Background:The primary aim of this research was to address the significant challenge of low and unpredictable drug absorption following oral administration,which often occurs due to poor water solubility.Niosomes,whic...Background:The primary aim of this research was to address the significant challenge of low and unpredictable drug absorption following oral administration,which often occurs due to poor water solubility.Niosomes,which are lipid-based vesicles,have been explored as potential solutions to increase the solubility of water-insoluble drugs.Methods:Niosomal suspensions were prepared with the thin-film hydration method.Various concentrations of Span 20,Span 40,Tween 60,and cholesterol were used to optimize the formulation.The resulting formulations were characterized,and their properties were assessed.Results:The optimal formulation,namely,NS6,which was composed of Span 40(200 mg)and cholesterol(40 mg),had a size of 206.1 nm and a zeta potential of-36.5 mV.Adjusting the surfactant concentration resulted in a maximum drug entrapment efficiency of 88.89%.Statistical analysis confirmed that NS6 was the optimal formulation.Conclusion:This study demonstrates that niosomal suspensions are promising drug delivery systems with potential for use in treating type 2 diabetes.Niosomes facilitate the sustained release and enhanced solubility of drugs,rendering them convenient and effective tools for enhancing drug delivery to target sites.展开更多
文摘Background:The primary aim of this research was to address the significant challenge of low and unpredictable drug absorption following oral administration,which often occurs due to poor water solubility.Niosomes,which are lipid-based vesicles,have been explored as potential solutions to increase the solubility of water-insoluble drugs.Methods:Niosomal suspensions were prepared with the thin-film hydration method.Various concentrations of Span 20,Span 40,Tween 60,and cholesterol were used to optimize the formulation.The resulting formulations were characterized,and their properties were assessed.Results:The optimal formulation,namely,NS6,which was composed of Span 40(200 mg)and cholesterol(40 mg),had a size of 206.1 nm and a zeta potential of-36.5 mV.Adjusting the surfactant concentration resulted in a maximum drug entrapment efficiency of 88.89%.Statistical analysis confirmed that NS6 was the optimal formulation.Conclusion:This study demonstrates that niosomal suspensions are promising drug delivery systems with potential for use in treating type 2 diabetes.Niosomes facilitate the sustained release and enhanced solubility of drugs,rendering them convenient and effective tools for enhancing drug delivery to target sites.
