Optical sorting combines optical tweezers with diverse techniques,including optical spectrum,artificial intelligence(AI)and immunoassay,to endow unprecedented capabilities in particle sorting.In comparison to other me...Optical sorting combines optical tweezers with diverse techniques,including optical spectrum,artificial intelligence(AI)and immunoassay,to endow unprecedented capabilities in particle sorting.In comparison to other methods such as microfluidics,acoustics and electrophoresis,optical sorting offers appreciable advantages in nanoscale precision,high resolution,non-invasiveness,and is becoming increasingly indispensable in fields of biophysics,chemistry,and materials science.This review aims to offer a comprehensive overview of the history,development,and perspectives of various optical sorting techniques,categorised as passive and active sorting methods.To begin,we elucidate the fundamental physics and attributes of both conventional and exotic optical forces.We then explore sorting capabilities of active optical sorting,which fuses optical tweezers with a diversity of techniques,including Raman spectroscopy and machine learning.Afterwards,we reveal the essential roles played by deterministic light fields,configured with lens systems or metasurfaces,in the passive sorting of particles based on their varying sizes and shapes,sorting resolutions and speeds.We conclude with our vision of the most promising and futuristic directions,including AI-facilitated ultrafast and bio-morphology-selective sorting.It can be envisioned that optical sorting will inevitably become a revolutionary tool in scientific research and practical biomedical applications.展开更多
基金supported by National Key Research and Development Program of China(2023YFF0613600)National Natural Science Foundation of China(61925504,62205246,61621001,62192770,62192772,12274296,62020106009 and 62111530053)+4 种基金Shanghai Pujiang Program(23PJ1413700)Shanghai Pilot Program for Basic Research,Science and Technology Commission of Shanghai Municipality(17JC1400800,20JC1414600,21JC1406100 and 22ZR1432400)the“Shu Guang”project supported by Shanghai Municipal Education Commission and Shanghai Education(17SG22)Fundamental Research Funds for the Central Universities.Q.S.acknowledges the funding support from the National Natural Science Foundation of China(No.12204264)the Shenzhen Stability Support Program(No.WDZC20220810152404001).
文摘Optical sorting combines optical tweezers with diverse techniques,including optical spectrum,artificial intelligence(AI)and immunoassay,to endow unprecedented capabilities in particle sorting.In comparison to other methods such as microfluidics,acoustics and electrophoresis,optical sorting offers appreciable advantages in nanoscale precision,high resolution,non-invasiveness,and is becoming increasingly indispensable in fields of biophysics,chemistry,and materials science.This review aims to offer a comprehensive overview of the history,development,and perspectives of various optical sorting techniques,categorised as passive and active sorting methods.To begin,we elucidate the fundamental physics and attributes of both conventional and exotic optical forces.We then explore sorting capabilities of active optical sorting,which fuses optical tweezers with a diversity of techniques,including Raman spectroscopy and machine learning.Afterwards,we reveal the essential roles played by deterministic light fields,configured with lens systems or metasurfaces,in the passive sorting of particles based on their varying sizes and shapes,sorting resolutions and speeds.We conclude with our vision of the most promising and futuristic directions,including AI-facilitated ultrafast and bio-morphology-selective sorting.It can be envisioned that optical sorting will inevitably become a revolutionary tool in scientific research and practical biomedical applications.
