Materials & Continua》 SCIE EI 2024年第2期1631-1648,共18页
Unsupervised methods based on density representation have shown their abilities in anomaly detection,but detection performance still needs to be improved.Specifically,approaches using normalizing flows can accurately ... Unsupervised methods based on density representation have shown their abilities in anomaly detection,but detection performance still needs to be improved.Specifically,approaches using normalizing flows can accurately evaluate sample distributions,mapping normal features to the normal distribution and anomalous features outside it.Consequently,this paper proposes a Normalizing Flow-based Bidirectional Mapping Residual Network(NF-BMR).It utilizes pre-trained Convolutional Neural Networks(CNN)and normalizing flows to construct discriminative source and target domain feature spaces.Additionally,to better learn feature information in both domain spaces,we propose the Bidirectional Mapping Residual Network(BMR),which maps sample features to these two spaces for anomaly detection.The two detection spaces effectively complement each other’s deficiencies and provide a comprehensive feature evaluation from two perspectives,which leads to the improvement of detection performance.Comparative experimental results on the MVTec AD and DAGM datasets against the Bidirectional Pre-trained Feature Mapping Network(B-PFM)and other state-of-the-art methods demonstrate that the proposed approach achieves superior performance.On the MVTec AD dataset,NF-BMR achieves an average AUROC of 98.7%for all 15 categories.Especially,it achieves 100%optimal detection performance in five categories.On the DAGM dataset,the average AUROC across ten categories is 98.7%,which is very close to supervised methods. 展开更多
关键词 Anomaly detection normalizing flow source domain feature space target domain feature space bidirectional mapping residual network
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Unravelling the target landscape of tranylcypromines for new drug discovery
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作者 Yihui Song Junbiao Chang Bin Yu 《Acta Pharmaceutica Sinica B》 2025年第6期2985-3007,共23页
Molecular editing around privileged scaffolds,also known as periphery editing,is a commonly used strategy in contemporary drug discovery and development.Tranylcypromine(TCP)is a widely acknowledged scaffold with diver... Molecular editing around privileged scaffolds,also known as periphery editing,is a commonly used strategy in contemporary drug discovery and development.Tranylcypromine(TCP)is a widely acknowledged scaffold with diverse pharmacological activities.TCP-derived compounds target different enzymes and cellular receptors such as amine oxidase,platelet P2Y_(12) receptor,and cytochrome P450 superfamily.These compounds have demonstrated various effects including antidepressant,anticancer,antiviral properties,involvement in prostaglandin synthesis,and mediation of drug metabolism.Notably,the first reversible oral P2Y_(12) receptor antagonist,ticagrelor,is currently used to prevent future myocardial infarction,stroke,and cardiovascular death.Several TCP-based lysine demethylase 1(LSD1)inhibitors are currently undergoing clinical assessment.MIV-150,a third-generation non-nucleoside reverse transcriptase inhibitor,has progressed to the clinical stage for treating human immunodeficiency virus type 1(HIV-1)seronegative patients suffering from acute coronary syndrome.This review aims to explore the target landscape of TCPs,highlight key structureeactivity relationships(SARs),and emphasize the therapeutic potential of TCPs for treating various diseases.Finally,the lessons learned from our medicinal chemistry practice,challenges and future directions of TCP-based drug discovery are briefly discussed. 展开更多
关键词 TRANYLCYPROMINE Privileged scaffold target space New drug discovery Amine oxidase Platelet P2Y_(12)receptor Cytochrome P450 superfamily Human immunodeficiency virus type 1
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Potential Synergistic and Multitarget Effect of Herbal Pair Chuanxiong Rhizome-Paeonia Albifora Pall on Osteoarthritis Disease:A Computational Pharmacology Approach 被引量:6
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作者 叶蕻芝 郑春松 +2 位作者 徐筱杰 吴明霞 刘献祥 《Chinese Journal of Integrative Medicine》 SCIE CAS 2011年第9期698-703,共6页
Objective:To study the polypharmacological mechanism of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall(HP CXR-PAP) on the treatment for osteoarthritis(OA).Methods:Chemical space was used to discuss the sim... Objective:To study the polypharmacological mechanism of herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall(HP CXR-PAP) on the treatment for osteoarthritis(OA).Methods:Chemical space was used to discuss the similarities and differences between the molecule sets of HP CXR-PAP and drugs.Docking protocol was used to study the interaction between HP CXR-PAP and OA target enzymes.The similarities and differences of HP CXR-PAP and drugs in target spaces were elucidated by network features.Results:The plots between the molecule sets of HP CXR-PAP and drugs in chemical space had the majority in the same region, and compounds from HP CXR-PAP covered a much larger additional region of space than drug molecules, which denoted the diverse structural properties in the molecule set of HP CXR-PAP.The molecules in HP CXR-PAP had the properties of promiscuous drugs and combination drug,and both HP CXR-PAP ligand-target interaction network and drug ligand-target interaction network were similar in the interaction profiles and network features,which revealed the effects of multicomponent and multitarget.Conclusion:The clue of potential synergism was obtained in curing OA disease by Chinese medicine,which revealed the advantages of Chinese medicine for targeting osteoarthritis disease. 展开更多
关键词 herbal pair Chuanxiong Rhizome-Paeonia Albifora Pall chemical space virtual screening target space computational pharmacology OSTEOARTHRITIS
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Design of De-tumbling Device for Improving the De-tumbling Performance of Uncooperative Space Target
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作者 Lei Du Zhen Chen +2 位作者 Hengzai Hu Xiangdong Liu Youguang Guo 《Space(Science & Technology)》 2024年第1期10-19,共10页
This article presents the design of an optimal coil structure for 2 de-tumbling devices, each is carried by a de-tumbling robot. The design is based on electromagnetic eddy current method and aims to reduce the angula... This article presents the design of an optimal coil structure for 2 de-tumbling devices, each is carried by a de-tumbling robot. The design is based on electromagnetic eddy current method and aims to reduce the angular velocity of uncooperative space targets. It proposes an optimization framework with the advantages of safety and high performance. The magnetic field analytical model is established by the designed coil’s structure parameters, and the optimal structure parameters of the coil are determined. To further ensure the maximum magnetic field at the target, the electromagnetic characteristics under different current directions in the 2 coils are analyzed based on magnetic field analytical model, and their accuracy is verified using finite element method (FEM). Additionally, an improved Maxwell’s stress tensor method is proposed to calculate the de-tumbling torque, and its accuracy is assessed using traditional Maxwell’s stress tensor and virtual displacement method. The proposed optimal coil structure and its optimization framework can de-tumble over 1 million targets of various sizes, demonstrating universality. 展开更多
关键词 uncooperative space target optimal structure parameters detumbling optimization framework electromagnetic eddy current reduce angular velocity electromagnetic eddy current method coil structure
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