Oleogels contain oil or a non-polar liquid which is gelled with an agent called an organogelator. The aim of this study was to evaluate the effects of the addition of silicone oil(cyclopentasiloxane) to the gelation p...Oleogels contain oil or a non-polar liquid which is gelled with an agent called an organogelator. The aim of this study was to evaluate the effects of the addition of silicone oil(cyclopentasiloxane) to the gelation process and to the properties of sorbitan monostearate(SMS)–sesame oil oleogel and compared with that of SMS–sesame oil oleogel and SMS–cyclopentasiloxane oleogel. Three different oil phases; sesame oil phase, cyclopentasiloxane phase and a mixture of cyclopentasiloxane and sesame oil, were used to prepare oleogels with SMS gelator. The critical gelling concentrations(CGC) for oleogels were determined using different concentration of SMS in a range of 5%–22%(w/w). The characterization of the developed oleogels was done using Fourier transform infrared spectroscopy(FTIR), polarized light microscope, rheometer, X-ray diffraction(XRD) and differential scanning calorimetry(DSC). The addition of cyclopentasiloxane reduced the CGC of SMS–sesame oil oleogel from 20% to 10%(w/w). In microscopic characterization, the oleogels with a mixture of oil phases showed the longer and thicker three-dimensional gel network than that of oleogels with sesame oil and cyclopentasiloxane. FTIR studies demonstrated that this network formation was mainly due to hydrogen bonding. Rheological measurements revealed that the combination of cyclopentasiloxane and sesame oil produced strong gel with higher complex modulus values and longer linear viscoelastic region than oleogels prepared with sesame oil and cyclopentasiloxane. In addition, oleogels with the combination of the two oils had higher enthalpy( H m) and entropy( S m) thus could increase thermodynamic stability of the oleogels. Therefore, the addition of cyclopentasiloxane can improve the physical, ther-mal properties and stability of SMS–sesame oil oleogel, provide greater sensory profile and better product aesthetics. The developed oleogel can be a novel carrier for topical drug delivery.展开更多
Hollow calcium carbonate （ CaCO3 ） microspheres were prepared in aqueous solution with the presence of polyoxyethylene （20） sorbitan monolaurate （ Tween20 ） and sodium dodecyl sulfate （SDS）. The microspheres w...Hollow calcium carbonate （ CaCO3 ） microspheres were prepared in aqueous solution with the presence of polyoxyethylene （20） sorbitan monolaurate （ Tween20 ） and sodium dodecyl sulfate （SDS）. The microspheres were characterized with X-ray diffraction （XRD） , scanning electron microscopy （SEM） and transmission electron microscope （TEM）. The X-ray diffraction data showed that the hollow CaCO3 microsphere consisted of calcite crystals. The influence of Tween20 and SDS concentrations on the morphology of CaCO3 crystals was investigated. The results suggested that the ＂core-shell model＂ of Tween20/SDS micelle aggregated as templates, which could control the growth of hollow CaCO3 microspheres. The interaction between mixed surfactants and calcium ions played a critical role in organizing calcium carbonate in microscopic level.展开更多
研究了微波-表面活性剂协同提取法(MAME)提取山竹外衣色素的工艺条件与过程。考察了提取剂中表面活性剂类型和含量、提取液pH、微波提取功率、时间、浸泡固液质量比和时间对色素提取率的影响,实验结果表明:pH=1时,以w(聚氧乙烯十二酸失...研究了微波-表面活性剂协同提取法(MAME)提取山竹外衣色素的工艺条件与过程。考察了提取剂中表面活性剂类型和含量、提取液pH、微波提取功率、时间、浸泡固液质量比和时间对色素提取率的影响,实验结果表明:pH=1时,以w(聚氧乙烯十二酸失水山梨醇单酯)=0.08%的乙醇溶液〔φ(CH3CH2OH)=70%〕为提取剂,山竹外衣按m(山竹外衣)∶m(提取剂)=1∶263浸泡于提取剂中5 m in、微波功率800 W下提取25 s,色素提取率为96.26%。该法一次提取率是传统溶剂法的1.78倍,提取时间是溶剂法的1/240,聚氧乙烯十二酸失水山梨醇单酯对色素提取有增溶作用。展开更多
