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An Optimization Approach for Convolutional Neural Network Using Non-Dominated Sorted Genetic Algorithm-Ⅱ
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作者 Afia Zafar Muhammad Aamir +6 位作者 Nazri Mohd Nawi Ali Arshad Saman Riaz Abdulrahman Alruban Ashit Kumar Dutta Badr Almutairi Sultan Almotairi 《Computers, Materials & Continua》 SCIE EI 2023年第3期5641-5661,共21页
In computer vision,convolutional neural networks have a wide range of uses.Images representmost of today’s data,so it’s important to know how to handle these large amounts of data efficiently.Convolutional neural ne... In computer vision,convolutional neural networks have a wide range of uses.Images representmost of today’s data,so it’s important to know how to handle these large amounts of data efficiently.Convolutional neural networks have been shown to solve image processing problems effectively.However,when designing the network structure for a particular problem,you need to adjust the hyperparameters for higher accuracy.This technique is time consuming and requires a lot of work and domain knowledge.Designing a convolutional neural network architecture is a classic NP-hard optimization challenge.On the other hand,different datasets require different combinations of models or hyperparameters,which can be time consuming and inconvenient.Various approaches have been proposed to overcome this problem,such as grid search limited to low-dimensional space and queuing by random selection.To address this issue,we propose an evolutionary algorithm-based approach that dynamically enhances the structure of Convolution Neural Networks(CNNs)using optimized hyperparameters.This study proposes a method using Non-dominated sorted genetic algorithms(NSGA)to improve the hyperparameters of the CNN model.In addition,different types and parameter ranges of existing genetic algorithms are used.Acomparative study was conducted with various state-of-the-art methodologies and algorithms.Experiments have shown that our proposed approach is superior to previous methods in terms of classification accuracy,and the results are published in modern computing literature. 展开更多
关键词 Non-dominated sorted genetic algorithm convolutional neural network hyper-parameter OPTIMIZATION
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New event detection based on sorted subtopic matching algorithm
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作者 翟东海 CUI Jing-jing +1 位作者 NIE Hong-yu DU Jia 《Journal of Chongqing University》 CAS 2013年第4期179-186,共8页
How to quickly and accurately detect new topics from massive data online becomes a main problem of public opinion monitoring in cyberspace. This paperpresents a new event detection method for the current new event det... How to quickly and accurately detect new topics from massive data online becomes a main problem of public opinion monitoring in cyberspace. This paperpresents a new event detection method for the current new event detection system, based on sorted subtopic matching algorithm and constructs the entire design framework. In this p^per, the subtopics contained in old topics (or news stories) are sorted in descending order according to their importance to the topic(or news stories), and form a sorted subtopic sequence. In the process of subtopic matching, subtopic scoring matrix is used to determine whether a new story is reporting a new event. Experimental results show that the sorted subtopic matching model improved the accuracy and effectiveness ofthenew event detection system in cyberspace. 展开更多
关键词 new event detection topic detection scoring matrix sorted subtopic matching model subtopic sequence
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Heuristic file sorted assignment algorithm of parallel I/O on cluster computing system
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作者 陈志刚 曾碧卿 +3 位作者 熊策 邓晓衡 曾志文 刘安丰 《Journal of Central South University of Technology》 EI 2005年第5期572-577,共6页
A new file assignment strategy of parallel I/O, which is named heuristic file sorted assignment algorithm was proposed on cluster computing system. Based on the load balancing, it assigns the files to the same disk ac... A new file assignment strategy of parallel I/O, which is named heuristic file sorted assignment algorithm was proposed on cluster computing system. Based on the load balancing, it assigns the files to the same disk according to the similar service time. Firstly, the files were sorted and stored at the set I in descending order in terms of their service time, then one disk of cluster node was selected randomly when the files were to be assigned, and at last the continuous files were taken orderly from the set I to the disk until the disk reached its load maximum. The experimental results show that the new strategy improves the performance by 20.2% when the load of the system is light and by 31.6% when the load is heavy. And the higher the data access rate, the more evident the improvement of the performance obtained by the heuristic file sorted assignment algorithm. 展开更多
关键词 cluster computing parallel I/O file sorted assignment variance of service time
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Household Waste Reduction Effect of Sorted Collection of Recyclable Waste in Japan
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作者 Ken'ichi Matsumoto Misaki Nakajima 《Journal of Environmental Science and Engineering(B)》 2013年第3期135-141,共7页
The purpose of this study is to analyze the household waste reduction effect of sorted collection of recyclable waste in Japan using a panel data analysis, which considers time-series and cross-section data simultaneo... The purpose of this study is to analyze the household waste reduction effect of sorted collection of recyclable waste in Japan using a panel data analysis, which considers time-series and cross-section data simultaneously. Also, the study shows the effect of the type of sorted items on the quantity of household waste disposed. We used the data attained from 103 cities recorded over three years, and applied the quantity of total waste disposed, the quantity of combustible waste, the quantity of other waste (waste excluding combustible and recyclable waste), and the quantity of combustible plus other waste as objective variables, respectively, in the models. The result suggests that when the number of sorted items is increased marginally, the quantity of household waste decreases by about 0.5%-3.3% or 1.28-4.17 grams per capita per day. In addition, it is shown that sorting out white trays is effective in reducing the quantity of combustible waste. Sorting out paper containers and packages is also effective in reducing the quantity of other waste and combustible plus other waste. 展开更多
关键词 Household waste sorted collection recyclable waste waste reduction panel data analysis.
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Visual Basic中Sorted属性的认识
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作者 黄步根 《电脑编程技巧与维护》 2001年第10期21-23,共3页
本文通过Visual Basic中Sorted属性的认识,探讨计算机程序设计学习过程中如何发现、分析并解决问题。
关键词 VISUAL Basic sorted属性 程序设计学习 调试 日志文件 编程
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“See it.Say it.Sorted.”英国伦敦地铁的创意
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作者 陈俊杰 《中国广告》 2025年第5期18-21,共4页
“See it, Say it, Sorted.”就是告诉乘客,你要是看到了什么可疑的行为,就找工作人员说出来,我们协助你解决。2005年,在伦敦经历了地铁恐怖袭击之后,英国国家铁路(NationalRail)和英国交通警察局(British Transport Police)与安全专家... “See it, Say it, Sorted.”就是告诉乘客,你要是看到了什么可疑的行为,就找工作人员说出来,我们协助你解决。2005年,在伦敦经历了地铁恐怖袭击之后,英国国家铁路(NationalRail)和英国交通警察局(British Transport Police)与安全专家、传播学者以及广告创意团队进行了多次讨论与头脑风暴。团队希望创造出一条易于理解、易于记忆,同时能促使行动的标语,“Seeit.Say it. Sorted.”由此诞生。 展开更多
关键词 英国国家铁路 英国交通警察局 恐怖袭击 sorted
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基于神经网络和抛物特征的改进MOG-SORT高空抛物检测算法
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作者 陈卫东 刘萌 武文龙 《燕山大学学报》 北大核心 2026年第1期68-75,共8页
随着高楼的不断增多,高空抛物事件日益增加,给个人安全和公共安全都带来了挑战。高空抛物检测过程中存在背景复杂、抛物目标小、抛物外观特征不明显、抛物跟踪易丢失等问题。本文使用神经网络对混合高斯背景建模算法进行扩展,并根据抛... 随着高楼的不断增多,高空抛物事件日益增加,给个人安全和公共安全都带来了挑战。高空抛物检测过程中存在背景复杂、抛物目标小、抛物外观特征不明显、抛物跟踪易丢失等问题。本文使用神经网络对混合高斯背景建模算法进行扩展,并根据抛物特征改进简单在线实时跟踪(SORT)算法解决上述高空抛物问题。首先,为解决小目标抛物及复杂背景问题,引入区域条件滤波减少前景检测中的非抛物前景;其次,为解决抛物外观特征不明显的问题,使用多帧融合技术增强运动特征并设计轻量级分类网络来区分抛物物体:最后,为解决抛物跟踪易丢失的问题,根据抛物特征改进了SORT的状态空间和匹配度量。实验结果表明:改进后的混合高斯背景建模算法,在召回率下降6.50%的情况下,检测数量减少97.14%;改进后的SORT算法,ID切换数量减少51.61%,MOTA指标提升8.74%,TIOU指标提升8.02%. 展开更多
关键词 高空抛物检测 运动小目标检测 混合高斯背景建模 SORT
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基于水平相似度匹配机制的鱼群追踪与计数方法
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作者 方斌 邹青青 +7 位作者 巨浩飞 鲍江辉 段瑞 张东旭 吕华飞 王翔 许鹏飞 段明 《计算机工程》 北大核心 2026年第3期364-375,共12页
鱼群多目标准确计数是水生态智能监测和集约化养殖产业中的重要环节,对水域生态环境智能保护和水产养殖现代化具有重要作用。现有鱼群多目标准确追踪和计数方法主要适用于鱼群外观清晰、游速缓慢和方向稳定等较理想的情况,难以有效适用... 鱼群多目标准确计数是水生态智能监测和集约化养殖产业中的重要环节,对水域生态环境智能保护和水产养殖现代化具有重要作用。现有鱼群多目标准确追踪和计数方法主要适用于鱼群外观清晰、游速缓慢和方向稳定等较理想的情况,难以有效适用于现实情况下存在的鱼群互相遮挡、游动迅速和方向多变等复杂情况。为此,结合轻量化目标检测模型YOLOv5n,提出基于水平相似度匹配机制的鱼群追踪与计数方法。将鱼群计数问题视为多目标检测与追踪问题,设计水平相似度匹配机制,并对SORT(Simple Online and Realtime Tracking)算法进行优化。通过高速水流中鱼群个体在帧与帧之间的位置关系对检测框中心点的水平距离进行限制,以有效解决SORT算法存在的目标匹配混乱问题,显著提高追踪效果。实验结果表明,所提方法在鱼群多目标追踪数据集上的性能显著优于现有追踪方法,对目标遮挡、方向变化等情况目标追踪性能提升显著,并且该方法结构简单,易于实际应用。 展开更多
关键词 多目标追踪 鱼群计数 水平相似度 SORT算法 距离交并比
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Nonconvex Sorted l1 Minimization for Sparse Approximation 被引量:1
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作者 Xiao-Lin Huang Lei Shi Ming Yan 《Journal of the Operations Research Society of China》 EI CSCD 2015年第2期207-229,共23页
The l1 norm is the tight convex relaxation for the l0 norm and has been successfully applied for recovering sparse signals.However,for problems with fewer samples than required for accurate l1 recovery,one needs to ap... The l1 norm is the tight convex relaxation for the l0 norm and has been successfully applied for recovering sparse signals.However,for problems with fewer samples than required for accurate l1 recovery,one needs to apply nonconvex penalties such as lp norm.As one method for solving lp minimization problems,iteratively reweighted l1 minimization updates the weight for each component based on the value of the same component at