基金the financial support received from the Faculty of Pharmacy,Silpakorn University(Grant no.RGG 001/2558)
文摘Oleogels contain oil or a non-polar liquid which is gelled with an agent called an organogelator. The aim of this study was to evaluate the effects of the addition of silicone oil(cyclopentasiloxane) to the gelation process and to the properties of sorbitan monostearate(SMS)–sesame oil oleogel and compared with that of SMS–sesame oil oleogel and SMS–cyclopentasiloxane oleogel. Three different oil phases; sesame oil phase, cyclopentasiloxane phase and a mixture of cyclopentasiloxane and sesame oil, were used to prepare oleogels with SMS gelator. The critical gelling concentrations(CGC) for oleogels were determined using different concentration of SMS in a range of 5%–22%(w/w). The characterization of the developed oleogels was done using Fourier transform infrared spectroscopy(FTIR), polarized light microscope, rheometer, X-ray diffraction(XRD) and differential scanning calorimetry(DSC). The addition of cyclopentasiloxane reduced the CGC of SMS–sesame oil oleogel from 20% to 10%(w/w). In microscopic characterization, the oleogels with a mixture of oil phases showed the longer and thicker three-dimensional gel network than that of oleogels with sesame oil and cyclopentasiloxane. FTIR studies demonstrated that this network formation was mainly due to hydrogen bonding. Rheological measurements revealed that the combination of cyclopentasiloxane and sesame oil produced strong gel with higher complex modulus values and longer linear viscoelastic region than oleogels prepared with sesame oil and cyclopentasiloxane. In addition, oleogels with the combination of the two oils had higher enthalpy( H m) and entropy( S m) thus could increase thermodynamic stability of the oleogels. Therefore, the addition of cyclopentasiloxane can improve the physical, ther-mal properties and stability of SMS–sesame oil oleogel, provide greater sensory profile and better product aesthetics. The developed oleogel can be a novel carrier for topical drug delivery.
基金Supported by the Beijing Natural Science Foundation(2082021)the National Science & Technology Pillar Program in the 12th Five-Year Plan Period (2011BAE06B06-2)
文摘Hollow calcium carbonate （ CaCO3 ） microspheres were prepared in aqueous solution with the presence of polyoxyethylene （20） sorbitan monolaurate （ Tween20 ） and sodium dodecyl sulfate （SDS）. The microspheres were characterized with X-ray diffraction （XRD） , scanning electron microscopy （SEM） and transmission electron microscope （TEM）. The X-ray diffraction data showed that the hollow CaCO3 microsphere consisted of calcite crystals. The influence of Tween20 and SDS concentrations on the morphology of CaCO3 crystals was investigated. The results suggested that the ＂core-shell model＂ of Tween20/SDS micelle aggregated as templates, which could control the growth of hollow CaCO3 microspheres. The interaction between mixed surfactants and calcium ions played a critical role in organizing calcium carbonate in microscopic level.
文摘研究了微波-表面活性剂协同提取法(MAME)提取山竹外衣色素的工艺条件与过程。考察了提取剂中表面活性剂类型和含量、提取液pH、微波提取功率、时间、浸泡固液质量比和时间对色素提取率的影响,实验结果表明:pH=1时,以w(聚氧乙烯十二酸失水山梨醇单酯)=0.08%的乙醇溶液〔φ(CH3CH2OH)=70%〕为提取剂,山竹外衣按m(山竹外衣)∶m(提取剂)=1∶263浸泡于提取剂中5 m in、微波功率800 W下提取25 s,色素提取率为96.26%。该法一次提取率是传统溶剂法的1.78倍,提取时间是溶剂法的1/240,聚氧乙烯十二酸失水山梨醇单酯对色素提取有增溶作用。