the previous iteration.It assigns large weights on small components in magnitude and small weights on large components in magnitude.The set of the weights is not fixed,and it makes the analysis of this method difficult.In this paper,we consider a weighted l1 penalty with the set of the weights fixed,and the weights are assigned based on the sort of all the components in magnitude.The smallest weight is assigned to the largest component in magnitude.This new penalty is called nonconvex sorted l1.Then we propose two methods for solving nonconvex sorted l1 minimization problems:iteratively reweighted l1 minimization and iterative sorted thresholding,and prove that both methods will converge to a local minimizer of the nonconvex sorted l1 minimization problems.We also show that both methods are generalizations of iterative support detection and iterative hard thresholding,respectively.The numerical experiments demonstrate the better performance of assigning weights by sort compared to assigning by value. 展开更多
关键词 Iteratively reweighted1 minimization Iterative sorted thresholding Local minimizer Nonconvex optimization Sparse approximation
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基于改进SORT算法的耙吸船挖掘土壤粒径参数测量研究
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作者 史誉州 谢云飞 +1 位作者 刘雅奇 王栋臣 《中国水运》 2026年第3期77-81,共5页
为了提高耙吸船的挖掘效率与施工质量,研究提出一种土壤粒径参数模型,借助改进的在线跟踪算法和目标检测算法提升粒径识别精度。实验证明,研究所提算法最终多目标跟踪精度稳定在64.85%,每秒传输帧数稳定在16.23帧/s,且当图像出现遮挡时... 为了提高耙吸船的挖掘效率与施工质量,研究提出一种土壤粒径参数模型,借助改进的在线跟踪算法和目标检测算法提升粒径识别精度。实验证明,研究所提算法最终多目标跟踪精度稳定在64.85%,每秒传输帧数稳定在16.23帧/s,且当图像出现遮挡时或更改数据集时对算法预测指标影响程度不大。在实际土壤粒径测量中,研究模型的平均均方根误差仅为0.0354mm。该模型的动态跟踪能力、测量精度和效率都很优越,能精准实时地测量土壤粒径参数,助力耙吸船智能化施工,推动疏浚行业高质量发展。 展开更多
关键词 SORT YOLOv8 耙吸船 土壤粒径 EMA
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Macrophages-derived NRG-1 promotes angiogenesis after ischemic stroke via the Akt-mTOR pathway
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作者 Jie Chen Bo Wang +4 位作者 Danyang Fan Xi Chen Lenv Gao Yun Luo Zhenhua Zhou 《Neural Regeneration Research》 2026年第7期3007-3016,共10页
Acute ischemic stroke remains a significant health concern owing to the limited efficacy of current therapeutic options.In recent years,Neuregulin-1 has exhibited promising neuroprotective effects in cerebral ischemia... Acute ischemic stroke remains a significant health concern owing to the limited efficacy of current therapeutic options.In recent years,Neuregulin-1 has exhibited promising neuroprotective effects in cerebral ischemia.However,the sources and functions of Neuregulin-1 have not yet been fully understood,which hinders its translation and broad application.Here,we collected paired clot and peripheral blood samples from patients with acute ischemic stroke to determine the sources of Neuregulin-1.In addition,we established an in vivo transient middle cerebral artery occlusion mouse model to investigate the therapeutic effects of Neuregulin-1 and its underlying molecular biological mechanisms.We observed a significant elevation in serum Neuregulin-1 levels among patients with acute ischemic stroke that correlated with severity of neurological impairment and clinical outcome.Using single-cell sequencing,we identified Neuregulin-1-positive macrophages among peripheral blood mononuclear cells that produced Neuregulin-1 post-ischemia.In addition,Neuregulin-1 promoted repair of the infarcted area,alleviating neuronal and myelin damage and improving overall behavioral recovery in mice.We found that Neuregulin-1 may exert these neuroprotective effects by promoting angiogenesis in the infarct area,and that this effect is mediated by Akt/mTOR/VEGF-dependent signaling.Our findings suggest that peripheral macrophages are a source of Neuregulin-1 post-stroke.Neuregulin-1 exerts its neuroprotective effects by promoting angiogenesis via Akt/mTOR/VEGF-dependent signaling,showing promising clinical translation potential. 展开更多
关键词 acute ischemic stroke ANGIOGENESIS CLOT ERBB4 fluorescence-activated cell sorting immune cell inflammation macrophages NEUREGULIN-1 NEUROPROTECTION
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An Intelligent Sorting System of Coal-Gangue Based on Machine Vision and Convolutional Neural Network
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作者 MIAO Shuguang ZHANG Qiuyue +2 位作者 GUO Mengxu FAN Sen DING Enjie 《Wuhan University Journal of Natural Sciences》 2026年第1期79-90,共12页
Gangue is inevitably mixed with coal during mining and transportation.Currently,the manual sorting and conventional mechanical separation technologies widely adopted in the coal mining industry are plagued by low effi... Gangue is inevitably mixed with coal during mining and transportation.Currently,the manual sorting and conventional mechanical separation technologies widely adopted in the coal mining industry are plagued by low efficiency,poor identification accuracy,severe environmental pollution,and other drawbacks.This paper proposes a machine vision-based intelligent coal gangue sorting robot system.Firstly,the OpenMV captures images of coal gangue and utilizes the MobileNetV20.35 lightweight convolutional neural network to train the FOMO(Faster Objects,More Objects)target detection model in the cloud.This enables prediction and recognition of gangue,along with the acquisition of its center point pixel coordinates.Secondly,the position information of the gangue is sent to the STM32 microcontroller using the serial communication protocol for coordinate system conversion,pose algorithm,and path planning.Finally,the STM32 microcontroller controls the start and stop of the conveyor belt through the working status of the relay.When the relay is absorbed,the conveyor belt stops,and at the same time,the robotic arm grasps the gangue for transfer action,thus realizing the sorting of coal and gangue.The experimental results demonstrate that the cloud-trained FOMO neural network model achieves an F1 score of 95.5%and a recall of 91.3%,with a test accuracy of 97.56%.The quantified model deployed on OpenMV can accurately identify multiple gangues and output their position information.The success rate of the robotic arm in tracking and sorting gangue reaches 90.13%,and the positioning error of the robotic arm is[9,12.5]mm.This system realizes high-precision identification,positioning,and intelligent sorting of coal and gangue,meeting the basic requirements for gangue sorting in coal mines. 展开更多
关键词 coal-gangue recognition intelligent sorting LIGHTWEIGHT FOMO(Faster Objects More Objects)model path planning
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MAV-UAV combat organization's force formation plan generation based on NSGA-Ⅲ
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作者 ZHONG Yun WAN Lujun ZHANG Jieyong 《Journal of Systems Engineering and Electronics》 2026年第1期307-317,共11页
Manned aerial vehicle-unmanned aerial vehicle(MAV-UAV)combat organization is a MAV-UAV combat collective formed from the perspective of organization design theory and methodology,and the generation of force formation ... Manned aerial vehicle-unmanned aerial vehicle(MAV-UAV)combat organization is a MAV-UAV combat collective formed from the perspective of organization design theory and methodology,and the generation of force formation plan is a key step in the organizational planning.Based on the description of the problem and the definition of organizational elements,the matching model of platform-target attack wave is constructed to minimize the redundancy of command and decision-making capability,resource capability and the number of platforms used.Based on the non-dominated sorting genetic algorithmⅢ(NSGA-Ⅲ)framework,which includes encoding/decoding method and constraint handling method,the generation model of organizational force formation plan is solved,and the effectiveness and superiority of the algorithm are verified by simulation experiments. 展开更多
关键词 manned-unmanned aerial vehicle combat organization force formation plan command and decision-making capability resource capability non-dominated sorting genetic algorithmⅢ(NSGA-Ⅲ)
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Overexpression of mitofusin 2 ameliorates inflammation and oxidative stress in lipopolysaccharide-induced mastitis model by regulating phosphofurin acidic cluster sorting protein 2
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作者 Xiechen Zhou Yufei Zhang +5 位作者 He Ma Shoupeng Fu Juxiong Liu Wenjin Guo Xiaofeng Tian Bingxu Huang 《Animal Models and Experimental Medicine》 2026年第1期154-167,共14页
Background:Mastitis seriously affects the mammary health of humans and animals.Studies have found that inflammation and oxidative stress play key roles in the occur-rence and development of mastitis.Therefore,in-depth... Background:Mastitis seriously affects the mammary health of humans and animals.Studies have found that inflammation and oxidative stress play key roles in the occur-rence and development of mastitis.Therefore,in-depth research on related molecular mechanisms is of great significance.Methods:Postpartum mice were anesthetized with pentobarbital and administered lipopolysaccharide to develop the mouse mastitis model.Proteomic analysis was per-formed to compare protein expression in mitochondria-associated endoplasmic retic-ulum membranes(MAM)from two mouse mammary gland groups.Western blot was used to detect the expression of MAM-related proteins in mitochondria.AlphaFold3 was used to predict the molecular structures of phosphofurin acidic cluster sorting protein 2(PACS2)and mitofusin 2(MFN2)and their interaction levels.The MFN2-PACS2 interaction was investigated using co-immunoprecipitation and small interfer-ing RNA.Results:The results showed that the inflammation level in the mammary gland tissue of mice with mastitis significantly increased,the total antioxidant capacity decreased,and the expression of MAM-related proteins MFN2 and PACS2 was significantly downregulated.In cell experiments,overexpression of MFN2 can inhibit inflamma-tion and oxidative stress responses,and promote the interaction between MFN2 and PACS2 to affect the formation of MAMs.Conclusion:In summary,this study suggests that mastitis can alter the expression of MAM-related proteins in mouse breast tissue.The interaction between MFN2 and PACS2 regulates the formation of MAMs.Overexpression of MFN2 can promote the formation of MAMs and inhibit inflammation and oxidative stress response in mam-mary epithelial cells.Our results provided a new theoretical basis and potential thera-peutic targets for the prevention and treatment of mastitis. 展开更多
关键词 MASTITIS mitochondria-associated endoplasmic reticulum membranes(MAM) mitofusin 2(MFN2) phosphofurin acidic cluster sorting protein 2(PACS2)
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Minimal Model Semantics for Sorted Constraint Representation
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作者 廖乐健 史忠植 《Journal of Computer Science & Technology》 SCIE EI CSCD 1995年第5期439-446,共8页
Sorted constraint representation is a very useful representation in AI which combines class hierarchies and constraint networks. For such sorted constraint representation, a problem is how to generalize the idea of de... Sorted constraint representation is a very useful representation in AI which combines class hierarchies and constraint networks. For such sorted constraint representation, a problem is how to generalize the idea of default inheritance to constraint network, where the attributes in a class or between different classes interact with each other via the network. To give a formal account for the defeasible reasoning in such representation, a general sorted constraint logic is proposed, and a minimal-model semantics for the logic is presented. 展开更多
关键词 CONSTRAINT SORT MODEL
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基于视频监控的煤矿井下电子围栏入侵人员识别技术研究 被引量:1
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作者 马骥 张杰文 +1 位作者 蒋栋 李浪平 《国外电子测量技术》 2025年第2期121-127,共7页
煤矿井下安全生产是保障矿工生命安全和能源稳定供应的核心环节,但传统监控方法在检测实时性和准确性方面存在明显不足。针对复杂井下环境中人员入侵识别精度低的问题,研究提出一种基于改进You Only Look Once version 5(YOLOv5)和深度... 煤矿井下安全生产是保障矿工生命安全和能源稳定供应的核心环节,但传统监控方法在检测实时性和准确性方面存在明显不足。针对复杂井下环境中人员入侵识别精度低的问题,研究提出一种基于改进You Only Look Once version 5(YOLOv5)和深度简单在线实时跟踪算法的电子围栏入侵检测技术。研究通过嵌入注意力机制增强模型对关键特征的感知能力,并利用扩展卡尔曼滤波与匈牙利算法提升跟踪稳定性。实验结果表明,改进后的模型的识别率最高,且随迭代次数的增加其识别率始终在90%以上。该技术在识别性能上,平均精度均值指标为92.5%,每秒帧数提升至116.7,训练时长缩短至8.5 h,漏检率显著降低。研究表明,该方法在光照不均、煤尘干扰等复杂场景下具备更高的检测精度与实时性。该技术的提出可为煤矿井下智能化安全管理提供有效技术支撑,从而提高煤矿安全生产水平,杜绝生产事故出现。 展开更多
关键词 煤矿井 电子围栏入侵检测 YOLOv5算法 Deep SORT AGPA 目标检测算法
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Design of Intelligent Garbage Handling Trolley Based on Single Chip Microcomputer 被引量:1
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作者 Yaxuan Ning Changlu Li 《Journal of Electronic Research and Application》 2025年第1期121-127,共7页
This paper introduces an intelligent garbage-handling trolley model based on an STM32 single chip microcomputer as the control core.The device is driven by four independent motors to achieve automatic tracking,automat... This paper introduces an intelligent garbage-handling trolley model based on an STM32 single chip microcomputer as the control core.The device is driven by four independent motors to achieve automatic tracking,automatic obstacle avoidance,and fixed-point docking.Using external execution structure to realize the car without the use of a mechanical arm,complete garbage collection,storage,and uninstall function.On this basis,the type of garbage is marked by color,and the color recognition sensor is applied to realize the type recognition after garbage collection and put into the corresponding unloading point,to realize its intelligent classification function.It can automatically complete the established task autonomously. 展开更多
关键词 STM32 microcontroller Intelligent car Garbage sorting and handling Serial communication
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SORT四步法在全身麻醉气管插管患者胃管置入术中的应用效果
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作者 覃荷英 刘秀丽 +2 位作者 韦滟美 韦柳平 刘健萍 《中国卫生标准管理》 2025年第16期185-189,共5页
目的探讨SORT四步法在全身麻醉气管插管患者胃管置入术中的应用效果。方法选取2023年1—12月广西中医药大学附属瑞康医院收治的需行胃管置入术的全身麻醉气管插管患者106例为研究对象,采用随机数字表法,分为对照组与研究组,每组53例,对... 目的探讨SORT四步法在全身麻醉气管插管患者胃管置入术中的应用效果。方法选取2023年1—12月广西中医药大学附属瑞康医院收治的需行胃管置入术的全身麻醉气管插管患者106例为研究对象,采用随机数字表法,分为对照组与研究组,每组53例,对照组采用标准常规方法,研究组采用SORT四步法,比较2组的置管情况、血流动力学指标水平及不良事件发生情况。结果研究组的喉镜辅助率为1.89%,低于对照组的15.09%,差异有统计学意义(P<0.05)。研究组的置管1、2、3、4次成功率分别为94.34%、1.89%、3.77%、0,置管成功情况优于对照组(58.49%、26.42%、13.21%、1.89%),且1次成功率高于对照组,置管时间为(3.17±1.03)min,短于对照组的(7.43±1.62)min,差异均有统计学意义(P<0.05)。2组入室时(T0)、胃管置入前(T1)、胃管置入食管时(T2)、胃管置入成功时(T3)的整体比较,心率(heart rate,HR)、舒张压(diastolic blood pressure,DBP)、收缩压(systolic blood pressure,SBP)的时点、交互(时点与组间)、组间比较,差异均有统计学意义(P<0.05)。T2时点,研究组的HR、DBP、SBP水平分别为(82.08±12.07)次/min、(80.13±13.56)mmHg、(131.51±12.73)mmHg,低于对照组的(101.68±11.41)次/min、(91.04±4.27)mmHg、(142.04±15.57)mmHg;T3时点,研究组的HR、DBP、SBP水平分别为(83.74±12.82)次/min、(78.72±13.23)mmHg、(133.74±14.77)mmHg,低于对照组的(103.49±15.02)次/min、(98.30±11.43)mmHg、(148.77±15.29)mmHg,差异均有统计学意义(P<0.05)。研究组的不良事件总发生率为3.77%,低于对照组的18.87%,差异有统计学意义(P<0.05)。结论SORT四步法应用于需要胃管置入术的全身麻醉气管插管患者,可提高一次置管成功率,缩短置管时间,稳定血流动力学,降低不良事件的发生率。 展开更多
关键词 全身麻醉 气管插管 胃管置入 SORT四步法 嗅物位 胃管方向 对侧旋转 扭转运动 血流动力学
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SORT1在胃癌组织中的表达及其对胃癌细胞生物学的影响
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作者 肖林雨 段婷 +3 位作者 夏勇生 陈悦 闫兴洲 胡建国 《中国医学科学院学报》 北大核心 2025年第3期343-353,共11页
目的探讨SORT1在胃癌组织中的表达情况,分析其与患者临床预后的关系以及参与胃癌进展的途径及机制。方法采用基因表达谱交互分析数据库、Western blot和免疫组织化学染色预测并分析SORT1在胃癌及癌旁组织中的表达情况。收集2015年4月至2... 目的探讨SORT1在胃癌组织中的表达情况,分析其与患者临床预后的关系以及参与胃癌进展的途径及机制。方法采用基因表达谱交互分析数据库、Western blot和免疫组织化学染色预测并分析SORT1在胃癌及癌旁组织中的表达情况。收集2015年4月至2017年4月蚌埠医科大学第一附属医院行胃癌根治术的109例患者的临床病例资料,分析SORT1与患者临床病理参数以及预后的关系。采用CCK-8法和克隆形成实验检测胃癌细胞的增殖情况,细胞划痕实验和Transwell实验检测胃癌细胞的迁移及侵袭能力,Western blot检测胃癌细胞上皮间质转化(EMT)过程中相关蛋白表达,并进一步分析SORT1调控胃癌细胞EMT的分子机制。结果Western blot和免疫组织化学染色结果显示,SORT1在胃癌组织中呈高表达(P=0.003,P<0.001),且与肿瘤的恶性进展呈正相关(P均<0.05);Kaplan-Meier生存分析显示,SORT1高表达患者的术后生存期明显缩短(P<0.001);Cox回归模型显示,SORT1表达是影响胃癌患者术后5年生存率的独立危险因素(P<0.001)。上调SORT1表达显著促进胃癌细胞的增殖、迁移、侵袭以及EMT过程(P均<0.05),而下调SORT1结果则相反(P均<0.05)。Western blot结果显示,高表达SORT1显著促进β-连环蛋白、细胞周期蛋白D1及c-Myc的蛋白表达(P均<0.05),且体外使用Wnt/β-连环蛋白通路抑制剂(XAV939)能够明显抑制高表达SORT1导致的胃癌细胞EMT能力的增强(P均<0.05)。结论SORT1在胃癌中高表达且影响患者术后生存期,其参与胃癌细胞的增殖、迁移和侵袭,并可能通过激活Wnt/β-连环蛋白通路促进胃癌细胞EMT过程。 展开更多
关键词 胃癌 SORT1 预后 上皮间质转化 Wnt/β-连环蛋白通路
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